Jump to content

Bartleby: Almost there....then this


Recommended Posts

I joined the site several months ago thinking i would find useful information to complete my taper. Now, after tapering from 20 to 2 Mg. Lexapro (known as Cipralex here in Canada), in about one year, i find myself back to where i started with serious depression. I am 69 years old and have been taking Lexapro for 20+ years. In 2015 i came to the conclusion that the Lexapro was having a counterproductive effect and after becoming acquainted with Dr. Breggin's work decided to begin tapering. To assist in the taper, i was prescribed 20-25 Mg. Dexedrine. I found that to be very helpful but planned to taper that after i was safely off the Lexapro.


About 6 weeks ago i incurred a traffic accident in which i was struck by a car while riding my bicycle and breaking 7 ribs and a lot of soft tissue damage. I was given various morphine formulations as well as Tylenol 3 with codeine. For the first 4 weeks , despite the pain, i avoided going into depression. However during week five a became aware that the dexedrine was no longer having any effect. I am puzzled and frightened at having lost my mood lifter. I don't know why it has stopped working and wonder whether it will again be effective after my healing is complete in three to 4 months.


I would be very thankful if anyone can shed some light on my dilemma.


Thank you!

Link to comment

So sorry you have run in to difficulties. The pain medication you were taking may have contributed to your low mood particularly if you had been taking it regularly and then stopped it suddenly. Equally your traffic accident has no doubt caused you distress and you have probably suffered a degree of shock from it.

Just like you I am a long term ssri user although I have been on various types with Lexapro being the most recent about 5 years ago. I have tried a slow taper on three previous occasions and sadly run in to major problems. This most recent taper has been ongoing for the last 3.5 years. Even though you have taken a year out, to go from 20mgs down to 2mgs may still have been a little too fast (we cannot underestimate the power of this crap).

I have at times increased my dose by the smallest amount possible when things have got tough just to get me through, hold a while longer and then slowly reduce again- may be this is something for you to consider. many people on here trying to get off Lexapro have problems due to it's potency. Don't be discouraged though as you have clearly done very well. i found the lower the dose the more I noticed symptoms and had to adjust my reducing regime to manage it.

Your accident was significant and you need to recover from that too. Others will no doubt be along to give advice. 


Best wishes for a speedy recovery


PN x

1995-1998 various SSRIs then withdrawal

2000 Sertraline

2003 Sertraline then changed to Prozac to attempt withdrawal.

2004 failed at withdrawal so Citalopram.

2010 attempted slow withdrawal over 12 months but failed- sever episode depression 2012

2012 3 days of Mirtazepine with bad reaction so started escitalopram 20mgs

2013 started very very slow taper with a number of slight reinstatements

Currently on between 0.5 and 1mg escitalopram drops at day.

Link to comment

Welcome Bartleby

Sorry to read of your traffic accident ...7 ribs, ouch!! Dont  worry i wont crack any jokes. I cracked a rib once playing squash the other player ran into me, i prefer racquet sports with nets where the oposition keeps well away actually, anyway i can only imagine what 7 cracked ribs  must be like.


That one year taper was far too fast. I know that is hard to accept but its a fact and the difficulty getting off these drugs has been hidden by pharma.

Are you currently taking 2 mg or did you jump off at 2 mg ?

Are you able to complete a drug signature with drugs, doses and dates of changes.


Here are a few of moderator chessies favourite threads and i like them too:


Why taper by 10% of my dosage?


What is withdrawal syndrome? 


The Windows and Waves Pattern of Stabilization



You say

i find myself back to where i started with serious depression.


What you are calling depression is most likely withdrawal symptoms from the too fast taper off of lexapro. You may well have needed to put aside something like 2-3 years to taper off.


Taking more drugs is not the way out of this.

Have you read the book by Breggin Your drug may be your problem.

Im sure Breggin would not be calling these drugs 'mood lifters' Im sure he would refer to them as brain disablers.

Thought for the day: Lets stand up, and let’s speak out , together. G Olsen

We have until the 14th. Feb 2018. 

URGENT REQUEST Please consider submitting  for the petition on Prescribed Drug Dependence and Withdrawal currently awaiting its third consideration at the Scottish Parliament. You don't even have to be from Scotland. By clicking on the link below you can read some of the previous submissions but be warned many of them are quite harrowing.


Please tell them about your problems taking and withdrawing from antidepressants and/or benzos.

Send by email to petitions@parliament.scot and quote PE01651 in the subject heading. Keep to a maximum of 3 sides of A4 and you can't name for legal reasons any doctor you have consulted. Tell them if you wish to remain anonymous. We need the numbers to help convince the committee members we are not isolated cases. You have until mid February. Thank you

Recovering paxil addict

None of the published articles shed light on what ssri's ... actually do or what their hazards might be. Healy 2013. 

This is so true, with anything you get on these drugs, dependance, tapering, withdrawal symptoms, side effects, just silent. And if there is something mentioned then their is a serious disconnect between what is said and reality! 

  "Every time I read of a multi-person shooting, I always presume that person had just started a SSRI or had just stopped."  Dr Mosher. Me too! 

Over two decades later, the number of antidepressant prescriptions a year is slightly more than the number of people in the Western world. Most (nine out of 10) prescriptions are for patients who faced difficulties on stopping, equating to about a tenth of the population. These patients are often advised to continue treatment because their difficulties indicate they need ongoing treatment, just as a person with diabetes needs insulin. Healy 2015

I believe the ssri era will soon stand as one of the most shameful in the history of medicine. Healy 2015

Let people help people ... in a natural, kind, non-addictive (and non-big pharma) way. J Broadley 2017



Link to comment

you were likely able to do a faster wd because of the upper... same old drugs they called uppers in the old days


Stopping Dexedrine - Google Groups

Mar 26, 1999 - If you are going off this "cold turkey" you are SUFFERNG. I beleiveDexedrine withdrawal is one of the worst. Its best to titrate off these drugs, ...


Pain drugs mess with everything... if you take uppers and pain pills I am sure that would have a different effect than each alone.  


From what I hear in Canada the hosp have a program they can punch a bunch of drugs into and see what the effects would be it is only available in hospitals here in Ontario it may be the same where you live is your doctor has hosp privileges he may do this for you. 


If your off the pain pills and still on the upper it maybe the upper will still have the same effect after the wd from the pain pills end. I can't be sure it is just a thought. 

Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 


There is a crack in everything ..That's how the light gets in :)

Link to comment
  • Administrator

Welcome, Bartleby.
Are you taking 2mg Cipralex and 20-25 Mg. Dexedrine?


To help us out, see these instructions Please put your drug and withdrawal history in your signature


It is possible your recent drug intake changed the way your body responds to the drugs. It is also possible this has caused tolerance to dexedrine, a truly addictive drug.


Substituting dexedrine for Cipralex was not a very good idea on your doctor's part. The advantage of the SSRIs supposedly is that they are not addictive like the older drugs such as dexedrine, which is an old-fashioned amphetamine known as "speed."


In addition, taking a drug in anticipation of a return of depression doesn't make any sense. Over time, your nervous system changes, it's very possible you would have found going off Cipralex would not have brought a return of your original depression (though it might have caused withdrawal symptoms).


So, you are stuck on dexedrine. We can't help you with the tolerance issue, it would require increasing the dosage. I suggest you speak to another doctor about your dependency on dexedrine and what you should do about it. This might involve going to a drug rehabilitation clinic.


As for the Cipralex, if you haven't had any withdrawal symptoms so far, I would not worry about further reducing it gradually to zero. The dexedrine is a much more serious problem.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Link to comment

Bartleby...were you given any antibiotics during your treatment for your recent injuries?


Revisiting my own expjerience, I realize that the two major depressive episodes I have experienced followed close on courses of AB treatment.

One course was treatment for a UTI and the second following surgery. There's a dawning conviction that inflammation is a factor in depression and AB's murder your gut microbes (and we NEED most of those guys) and cause 'leaky gut' and inflammation.


Try adding fiber to your diet and taking a good probiotic. Worked for me, although it took a couple of weeks.

June 2016: Diagnosed with first-ever depression at age 80 and hospitalised for seven days

Discharged (well...discharged self actually) with meds. 30mg Mirtazipene 50mg Serequol.

Mirtazipene dose raised to 45mg late August.

GP raised it again to 60mg less than a week later.

Had major surgery (shoulder replacement) September 21 and subsequently depression worse than ever.

Case worker added Effexor late September but I couldn't take the stuff...turned me into a log of wood and completely deadened any emotion. Took only two doses and quit. No way was I going to make myself feel like that. Basket case!

Case worker wanted to raise Mirtazipene to 75 but I didn't take the increased dose. Decided instead to taper off the lot.

Reduced Mirtazipene by 7.5 to 52.8 Nov. 8th and another 7.5 (to 45) Nov. 19th.

Reduced Serequol by 12.5 (To 35.5) Nov. 12.

So far so good...but on advice from scallywag will now reduce one med at a time and at four week intervals.

Serequol first...research suggest that Serequol is the nastiest.

Link to comment

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
  • Create New...

Important Information

Terms of Use Privacy Policy