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https://blog.23andme.com/23andme-research/new-genetic-findings-on-depression/

 

onathan Flint, a geneticist at the University of Oxford and a key researcher in the PGC study, concluded that he either needed more data from more individuals to find a signal or a more select group of individuals to study, according to an article in the journal Nature. Flint took the latter strategy studying data from about 10,000 individuals in China, a cohort that was relatively homogenous and had the most severe depression. Last year he and other researchers published their findings, uncovering two variants associated with the condition among people of Han Chinese ancestry, but  those variants do not appear to influence the condition in people of European descent.

Another approach would be to find a much larger cohort of individuals and that’s what this latest study has done by tapping into 23andMe’s data from customers. The study includes more than 450,000 customers, who consented to participate in research, about 120,000 of whom reported being diagnosed with depression.

By using 23andMe’s online method and collecting data from a very large group of individuals, the researchers were able to gather enough data to power their study. The sheer volume of data — the number of people, the amount of both phenotypic and genotypic data — allowed the scientists to see signals that they may not have seen otherwise.

The variant most strongly associated with depression was found in a gene region involved with brain function.

The most statistically significant variant is located between two genes that are expressed in the brain, MEF2C and TMEM161B. MEF2C is involved in the regulation of synapses and studies have associated variants in this gene with epilepsy and intellectual disability.

The remainder of the single nucleotide polymorphisms found to reach genome-wide significance for association with depression were in 13 other genes or gene regions. Many of these are expressed in the central nervous system for neurodevelopment or have been identified in other genome-wide association studies to be related to different psychiatric traits.

All of these variants are different than the two variants associated with depression in people of Han Chinese ancestry, but the variants found in both studies may help in the ongoing effort to understand the underlying biology of depression.

Researchers hope these new findings will offer a better understanding of the biology of the disease and could help in the search for the right treatments for depression.

This study can be found in the journal Nature Genetics.

Read more at https://blog.23andme.com/23andme-research/new-genetic-findings-on-depression/#5RP9JLzK9ar0qMR3.99

 

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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https://www.snpedia.com/index.php/Depression

Depression
 

 

For a fine introduction to clinical depression, see Wikipedia's entry. Note that there are distinct types of depression, and studies of genetic influences typically focus on one type.

SNPs may play a role in predisposing an individual to depression and also in how patients respond to anti-depressant medications.

SNPs potentially predisposing individuals to depression include (in no particular order):

SNPs potentially influencing how patients respond to anti-depressant medications include:

http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3623.html Identification of 15 genetic loci associated with risk of major depression in individuals of European descent via data in excel

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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