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genetics ssri snri response


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rs2032583

 

 

Orientation minus
Stabilized minus
Geno Mag Summary
(C;C) 1.9 7x more likely to respond to certain antidepressants.
(C;T) 1.9 7x more likely to respond to certain antidepressants.
(T;T) 2 7x less likely to respond to certain antidepressants.
Reference GRCh38 38.1/142
Chromosome 7
Position 87531245
Gene ABCB1
is a snp
is mentioned by
dbSNP rs2032583
ClinGen rs2032583
ebi rs2032583
HLI rs2032583
Exac rs2032583
Varsome rs2032583
Map rs2032583
PheGenI rs2032583
hapmap rs2032583
1000 genomes rs2032583
hgdp rs2032583
ensembl rs2032583
gopubmed rs2032583
geneview rs2032583
scholar rs2032583
google rs2032583
pharmgkb rs2032583
gwascentral rs2032583
openSNP rs2032583
23andMe rs2032583
23andMe all rs2032583
SNP Nexus

SNPshot rs2032583
SNPdbe rs2032583
MSV3d rs2032583
GWAS Ctlg rs2032583
GMAF 0.1318
Max Magnitude 2
? (C;C) (C;T) (T;T) 28
chart?cht=bhs&chd=t:0.9,0.0,0.9,8.2,3.5,0.0,0.0,2.0,6.4,0.0,6.4,1.0,2.4416666666667|27.4,9.5,15.9,35.6,31.6,9.5,6.4,32.7,32.1,20.7,32.1,27.7,23.433333333333|71.7,90.5,83.2,56.2,64.9,90.5,93.6,65.3,61.5,79.3,61.5,71.3,74.125&chs=275x228&chbh=8,5&chxl=0:|1:|AVG|TSI|MKK|MEX|LWK|GIH|CHD|CHB|ASW|YRI|JPT|HCB|CEU||&chxt=x,y&chco=CD853F,30FF30,0000FF,FF00FF&chls=1,1,0|1,1,0|1,1,0|1,1,0
rs2032583 is a SNP in the ABCB1 gene (also known as the MDR1 gene), which encodes a protein that transports certain molecules across the blood-brain barrier. SNPs in ABCB1 may thus influence the intracerebral concentrations of certain drugs and thus their efficacy or potential for adverse side effects. rs2032583 is one of 9 SNPs found within a tight linkage block (r2 >= 0.8 ) such that the minor allele at any one of them predicts (with ~80%+ accuracy) that the other SNPs will also be the minor allele. The list of the 9 SNPs is shown below.

When treated for depression with substrates of the protein encoded by ABCB1, carriers of one or two minor alleles at these ABCB1 SNPs have been reported to respond better than non-carriers. The antidepressant drugs that are known to be substrates include citalopram, paroxetine, amitriptyline, and venlafaxine. The relative odds of better response for rs2032583(C) carriers is 7.72 (CI: 2.8-21.3, p=0.000065) based on a study of ~400 primarily Caucasian patients.10.1016/j.neuron.2007.11.017

The 9 SNPs in the linkage block identified are 10.1016/j.neuron.2007.11.017:

[PMID 19107781] rs10248420 and rs2032583 associated with colonic disease

Neighbor rs2032582
Distance 57
[PMID 15197162OA-icon.png] Identifying candidate causal variants responsible for altered activity of the ABCB1 multidrug resistance gene.


[PMID 18424454OA-icon.png] ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence.


[PMID 19844206OA-icon.png] Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans.


[PMID 21172166OA-icon.png] Pharmacogenetics of antidepressant response.


[PMID 21827404] The clinical impact of ABCB1 polymorphisms on the treatment of psychiatric diseases.


[PMID 21987299] Associations between variants in the ABCB1 (MDR1) gene and corticosteroid dependence in children with Crohn's disease.


[PMID 22641028] ABCB1 gene variants influence tolerance to selective serotonin reuptake inhibitors in a large sample of Dutch cases with major depressive disorder.

 

GET Evidence
rs2032583
aa_change  
aa_change_short  
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.14505
summary  

 

 

[PMID 22672924] Polymorphisms of the drug transporter gene ABCB1 predict side effects of treatment with cabergoline in patients with PRL adenomas


[PMID 23093106] Detection of frequent ABCB1 polymorphisms by high-resolution melting curve analysis and their effect on breast carcinoma prognosis

I am 7 x less likely to respond... 
according to 23 and me test results ran thru the Promethease program for a big five bucks. 
their report looks like this 
7x less likely to respond to certain antidepressants. This version of a blood brain barrier protein blocks many common antidepressants from entering the brain, including: amitriptyline (Elavil), citalopram (Celexa), paroxetine (Paxil), and venlafaxine (Effexor). That makes those antidepressants 7 times less effective.
rs2032583 is a SNP in the ABCB1 gene (also known as the MDR1 gene), which encodes a protein that transports certain molecules across the blood-brain barrier. SNPs in ABCB1 may thus influence the intracerebral concentrations of certain drugs and thus their efficacy or potential for adverse side effects. rs2032583 is one of 9 SNPs found within a tight linkage block (r<sup>2</sup> >= 0.8 ) such that the minor allele at any one of them predicts (with ~80%+ accuracy) that the other SNPs will also be the minor allele. The list of the 9 SNPs is shown below. When treated for depression with substrates of the protein encoded by ABCB1, carriers of one or two minor alleles at these ABCB1 SNPs have been reported to respond better than non-carriers. The antidepressant drugs that are know... 
 more info
they have a presellected list of drugs you can check. including specific antidepressants... with different causes of reaction or reasons they don't work or do work for you. 
peace

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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