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Chachi: Pristiq making me cold hearted


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I started taking pristiq some time in June. I started feeling like I wanted to avoid my family and just go out by myself. I never want to cuddle or be intimate with my husband anymore and I all of a sudden want attention from other people. This is extremely out of character for me. I dont know if its the medication or what but its really scaring me. I feel like i could just run away from my life and not look back but I know this isnt me. Has any been in a similat situation??? I'm feeling so helpless.

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  • ChessieCat changed the title to Chachi: Pristiq making me cold hearted
  • Moderator Emeritus

Hi Chachi, welcome to SA.  Your issues could very well be from the medication - this kind of symptom is not uncommon and has been known to cause relationship problems (see our relationships forum).


Are you currently taking any other meds?  Have you taken other meds previously?  It would be helpful if you could create a signature containing a summary of your med history, including all drugs, doses and dates (starting and stopping).  Your signature appears below every post you make, and helps us see your situation easily without having to read from the top every time.   You could look at my signature for an example.  Instructions for creating your signature are here: Please put your withdrawal history in your signature.  You can edit your signature here: edit your signature in Account Settings.


If you are interested in tapering off Pristiq, you may find these topics helpful:


why taper by 10% of my dosage?


before you begin tapering - what you need to know


Tips for tapering off Pristiq (desvenlafaxine)


Please post all your updates and questions about your situation here in your introduction topic, and we will try to help you as best we can.



2001–2002 paroxetine

2003  citalopram

2004-2008  paroxetine (various failed tapers) 
2008  paroxetine slow taper down to

2016  Aug off paroxetine
2016  citalopram May 20mg  Oct 15mg … slow taper down
2018  citalopram 13 Feb 4.6mg 15 Mar 4.4mg 29 Apr 4.2mg 6 Jul 4.1mg 17 Aug 4.0mg  18 Nov 3.8mg
2019  15 Mar 3.6mg  21 May 3.4mg  26 Dec 3.2mg 

2020  19 Feb 3.0mg 19 Jul 2.9mg 16 Sep 2.8mg 25 Oct 2.7mg 23 Oct 2.6mg 24 Dec 2.5mg

2021   29 Aug 2.4mg   15 Nov 2.3mg

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