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I have developed PGAD 8 times in my life while on a variety of antidepressants (Prozac, Zoloft, Pristiq, Lexapro, Seroquel, Lamotrigine, and most recently Amitryptiline). On Prozac it was severe and lasted 2 years. The other times it went away within days/weeks of stopping the drugs. I’ve currently had a mild case caused by Amytripline for 3 weeks now. I stopped the drug two weeks after starting it as soon as I felt the pgad begin. I am worried this time it won’t go away which is terrifying because there isn’t really a successful treatment for it. This is my fear every time I get it. My issue is that I have severe depression, anxiety and depersonalization disorder and feel I cannot get better without psych meds. Each time I try a new psych med it either gives me PGAD or doesn’t help my depression/anxiety. I am at a loss for what to do. I have an amazing life that I can’t enjoy and since I can’t seem to tolerate any drugs even a partial recovery seems hopeless. Any advice would be appreciated! Not sure what to do anymore. 

Edited by Shep
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  • Administrator

Hi, rnnstr91.


Welcome to SA.


We have a number of people dealing with PGAD, so you'll find helpful information and advice here. For more, please see:


Persistent genital arousal disorder (PGAD)


Some information on withdrawal symptoms:


What is withdrawal syndrome? 


The Windows and Waves Pattern of Stabilization


Healing from antidepressants. Patterns of recovery video (4 minutes)


Depending on your history, you may benefit from a small reinstatement, but we'll need more information first.


Please add a signature.  Include drugs, doses, dates, and discontinuations & reinstatements in the last 12-24 months. Also include supplements. This will help us give you the most accurate advice we can. 

  • Any drugs and supplements prior to 24 months ago can just be listed with start and stop years. 
  • Please use actual dates or approximate dates (mid-June, Late October) rather than relative time frames (last week, 3 months ago) 
  • Spell out months, e.g. "October" or "Oct."; 9/1/2016 can be interpreted as Jan. 9, 2016 or Sept. 1, 2016. 
  • Please leave out symptoms and diagnoses. 
  • A list is easier to understand than one or multiple paragraphs. 
  • This is a direct link to your signature:  Account Settings – Create or Edit a signature.


Please use this thread to document your symptoms and to ask questions. 

Drug free May 22, 2015 after 30 years of neuroleptics, benzos, z-drugs, so-called "anti"-depressants, and amphetamines 


My Success Story:  Shep's Success: "Leaving Plato's Cave"


And what is good, Phaedrus, and what is not good — need we ask anyone to tell us these things? ~ Zen and the Art of Motorcycle Maintenance

I am not a medical professional and this is not medical advice, but simply information based on my own experience, as well as other members who have survived these drugs.


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  • 3 weeks later...

Dear rnnstr91,


I also have PGAD since taking and withdrawing too fast from the SRI Sertraline (zoloft) 50 mg, 9 months ago.  I am really sorry to read you've got PGAD from Amitryptiline because I thought the tricyclic antidepressants weren't supposed to trigger PGAD (only the SSRI and SNRI). When you were on Prozac did you have PGAD while on Prozac or did you spend 2 years without taking any antidepressant and PGAD stayed for 2 years and slowly disapeared ?


There are 2 groups that can answer a lot of questions on PGAD ( I hope Alto and the Surviving Antidepressant moderators don't mind if I post their contact references)


The forum dedicated to people who suffer from Pudendal Neuralgia (PGAD can be a symptom of Pudendal Neuralgia) are following a lot of researches on PGAD and know the condition well. 




And the PGAD  Facebook Support Group for women who suffer from PGAD. There are women in the Facebook group  including me who have a PGAD induced from antidepressants alongside women suffering from PGAD related to PN, IC and Restless Leg Syndrom  :




Maybe they can also give you support regarding PGAD.


I hope your PGAD will disapear soon and that you will get better.


Take care



- From January 4th 2017 to April 17th 2017:  1 Xanax 0.25 mg in January, replaced by 1 Lyxansia 10 mg in February, replaced by 1 Bromazepam 6 mg a day  in March then back to 1 Xanax 0.25 mg  in April. Every pill was stopped cold turkey.

- April 17th (Easter Monday) started  Sertraline 50.  Xanax 0.25 mg  stopped cold turkey. 

- April 17th to May 4th 1 Sertraline 50, a 25 dose in the morning, a 25 dose at night and half a Zopiclone 7.5 at night

- May 4th  Reduced to 1 Sertraline  25.

-June 1st to June 8th.Tappering off Sertraline every 2 days for a week and put on 1 Risperidone 1 mg a day.June 8th Sertraline 25 replaced by 1 Anafranil 25mg, 1 Risperidone 1 mg a day and 1 zoplicone 7.5 at night, a week later, the Anafranil 25mg and Risperidone 1g was stopped cold turkey and replaced by 1 Xanax 0.25 mg 3 times a day. Since  June 17th : 1 Xanax 0.25 mg 3 times a day and 1 zoplicone 7.5 at night. Other medications  from June 1st to June 15th : Augmentin antibiotics, Chorticoid tablets,  Lanzoprazole, Toviaz. Symptoms : tremors, shaking ,suicidal thoughts, smell and light sensitivity, hyperacusis, floaters, earworms, akathisia, high pitched tinnitus, PGAD.








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  • 3 months later...

hello everyone i m too suffering from pgad after abruptly stopping antidepressant please someone guide me

i took different antidepressants medications for depression and anciety 

from 2013 to 2017 with no benefit i kept on changing the ads but of no use and i gave up...and then the pgad started..


prozac for 2 weeks

lexapro for 3 weeks

seroxat for 10 days

Now i am antidepressants free 

2017 december was the last time i took ads since then i havent taken any ads medication

My main symptom is pgad 

i get stabbing pain in genital area which is interfering in my daily life..

and very mild arousals which dosent bother me.


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  • Administrator

time, please start a topic for yourself in the Introductions forum.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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