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Eby, 2006 Rapid recovery from major depression using magnesium treatment


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Rapid recovery from major depression

using magnesium treatment


George A. Eby *, Karen L. Eby

George Eby Research, 14909-C Fitzhugh Road, Austin, TX 78736, United States

Received 18 January 2006; accepted 20 January 2006


Summary Major depression is a mood disorder characterized by a sense of inadequacy, despondency, decreased

activity, pessimism, anhedonia and sadness where these symptoms severely disrupt and adversely affect the person’s

life, sometimes to such an extent that suicide is attempted or results. Antidepressant drugs are not always effective and

some have been accused of causing an increased number of suicides particularly in young people. Magnesium deficiency

is well known to produce neuropathologies. Only 16% of the magnesium found in whole wheat remains in refined flour,

and magnesium has been removed from most drinking water supplies, setting a stage for human magnesium deficiency.

Magnesium ions regulate calcium ion flow in neuronal calcium channels, helping to regulate neuronal nitric oxide

production. In magnesium deficiency, neuronal requirements for magnesium may not be met, causing neuronal damage

which could manifest as depression. Magnesium treatment is hypothesized to be effective in treating major depression

resulting from intraneuronal magnesium deficits. These magnesium ion neuronal deficits may be induced by stress

hormones, excessive dietary calcium as well as dietary deficiencies of magnesium. Case histories are presented showing

rapid recovery (less than 7 days) from major depression using 125–300 mg of magnesium (as glycinate and taurinate)

with each meal and at bedtime. Magnesium was found usually effective for treatment of depression in general use.

Related and accompanying mental illnesses in these case histories including traumatic brain injury, headache, suicidal

ideation, anxiety, irritability, insomnia, postpartum depression, cocaine, alcohol and tobacco abuse, hypersensitivity to

calcium, short-term memory loss and IQ loss were also benefited. Dietary deficiencies of magnesium, coupled with

excess calcium and stress may cause many cases of other related symptoms including agitation, anxiety, irritability,

confusion, asthenia, sleeplessness, headache, delirium, hallucinations and hyperexcitability, with each of these having

been previously documented. The possibility that magnesium deficiency is the cause of most major depression and

related mental health problems including IQ loss and addiction is enormously important to public health and is

recommended for immediate further study. Fortifying refined grain and drinking water with biologically available

magnesium to pre-twentieth century levels is recommended.

c 2006 Elsevier Ltd. All rights reserved.


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I came off Seroxat in August 2005 after a 4 month taper. I was initially prescibed a benzo for several months and then Prozac for 5 years and after that, Seroxat for 3 years and 9 months.


"It's like in the great stories Mr.Frodo, the ones that really mattered. Full of darkness and danger they were, and sometimes you didn't want to know the end because how could the end be happy? How could the world go back to the way it was when so much bad had happened? But in the end it's only a passing thing this shadow, even darkness must pass. A new day will come, and when the sun shines it'll shine out the clearer."  Samwise Gamgee, Lord of the Rings, The Two Towers

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The article was written in 2006. Wonder if there has been further study? It does seem too good to be true.



Charter Member 2011

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There are some of us who get worse with magnesium. I'm one of them, even though it did seem to help me sleep better when I first began taking it.

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Whenever you run into a problem with a supplement, reduce or discontinue taking it.


Paradoxical reactions can also happen. The alerting system wants you to stay on high alert. Anything that's too calming can cause a paradoxical reaction.


So you may want to settle for just taking the edge off a symptom, and not taking too much of anything.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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