Jump to content
DaisyBell

Tips for tapering Promethazine (Phenergan)

Recommended Posts

DaisyBell

Does anyone have ideas on a tapering schedule for those that have been using Phenergan more than 6 months. It comes in 10 and 25 mg oral tablets. It has moderate anticholinegic effects and is a mild dopamine antagonist alongside strong H1 histamine action. Given that I assume tapering is important.

Share this post


Link to post
Share on other sites
ChessieCat

I think Phenergan is available as a liquid.  That might be the easiest way to get doses.

Share this post


Link to post
Share on other sites
DaisyBell
47 minutes ago, ChessieCat said:

I think Phenergan is available as a liquid.  That might be the easiest way to get doses.

Thanks ChessieCat. Wondering what time schedule e.g 25 % drop every week ok? Also read that liquid is absorbed more so may be best to stay with tablets. 

Share this post


Link to post
Share on other sites
Altostrata

@DaisyBell How often are you taking promethazine? It's basically an antihistamine. Are you taking it for sleep?

 

https://www.drugs.com/monograph/promethazine-hydrochloride.html

 

Quote

 

Duration

Duration of sedative effects usually about 2–8 hours117 133 a b (depending on the dose and route of administration);a b effects may persist for 12 hours.100 117 133

....

Half-life

9–16 hours (following IV use) and about 9.8 hours (following IM use).117

 

 

If you're only taking it only once a day, it doesn't need much tapering. You might reduced it by 25% every few days.

 

In the US, it comes in a liquid form.

Share this post


Link to post
Share on other sites
DaisyBell
31 minutes ago, Altostrata said:

@DaisyBell How often are you taking promethazine? It's basically an antihistamine. Are you taking it for sleep?

 

https://www.drugs.com/monograph/promethazine-hydrochloride.html

 

 

If you're only taking it only once a day, it doesn't need much tapering. You might reduced it by 25% every few days.

 

In the US, it comes in a liquid form.

Thank you so much. I've taken 25 mg nearly per day for between 6-12 months. I stopped C T a few days ago and then two days later started crying at everything.

Share this post


Link to post
Share on other sites
DaisyBell

And yes for sleep 😴 

Share this post


Link to post
Share on other sites
Altostrata

Did your sleep pattern change after you stopped it?

Share this post


Link to post
Share on other sites
Songbird

Promethazine is a phenothiazine drug,  closely related to other meds used as anti-psychotics, so I would be inclined to be cautious with tapering speed.  You may be able to buy it as a liquid.

Share this post


Link to post
Share on other sites
DaisyBell

Yes I started to wake at 3am on second day after CT. I also take melatonin 1mg. I need to stop it for longer to see if there's a profound effect on my sleep patterns. 

 

I can only buy tablets. Which is fine.

 

Just need to know tapering schedule for safe withdrawal given its properties beyond its histamine action. Searched the internet without finding anything about a tapering schedule. I also searched for a taper schedule for Benadryl (thinking it could be similar) and found nothing. 

 

 

Share this post


Link to post
Share on other sites
Songbird

I would taper by how my body feels, rather than a strict timetable.  Try a reduced dose for a few days, maybe a 25% drop as Alto suggested, and see how it goes.  If you do have symptoms from the drop, you can hold until they ease off.  I've tapered off quite a few things this way.  You can buy Phenergan elixir in New Zealand - if you can't get it in your local pharmacy, it is available from online pharmacies (e.g. Netpharmacy).

Share this post


Link to post
Share on other sites
DaisyBell

Thank you Alto, Songbird and Chessie cat.  

Share this post


Link to post
Share on other sites
Songbird

Keep us updated, DaisyBell.

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

×

Important Information

By using this site, you agree to our Terms of Use.