Jump to content
Kernol

Kernol: was doing well on my sertraline taper but now in hell and doc reinstated

Recommended Posts

Altostrata

I don't know what the effect of bioidentical hormones might be. Be sure to try a very tiny dose.

 

It could very well be that increased diazepam has increased blood level of sertraline, their interaction being a major concern. This would occur an hour or so after a dose of diazepam.

 

It is possible a reduction in sertraline would reduce this.

 

 


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Share this post


Link to post
Kernol

Thanks @Altostrata I am not sure I can consider a reduction in sertraline at the moment I am so sick as it is I am scared of what that might do. I have to lie down all afternoon as the nausea is so extreme -  lying down seems to help a bit. 
 

Will the genetic results help to determine if there is a likely interaction or not going on between the two?  I hope to get the results next week. It would be great to know if that is a major issue or if it is just that diazepam only masks my sertraline symptoms a tiny bit and for a short period of time as it doesn’t seem to make a difference whether i take a 1mg or 2mg dose - the relief is only ever 1.5 hours. 
 

re the hormones -, I will consider a low dose of estrogen and if it doesn’t suit me I will just stop it. I will have my hormones tested again this week as well to see if there are any clues there. I have already been given progesterone cream by a doctor but I only put it on once as I got scared as I read it can cause a withdrawal like a Benzo. When I did put the cream on, I definitely noticed a slight calming effect on the anxiety but it only lasted an hour or so - almost like I had taken a short acting Benzo? Maybe I should have kept using it but I got too scared about it not working and then having a withdrawal from that to deal with... 


10 years on Sertraline 100mg. 75mg Dec 2016 - Apr 2017, 50mg May 2017 - Oct 2017, 37.5mg

 

2018 - Sertraline 25mg Mar -  July 2018, 13.75mg Aug- Sept 1.5 month (‘not accurately measured), came off completely 10 October, reinstated by doctor on 10 November 25 mg. 25 November raised to 50mg 2 December 100mg 11 December 150mg 30 November. Lorazepam started 2mg x daily 1 November

2019 - Sertraline reduced  to 100mg 5 Feb, 23 Feb 75mg, 18 Mar 50mg, 23 Apr 37.5mg, 1 Jun 25mg, 3 Jul 16mg, 3 Aug 8mg, updosed on 1 Sept to 16.67mg 

20 Feb lorazepam 2mg x day crossed over to diazepam 20mg x day over 2 week period to taper. diazepam reduced by 1mg every 2/3 weeks got down to 3.5mg in August. 

22 Sept resorted to taking 1mg lorazepam after sertraline destabilisation instead of diazepam. took lorazepam 1mg  x day 22 Sept - 28 Sept then returned to diazepam on 29  Sept 4mg,, 30 Sept 4.5mg  1 Oct 5mg 2 Oct 5mg  16 Nov 4.75mg. 15 Dec 5mg 29 Dec 4.75mg   Vortioxetine 5mg started 1 July. 14 July 10mg -Reduced on 20 July to 5mg. 12 Sept reduced to  3.75mg, 19 Sept reduced to 2.5mg, 15 Oct reduced to 2mg, 22 Oct 1.9mg, 29 Oct 1.8mg reduced down every 3 days and then daily stopped on 2 Dec

2020 - sertraline  8 Apr - 16mg 29 Apr - 15.5mg 13 may - 15.25mg may 19 - 15mg may 22- 14.75mg 22 Jun 14mg 6 July 13.3 - 20 July 12.6 - 3 August - 11.97 - 17 August 11.37

diazepam 19 Apr - 4.25mg 20 May - 4mg 20 Jun 3.75mg  4.25mg 22 Sept 4.5mg 29 Sept. 4.75ng Oct 5 

 

 

Share this post


Link to post
Altostrata

The genetic results will indicate if you have an absolute inability to metabolize sertraline. My intuition is sertraline is causing adverse effects and should be reduced.


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Share this post


Link to post
Kernol

Thanks @Altostrata - if I took the drug and did well on it for 11 years,  it worked therapeutically without a doubt and I had no real side effects on it all those years whilst on it  would that not rule out the possibility I can’t metabolise sertraline or have i got that wrong?? Sorry it’s all a bit beyond me


10 years on Sertraline 100mg. 75mg Dec 2016 - Apr 2017, 50mg May 2017 - Oct 2017, 37.5mg

 

2018 - Sertraline 25mg Mar -  July 2018, 13.75mg Aug- Sept 1.5 month (‘not accurately measured), came off completely 10 October, reinstated by doctor on 10 November 25 mg. 25 November raised to 50mg 2 December 100mg 11 December 150mg 30 November. Lorazepam started 2mg x daily 1 November

2019 - Sertraline reduced  to 100mg 5 Feb, 23 Feb 75mg, 18 Mar 50mg, 23 Apr 37.5mg, 1 Jun 25mg, 3 Jul 16mg, 3 Aug 8mg, updosed on 1 Sept to 16.67mg 

20 Feb lorazepam 2mg x day crossed over to diazepam 20mg x day over 2 week period to taper. diazepam reduced by 1mg every 2/3 weeks got down to 3.5mg in August. 

22 Sept resorted to taking 1mg lorazepam after sertraline destabilisation instead of diazepam. took lorazepam 1mg  x day 22 Sept - 28 Sept then returned to diazepam on 29  Sept 4mg,, 30 Sept 4.5mg  1 Oct 5mg 2 Oct 5mg  16 Nov 4.75mg. 15 Dec 5mg 29 Dec 4.75mg   Vortioxetine 5mg started 1 July. 14 July 10mg -Reduced on 20 July to 5mg. 12 Sept reduced to  3.75mg, 19 Sept reduced to 2.5mg, 15 Oct reduced to 2mg, 22 Oct 1.9mg, 29 Oct 1.8mg reduced down every 3 days and then daily stopped on 2 Dec

2020 - sertraline  8 Apr - 16mg 29 Apr - 15.5mg 13 may - 15.25mg may 19 - 15mg may 22- 14.75mg 22 Jun 14mg 6 July 13.3 - 20 July 12.6 - 3 August - 11.97 - 17 August 11.37

diazepam 19 Apr - 4.25mg 20 May - 4mg 20 Jun 3.75mg  4.25mg 22 Sept 4.5mg 29 Sept. 4.75ng Oct 5 

 

 

Share this post


Link to post
Altostrata

Did you take sertraline with other drugs at the same time?


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Share this post


Link to post
Kernol

Hi @Altostrata only for the first 10 months I took lorazepam 1mg with it for the first 3 months and then cross tapered to diazepam for 7 months and came off it and was fine but of course I did not have withdrawal syndrome then 


10 years on Sertraline 100mg. 75mg Dec 2016 - Apr 2017, 50mg May 2017 - Oct 2017, 37.5mg

 

2018 - Sertraline 25mg Mar -  July 2018, 13.75mg Aug- Sept 1.5 month (‘not accurately measured), came off completely 10 October, reinstated by doctor on 10 November 25 mg. 25 November raised to 50mg 2 December 100mg 11 December 150mg 30 November. Lorazepam started 2mg x daily 1 November

2019 - Sertraline reduced  to 100mg 5 Feb, 23 Feb 75mg, 18 Mar 50mg, 23 Apr 37.5mg, 1 Jun 25mg, 3 Jul 16mg, 3 Aug 8mg, updosed on 1 Sept to 16.67mg 

20 Feb lorazepam 2mg x day crossed over to diazepam 20mg x day over 2 week period to taper. diazepam reduced by 1mg every 2/3 weeks got down to 3.5mg in August. 

22 Sept resorted to taking 1mg lorazepam after sertraline destabilisation instead of diazepam. took lorazepam 1mg  x day 22 Sept - 28 Sept then returned to diazepam on 29  Sept 4mg,, 30 Sept 4.5mg  1 Oct 5mg 2 Oct 5mg  16 Nov 4.75mg. 15 Dec 5mg 29 Dec 4.75mg   Vortioxetine 5mg started 1 July. 14 July 10mg -Reduced on 20 July to 5mg. 12 Sept reduced to  3.75mg, 19 Sept reduced to 2.5mg, 15 Oct reduced to 2mg, 22 Oct 1.9mg, 29 Oct 1.8mg reduced down every 3 days and then daily stopped on 2 Dec

2020 - sertraline  8 Apr - 16mg 29 Apr - 15.5mg 13 may - 15.25mg may 19 - 15mg may 22- 14.75mg 22 Jun 14mg 6 July 13.3 - 20 July 12.6 - 3 August - 11.97 - 17 August 11.37

diazepam 19 Apr - 4.25mg 20 May - 4mg 20 Jun 3.75mg  4.25mg 22 Sept 4.5mg 29 Sept. 4.75ng Oct 5 

 

 

Share this post


Link to post
Altostrata

Did you take the benzos with sertraline because you had adverse effects when you were starting it up?


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Share this post


Link to post
Kernol

Hi @Altostrata No I don’t think so that I can remember it was because I had a bad nervous breakdown and they wanted to calm me down however it could well have masked the activating symptoms that I have had when starting other ssris in the past 


10 years on Sertraline 100mg. 75mg Dec 2016 - Apr 2017, 50mg May 2017 - Oct 2017, 37.5mg

 

2018 - Sertraline 25mg Mar -  July 2018, 13.75mg Aug- Sept 1.5 month (‘not accurately measured), came off completely 10 October, reinstated by doctor on 10 November 25 mg. 25 November raised to 50mg 2 December 100mg 11 December 150mg 30 November. Lorazepam started 2mg x daily 1 November

2019 - Sertraline reduced  to 100mg 5 Feb, 23 Feb 75mg, 18 Mar 50mg, 23 Apr 37.5mg, 1 Jun 25mg, 3 Jul 16mg, 3 Aug 8mg, updosed on 1 Sept to 16.67mg 

20 Feb lorazepam 2mg x day crossed over to diazepam 20mg x day over 2 week period to taper. diazepam reduced by 1mg every 2/3 weeks got down to 3.5mg in August. 

22 Sept resorted to taking 1mg lorazepam after sertraline destabilisation instead of diazepam. took lorazepam 1mg  x day 22 Sept - 28 Sept then returned to diazepam on 29  Sept 4mg,, 30 Sept 4.5mg  1 Oct 5mg 2 Oct 5mg  16 Nov 4.75mg. 15 Dec 5mg 29 Dec 4.75mg   Vortioxetine 5mg started 1 July. 14 July 10mg -Reduced on 20 July to 5mg. 12 Sept reduced to  3.75mg, 19 Sept reduced to 2.5mg, 15 Oct reduced to 2mg, 22 Oct 1.9mg, 29 Oct 1.8mg reduced down every 3 days and then daily stopped on 2 Dec

2020 - sertraline  8 Apr - 16mg 29 Apr - 15.5mg 13 may - 15.25mg may 19 - 15mg may 22- 14.75mg 22 Jun 14mg 6 July 13.3 - 20 July 12.6 - 3 August - 11.97 - 17 August 11.37

diazepam 19 Apr - 4.25mg 20 May - 4mg 20 Jun 3.75mg  4.25mg 22 Sept 4.5mg 29 Sept. 4.75ng Oct 5 

 

 

Share this post


Link to post
Altostrata

Whatever your sensitivities to SSRIs, it seems possible that sertraline is aggravating them.


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Share this post


Link to post
Kernol

Hi @Altostrata I’m certainly sensitive to it now that’s for sure but getting off it seems like an impossible task for me - I get sicker the lower the dose gets. If only I hadn’t been put back on it in 2018 I expect I would be well by now - 2 years off it.  Kindled right? That’s why this second withdrawal is so much harder than  the first? 
 

I am still bed ridden with the extreme nausea and flu symptoms - I have been like this for weeks On end now and no sign of it letting up yet. I really hope it will settle a bit soon and the awful mental symptoms.  I will take 10 or 20% better right now!! 
 

 


10 years on Sertraline 100mg. 75mg Dec 2016 - Apr 2017, 50mg May 2017 - Oct 2017, 37.5mg

 

2018 - Sertraline 25mg Mar -  July 2018, 13.75mg Aug- Sept 1.5 month (‘not accurately measured), came off completely 10 October, reinstated by doctor on 10 November 25 mg. 25 November raised to 50mg 2 December 100mg 11 December 150mg 30 November. Lorazepam started 2mg x daily 1 November

2019 - Sertraline reduced  to 100mg 5 Feb, 23 Feb 75mg, 18 Mar 50mg, 23 Apr 37.5mg, 1 Jun 25mg, 3 Jul 16mg, 3 Aug 8mg, updosed on 1 Sept to 16.67mg 

20 Feb lorazepam 2mg x day crossed over to diazepam 20mg x day over 2 week period to taper. diazepam reduced by 1mg every 2/3 weeks got down to 3.5mg in August. 

22 Sept resorted to taking 1mg lorazepam after sertraline destabilisation instead of diazepam. took lorazepam 1mg  x day 22 Sept - 28 Sept then returned to diazepam on 29  Sept 4mg,, 30 Sept 4.5mg  1 Oct 5mg 2 Oct 5mg  16 Nov 4.75mg. 15 Dec 5mg 29 Dec 4.75mg   Vortioxetine 5mg started 1 July. 14 July 10mg -Reduced on 20 July to 5mg. 12 Sept reduced to  3.75mg, 19 Sept reduced to 2.5mg, 15 Oct reduced to 2mg, 22 Oct 1.9mg, 29 Oct 1.8mg reduced down every 3 days and then daily stopped on 2 Dec

2020 - sertraline  8 Apr - 16mg 29 Apr - 15.5mg 13 may - 15.25mg may 19 - 15mg may 22- 14.75mg 22 Jun 14mg 6 July 13.3 - 20 July 12.6 - 3 August - 11.97 - 17 August 11.37

diazepam 19 Apr - 4.25mg 20 May - 4mg 20 Jun 3.75mg  4.25mg 22 Sept 4.5mg 29 Sept. 4.75ng Oct 5 

 

 

Share this post


Link to post
Altostrata

Are these symptoms still worse a couple hours after you take diazepam?


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Share this post


Link to post
Kernol

Hi @Altostrata It tends to get worse in between doses of diazepam apart from in the evening it isn’t so marked so I just get very short and very weak dampening down of symptoms from the diazepam. That‘a been the case the whole time. It’s also very bad before the first diazepam dose in the morning so I don’t think it points to an interaction particularly? 


10 years on Sertraline 100mg. 75mg Dec 2016 - Apr 2017, 50mg May 2017 - Oct 2017, 37.5mg

 

2018 - Sertraline 25mg Mar -  July 2018, 13.75mg Aug- Sept 1.5 month (‘not accurately measured), came off completely 10 October, reinstated by doctor on 10 November 25 mg. 25 November raised to 50mg 2 December 100mg 11 December 150mg 30 November. Lorazepam started 2mg x daily 1 November

2019 - Sertraline reduced  to 100mg 5 Feb, 23 Feb 75mg, 18 Mar 50mg, 23 Apr 37.5mg, 1 Jun 25mg, 3 Jul 16mg, 3 Aug 8mg, updosed on 1 Sept to 16.67mg 

20 Feb lorazepam 2mg x day crossed over to diazepam 20mg x day over 2 week period to taper. diazepam reduced by 1mg every 2/3 weeks got down to 3.5mg in August. 

22 Sept resorted to taking 1mg lorazepam after sertraline destabilisation instead of diazepam. took lorazepam 1mg  x day 22 Sept - 28 Sept then returned to diazepam on 29  Sept 4mg,, 30 Sept 4.5mg  1 Oct 5mg 2 Oct 5mg  16 Nov 4.75mg. 15 Dec 5mg 29 Dec 4.75mg   Vortioxetine 5mg started 1 July. 14 July 10mg -Reduced on 20 July to 5mg. 12 Sept reduced to  3.75mg, 19 Sept reduced to 2.5mg, 15 Oct reduced to 2mg, 22 Oct 1.9mg, 29 Oct 1.8mg reduced down every 3 days and then daily stopped on 2 Dec

2020 - sertraline  8 Apr - 16mg 29 Apr - 15.5mg 13 may - 15.25mg may 19 - 15mg may 22- 14.75mg 22 Jun 14mg 6 July 13.3 - 20 July 12.6 - 3 August - 11.97 - 17 August 11.37

diazepam 19 Apr - 4.25mg 20 May - 4mg 20 Jun 3.75mg  4.25mg 22 Sept 4.5mg 29 Sept. 4.75ng Oct 5 

 

 

Share this post


Link to post
Altostrata

Please post daily notes with your symptom pattern.


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Share this post


Link to post
Kernol

Hi @Altostrata daily notes from yesterday - follows same pattern for some weeks 

 

5am wake with strong cortisol rush and burning skin head tingling and teeth smashing 

5am-7am a bombardment of bizarre sounds and random memories and hallucinations whilst falling in and out of sleep along with extremely strong emotional pain and dark depression. So intense I can’t describe. As I wake I feel disorientated time travelled into the past I feel psychotic delirious 

8.00am get up have shower - nausea starts emotional pain depression random memories still feel very ungrounded 

9.00am take 1.5mg diazepam 

10.40am nausea feels tiny bit better all mental symptoms stay same - intense and unrelenting 

12.45pm chills and whole body shivers start and nausea ramps up to extreme

1.00pm take 1.5mg diazePam

1.30pm no change nausea still extreme chills bad must lie down

2.00pm in bed breathing with extreme nausea all afternoon Mental symptoms still intense 

5.30pm take 1.75mg diazepam. 
6.30pm nausea finally lessens.

7.00pm manage small meal. Mental symptoms reduced by 20% 

8.30pm restless leg syndrome 

9.00pm take 11.37mg sertraline
10.00pm fall asleep

2.00am wake with nightmares and nightsweats With a chemical dark emotion I can’t even put a name to

5.00am wake with strong cortisol rush and burning sizzling skin all over my side and legs and burning brain. Random memories and strange songs and hymns in my head that sound like they are actually outside my head but are not. 

 

 

Should I ask the doctor to prescribe something for the extreme nausea? I have tried ginger and I have tried the pink pepto bismol but did nothing.  It is every day and i have to go to bed with this flu feeling all afternoon. I am finding it so hard to keep anything down even liquids apart from in evening. This started at end of August and has just got worse and worse


10 years on Sertraline 100mg. 75mg Dec 2016 - Apr 2017, 50mg May 2017 - Oct 2017, 37.5mg

 

2018 - Sertraline 25mg Mar -  July 2018, 13.75mg Aug- Sept 1.5 month (‘not accurately measured), came off completely 10 October, reinstated by doctor on 10 November 25 mg. 25 November raised to 50mg 2 December 100mg 11 December 150mg 30 November. Lorazepam started 2mg x daily 1 November

2019 - Sertraline reduced  to 100mg 5 Feb, 23 Feb 75mg, 18 Mar 50mg, 23 Apr 37.5mg, 1 Jun 25mg, 3 Jul 16mg, 3 Aug 8mg, updosed on 1 Sept to 16.67mg 

20 Feb lorazepam 2mg x day crossed over to diazepam 20mg x day over 2 week period to taper. diazepam reduced by 1mg every 2/3 weeks got down to 3.5mg in August. 

22 Sept resorted to taking 1mg lorazepam after sertraline destabilisation instead of diazepam. took lorazepam 1mg  x day 22 Sept - 28 Sept then returned to diazepam on 29  Sept 4mg,, 30 Sept 4.5mg  1 Oct 5mg 2 Oct 5mg  16 Nov 4.75mg. 15 Dec 5mg 29 Dec 4.75mg   Vortioxetine 5mg started 1 July. 14 July 10mg -Reduced on 20 July to 5mg. 12 Sept reduced to  3.75mg, 19 Sept reduced to 2.5mg, 15 Oct reduced to 2mg, 22 Oct 1.9mg, 29 Oct 1.8mg reduced down every 3 days and then daily stopped on 2 Dec

2020 - sertraline  8 Apr - 16mg 29 Apr - 15.5mg 13 may - 15.25mg may 19 - 15mg may 22- 14.75mg 22 Jun 14mg 6 July 13.3 - 20 July 12.6 - 3 August - 11.97 - 17 August 11.37

diazepam 19 Apr - 4.25mg 20 May - 4mg 20 Jun 3.75mg  4.25mg 22 Sept 4.5mg 29 Sept. 4.75ng Oct 5 

 

 

Share this post


Link to post
Altostrata

When did you move sertaline to 9 p.m.?

 

7 hours ago, Kernol said:

2.00am wake with nightmares and nightsweats With a chemical dark emotion I can’t even put a name to

5.00am wake with strong cortisol rush and burning sizzling skin all over my side and legs and burning brain. Random memories and strange songs and hymns in my head that sound like they are actually outside my head but are not. 

 

Was this different from your usual nighttime pattern?


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Share this post


Link to post
Kernol

Hi @Altostrata in April as I was having  lots of issues with getting to sleep. It did help I can get off to sleep better now. 


10 years on Sertraline 100mg. 75mg Dec 2016 - Apr 2017, 50mg May 2017 - Oct 2017, 37.5mg

 

2018 - Sertraline 25mg Mar -  July 2018, 13.75mg Aug- Sept 1.5 month (‘not accurately measured), came off completely 10 October, reinstated by doctor on 10 November 25 mg. 25 November raised to 50mg 2 December 100mg 11 December 150mg 30 November. Lorazepam started 2mg x daily 1 November

2019 - Sertraline reduced  to 100mg 5 Feb, 23 Feb 75mg, 18 Mar 50mg, 23 Apr 37.5mg, 1 Jun 25mg, 3 Jul 16mg, 3 Aug 8mg, updosed on 1 Sept to 16.67mg 

20 Feb lorazepam 2mg x day crossed over to diazepam 20mg x day over 2 week period to taper. diazepam reduced by 1mg every 2/3 weeks got down to 3.5mg in August. 

22 Sept resorted to taking 1mg lorazepam after sertraline destabilisation instead of diazepam. took lorazepam 1mg  x day 22 Sept - 28 Sept then returned to diazepam on 29  Sept 4mg,, 30 Sept 4.5mg  1 Oct 5mg 2 Oct 5mg  16 Nov 4.75mg. 15 Dec 5mg 29 Dec 4.75mg   Vortioxetine 5mg started 1 July. 14 July 10mg -Reduced on 20 July to 5mg. 12 Sept reduced to  3.75mg, 19 Sept reduced to 2.5mg, 15 Oct reduced to 2mg, 22 Oct 1.9mg, 29 Oct 1.8mg reduced down every 3 days and then daily stopped on 2 Dec

2020 - sertraline  8 Apr - 16mg 29 Apr - 15.5mg 13 may - 15.25mg may 19 - 15mg may 22- 14.75mg 22 Jun 14mg 6 July 13.3 - 20 July 12.6 - 3 August - 11.97 - 17 August 11.37

diazepam 19 Apr - 4.25mg 20 May - 4mg 20 Jun 3.75mg  4.25mg 22 Sept 4.5mg 29 Sept. 4.75ng Oct 5 

 

 

Share this post


Link to post
Kernol
16 hours ago, Altostrata said:

When did you move sertaline to 9 p.m.?

 

 

Was this different from your usual nighttime pattern?


hi @Altostrata no it’s no different from my usual nighttime pattern really. 


10 years on Sertraline 100mg. 75mg Dec 2016 - Apr 2017, 50mg May 2017 - Oct 2017, 37.5mg

 

2018 - Sertraline 25mg Mar -  July 2018, 13.75mg Aug- Sept 1.5 month (‘not accurately measured), came off completely 10 October, reinstated by doctor on 10 November 25 mg. 25 November raised to 50mg 2 December 100mg 11 December 150mg 30 November. Lorazepam started 2mg x daily 1 November

2019 - Sertraline reduced  to 100mg 5 Feb, 23 Feb 75mg, 18 Mar 50mg, 23 Apr 37.5mg, 1 Jun 25mg, 3 Jul 16mg, 3 Aug 8mg, updosed on 1 Sept to 16.67mg 

20 Feb lorazepam 2mg x day crossed over to diazepam 20mg x day over 2 week period to taper. diazepam reduced by 1mg every 2/3 weeks got down to 3.5mg in August. 

22 Sept resorted to taking 1mg lorazepam after sertraline destabilisation instead of diazepam. took lorazepam 1mg  x day 22 Sept - 28 Sept then returned to diazepam on 29  Sept 4mg,, 30 Sept 4.5mg  1 Oct 5mg 2 Oct 5mg  16 Nov 4.75mg. 15 Dec 5mg 29 Dec 4.75mg   Vortioxetine 5mg started 1 July. 14 July 10mg -Reduced on 20 July to 5mg. 12 Sept reduced to  3.75mg, 19 Sept reduced to 2.5mg, 15 Oct reduced to 2mg, 22 Oct 1.9mg, 29 Oct 1.8mg reduced down every 3 days and then daily stopped on 2 Dec

2020 - sertraline  8 Apr - 16mg 29 Apr - 15.5mg 13 may - 15.25mg may 19 - 15mg may 22- 14.75mg 22 Jun 14mg 6 July 13.3 - 20 July 12.6 - 3 August - 11.97 - 17 August 11.37

diazepam 19 Apr - 4.25mg 20 May - 4mg 20 Jun 3.75mg  4.25mg 22 Sept 4.5mg 29 Sept. 4.75ng Oct 5 

 

 

Share this post


Link to post
Altostrata

https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/019839s070,020990s032lbl.pdf

Quote

peak plasma concentrations (Cmax) of sertraline occurred between 4.5 to 8.4 hours post-dosing.

 

Since you seem to get more intense symptoms after you take sertraline, they do not appear to be sertraline withdrawal symptoms, they appear to be adverse effects of sertraline.

 

If I were you, I'd reduce to 11mg.

 

 


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Share this post


Link to post
Kernol

Hi @Altostrata I had a similar pattern though when I took it during the day and sometimes my worst symptoms are in the afternoon plus if it was an adverse reaction why would I be so much worse now having reduced the drug down over the past months. Surely it would have relieved some of it not crashed my system into such a bad destabilisation? I honestly don’t know what to do. 


10 years on Sertraline 100mg. 75mg Dec 2016 - Apr 2017, 50mg May 2017 - Oct 2017, 37.5mg

 

2018 - Sertraline 25mg Mar -  July 2018, 13.75mg Aug- Sept 1.5 month (‘not accurately measured), came off completely 10 October, reinstated by doctor on 10 November 25 mg. 25 November raised to 50mg 2 December 100mg 11 December 150mg 30 November. Lorazepam started 2mg x daily 1 November

2019 - Sertraline reduced  to 100mg 5 Feb, 23 Feb 75mg, 18 Mar 50mg, 23 Apr 37.5mg, 1 Jun 25mg, 3 Jul 16mg, 3 Aug 8mg, updosed on 1 Sept to 16.67mg 

20 Feb lorazepam 2mg x day crossed over to diazepam 20mg x day over 2 week period to taper. diazepam reduced by 1mg every 2/3 weeks got down to 3.5mg in August. 

22 Sept resorted to taking 1mg lorazepam after sertraline destabilisation instead of diazepam. took lorazepam 1mg  x day 22 Sept - 28 Sept then returned to diazepam on 29  Sept 4mg,, 30 Sept 4.5mg  1 Oct 5mg 2 Oct 5mg  16 Nov 4.75mg. 15 Dec 5mg 29 Dec 4.75mg   Vortioxetine 5mg started 1 July. 14 July 10mg -Reduced on 20 July to 5mg. 12 Sept reduced to  3.75mg, 19 Sept reduced to 2.5mg, 15 Oct reduced to 2mg, 22 Oct 1.9mg, 29 Oct 1.8mg reduced down every 3 days and then daily stopped on 2 Dec

2020 - sertraline  8 Apr - 16mg 29 Apr - 15.5mg 13 may - 15.25mg may 19 - 15mg may 22- 14.75mg 22 Jun 14mg 6 July 13.3 - 20 July 12.6 - 3 August - 11.97 - 17 August 11.37

diazepam 19 Apr - 4.25mg 20 May - 4mg 20 Jun 3.75mg  4.25mg 22 Sept 4.5mg 29 Sept. 4.75ng Oct 5 

 

 

Share this post


Link to post
Altostrata

Many things could be going on here, but sertaline withdrawal seems less likely, because your symptoms do not get even a little better after you take sertraline.

 

Can you increase diazepam a bit?


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Share this post


Link to post
Kernol

Hi @Altostrata yes I can increase it but to be honest I think I would need to double what I am currently on to provide any relief. When I took the lorazepam rescue doses of 1mg were the only days I did not have the extreme nausea and vomiting - I still had nausea but it was tolerable and it muted the mental symptoms a bit more. 
 

the gp is suggesting an anti-emetic for the nausea and vomiting as I have lost so much weight but I am concerned they all seem to affect either dopamine or sertraline blockers in the brain? I am a bit concerned about this but I obviously can’t go on with this every day it has been 2 months now


10 years on Sertraline 100mg. 75mg Dec 2016 - Apr 2017, 50mg May 2017 - Oct 2017, 37.5mg

 

2018 - Sertraline 25mg Mar -  July 2018, 13.75mg Aug- Sept 1.5 month (‘not accurately measured), came off completely 10 October, reinstated by doctor on 10 November 25 mg. 25 November raised to 50mg 2 December 100mg 11 December 150mg 30 November. Lorazepam started 2mg x daily 1 November

2019 - Sertraline reduced  to 100mg 5 Feb, 23 Feb 75mg, 18 Mar 50mg, 23 Apr 37.5mg, 1 Jun 25mg, 3 Jul 16mg, 3 Aug 8mg, updosed on 1 Sept to 16.67mg 

20 Feb lorazepam 2mg x day crossed over to diazepam 20mg x day over 2 week period to taper. diazepam reduced by 1mg every 2/3 weeks got down to 3.5mg in August. 

22 Sept resorted to taking 1mg lorazepam after sertraline destabilisation instead of diazepam. took lorazepam 1mg  x day 22 Sept - 28 Sept then returned to diazepam on 29  Sept 4mg,, 30 Sept 4.5mg  1 Oct 5mg 2 Oct 5mg  16 Nov 4.75mg. 15 Dec 5mg 29 Dec 4.75mg   Vortioxetine 5mg started 1 July. 14 July 10mg -Reduced on 20 July to 5mg. 12 Sept reduced to  3.75mg, 19 Sept reduced to 2.5mg, 15 Oct reduced to 2mg, 22 Oct 1.9mg, 29 Oct 1.8mg reduced down every 3 days and then daily stopped on 2 Dec

2020 - sertraline  8 Apr - 16mg 29 Apr - 15.5mg 13 may - 15.25mg may 19 - 15mg may 22- 14.75mg 22 Jun 14mg 6 July 13.3 - 20 July 12.6 - 3 August - 11.97 - 17 August 11.37

diazepam 19 Apr - 4.25mg 20 May - 4mg 20 Jun 3.75mg  4.25mg 22 Sept 4.5mg 29 Sept. 4.75ng Oct 5 

 

 

Share this post


Link to post
Altostrata

Increasing the benzo would be your best bet, not adding in another drug which, as you have observed, can throw yet another spanner into the works.


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Share this post


Link to post
Kernol

Ok @Altostrata I will try it but the small increases I have made in the diazepam have not made any difference so far so what schedule should I increase by to on one hand to hopefully provide some level of relief as soon as possible whilst balancing the risk of kindling myself on it?  


10 years on Sertraline 100mg. 75mg Dec 2016 - Apr 2017, 50mg May 2017 - Oct 2017, 37.5mg

 

2018 - Sertraline 25mg Mar -  July 2018, 13.75mg Aug- Sept 1.5 month (‘not accurately measured), came off completely 10 October, reinstated by doctor on 10 November 25 mg. 25 November raised to 50mg 2 December 100mg 11 December 150mg 30 November. Lorazepam started 2mg x daily 1 November

2019 - Sertraline reduced  to 100mg 5 Feb, 23 Feb 75mg, 18 Mar 50mg, 23 Apr 37.5mg, 1 Jun 25mg, 3 Jul 16mg, 3 Aug 8mg, updosed on 1 Sept to 16.67mg 

20 Feb lorazepam 2mg x day crossed over to diazepam 20mg x day over 2 week period to taper. diazepam reduced by 1mg every 2/3 weeks got down to 3.5mg in August. 

22 Sept resorted to taking 1mg lorazepam after sertraline destabilisation instead of diazepam. took lorazepam 1mg  x day 22 Sept - 28 Sept then returned to diazepam on 29  Sept 4mg,, 30 Sept 4.5mg  1 Oct 5mg 2 Oct 5mg  16 Nov 4.75mg. 15 Dec 5mg 29 Dec 4.75mg   Vortioxetine 5mg started 1 July. 14 July 10mg -Reduced on 20 July to 5mg. 12 Sept reduced to  3.75mg, 19 Sept reduced to 2.5mg, 15 Oct reduced to 2mg, 22 Oct 1.9mg, 29 Oct 1.8mg reduced down every 3 days and then daily stopped on 2 Dec

2020 - sertraline  8 Apr - 16mg 29 Apr - 15.5mg 13 may - 15.25mg may 19 - 15mg may 22- 14.75mg 22 Jun 14mg 6 July 13.3 - 20 July 12.6 - 3 August - 11.97 - 17 August 11.37

diazepam 19 Apr - 4.25mg 20 May - 4mg 20 Jun 3.75mg  4.25mg 22 Sept 4.5mg 29 Sept. 4.75ng Oct 5 

 

 

Share this post


Link to post
Altostrata

As diazepam has a very long half-life, I would go up gradually, not faster than 0.5mg every 2 weeks, see what it does.

 

If you have withdrawal from lorazepam and sertraline, this may help.


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Share this post


Link to post
Kernol

Hi @Gridley I hope you can help. I saw someone mentioned you talking about extreme swings between good short windows and bad waves not being a good sign and this seems to be the case for me. I am hoping you might be able to shed some light on what has happened:

 

after high reinstatement of sertraline in Nov 2018 I have reduced it a second time (I believe the reinstatement kindled me) over the last 2 years. When I got to the lower doses under 25mg last September I went too fast and then updosed and my symptoms became much worse like a permanent bad acid trip and severe Bruxism and many more developed etc so I live in survival mode every day. I held for 8 months both sertraline at 16.76mg and did not reduce diazepam further. I also came off vortioxetine which I was put on to help me get off sertraline. I don’t believe the vortioxetine did much either way to affect my withdrawal. I did have a one week window after finishing it last December (my first window). I never stabilised during holding unfortunately.
 

So as holding did not help in April this year  I started to taper the sertraline again at 10% a month and I started experiencing windows of much reduced symptoms within days but only in the Second half of my hormonal cycle then I would go into a bad wave in the first half of my cycle and this continued for 3 months with each wave getting worse than the last. The last window I had was my longest in July for 3 weeks then as my hormonal cycle ended I completely crashed and here I am 3 months later still the worst wave of my 2 year journey with much worse mental symptoms and new physical symptoms constant nausea vomiting and chills. No let up and no more strange windows. Every time I got a window I would sneeze on waking every morning but no more sneezing since. I don’t know what the sneezing means but I don’t get a window without the sneezing happening.

 

i stopped the taper but I am intrigued into whether you think those strange windows were actually a sign of destabilisation and I was about to crash? I don’t know what this means for my future tapering and if there is anything I can learn? 
 

thank you 


10 years on Sertraline 100mg. 75mg Dec 2016 - Apr 2017, 50mg May 2017 - Oct 2017, 37.5mg

 

2018 - Sertraline 25mg Mar -  July 2018, 13.75mg Aug- Sept 1.5 month (‘not accurately measured), came off completely 10 October, reinstated by doctor on 10 November 25 mg. 25 November raised to 50mg 2 December 100mg 11 December 150mg 30 November. Lorazepam started 2mg x daily 1 November

2019 - Sertraline reduced  to 100mg 5 Feb, 23 Feb 75mg, 18 Mar 50mg, 23 Apr 37.5mg, 1 Jun 25mg, 3 Jul 16mg, 3 Aug 8mg, updosed on 1 Sept to 16.67mg 

20 Feb lorazepam 2mg x day crossed over to diazepam 20mg x day over 2 week period to taper. diazepam reduced by 1mg every 2/3 weeks got down to 3.5mg in August. 

22 Sept resorted to taking 1mg lorazepam after sertraline destabilisation instead of diazepam. took lorazepam 1mg  x day 22 Sept - 28 Sept then returned to diazepam on 29  Sept 4mg,, 30 Sept 4.5mg  1 Oct 5mg 2 Oct 5mg  16 Nov 4.75mg. 15 Dec 5mg 29 Dec 4.75mg   Vortioxetine 5mg started 1 July. 14 July 10mg -Reduced on 20 July to 5mg. 12 Sept reduced to  3.75mg, 19 Sept reduced to 2.5mg, 15 Oct reduced to 2mg, 22 Oct 1.9mg, 29 Oct 1.8mg reduced down every 3 days and then daily stopped on 2 Dec

2020 - sertraline  8 Apr - 16mg 29 Apr - 15.5mg 13 may - 15.25mg may 19 - 15mg may 22- 14.75mg 22 Jun 14mg 6 July 13.3 - 20 July 12.6 - 3 August - 11.97 - 17 August 11.37

diazepam 19 Apr - 4.25mg 20 May - 4mg 20 Jun 3.75mg  4.25mg 22 Sept 4.5mg 29 Sept. 4.75ng Oct 5 

 

 

Share this post


Link to post
Gridley
21 minutes ago, Kernol said:

saw someone mentioned you talking about extreme swings between good short windows and bad waves not being a good sign

No, this is normal for waves and windows.

 

21 minutes ago, Kernol said:

strange windows were actually a sign of destabilisation and I was about to crash?

I don't think they're a sign of destabilization.  A lot of it is tied in with the hormonal cycle and a lot of it is just out of the blue.  The fact that you experienced very good windows is a sign of healing.  It's impossible to predict how the waves and windows are going to manifest because there is so much we don't know about withdrawal.  You've probably read this link, but in case you haven't, here it is and it would probably be worth a re-read.

 

The Windows and Waves Pattern of Stabilization

 

Edited by Gridley

Gridley Introduction

 

Lexapro 20 mg since 2004.  Begin Brassmonkey Slide Taper Jan. 2017.   

End 2017 year 1 of taper at 9.25mg 

End 2018 year 2 of taper at 4.1mg

End 2019 year 3 of taper at 1.0mg  

Oct. 30, 2020  Jump to zero from 0.025mg.  Current dose: 0.000mg

3 year, 10 month taper is 100% complete.

 

Lorazepam 1 mg 1986-1991 CT, resumed a few months later. CT 2000.  1 mg 2011-2016.  Sept, 2016 increased to 0.5 X 3 in split dose. Sept. 2019 increased to 0.625 X 3 after crossover to new brand

 

Imipramine 75 mg daily since 1986.  Jan. 2016 began every 3-weeks 10% taper, down to 15mg.  Aug 2016, discovered SA, updosed to 25mg and holding.  Taper is 66% complete.  

  

Supplements: omega, vitamins E and D3, magnesium glycinate, probiotic, melatonin .3mg


I am not a medical professional and this is not medical advice, but simply information based on my own experience, as well as other members who have survived these drugs.

Share this post


Link to post
Kernol

Thanks so much @Gridley that is reassuring. I was just concerned because my baseline was getting worse in each wave following these windows with new symptoms etc. 
 

do people that have been kindled like me and are finding it almost impossible to get off the drug a second time always go on to have a protracted withdrawal? I have seen many people saying this and I am scared this is my fate. I know we can’t predict but it would sure help to see people who have been in acute for so long tapering that did not go on to have a protracted post withdrawal. I feel quite lost as to what to do next. 


10 years on Sertraline 100mg. 75mg Dec 2016 - Apr 2017, 50mg May 2017 - Oct 2017, 37.5mg

 

2018 - Sertraline 25mg Mar -  July 2018, 13.75mg Aug- Sept 1.5 month (‘not accurately measured), came off completely 10 October, reinstated by doctor on 10 November 25 mg. 25 November raised to 50mg 2 December 100mg 11 December 150mg 30 November. Lorazepam started 2mg x daily 1 November

2019 - Sertraline reduced  to 100mg 5 Feb, 23 Feb 75mg, 18 Mar 50mg, 23 Apr 37.5mg, 1 Jun 25mg, 3 Jul 16mg, 3 Aug 8mg, updosed on 1 Sept to 16.67mg 

20 Feb lorazepam 2mg x day crossed over to diazepam 20mg x day over 2 week period to taper. diazepam reduced by 1mg every 2/3 weeks got down to 3.5mg in August. 

22 Sept resorted to taking 1mg lorazepam after sertraline destabilisation instead of diazepam. took lorazepam 1mg  x day 22 Sept - 28 Sept then returned to diazepam on 29  Sept 4mg,, 30 Sept 4.5mg  1 Oct 5mg 2 Oct 5mg  16 Nov 4.75mg. 15 Dec 5mg 29 Dec 4.75mg   Vortioxetine 5mg started 1 July. 14 July 10mg -Reduced on 20 July to 5mg. 12 Sept reduced to  3.75mg, 19 Sept reduced to 2.5mg, 15 Oct reduced to 2mg, 22 Oct 1.9mg, 29 Oct 1.8mg reduced down every 3 days and then daily stopped on 2 Dec

2020 - sertraline  8 Apr - 16mg 29 Apr - 15.5mg 13 may - 15.25mg may 19 - 15mg may 22- 14.75mg 22 Jun 14mg 6 July 13.3 - 20 July 12.6 - 3 August - 11.97 - 17 August 11.37

diazepam 19 Apr - 4.25mg 20 May - 4mg 20 Jun 3.75mg  4.25mg 22 Sept 4.5mg 29 Sept. 4.75ng Oct 5 

 

 

Share this post


Link to post
Gridley
22 minutes ago, Kernol said:

 

do people that have been kindled like me and are finding it almost impossible to get off the drug a second time always go on to have a protracted withdrawal?

I wish I could give you a definite answer, but there is just no way to predict who will go on to paws and who won't.

 

24 minutes ago, Kernol said:

I am scared this is my fate.

The best approach is to assume the best.  Worrying causes stress which makes you feel worse.


Gridley Introduction

 

Lexapro 20 mg since 2004.  Begin Brassmonkey Slide Taper Jan. 2017.   

End 2017 year 1 of taper at 9.25mg 

End 2018 year 2 of taper at 4.1mg

End 2019 year 3 of taper at 1.0mg  

Oct. 30, 2020  Jump to zero from 0.025mg.  Current dose: 0.000mg

3 year, 10 month taper is 100% complete.

 

Lorazepam 1 mg 1986-1991 CT, resumed a few months later. CT 2000.  1 mg 2011-2016.  Sept, 2016 increased to 0.5 X 3 in split dose. Sept. 2019 increased to 0.625 X 3 after crossover to new brand

 

Imipramine 75 mg daily since 1986.  Jan. 2016 began every 3-weeks 10% taper, down to 15mg.  Aug 2016, discovered SA, updosed to 25mg and holding.  Taper is 66% complete.  

  

Supplements: omega, vitamins E and D3, magnesium glycinate, probiotic, melatonin .3mg


I am not a medical professional and this is not medical advice, but simply information based on my own experience, as well as other members who have survived these drugs.

Share this post


Link to post

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
×
×
  • Create New...

Important Information

Terms of Use Privacy Policy