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Shirl1 Liquid sertraline


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I’ve been given liquid sertraline to help me taper off more easily. I started taking it 4 days ago ,I fill the syringe and put the liquid straight into my mouth. The thing is I’ve been getting really bad heartburn. I’ve read on various sites that you should mix liquid sertraline in water but it doesn’t say to mix it with water anywhere in the instructions does anyone else take this straight instead of mixing with another liquid. Thanks for any info

Started sertraline in 2016 for panic and anxiety 

tapering by 5%.

changed from pill to liquid form in April 2018 so have just started a 5% taper 

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  • 2 weeks later...
  • Moderator Emeritus


Sorry it took a while to respond -- Are you still having the heartburn? 


If the instructions don't say to mix it in water, it's not a good idea to do it. Adding water would dilute it.


2020: After 18+ years (entire adult life) on Paxil, a dangerous doctor-led "taper" in 2015, and four years tapering off the last 1 mg thanks to SA and the Brassmonkey slide, 

I AM COMPLETELY FREE OF PAXIL! ! ! ! ! ! ! ! Forever.


2021: Began conservative, proper, CNS-respecting taper of Zoloft, led by the only expert on me -- me. Making own liquid. 5-10% plus holds.

2022: Holding on Zoloft for now. Current dose 47 mg. Hanging in, hanging on. Severe protracted PAWS, windows and waves. While I may not be doing "a lot" by outside standards, things are graaaaadually getting better


Yoga (gentle to medium); walks; daily breath practice; nutrition, fruits/veg; nature; water; EastEnders (lol); practicing self-compassion, self-care; boundaries; connection; allowing feelings; t r u s t ing that I, too, will heal. (--> may need to be reminded of this.)

"You are not alone, and this is not the end of your story." - Baylissa

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  • Altostrata changed the title to Shirl1 Liquid sertraline
  • Administrator

Hello, Shirl. You can use the syringe to put your dose in some water. Here are the US instructions. Check with your pharmacist to make sure this applies to the liquid you have.






Preparation of Sertraline Hydrochloride Oral Solution

Sertraline hydrochloride oral solution must be diluted before use.

  • Use the supplied calibrated dispensing syringe to measure the amount of sertraline hydrochloride oral solution needed
  • Note: The supplied calibrated dispensing syringe has 25 mg and 50 mg graduation marks only
  • Mix with 4 ounces (1/2 cup) of water, ginger ale, lemon/lime soda, lemonade or orange juice ONLY. After mixing, a slight haze may appear, which is normal.


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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