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Antichoninergic Activity of SSRI meds


music321
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Acetylcholine is a neurotransmitter.  In my brief searches, it seems that Paroxetine (Paxil) markedly decreases the activity of acetylcholine, while Fluoxetine (Proxac) does so to a lesser extent. Drugs that decrease the effects of acetylcholine are known as "anticholinergics".  If you do a search, so long as net neutrality rules are still in effect and Pharma companies can't pay to have negative search results hidden, you will find relevant info.  Long-term use of anticholinergics have been linked to too many side effects to list here, as well as cognitive decline and dementia later in life.  

 

I thought everyone should be warned of this.

various SSRI for years

 

20 mg Lyrica 2010

30 mg to 0 mg Prozac 2012

Reinstate 20 mg Prozac 2012

Drop to 19 mg Prozac 2013

Reinstate 20 mg Prozac 1 month later (2013)

Gradual decrease of Prozac dosage starting in late summer of 2015, currently at 11.2 mg/day

 

use of vitamin D3, fish oil, and magnesium at various times

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Hey music321, Yeah, I read about this, too. I guess it's why long-term use of paroxetine makes some people forgetful and less sharp. I've experimented with citicoline (Cognizin) and Huperzine A, both acetylcholine-boosters, and they do help to make me feel less sluggish in my head. 

Paxil/Seroxat/paroxetine 10 mg for over 20 years

Several failed attempts at quitting

Slow tapering since June 2016 using liquid paroxetine

Presently stabilising at 0,15 ml (0,3 mg) because of the worst withdrawal so far

June 2017: tried tapering further to 0,1 ml (0,2 mg) but that backfired badly. Stabilising again at 0,15 ml.

July 15, 2017: down to 0

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This is a list of medications with anticholinergic activity:

 

http://www.agingbraincare.org/uploads/products/ACB_scale_-_legal_size.pdf

various SSRI for years

 

20 mg Lyrica 2010

30 mg to 0 mg Prozac 2012

Reinstate 20 mg Prozac 2012

Drop to 19 mg Prozac 2013

Reinstate 20 mg Prozac 1 month later (2013)

Gradual decrease of Prozac dosage starting in late summer of 2015, currently at 11.2 mg/day

 

use of vitamin D3, fish oil, and magnesium at various times

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