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Cannabis, marijuana, THC, and CBD or Hemp oil

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ChessieCat
52 minutes ago, ChessieCat said:

CBD inhibits the cytochrome P450 enzyme, which is involved in metabolizing many drugs.

 

 

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TreeElf

I had a severe reaction to one dose of CBD paste back in May. Absolutely horrific delirious panic that left me exhausted for about a week. I probably took too much for a first attempt, and was also only 6 months or so into withdrawal so yeah. Honestly, I've been smoking cannabis every day (except maybe one or two) for the past year, all through withdrawal. Not all day, often just in the evenings. But pretty much every day. It's probably exacerbated some things, although during good periods I don't notice many negative effects. The big thing is that it's helped me sleep, but the couple of days I went without it I struggled to, which concerned me a bit.

 

I used to be a heavy cocaine user, and in the past few years have stopped all drugs including alcohol earlier this year, and cigarettes the year before. I also have a pretty strict diet. It sounds pathetic but I've been terrified to stop smoking cannabis, as it's the only thing I look forward to most days. Without it I don't feel like I'll have anything to depend on to get me through. Typical addiction mindset really. It's not the weed itself that's the problem really, it's that my life has become so incredibly restricted I have very little I can rely on for escapism or mild dopamine rush. Ugh. I think I have to stop smoking it, it can't be helping some things.

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Centime

About a month ago I started taking CBD extract to help me sleep. I’ve had insomnia for years. My sister has a medical marijuana license because she has Parkinsons’, and a friend who lives in NM where pot is legal recommended the same source (Honey Stag Hemp). After having been on various psych meds over the years for sleep (Seroquel, Klonopin), I’m really surprised that it works. My sleep is much, much better. It’s also supposed to help with anxiety, but I haven’t noticed that yet.

 

I find that marijuana is the only thing that works for my relentless nausea as I go through withdrawal (from Paxil). It gives me a little energy and helps me get through times when I would simply rather be unconscious. Of course I’d rather not take anything, but am grateful for the small relief it gives me. 

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lalala
On 12/20/2018 at 12:24 PM, JanCarol said:

From the same article: https://bengreenfieldfitness.com/article/supplements-articles/how-to-use-cbd-oil/

 

CBD as Anti-Inflammatory:

 

 

I just started to taper klonopin .5  a few months ago and having very poor sleep wired and tired,  and I had insomnia the  last 2 years from discontinuing ssri and starting others and ct paxil after 4 months  so i'm not sure my chances  of improvement in the sleep area,I was suggested to take cbd with terpenes...  what are your thoughts?

I took an antihistamine and that made me ill the next day and sleep was awful...chemicals make me sick

any help appreciated...x

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JackieDecides

I have tried vaping CBD for anxiety and insomnia and it hasn't helped me at all. but everybody is different. 

when I am not having anxiety I like whole cannabis - in small amounts - just for fun, but none at all when anxious. 

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JanCarol
1 hour ago, lalala said:

I was suggested to take cbd with terpenes...  what are your thoughts?

 

All of us - benzo sufferers, antidepressant sufferers, antispychotic strugglers - ALL of us have struggled with sleep.

 

Thinking that a thing is going to *fix* sleep is an illusion.  These drugs hit right at the heart of sleep.  It will get better, but thinking that you have to do something about it is - illusory.

Some of us have survived on 5 minute naps throughout the day, others of us get extremely cranky and struggle to get an hour or two a day.  It is a phase that one goes through when trying to come off the drugs.

By all means feel free to try the CBD, but ensure you are getting a good quality product.  There are a lot of snake oil salesmen in CBD land, as it's the "latest greatest thing" in the USA.  It is expensive to get the good stuff.  I found it extremely helpful for pain and sleep, but also found that it was going to cost me $190 a month to get the right doses of the right product.  I used a bottle of 1500 mg. tincture every 2 weeks.  That was one full dropper 2x a day.   The brand was Nature's Love  in Colorado.  


Your mileage may vary, and perhaps you are one of those who can get by on a few drops a day.  Consumer Lab studied CBD and found that efficacy was around the 300 mg range.  (I was taking 100 mg per day).  Many people claim to get good results from less, some as little as 25 mg per day.  

I would try it again, with an effort to keep the doses down, but I would probably drift back up to that expensive and effective range.  At $95 / bottle (plus the hassle of getting CBD to Australia), this experiment will have to wait.

Let us know what you try and if you get results!

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lalala
On 1/30/2019 at 3:21 PM, JanCarol said:

 

All of us - benzo sufferers, antidepressant sufferers, antispychotic strugglers - ALL of us have struggled with sleep.

 

Thinking that a thing is going to *fix* sleep is an illusion.  These drugs hit right at the heart of sleep.  It will get better, but thinking that you have to do something about it is - illusory.

Some of us have survived on 5 minute naps throughout the day, others of us get extremely cranky and struggle to get an hour or two a day.  It is a phase that one goes through when trying to come off the drugs.

By all means feel free to try the CBD, but ensure you are getting a good quality product.  There are a lot of snake oil salesmen in CBD land, as it's the "latest greatest thing" in the USA.  It is expensive to get the good stuff.  I found it extremely helpful for pain and sleep, but also found that it was going to cost me $190 a month to get the right doses of the right product.  I used a bottle of 1500 mg. tincture every 2 weeks.  That was one full dropper 2x a day.   The brand was Nature's Love  in Colorado.  


Your mileage may vary, and perhaps you are one of those who can get by on a few drops a day.  Consumer Lab studied CBD and found that efficacy was around the 300 mg range.  (I was taking 100 mg per day).  Many people claim to get good results from less, some as little as 25 mg per day.  

I would try it again, with an effort to keep the doses down, but I would probably drift back up to that expensive and effective range.  At $95 / bottle (plus the hassle of getting CBD to Australia), this experiment will have to wait.

Let us know what you try and if you get results!

I know... unfortunately I have had insomnia for 2 year, do to tapering, stopping  and taking ssri's  and to top it off, I  took klonopin which stopped working after  a month  or less  stayed on it to stabilize  and now weaning of after 5 months and having terrible insomnia once more... I tried antihistamines  made me sick... i hope it does help I dont have lots of alternatives...

I had done my research,  I found some companies from the Uk  well priced... 

I guess you are off everything which is a smarter choice to try  cbd but heard mixed stories mostly successful 

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JanCarol
Posted (edited)

Hello,

On 5/7/2018 at 1:25 AM, Centime said:

Does anyone have any info about the interaction of marijuana and SSRIs?

 

Yes, Consumer Lab just posted their update on interactions.  This is from behind a paywall, but I have re-ordered and retyped it, and it's only a small exerpt:

 

Quote

Be aware the CBD may interact with other medications that…are metabolized in the body by cytochrome P450 enzymes CYP3A4 and CYP2C19.  By competing for these enzymes, CBD can reduce the metabolism of such drugs, raising their blood levels and possibly requiring downward adjustment of their doses.  For example, several hundred milligrams of CBD daily in epilepsy trials have caused sizeable increases in levels of the epilepsy medications clobazam, valproic acid, levitriracetam, felbamate, lamotrigine, and zonisamide (U.S. Department of Health; Yamaori, Life Sci 2011; Iffland, Cannabis Cannabinoid Res 2017).  Adding 50 mg to 300 mg of CBD to day per treatment with the epilepsy drug brivaracetam was found to increase blood levels of brivaracetam by as much as 95% to 280% (Klotz, Epilepsia 2019).  For the same reason, CBD may increase the blood-thinning effects of warfarin (Coumadin, Jantoven).  This was observed in a man with post-stroke epilepsy taking warfarin:  His INR (a measure of how long it takes blood to clot) began increasing several weeks after starting CBD (Epidiolex, Greenwich Biosciences, Inc.) for his seizures.  His CBD dosgin started with several hundred milligrams daily and increased to over 1,000 mg., at which point his warfarin dose had been reduced by approximately 30% (Grayson, Epilepsy Behav Case Rep 2017).  These effects are dose-dependent, and it’s possible that lower doses of CBD (single digits or tens of milligrams daily), as in many products in this (Consumer Labs Review) will have more modest effects.  Nevertheless if you take medications metabolized by these enzymes, including:

 

·         Macrolide antibiotics such as clarithromycin (Biaxin) and azithromycin (Zithromax), cyclosporine (Sandimmune),

 

·         Sildenafil (Viagra)

 

·         Certain statin medications such as atorvastatin (Lipitor) and simvastatin (Zocor), rosuvastatin (Crestor)

 

·         Testosterone, progesterone

 

·         Cardiac medications (blood pressure & others) Nifedipine (Procardia XL), metoprolol (Lopressor, Toprol XL), flecainide (Tambocor), clipidogrel (Plavix), propranolol (Inderal LA), losartan (Cozaar), valsartan (Diovan)

 

·         The proton pump inhibitor drug omeprazole (Zegerid, Prilosec OTC)

 

·         The antipsychotic drug risperidone (Risperdal)

 

·         Ondansetron (Zofran)

 

·         Paroxetine (Paxil), fluoxetine (Prozac), fluvoxamine (Luvox)

 

·         Carisoprodol (Soma)

 

·         Cancer drugs cyclophosphamide (Cytoxin), enzalutamide (Xtandi – also an anti-androgen)

 

·         Anti-fungal drugs fluconazole (Diflucan), ketoconazole (Nozoral, Xolegel, Extina) (this drug increased CBD blood levels)

 

·         Antiretroviral efavirenz (Sustiva, Stocrin)

 

·         NSAIDS celecoxib (Celebrex), naproxen (Aleve)

 

·         Diabetes drug (whole class) sulfonylureas (Amaryl, Glynase)

 

 

Additionally, a dangerous synthetic cannabinoid (AB-FUBINACA) has been found in CBD products, including e-cigarette fluid and incense, as well as CBD oil purchased from a “reputable online distributor from Colorado) which can increase seizures, cause agitation, delirium, dilated pupils and rapid heartbeat.  Consumer Labs will screen for synthetic cannabinoids in future tests.

 

 

Please note how many of the psych drugs - "mood stabilisers," "antipsychotics," and "antidepressants" are included in this.  Taking CBD while going through withdrawal, especially during tapering, could very well alter the dose you are getting.

 

 

On 9/20/2018 at 12:09 AM, Sampo said:

have someone here tried Kannaway's Pure Gold? It is THC-free oil.

 

Consumer Lab reports that Kannaway "Revive" was not recommended as it did not contain enough CBD.  0.5% of the oil in the bottle was CBD.  Their "Pure Gold" might be stronger, however, if they skimp on one product, they might skimp on their others.  It's a wild west of CBD oils, and there are many oils which either a) don't advertise the potency of their product, or b) don't provide the potency that they claim on the label.  I would posit that Kannaway is one of these, and if they do it on one product, I don't trust any of their products.

 

On 12/13/2018 at 7:21 AM, Annesj said:

Is this CBD without thc you are refering to?


Yes.
 

These supplements are expensive!  A subscription to Consumer Labs is not.  You will waste a lot less money if you subscribe to Consumer Labs and follow their reports and recommendations.   

 

Edited by ChessieCat
increased boldness of some info

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woof

Hello All,

I completed my Valium withdrawal about 4 months ago and am doing very well; my neuro-emotions are back to normal...at least for me. 🙄

 

At this point my only issue is that I used to enjoy cannabis from time to time.  I live in a Cannabis friendly state and about a month ago I tried some cannabis and while it did make me relax and want to go to sleep, I experienced no euphoria or sense of well being, both of which I would always experience with cannabis prior to the past 4 years when I began on this hellish journey of Cymbalta and Valium problems.  

 

Is anyone aware of this being a problem post benzo (or AD CT and full reinstatement) withdrawal problem?  Or does anyone have any suggestions as to where I might gain more knowledge regarding this issue? 

 

Thank you,

Woof

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ChessieCat
32 minutes ago, woof said:

while it did make me relax and want to go to sleep, I experienced no euphoria or sense of well being, both of which I would always experience with cannabis prior to the past 4 years

 

Instead of seeking the same experience that you got years ago, I would be very thankful that you didn't experience anything bad.

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woof

Hello ChessieCat,

I do, I really do appreciate the fact that I have just come from a few years of hell. 

 

And I am thankful everyday that anxiety has finally completely left me, I can enjoy things again and that I sleep everynight. 🙏

 

Thanks Woof,

Woof😀

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JackieDecides
On 8/18/2019 at 8:07 AM, woof said:

Hello ChessieCat,

I do, I really do appreciate the fact that I have just come from a few years of hell. 

 

And I am thankful everyday that anxiety has finally completely left me, I can enjoy things again and that I sleep everynight. 🙏

 

Thanks Woof,

Woof😀

 

 

I love to read about success as I am not quite there yet but hope to be.  I never had so much trouble with anxiety BEFORE I was put on SSRIs! I look forward to being free from it and it's already a lot better.

 

and regular sleep:  what a blessing. 

 

I have the same relationship with cannabis - and with coffee! - as you: I used to enjoy it and I'd like to do so again. 

same as with coffee, I find a small amount is sometimes OK and sometimes not and I probably should be waiting until I am free from anxiety all together (at least regularly) to "enjoy in moderation" again. 

 

that said, are you paying attention to strains, besides dose, and how you take it? I know that I find edibles a more mild high, but they last longer.  there was a time I considered 10 mg of TCH to be "one dose" and now that is way too much. even 5 mg can be too much, but with tinctures I can get smaller doses. since you are in a legal state, do you talk to staff at dispensaries about this?

 

 

 

 

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SeasideDiva

JanCarol,

I think I'm going to try CBD oil for my newly acquired, over the top anxiety that sprang up when I thought I might try a different blood pressure medicine (ACE inhibitor) in the "hopes" that my current Beta blocker might be contributing to my "normal" anxiety/depressive symptoms. I had a major meltdown (crying, panicky, digestive issues) and went back on the beta blocker (which supposedly helps with anxiety) but my anxiety seems to be stuck on the fight or flight mode most of the day. The doc gave me an additional small dose of another Beta blocker to try with my regular dose, as  I have refused the current tranquilizer options (but I'm starting to consider ANYTHING to get out of this hell.) I have taken it only for 2 days, and thought maybe it helped a bit yesterday, but today again I'm with the racing heart and panicky feeling. At the same time I am buying/selling a house, and though it's a positive thing and things are going smoothly, I have barely been able to handle it or enjoy that I seem to be leaving a place that depresses me. All this has brought on daily persistent obsessive thoughts that make me think they will continue to return and my life won't be livable any more. Of course my sleep is disrupted even more so, and the fatigue contributes. Sorry for the long explanation, but I haven't written here in a long time, and I found your comment and how you are helped by CBD oil. From what I gather from what I read, there was an opinion that the "type 3 CBD dominant" with little THC seemed to be considered the most effective. I can't think straight or absorb all the info, so I'm hoping you can lead me in the right direction, though we are all different of course. I intend to go to a local dispensary and start at a low dose. And input is greatly appreciated.

 

Not sure where my signature is ?? but i was on SSRi's for over 20 years and quit over a 2 week period. Just passed my 4 year mark of drug-free, and would happily have stayed on them had I known the hell awaiting me. By the time I found this site it was too late to re-instate, or I surely would have. Only quit because I thought it might be healthier for me. Dear god. My feelings now are I would have never gone on them in the first place, but also would never have gone off knowing what I know.

 

Just saw my signature appear when I submitted this...I am now almost 68 years old.

Edited by SeasideDiva

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LiaJ

Topic title:  CBD: Does it help?

 

I'm sure this question has been posed in this forum, but I'm curious to know of anyone's experience with CBD oil during the tapering process, to assist with issues like sleep and anxiety.

 

Edited by ChessieCat
added topic title

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