Nivsch Posted August 11, 2020 Share Posted August 11, 2020 On 6/15/2011 at 10:36 AM, poodlebell said: Grapefruit juice, which contains naringenin, slows down Phase I enzyme activity. It decreases the rate of elimination of drugs from the blood and has been found to substantially alter their clinical activity and toxicity. Eight ounces of grapefruit juice contains enough of the flavonoid naringenin to decrease cytochrome P450 activity by a remarkable 30%. Edited: after thinking again i think it might be problematic but if you think differently and you had good experience with a very little amounts of this juice please tell. What do you think about grapefruit juice during tapering? Can it increase the half life of cymbalta and lessen the withdrawl symptoms? 2010-2015 Cipramil 20-40mg. half-year break in the middle which was tough. 2015-2020 Venlafaxine 150-225 mg. Venlafaxine duloxetine cross taper details 150 for half-year then 225 for a period than stabilized in ~187.5 (1.25 pills) for 2 years than reduced to ~168.5 (1.125 pills). 3.2020 - Duloxetine 60mg. 19.05.2020 - started to taper - 59! 20.5 - 58.5. June 2020: 57. end of June - 55.5 Summer 2020: 5.7 - 54, 9.7 - 52, 12.7 - updose to 53+, 19.7 - 52.3, 26.7 - 51.8, 4.8 - 51.3, 11.8 - 50.8, 15.8 - updose to 51.0, 17.8 - 50.5, 19.8 - 50.3, 19.9 - 49.3 Autumn-winter: 7.10 - 46.8, 1.12 - 45.8, 17.12 - 44.4, 30.12 - 42.4, 21.1 - 40.8. 17.2 - 40.1, end of feb - 38.6, spring: mid march updose to 40.1, 28.3 - 38.6, 15.4 - 37.5, 14.5 - 36.8, end of may 37.5+ and after a week 39 Summer 2021: mid of june again to 36.7, end of july 39.5. 11.10.2021 - 40.7 📌 Link to comment Share on other sites More sharing options...
Moderator Frogie Posted August 11, 2020 Moderator Share Posted August 11, 2020 5 hours ago, Nivsch said: Edited: after thinking again i think it might be problematic but if you think differently and you had good experience with a very little amounts of this juice please tell. What do you think about grapefruit juice during tapering? Can it increase the half life of cymbalta and lessen the withdrawl symptoms? I found this about grapefruit juice: Mixing Cymbalta with grapefruit or grapefruit juice may increase the risk of side effects or overdose. The acidic fruit interferes with the metabolism of the drug and may allow it to build up in the patient. PREVIOUS medications and discontinuations: Have been on medications since 1996. Valium, Gabapentin, Lamictal, Prilosec and Zantac from 2000 to 2015 with a fast taper by a psychiatrist. Liquid Lexapro Nov, 2016 to 31-March, 2019 Lexapro free!!! (total Lexapro taper was 4 years-started with pill form) ---CURRENT MEDICATIONS:Supplements:Milk Thistle, Metamucil, Magnesium Citrate, Vitamin D3, Levothyroxine 25mcg, Vitamin C, Krill oil. Xanax 1mg 3x day June, 2000 to 19-September, 2020 Went from .150 grams (average weight of 1 Xanax) 3x day to .003 grams 3x day. 19-September, 2020 Xanax free!!! (total Xanax taper was 15-1/2 months-1-June, 2019-19-September, 2020) I am not a medical professional. The suggestions I make are based on personal experience. Link to comment Share on other sites More sharing options...
Moderator brassmonkey Posted August 11, 2020 Moderator Share Posted August 11, 2020 In general it is not a good idea to mix any medication with grapefruit juice. There are several things in grapefruit juice that make it to react badly with many different medications causing them to not work properly. The decreased enzyme activity causes mal-absorption and reduced the bio-availability of many drugs which in turn causes misdosing. Most other citrus juices are fine, but there is just something about grapefruit that makes it a no go. 20 years on Paxil starting at 20mg and working up to 40mg. Sept 2011 started 10% every 6 weeks taper (2.5% every week for 4 weeks then hold for 2 additional weeks), currently at 7.9mg. Oct 2011 CTed 15oz vodka a night, to only drinking 2 beers most nights, totally sober Feb 2013. Since I wrote this I have continued to decrease my dose by 10% every 6 weeks (2.5% every week for 4 weeks and then hold for an additional 2 weeks). I added in an extra 6 week hold when I hit 10mg to let things settle out even more. When I hit 3mgpw it became hard to split the drop into 4 parts so I switched to dropping 1mgpw (pill weight) every week for 3 weeks and then holding for another 3 weeks. The 3 + 3 schedule turned out to be too harsh so I cut back to dropping 1mgpw every 4 weeks which is working better. Final Dose 0.016mg. Current dose 0.000mg 04-15-2017 "It's also important not to become angry, no matter how difficult life is, because you can loose all hope if you can't laugh at yourself and at life in general." Stephen Hawking Link to comment Share on other sites More sharing options...
Sicksagittarius Posted October 28, 2021 Share Posted October 28, 2021 If I eat too much broccoli or high protein will that contribute to detoxing phase 1 and therefore stress out my nervous system and increase my WD symptoms? -2014: Lexapro/escitalopram 10 mg, 2015-2021: Lexapro/escitalopram 20 mg -10/2020-3/2021: decreased 20 mg to 15 mg, 1 mg a month -4/2021: decreased to 10 mg, held for 11 days, 4/2021: decreased to 5 mg, held for 8 days -4/2021: 3-6 days cold turkey lexapro, withdrawal symptoms so reinstated 2.5 mg -omeprazole taper: 9/2021 cut 25%, 10/20/21 25% cut, 12/1/21 25%, 12/28/21 25% cut, (9/36 beads of 40 mg) -11/2020 omeprazole 20 mg, 3/2021: omeprazole 40 mg, -Nordic Naturals Ultimate omega 3 fish pill: 1280 mg -montelukast: 10 mg daily, zyrtec: 10 mg daily -3/20/2021-7/25: mesalamine 1.2 GM, 3 times a day - dropped -birth control: Trilinyah 2014- 2/1/2021 quit cold turkey middle of pack 7/16/2021-8/1/2021 Quicksilver Liposomal multivitamin liquid: biotin, zinc, Vitamins A, C, D E, K, Niacin,, Thiomine, Riboflavin,Vitamin B6, B12, 7/16/2021- 8/25/2021 - boswelia complex (tumeric. ginger, celery) - 2 a day - dropped 7/16/2021 - probiophage probiotic - dropped Link to comment Share on other sites More sharing options...
Sicksagittarius Posted October 29, 2021 Share Posted October 29, 2021 Can switching from non organic to organic foods not gradually cause a shift in WD symptoms from detoxing? -2014: Lexapro/escitalopram 10 mg, 2015-2021: Lexapro/escitalopram 20 mg -10/2020-3/2021: decreased 20 mg to 15 mg, 1 mg a month -4/2021: decreased to 10 mg, held for 11 days, 4/2021: decreased to 5 mg, held for 8 days -4/2021: 3-6 days cold turkey lexapro, withdrawal symptoms so reinstated 2.5 mg -omeprazole taper: 9/2021 cut 25%, 10/20/21 25% cut, 12/1/21 25%, 12/28/21 25% cut, (9/36 beads of 40 mg) -11/2020 omeprazole 20 mg, 3/2021: omeprazole 40 mg, -Nordic Naturals Ultimate omega 3 fish pill: 1280 mg -montelukast: 10 mg daily, zyrtec: 10 mg daily -3/20/2021-7/25: mesalamine 1.2 GM, 3 times a day - dropped -birth control: Trilinyah 2014- 2/1/2021 quit cold turkey middle of pack 7/16/2021-8/1/2021 Quicksilver Liposomal multivitamin liquid: biotin, zinc, Vitamins A, C, D E, K, Niacin,, Thiomine, Riboflavin,Vitamin B6, B12, 7/16/2021- 8/25/2021 - boswelia complex (tumeric. ginger, celery) - 2 a day - dropped 7/16/2021 - probiophage probiotic - dropped Link to comment Share on other sites More sharing options...
Moderator Emeritus ChessieCat Posted October 29, 2021 Moderator Emeritus Share Posted October 29, 2021 (edited) If you know that you are sensitive, or do not know if you are, it is generally a good idea to make any changes gradually. For example if you drink 6 cups of caffeinated coffee each day you would not stop completely but gradually either reduce the number you drink or gradually switch to decaf. And you only make one change at a time, otherwise you might not be able to pin point what is causing any issues or is helping. As an example of this, I have just had a blood test and my cholesterol and blood glucose are both too high. She expected me to start medication at the same time as changing my diet. I told her that I will change my diet and get another blood test after 3 months and then reassess. And even with changing my diet I have not made a drastic change, I am doing it in stages. And of course we need to listen to our body/symptoms whilst making any change. And keep a food diary and note your symptoms can be helpful. And remember that we are all individuals and what another person might have no issues doing might be difficult for you and vice versa. Post #1 of the following topic is aimed at drugs, however the same rules might apply to other things: the-rule-of-3kis-keep-it-simple-keep-it-slow-keep-it-stable Edited October 29, 2021 by ChessieCat Please DO NOT TAG me - thank you PLEASE NOTE: I am not a medical professional. I provide information and make suggestions. MISSION ACCOMPLISHED: (6 year taper) 0mg Pristiq on 13th November 2021 ADs since ~1992: 25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq: 50mg 2012, 100mg beg 2013 (Serotonin Toxicity) Tapering from Oct 2015 - 13 Nov 2021 LAST DOSE 0.0025mg Post 0 updates start here My tapering program My Intro (goes to tapering graph) VIDEO: Antidepressant Withdrawal Syndrome and its Management Link to comment Share on other sites More sharing options...
Sicksagittarius Posted October 29, 2021 Share Posted October 29, 2021 21 hours ago, ChessieCat said: If you know that you are sensitive, or do not know if you are, it is generally a good idea to make any changes gradually. For example if you drink 6 cups of caffeinated coffee each day you would not stop completely but gradually either reduce the number you drink or gradually switch to decaf. And you only make one change at a time, otherwise you might not be able to pin point what is causing any issues or is helping. As an example of this, I have just had a blood test and my cholesterol and blood glucose are both too high. She expected me to start medication at the same time as changing my diet. I told her that I will change my diet and get another blood test after 3 months and then reassess. And even with changing my diet I have not made a drastic change, I am doing it in stages. And of course we need to listen to our body/symptoms whilst making any change. And keep a food diary and note your symptoms can be helpful. And remember that we are all individuals and what another person might have no issues doing might be difficult for you and vice versa. Post #1 of the following topic is aimed at drugs, however the same rules might apply to other things: the-rule-of-3kis-keep-it-simple-keep-it-slow-keep-it-stable Thank you so much for your helpful advice. If I dropped two different foods for a week and a half without doing it gradually, should I add them back in to help keep me stable or just ride it out depending on how I feel? -2014: Lexapro/escitalopram 10 mg, 2015-2021: Lexapro/escitalopram 20 mg -10/2020-3/2021: decreased 20 mg to 15 mg, 1 mg a month -4/2021: decreased to 10 mg, held for 11 days, 4/2021: decreased to 5 mg, held for 8 days -4/2021: 3-6 days cold turkey lexapro, withdrawal symptoms so reinstated 2.5 mg -omeprazole taper: 9/2021 cut 25%, 10/20/21 25% cut, 12/1/21 25%, 12/28/21 25% cut, (9/36 beads of 40 mg) -11/2020 omeprazole 20 mg, 3/2021: omeprazole 40 mg, -Nordic Naturals Ultimate omega 3 fish pill: 1280 mg -montelukast: 10 mg daily, zyrtec: 10 mg daily -3/20/2021-7/25: mesalamine 1.2 GM, 3 times a day - dropped -birth control: Trilinyah 2014- 2/1/2021 quit cold turkey middle of pack 7/16/2021-8/1/2021 Quicksilver Liposomal multivitamin liquid: biotin, zinc, Vitamins A, C, D E, K, Niacin,, Thiomine, Riboflavin,Vitamin B6, B12, 7/16/2021- 8/25/2021 - boswelia complex (tumeric. ginger, celery) - 2 a day - dropped 7/16/2021 - probiophage probiotic - dropped Link to comment Share on other sites More sharing options...
Moderator Emeritus ChessieCat Posted October 30, 2021 Moderator Emeritus Share Posted October 30, 2021 1 hour ago, Sicksagittarius said: If I dropped two different foods for a week and a half without doing it gradually, should I add them back in Are you joking?!?!?!? You are asking this question? Yes, I am exasperated. As previously stated, SA is a site for tapering psychiatric drugs. The staff do sometimes offer suggestions about other things, which I have already done. Just as with tapering and withdrawal members need to do their own research, listen to their symptoms and and make up their own minds how they will do things. This site is not here for staff or members to help manage the minutae/very small details of a member's life. Please use your common sense. For anyone wondering about the tone of my post, please see this post in member's intro topic. Please DO NOT TAG me - thank you PLEASE NOTE: I am not a medical professional. I provide information and make suggestions. MISSION ACCOMPLISHED: (6 year taper) 0mg Pristiq on 13th November 2021 ADs since ~1992: 25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq: 50mg 2012, 100mg beg 2013 (Serotonin Toxicity) Tapering from Oct 2015 - 13 Nov 2021 LAST DOSE 0.0025mg Post 0 updates start here My tapering program My Intro (goes to tapering graph) VIDEO: Antidepressant Withdrawal Syndrome and its Management Link to comment Share on other sites More sharing options...
GGGG Posted February 26 Share Posted February 26 Has anyone tried enema during withdrawl. It was recommended by a naturopath. Year 2010 to 2020 remeron, Buspar, atenelol, Ativan as needed (once a week) remeron stopped working (pooped out) oct 2020 started amitryptyline took it 3 months Dec started wellbutrin, Stopped it 3 months later Started Paxil again for 3 months took vibryd for 1 month, Stopped it in 5 days Started sam e 100mgs 3x a day, Tyrosine 1000mgs 3 x a dayfor 6 months August 2020 - Off all antidepressants 16 th of Feb, 2023 started taperingsam e the 100mg 2 x a day of sam e. I stopped taking the afternoon one. And started every other day then every r day. Link to comment Share on other sites More sharing options...
Moderator Onmyway Posted March 7 Moderator Share Posted March 7 @GGGG, please do not start new threads for topics that already exist. We try to keep the site tidy so as to have relevant information in one place. Please do a search before you post. I am merging your new post here. It takes a lot of moderator and admin time for us to keep cleaning after people. Thank you, OMW "Nothing so small as a moment is insurmountable, and moments are all that we have. You have survived every trial and tribulation that life has thrown at you up until this very instant. When future troubles come—and they will come—a version of you will be born into that moment that can conquer them, too." - Kevin Koenig I am not a doctor and this should not be considered medical advice. You can use the information and recommendations provided in whatever way you want and all decisions on your treatment are yours. If you would like to get a response from me directly please type @Onmyway some place in your message so I get notified of your post. I am not able to follow all of the threads all the time. Aug 2000 - July 2003 (ct, 4-6 wk wd) , citalopram 20 mg, xanax prn, wellbutrin for a few months, trazodone prn Dec 2004 - July 2018 citalopram 20 mg, xanax prn (rarely used) Aug 2018 - citalopram 40 mg (self titrated up) September 2018 - January 2019 tapered citalopram - 40/30/20/10/5 no issues until a week after reaching 0 Feb 2019 0.25 xanax - 0.5/day (3 weeks) over to klonopin 0.25 once a day to manage severe wd March 6, reinstated citalopram 2.5 mg (liquid), klonopin 0.25 mg for sleep 2-3 times a week Apr 1st citalopram 2.0 mg (liquid), klonopin 0.25 once a week, citalopram (liquid) 4/14/19 -1.8 mg, 5/8/19 - 1.6 mg, 7/27/19 -1.5 mg, 8/15/19 - 1.35, 2/21/21 - 1.1 (smaller drops in between), 6/20/21 - 1.03 mg, 8/7/21- 1.025, 8/11/21 - 1.02, 8/15/21 - 1.015, 9/3/21 - 0.925 (fingers crossed!), 10/8/21 - 0.9, 10/18/21 - 0.875, 12/31/21 - 0.85, 1/7/22 - 0.825, 1/14/22 - 0.8, 1/22/22 - 0.785, 8/18/22 - 0.59, 12/15/2022 - 0.48 Supplements: magnesium citrate and bi-glycinate Link to comment Share on other sites More sharing options...
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