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I found this interesting description of sensitization... why after taking an Ad or other drug for a time we can't go back on the same dose.... 

from an interesting site 

http://www.mcsrr.org/PowerPt/why%20poe%20was%20right_files/frame.htm

it comes up in brief pages of which this is one 

 

But Edgar Allan Poe (1809-1849) 
first recognized the essence of sensitization

 

Poe changed from having a high tolerance for alcohol and 
partying in his college years to low tolerance later in life:

“My sensitive temperament could not stand an excitement 
which was an everyday matter to my companions. ... 
For some days after each excess I was invariably confined to bed.”                         EAP, letter to Dr. Joseph Snodgrass, 8/1/1841

Poe became hypersensitive not just to alcohol but to all types ofsensory stimuli (aka, Multi-Sensory Sensitivity):

““True!—nervous—very, very dreadfully nervous I had been and am;but why will you say that I am mad? The disease had sharpened mysenses—not destroyed, not dulled them. … Have I not told you thatwhat you mistake for madness is but overacuteness of the senses?” 

EAP, The Tell Tale Heart, 1843 uPoe changed from having a high tolerance for alcohol and 
partying in his college years to low tolerance later in life:

“My sensitive temperament could not stand an excitement 
which was an everyday matter to my companions. ... 
For some days after each excess I was invariably confined to bed.”                         EAP, letter to Dr. Joseph Snodgrass, 8/1/1841

Poe became hypersensitive not just to alcohol but to all types ofsensory stimuli (aka, Multi-Sensory Sensitivity):

““True!—nervous—very, very dreadfully nervous I had been and am;but why will you say that I am mad? The disease had sharpened mysenses—not destroyed, not dulled them. … Have I not told you thatwhat you mistake for madness is but overacuteness of the senses?” EAP, The Tell Tale Heart, 1843 

 

 
Edited by ChessieCat
reformatted text

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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©2006 Albert Donnay

 

Poe’s Most Explicit Description of Sensitizationis in Fall of the House of Usher (1839)

This was early wd for me...................“[Roderick Usher] suffered much sorry

from a morbid acuteness of the senses:s

insipid food was alone endurable;

he could wear only garments of certain texture;

the odors of all flowers were oppressive;

his eyes were tortured by even a faint light; and

there were but peculiar sounds, and these from stringed instruments, which did not inspire him with horror”

“[Roderick Usher] suffered much 
from a morbid acuteness of the senses:

insipid food was alone endurable;

he could wear only garments of certain texture;

the odors of all flowers were oppressive;

his eyes were tortured by even a faint light; and

there were but peculiar sounds, and these from stringed instruments, which did not inspire him with horror”

 

Edited by ChessieCat
reformatted text

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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Paracelsus’ Dose Response paradigm fails to account for 
exposure history and the potential for both:

a) asymptomatic habituation to high levels of exposure from chronic or frequently repeated exposures; and

hyper symptomatic sensitization to very low levels of exposure following extended withdrawal from such habituation

Individual dose response curves shift and change shape over timedepending on both recent and long-term exposure history.

Animal and human studies that do not control for their subjects’ prior exposure history may be undermined by these differences.   

Occupational and public exposure limits based on the experience of highly exposed (habituated) populations are not protective of 
de-habituated and sensitized populations 

 

Edited by ChessieCat
reformatted text

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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Any animal may have a positive, negative or neutral non-response to any given dose of any toxin at any time depending on the habituating vs. sensitizing nature of the magnitude, frequency, duration and route of all their prior exposures

 

These parameters are studied in exposure assessment models but not integrated into exposure standards basedon dose response models that focus on time weighted averages or total cumulative doses.  

 

Toxicological studies need to assess different exposure patterns: naïve (no prior exposure), habituated (aka addiction), and sensitized (post addiction).

 

Edited by ChessieCat
reformatted text

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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so far I don't believe this part about being able to party again if you were to just practise more ... think a beer would kill me

 

Poe was right: sensitization is not madness!  

you can’t party like you used to because 
you no longer party as frequently as you used to, 
which has caused you to lose your tolerance 
for all the sensory stressors involved.  

Good News!  You may be able to party hard again 
but only if you resume partying hard again on a regular basis…  

OR

You could start smoking regularly, which will greatly increase your CO level and thus also your tolerance for the much lowe rlevels of CO produced endogenously by HO-1, the universal stress enzyme, in response to all kinds of sensory stressors.

 

Edited by ChessieCat
reformatted text

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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Share on other sites

 
 
 
 
 
 
HO-CO controls sensitization and habituation to stressors of all kinds.
uChronic repeated exposures to any stressor induces habituation, 
so that higher doses are tolerated with less or no sensory awareness.
uIsolated acute exposures (and de-habituation, as in ex-smokers)induce sensitization, so that lower doses are less tolerated with moresensory awareness.
uWhile exogenous stressors (heat, drugs, alcohol) may be avoided,endogenous CO produced by HO in response to ANY stressor cannot.
uSo if/once sensitized to CO via exogenous poisoning or dehabituation,increased sensory awareness may be provoked by ANY stressor.
uResult is multi-sensory sensitivity to odors, lights, sounds, foods, etcaka MUSES Syndrome (aka MCS in adults or Autism in children

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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