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AntidepressantsFacts.com


Barbarannamated
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Posting link to CG.'s site AntidepressantFacts. There is an overwhelming amount of info and links to studies and case reports here, although new material slowed in the early 2000s (a trend I've noticed in most medical literature).

The term 'epileptiform' behavior is used to describe the brain zaps. I had not heard that before. Is anyone else familiar wih that characterization or explanation?

http://www.antidepressantsfacts.com/addiction-withdrawal.htm

Edited by Altostrata
name changed by request

Pristiq tapered over 8 months ending Spring 2011 after 18 years of polydrugging that began w/Zoloft for fatigue/general malaise (not mood). CURRENT: 1mg Klonopin qhs (SSRI bruxism), 75mg trazodone qhs, various hormonesLitigation for 11 years for Work-related injury, settled 2004. Involuntary medical retirement in 2001 (age 39). 2012 - brain MRI showing diffuse, chronic cerebrovascular damage/demyelination possibly vasculitis/cerebritis. Dx w/autoimmune polyendocrine failure.<p>2013 - Dx w/CNS Sjogren's Lupus (FANA antibodies first appeared in 1997 but missed by doc).

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This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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I've looked at his site. He recommends a low protein diet high in raw veggies if I recall. He's very specific even. Has anyone tried this diet with success? Or does anyone know the basis for his recommendation? Is that simply what he ate? My main issue is trying to eat the way my nerves want. I can only guess at this. While my symptoms are improving, it's a slog. Like 4 up, 3 down. So I'm going sideways more than anything. It seems most of my symptoms come from what I consume. So nourishing myself is now experimenting on myself. I have no good guide. My PSSD has improved a lil of late, but I'm having other problems namely loss of feeling, pain, etc in the extremities which worsen when stressed. Arrgggg I'm curious why C makes such specific dietary recommendations. Alex

"Well my ship's been split to splinters and it's sinking fast
I'm drowning in the poison, got no future, got no past
But my heart is not weary, it's light and it's free
I've got nothing but affection for all those who sailed with me.

Everybody's moving, if they ain't already there
Everybody's got to move somewhere
Stick with me baby, stick with me anyhow
Things should start to get interesting right about now."

- Zimmerman

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It's one of the many mysteries on his site. I suspect it's something that worked for him.

 

He's on Facebook, you might be able to ask him.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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  • 1 month later...

I agree ~relate to very much on the Pineal Gland -Depression connection

Pristiq tapered over 8 months ending Spring 2011 after 18 years of polydrugging that began w/Zoloft for fatigue/general malaise (not mood). CURRENT: 1mg Klonopin qhs (SSRI bruxism), 75mg trazodone qhs, various hormonesLitigation for 11 years for Work-related injury, settled 2004. Involuntary medical retirement in 2001 (age 39). 2012 - brain MRI showing diffuse, chronic cerebrovascular damage/demyelination possibly vasculitis/cerebritis. Dx w/autoimmune polyendocrine failure.<p>2013 - Dx w/CNS Sjogren's Lupus (FANA antibodies first appeared in 1997 but missed by doc).

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Yes, there's some good stuff in this article. I wish it were written in a way that's less sensationalistic and a little more professional looking with citations.

 

One of the things mentioned that I think bears repeating is that there has never been any proof or scientific evidence that depression and serotonin are actually related in any way--in people who have never taken SSRIs. The serotonin levels and activity in never-medicated depressed people appears to be no different from nondepressed people.

 

Once you have taken SSRIs though and screwed up your neurotransmitters, you are then more prone to depressive episodes. But as the article mentions, those drugs act on many neurotransmitter and hormonal systems in the body, so it's hard to say exactly what's happening. I personally think glutamate is heavily implicated.

Started on Prozac and Xanax in 1992 for PTSD after an assault. One drug led to more, the usual story. Got sicker and sicker, but believed I needed the drugs for my "underlying disease". Long story...lost everything. Life savings, home, physical and mental health, relationships, friendships, ability to work, everything. Amitryptiline, Prozac, bupropion, buspirone, flurazepam, diazepam, alprazolam, Paxil, citalopram, lamotrigine, gabapentin...probably more I've forgotten. 

Started multidrug taper in Feb 2010.  Doing a very slow microtaper, down to low doses now and feeling SO much better, getting my old personality and my brain back! Able to work full time, have a full social life, and cope with stress better than ever. Not perfect, but much better. After 23 lost years. Big Pharma has a lot to answer for. And "medicine for profit" is just not a great idea.

 

Feb 15 2010:  300 mg Neurontin  200 Lamictal   10 Celexa      0.65 Xanax   and 5 mg Ambien 

Feb 10 2014:   62 Lamictal    1.1 Celexa         0.135 Xanax    1.8 Valium

Feb 10 2015:   50 Lamictal      0.875 Celexa    0.11 Xanax      1.5 Valium

Feb 15 2016:   47.5 Lamictal   0.75 Celexa      0.0875 Xanax    1.42 Valium    

2/12/20             12                       0.045               0.007                   1 

May 2021            7                       0.01                  0.0037                   1

 

I'm not a doctor. Any advice I give is just my civilian opinion.

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I merged soso's topic with the existing topic. C did a great job assembling the clues and publishing whatever he found. His theories are guesses based on his own symptoms. He hasn't updated the site in years. Take the information as a starting point for your own research. His theories may or may not be the scientific truth of withdrawal syndrome. (He's not a scientist or doctor, just an ordinary smart person.) More research needs to be done to verify them. Since the autonomic nervous system affects all the functions of the body, it's unlikely symptoms can be attributed to one gland or another. The functioning of all the organs is affected. Individual variations in biology account for symptoms seemingly located in one area or another.

Edited by Altostrata
name changed by request

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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  • 10 months later...

This is quite interesting -

 

http://www.antidepressantsfacts.com/taper.htm

17 years on seroxat/paxil CT off - thought I was dying luckily found this site. 21st May 2012 12mg seroxat

Stable - Tapered Diazepam slowish.1st June 10mg Seroxat

2nd June 1mg Diazepam.15th June 9mg seroxat

2nd July Changed to 2.5[ml liquid diazepam]2mg=5ml. 16th July 2ml Liquid Diazepam

2nd August 8mg/4ml Seroxat/Paxil 2nd August 1.5 ml Diazepam

18th Aug 2012 1ml Diazepam 1st - 5th Sept 0.5

Diazepam Free!

13th Oct 7mg/3.5ml seroxat - 26 Jan 2013 3.25ml/6.5mg-Mar 3ml-April 2.7ml-May 2.5ml

01/07/14 very slow taper over the last year now on 0.5 ml of liquid Seroxat ......November 14 Seroat Free!!!!!!!

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Thank you.

 

I am tapering off seroquel.

It has high affinity for the serotonin Type 2 (5HT2), according to this http://www.flexyx.com/S/Seroquel.html

pregan taper 600mg down to 240mg, daily cuts since xmas

valium, just over 75mg, tapering 0.1 a day, will keep this more udated, cos amounts going down

i have borderline personality, chronic ptsd, and suspected adhd and substance misuse as a symptom, which i am addressing with help of medical staff, drugs agencies & mh sta

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That is CG.'s site. C's is one of our success stories, see http://survivingantidepressants.org/index.php?/topic/1351-charly-g-recovered-from-prozac-withdrawal/

Edited by Altostrata
name changed by request

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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  • 3 years later...

I just came across this site independently and looked to see if it had already been posted before. This article has some interesting stuff about cortisol. 

 

"But why do I hear people talking about benefits from these SSRI-AntiDepressants?", you might want to ask in this stage. "They surely must work somehow don't they?" The answer is yes, they "work" somehow, but not in a very proper way. The mechanism of action on serotonergic neurons implies a lot of other neuro- endocrine responses. What actually happens when you increase serotonergic neuronal activity or elevate your serotonin levels is this: the stress hormones "Cortisol" & "Adrenaline" (Epinephrine) in the brain and body are triggered by increased serotonergic activity or elevated serotonin levels. It is a natural reaction from the body to combat the excessive serotonin levels. These released hormones, cortisol and adrenaline, are secreted from the "Adrenal Glands." They give the human personality a boost, producing a euphoric state, which can last for a prolonged period of time. In this manner SSRI-AntiDepressants initially produce the deceptive results the doctor and "patient" are both expecting. *

If a patient continues to ingest a particular SSRI-antidepressant over a prolonged period of time, eventually the bodies Adrenal Glands may lose their efficiency and "Adrenal Exhaustion Syndrome" will be the end result. Adrenal Exhaustion causes levels of adrenaline initially to fall and levels of cortisol to rise. Ultimately, also cortisol levels fall. When untreated, Adrenal Exhaustion will lead to seriously declining physical health. Many (former) SSRI-AntiDepressant users reported fatigue as a long term side-effect or were diagnosed with "Chronigue Fatigue Syndrome." People suffering from stress are generally diagnosed with this disorder. Symptoms range from simple exhaustion to much more complex problems that are secondary to excessive output of adrenal hormones in the bloodstream, leading to Adrenal Exhaustion. Unlike the other hormones, it takes a long time before the Adrenal Glands have their adrenaline levels restored. Could we say that the SSRI-AntiDepressant "works" by slowly excavating the body's Adrenal Glands?

 

 

 

There's also a part 2  and part 3 if you want to read in depth. 

2000: Use of venlafaxine for moderate depression for two years. Tapered off with no major problems. 

2010: Venlafaxine 5 years, doses between 75-150-300. Tolerated but only partially stabilised the severe depression & escallating side effects. 

Adverse reactions to citalopram (tried before venlafaxine), sertraline & mirtazapine (tried after venlafaxine became problematic) with suicidal ideation caused. 

2014: Adverse reaction to one prozac pill which I tried to begin taking in order to stabilise the withdrawal and actually made it horrendously worse. My body & brain went on fire two hours after taking the pill and severe WD began.

Spring 2014: CEASED ALL ANTIDEPRESSANTS. Did take occasional lorazepam (two weeks at first followed by the occasional half tablet at night sometimes.

2014: WD: living hell for five months, gradually improved a little by little for almost a year and a half but with frequent heart palpitations, weakness and anxiety and very poor sleep. Struggled to do things both physically & mentally but was improving slowly. 

2015: WD relapse with full symptoms. anxiety/panic triggered beyond initial anxiety resurgence by a couple of small half doses of Lorazepam that seem to have restarted all the WD symptoms I had in the beginning & ruined all the progress I had made. 

2017: Bad reaction to propranolol beta blockers. Nervous system kindled into violent shaking like withdrawal again. Alerting system on overdrive. 

 

Current Supplements: Omega 3 & Vitamin C, magnesium, potassium, pre/probiotics, brewer's yeast. 

 

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