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Zabegalov, 2018 Understanding antidepressant discontinuation syndrome (ADS) through preclinical experimental models.


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Eur J Pharmacol. 2018 Jun 15;829:129-140. doi: 10.1016/j.ejphar.2018.04.003. Epub 2018 Apr 5.

Understanding antidepressant discontinuation syndrome (ADS) through preclinical experimental models.

Zabegalov KN1, Kolesnikova TO1, Khatsko SL1, Volgin AD2, Yakovlev OA2, Amstislavskaya TG3, Alekseeva PA4, Meshalkina DA5, Friend AJ6, Bao W7, Demin KA5, Gainetdinov RR2, Kalueff AV8.

 

Abstract at https://www.ncbi.nlm.nih.gov/pubmed/29627310 Full text requested.

 

Antidepressant drugs are currently one of the most prescribed medications. In addition to treatment resistance and side effects of antidepressants, their clinical use is further complicated by antidepressant discontinuation syndrome (ADS). ADS is a common problem in patients following the interruption, dose reduction, or discontinuation of antidepressant drugs. Clinically, ADS resembles a classical drug withdrawal syndrome, albeit differing from it because antidepressants generally do not induce addiction. The growing clinical importance and prevalence of ADS necessitate novel experimental (animal) models of this disorder. Currently available preclinical models of ADS are mainly rodent-based, and study mostly serotonergic antidepressants and their combinations. Here, we systematically assess clinical ADS symptoms and discuss current trends and challenges in the field of experimental (animal) models of ADS. We also outline basic mechanisms underlying ADS pathobiology, evaluate its genetic, pharmacological and environmental determinants, and emphasize how using animal models may help generate important translational insights into human ADS condition, its prevention and therapy.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

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  • Altostrata changed the title to Zabegalov, 2018 Understanding antidepressant discontinuation syndrome (ADS) through preclinical experimental models.
  • 2 months later...
On 7/12/2018 at 4:46 PM, Altostrata said:

We also outline basic mechanisms underlying ADS pathobiology, evaluate its genetic, pharmacological and environmental determinants, and emphasize how using animal models may help generate important translational insights into human ADS condition, its prevention and therapy.

I am interested in ADS in people or animals that have genetic variances in the P 450 as I have.  I suspect there will be a connection between the two. I suspect there will be some with long term health issues at the end of all these studies it will be proven.  Since research is so very slow most of us may not live long enough to see the outcome. 

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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