Jump to content
Altostrata

Davies, 2018 A systematic review into the incidence, severity and duration of antidepressant withdrawal effects: Are guidelines evidence-based?

Recommended Posts

Altostrata

Addict Behav. 2018 Sep 4. pii: S0306-4603(18)30834-7. doi: 10.1016/j.addbeh.2018.08.027. [Epub ahead of print]

A systematic review into the incidence, severity and duration of antidepressant withdrawal effects: Are guidelines evidence-based?

Davies J1, Read J2.

 

Abstract at https://www.ncbi.nlm.nih.gov/pubmed/30292574 Full text PDF

 

INTRODUCTION:

The U.K.'s current National Institute for Health and Care Excellence and the American Psychiatric Association's depression guidelines state that withdrawal reactions from antidepressants are 'self-limiting' (i.e. typically resolving between 1 and 2weeks). This systematic review assesses that claim.

 

METHODS:

A systematic literature review was undertaken to ascertain the incidence, severity and duration of antidepressant withdrawal reactions. We identified 24 relevant studies, with diverse methodologies and sample sizes.

 

RESULTS:

Withdrawal incidence rates from 14 studies ranged from 27% to 86% with a weighted average of 56%. Four large studies of severity produced a weighted average of 46% of those experiencing antidepressant withdrawal effects endorsing the most extreme severity rating on offer. Seven of the ten very diverse studies providing data on duration contradict the UK and USA withdrawal Guidelines in that they found that a significant proportion of people who experience withdrawal do so for more than two weeks, and that it is not uncommon for people to experience withdrawal for several months. The findings of the only four studies calculating mean duration were, for quite heterogeneous populations, 5days, 10days, 43days and 79weeks.

 

CONCLUSIONS:

We recommend that U.K. and U.S.A. guidelines on antidepressant withdrawal be urgently updated as they are clearly at variance with the evidence on the incidence, severity and duration of antidepressant withdrawal, and are probably leading to the widespread misdiagnosing of withdrawal, the consequent lengthening of antidepressant use, much unnecessary antidepressant prescribing and higher rates of antidepressant prescriptions overall. We also recommend that prescribers fully inform patients about the possibility of withdrawal effects.

 

 

Discussions on this site:

 

Psychiatric drug withdrawal study gets news coverage in the UK

 

Template Letter Of Evidence To Doctors/Psychiatrists - feel free to use!

Luke Montagu: Millions are taking antidepressants 'they don't really need', fueling growing epidemic of addiction to prescription medicines

 

The Sedated Society, book by Dr. James Davies

 

 

 


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Share this post


Link to post
Share on other sites
India

It can also be read here 

https://prescribeddrug.org/wp-content/uploads/2018/10/Davies-Read.pdf

I didn't have much luck with the NIMH link


1999:  Paroxetine (20mg). Age 16. 2007-2008: Fluoxetine (Prozac) for 1.5 years (age 25) Citalopram 20mg 2002-2005, 2009: Escitalopram (20mg), 2 weeks, (age 26) (adverse manic reaction)/*Valium 5mg/Temazepam 10mg 2010: Mirtazipine (Remeron)( do not remember dosage) 2010, 5 months.                     

2010-2017: Citalopram (20mg) (age 27 to 34) 2016: i.1st Sept- 31st Oct Citalopram 10mg , ii.1st November 2017-30th November 2017, Citalopram 5mg iii.1st December 2017- 4th February 2018, Citalopram 0mg, iv.5th February 2018- March 2018 Citalopram 5mg (10mg every other day) 28th February- tried titration of 5mg ( some adverse effects)

2018: 1st March 2018- 1st June Citalopram 10 mg (tablet form) /started titration 8mg , then 7 mg.2018: June 15th- 10th July Citalopram 10 mg pill every other day 2018: 10th July - 13th Sept Citalopram- 0mg  (CBD oil first month of 0mg, passiflora on and off) 2018 13th Sept Citalopram  2mg ,  approx 16th Sept 4mg , approx 25th Sept 6mg held.  2019: 11 Feb 19: 7mg (instant bad rxn) 12 Feb 19 6mg held 1 May 19 5.4mg held 5 Oct 19 5.36mg 22 Oct 19 5.29mg 30 Oct 19 5.23mg 4/NOV/19 5.18mg 12 Nov 19 5.08mg 20 Nov 19 4.77mg

(Herbal/Supplements since 1st September: Omega Fish Oil 1200mg, 663mg of EPA- 2 tablets a day, magnesium and magnesium bath salts)

I did not die, and yet I lost life’s breath
- Dante

Share this post


Link to post
Share on other sites
Bunyapine

I have to thank @Altostrata for putting this on the SA site. I have a copy to take to the doctor and will also show to  the people who always use the phrase ‘Dr Google’ frequently with derision! When I first started experiencing withdrawal symptoms and could get  no explanation, it was very upsetting. Thank goodness I found this site! I feel what we are suffering is hard enough and not being taken seriously or just treated as ‘anxious’ person makes it so much harder to bear! 


1987 Anafranil

1987-1989 Prothiaden

1990-Jan 2015 Prozac 40mg Feb-Mar Prozac 30mg Ap-Nov Prozac 20mg (+10mg Zoloft for 1 week in Sept) Dec Prozac 10mg 2016 Jan-2017 Oct Prozac 15mg  Nov Prozac 14mg  Nov Prozac14.5mg

Other drugs Humira and Methotrexate for rheumatoid arthritisSupplements :Magnesium and calcium.Folic acid 5mg.

Inderal 10mg (stopped 2018 Dec).        

2018 Nov Quetiapine fumarate 25mg Dec 150-125mg 2019Jan 125-25mg Feb 25-12.5mg

2018 Dec Sertra 25-150-125mg

2018 Dec Pregabalin 75-150mg                                                                                                  

Share this post


Link to post
Share on other sites
Altostrata

Researcher Mark Horowitz recently gave a presentation at Royal College of Psychiatrists defending Davies & Read's paper and drawing out some interesting specifics:

 

 

 


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

×
×
  • Create New...

Important Information

Terms of Use Privacy Policy