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Targum, 2014 Identification and treatment of antidepressant tachyphylaxis.


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Innov Clin Neurosci. 2014 Mar;11(3-4):24-8.
Identification and treatment of antidepressant tachyphylaxis.
Targum SD1.

Abstract at https://www.ncbi.nlm.nih.gov/pubmed/24800130 Free full text at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008298/

Antidepressant tachyphylaxis describes a condition in which a depressed patient loses a previously effective antidepressant treatment response despite staying on the same drug and dosage for maintenance treatment. It has been suggested that antidepressant tachyphylaxis is a form of relapse related to evolving drug tolerance, but it is also clear that there are other possible reasons for the loss of treatment response unrelated to tolerance, such as medication nonadherence. It has been reported that depressed patients with "true" antidepressant tachyphylaxis may be less responsive to new treatment interventions. Therefore, it is important to identify these patients as part of a comprehensive treatment planning process.

KEYWORDS:
Antidepressant; antidepressant tachyphylaxis; antidepressant tolerance; breakthrough depression; drug tolerance; major depressive disorder

 

Note: The author works for a pharmaceutical consulting firm

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