For FDA information about regular Seroquel (immediate-release formulation), see http://www.drugs.com/pro/quetiapine-fumarate-tablets.html The immediate-release form is often taken twice a day. For FDA information about Seroquel XR (extended-release formulation), see http://www.drugs.com/pro/seroquel-xr.html     Reduce by 10% per month to start To minimize the risk of withdrawal symptoms, we recommend a conservative taper of 10% from the previous dosage every few week