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Giving Up Hope -- to go back on the drug


Shanti
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Sometimes I wonder, if someone is at the point that they can't take it, if they should just go back on the meds. Some of us manage because we have children to anchor us. But some of us don't, and some suffer worse symptoms.

 

If a person decides to go back on, maybe it's for the best. Maybe sometime in the future will be a better time. Like they'll have more strength, or maybe new remedies will come out to make it easier.

 

I have a friend that chose to go back on because she couldn't take it. I totally supported her and said I didn't blame her. I just let her know that if ever she decides to try again to let me know and I'll help her with remedies and support. I think it's encouraging her to see how I'm managing.

Taper from Cymbalta, Paxil, Prozac & Antipsychotics finished June 2012.

Xanax 5% Taper - (8/12 - .5 mg) - (9/12 - .45) - (10/12 - .43) - (11/12 - .41) - (12/12 - .38)

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Shanti,

let us know how she does. I never realized any noticeable benefit from ADs, just kept trying different ones, upping dosed, adding on for years. I think I got much worse thru it all. of course, just the emotional factors of disability being disabling, unemployment, all have effects. I think my life would have continued to become less grounded as I continued in AD fog, but everyone is different. I know people who go on Prozac very intermittently and say they are helped. PMDD perhaps.

Barb

Pristiq tapered over 8 months ending Spring 2011 after 18 years of polydrugging that began w/Zoloft for fatigue/general malaise (not mood). CURRENT: 1mg Klonopin qhs (SSRI bruxism), 75mg trazodone qhs, various hormonesLitigation for 11 years for Work-related injury, settled 2004. Involuntary medical retirement in 2001 (age 39). 2012 - brain MRI showing diffuse, chronic cerebrovascular damage/demyelination possibly vasculitis/cerebritis. Dx w/autoimmune polyendocrine failure.<p>2013 - Dx w/CNS Sjogren's Lupus (FANA antibodies first appeared in 1997 but missed by doc).

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If the person made the decision being fully informed without pressure from medical professionals and loved ones, then I would totally support them 100%.

 

To be honest, if I thought the risk/benefit issue was in my favor regarding meds, I would have considered going back on them. But they were pooping out on me and causing horrific side effects. I had to get off of them come heck or high water.

 

CS

Drug cocktail 1995 - 2010
Started taper of Adderall, Wellbutrin XL, Remeron, and Doxepin in 2006
Finished taper on June 10, 2010

Temazepam on a PRN basis approximately twice a month - 2014 to 2016

Beginning in 2017 - Consumption increased to about two times per week

April 2017 - Increased to taking it full time for insomnia

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I don't blame your friend either, Shanti. I say this after being off Lexapro and suffering a lot daily now as a result. I find myself thinking "I wish I was still on the Lexapro, at least I felt somewhat content".

 

You might want to ask your friend if she's had any adverse effects from going back on - akathesia can sometimes happen when you re-instate the drug after coming off it for a while. It's that which scares me from ever trying Lexapro again.

Off Lexapro since 3rd November 2011.

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I too, had no choice. I pooped-out on Paxil after only 5 months. I didn't tell her this, because she was already scared to death. I thought it best to just be there for her if and when that time does come.

Taper from Cymbalta, Paxil, Prozac & Antipsychotics finished June 2012.

Xanax 5% Taper - (8/12 - .5 mg) - (9/12 - .45) - (10/12 - .43) - (11/12 - .41) - (12/12 - .38)

My Paxil Website

My Intro

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Shanti,

Has your friend had a thorough endocrine workup? I just read an article about SSRIs effecting thyroid function. Another potential reason for the poop-out. I will upload article when on a real computer. I would encourage her (anyone!) to do that and not be on ADs long term. There are too many unknown risks--exacerbating depression, causing diabetes, possible effects of fertility.

 

There are many drugs --legal and illegal, FDA blessed and not -- that effect mood both positively and negatively. At one point, my psychiatrist said he thought it was ok to take opiates for depression occasionally. I believe it was when I was getting worse on ADs and had tried everything indicated or used for depression. Opiates definitely help my mood. Of course, they are 'addictive' although I never displayed addictive behaviors of escalating dosage, drug seeking, etc. That leads me to think that the mechanism of addiction/ tolerance/WD may differ for each individual and each drug and why some people can DC ADs w no problems and same for pain meds. I DC'd oxycodone after several years (of daily low dose use) in about 2 weeks w/o problem. I'm not suggesting that opiates be used as antidepressants across the board, but it forces me to look at the history of drug development and individual variations in response to diff drugs. There was a blog post a few moths ago about a compound that did not get FDA approval as AD because it worked too quickly and may cause addiction. WTF?! There is such a fear of abuse that effective treatments are being denied! SSRIs were originally thought to be a safe alternative to benzos in their calming effects and to exert their AD effect thru anxiolytic action (ie. blunting emotions) w/o the sedative effect of benzos. David Healy mentions this as do several others. For the most part, the ADs we are DCing are not activating aside drom Prozac/paroxetine and that MAY be b/c it is LESS selective for serotonin (or one of the many 5HT subtypes which theoretically have diff effects). That's getting into the bogus balancing act.

In reading the history of treatments for depression, many previous 'antidepressants' are now known to be addictive and so not used. Is SS/NRIs DC syndrome LESS of a problem than opiate dependence and detox?? I can only answer for myself-- an unequivocal NO!! SNRI WD is far worse and other risks are yet to be determined.

Among other agents used as antidepressants over the years: marijuana, amphetamines/stimulants (still used in some cases, esp elderly ill), benzos, estrogen, thyroid (3, 4 or both), of course, TCAs and MAOIs. Im sure there are many others.

Identifying the underlying cause (endocrine very likely) is something still overlooked. I think that should direct treatment. My depression was once described as a 'vegetative depression' w lack of energy being the hallmark. I understand many of you had an anxious depression which did respond to serotonergic agents b/c they are generally calming and not activating. I needed something activating and understand now why my condition worsened (and likely accelerated endocrine/autoimmune probs).

There is a program on The History Channel about psychotropic drug development and use through the ages. Very much along the lines of what we discuss here. I just happened to catch it yesterday. Has anyone seen it?

 

Sorry to get philosophical on ya, Shanti! I believe that 'what is an antidepressant?' is a question with many different answers (not all pharmacologic). Your 1st point that your friend does not have a child or something else to help ground her is a HUGE issue far more prevalent than most people imagine. A 'support system', IMHO, includes not only the obvious ones who GIVE support but also those who who need or rely on someone. Hope that makes sense. Topic for another thread!

Pristiq tapered over 8 months ending Spring 2011 after 18 years of polydrugging that began w/Zoloft for fatigue/general malaise (not mood). CURRENT: 1mg Klonopin qhs (SSRI bruxism), 75mg trazodone qhs, various hormonesLitigation for 11 years for Work-related injury, settled 2004. Involuntary medical retirement in 2001 (age 39). 2012 - brain MRI showing diffuse, chronic cerebrovascular damage/demyelination possibly vasculitis/cerebritis. Dx w/autoimmune polyendocrine failure.<p>2013 - Dx w/CNS Sjogren's Lupus (FANA antibodies first appeared in 1997 but missed by doc).

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Hi Barb. I never have trouble with Vicodin either. I've gone off and on it several times with no withdrawal. But it does get to where it doesn't work and you have to up the dose. That's the only trouble for me. I was thinking of getting California Poppy herb to try for anti-depressant. It's a sub-opiate.

 

I would love to see the article you're talking about.

Taper from Cymbalta, Paxil, Prozac & Antipsychotics finished June 2012.

Xanax 5% Taper - (8/12 - .5 mg) - (9/12 - .45) - (10/12 - .43) - (11/12 - .41) - (12/12 - .38)

My Paxil Website

My Intro

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When people do come to poop-out, they can switch to other antidepressants. Some people don't poop-out for many years. I'm talking here about people that are ready to give up and suicide. This is a much better option.

Taper from Cymbalta, Paxil, Prozac & Antipsychotics finished June 2012.

Xanax 5% Taper - (8/12 - .5 mg) - (9/12 - .45) - (10/12 - .43) - (11/12 - .41) - (12/12 - .38)

My Paxil Website

My Intro

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Yes, of course. im negatively biased b/c I never noticed anything positive w SS/NRIs. I have one friend who responded well to Zoloft w/I a week and that sticks in my mind as the only person I know who responded. I also know someone who takes Prozac occasionally short term. I meant no judgment! I think out loud too much sometimes. Absolutely, in a case like that, whatever helps that particular person. There is a med that works almost immediately that I've heard discussed for emergency situations. (ketamine, perhaps?) There are so many diff factors involved for diff people. I have to remember that some people do respond to SSRIs.

How is your friend doing? Did she respond well? I hope she's doing well, Shanti.

Pristiq tapered over 8 months ending Spring 2011 after 18 years of polydrugging that began w/Zoloft for fatigue/general malaise (not mood). CURRENT: 1mg Klonopin qhs (SSRI bruxism), 75mg trazodone qhs, various hormonesLitigation for 11 years for Work-related injury, settled 2004. Involuntary medical retirement in 2001 (age 39). 2012 - brain MRI showing diffuse, chronic cerebrovascular damage/demyelination possibly vasculitis/cerebritis. Dx w/autoimmune polyendocrine failure.<p>2013 - Dx w/CNS Sjogren's Lupus (FANA antibodies first appeared in 1997 but missed by doc).

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in my case, I suspect I had an underlying thyroid disorder for long time, in which case ADs wont work.

Pristiq tapered over 8 months ending Spring 2011 after 18 years of polydrugging that began w/Zoloft for fatigue/general malaise (not mood). CURRENT: 1mg Klonopin qhs (SSRI bruxism), 75mg trazodone qhs, various hormonesLitigation for 11 years for Work-related injury, settled 2004. Involuntary medical retirement in 2001 (age 39). 2012 - brain MRI showing diffuse, chronic cerebrovascular damage/demyelination possibly vasculitis/cerebritis. Dx w/autoimmune polyendocrine failure.<p>2013 - Dx w/CNS Sjogren's Lupus (FANA antibodies first appeared in 1997 but missed by doc).

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Yeah, and I already had a central nervous system disorder, so I pooped out at 5 months and other medications didn't work.

Taper from Cymbalta, Paxil, Prozac & Antipsychotics finished June 2012.

Xanax 5% Taper - (8/12 - .5 mg) - (9/12 - .45) - (10/12 - .43) - (11/12 - .41) - (12/12 - .38)

My Paxil Website

My Intro

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My advise to anyone that decides to go back on the drugs, is to use the time that you're feeling back to "normal" to build up your spirit. No matter your faith, get strong in spirit to ready yourself for when the time comes to try again. Lot's of prayer and song. It's a good time to look up more information on spiritual tools and practices, and envelop yourself in them. Such as prayer, meditation, yoga, decrees, mantras, and chanting, etc. You can also take all the vitamin supplements for the brain and nervous system, fish oil, flaxseed oil, magnesium and calcium.

Taper from Cymbalta, Paxil, Prozac & Antipsychotics finished June 2012.

Xanax 5% Taper - (8/12 - .5 mg) - (9/12 - .45) - (10/12 - .43) - (11/12 - .41) - (12/12 - .38)

My Paxil Website

My Intro

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