Longroadhome: think I may be tapering Seroxat / Paxil too fast

[ChessieCat]

Right at the top of Post #1

 

 

[Longroadhome]

Thank you 😊 @ChessieCat much appreciated 

 

[Erell]

Hello ☀️

 

Coughing can be exhausting.

Have you tried natural remedies ?

 

Hope you'll feel better soon

 

 

[Longroadhome]

Thank you @Erell

 

trying honey last few days and ginger in warm water 

don’t think damp weather is helping . 
dobt want to take antibiotics and my friend said they didn’t help with her cough she had to ride it out . 
 

How are you today ? 

[Erell]

10 minutes ago, Longroadhome said:

Thank you @Erell

 

trying honey last few days and ginger in warm water 

don’t think damp weather is helping . 
dobt want to take antibiotics and my friend said they didn’t help with her cough she had to ride it out . 
 

How are you today ? 

 

Yes it seems that with sensitised CNS we have to be careful with antibiotics.

For how long have you had this issue ?

Does it trouble you to sleep ?

 

When I was at my parents' house we spent a nice afternoon doing the honey : they have some hives. 

Too bad you're not in France, I could have sent you a pot ! 😊

[Altostrata]

You should confirm you have a bacterial infection before you take an antibiotic for anything. They are not effective for viruses.

[Longroadhome]

Thanks @Altostrata Will do 

 

[Longroadhome]

1 hour ago, Erell said:

 

Yes it seems that with sensitised CNS we have to be careful with antibiotics.

For how long have you had this issue ?

Does it trouble you to sleep ?

 

When I was at my parents' house we spent a nice afternoon doing the honey : they have some hives. 

Too bad you're not in France, I could have sent you a pot ! 😊

Three long weeks now came with infection rather like flu 

all family had it but I was hit the worst 

they are over it I’m left with itchy constant cough 

 

did you have to wear the overalls and face masks to get honey from hives ? 
 

no problem sleeping hope it continues 

[Longroadhome]

Paxil split dose

 

Has anyone had success splitting their Paxil dose between morning and evening ? 
At present I take 4.8mg Paxil at 8.30am each morning . However due to short half life I am experiencing  interdose  withdrawal  And before considering other options I was wondering if anyone had success with splitting the dose? 
thank you 

 

Edited August 20, 2020 by ChessieCat
added topic title

[ChessieCat]

Q:  Do you take your dose at the same time every day?  If no, then I suggest that you try doing that first before dose splitting.

 

I haven't heard of any members needing to split their Paxil dose.  However, according to https://www.drugs.com/pro/paxil.html

 

Quote

 

The mean elimination half-life is approximately 21 hours (CV 32%) after oral dosing of 30 mg tablets of Paxil daily for 30 days.

 

 

If you are a fast metaboliser then you might experience interdose withdrawal.

 

You could do this by moving 1/2 of the dose by 1 hour later each day (if you take it in the morning).  If you find that your sleep starts to be affected I suggest that you move the second dose back 1 hour.  If you find that you move the dose by 3 or 4 hours and your symptoms ease then, if it is convenient to continue taking your second dose at that time, you could try leaving it at those dose times for a while.

 

Only make one change at a time.

 

It suggest that you keep daily symptom notes (not required here unless we need to assess the situation) so that you can see how the dose splitting affects your symptoms and sleep.

[Altostrata]

How do you know you have interdose withdrawal?

 

To determine interdose withdrawal,  we look at your daily symptom pattern. Please keep daily notes of times of day you take your drugs, their dosages, and your symptoms throughout the day. Post 24 hours of notes at a time in this topic, in a simple list format with time of day on the left and notation (symptom or drug and dosage) on the right.

 

 

[Longroadhome]

7 hours ago, ChessieCat said:

Q:  Do you take your dose at the same time every day?  If no, then I suggest that you try doing that first before dose splitting.

 

I haven't heard of any members needing to split their Paxil dose.  However, according to https://www.drugs.com/pro/paxil.html

 

 

If you are a fast metaboliser then you might experience interdose withdrawal.

 

You could do this by moving 1/2 of the dose by 1 hour later each day (if you take it in the morning).  If you find that your sleep starts to be affected I suggest that you move the second dose back 1 hour.  If you find that you move the dose by 3 or 4 hours and your symptoms ease then, if it is convenient to continue taking your second dose at that time, you could try leaving it at those dose times for a while.

 

Only make one change at a time.

 

It suggest that you keep daily symptom notes (not required here unless we need to assess the situation) so that you can see how the dose splitting affects your symptoms and sleep.

Thank you @ChessieCat

the information is very useful 

[sunnysideup69]

Hello @Longroadhome, how are you doing? Was thinking of you, I'm back at work now. Waving at you.....is Birmingham in lockdown?

[Longroadhome]

Hi @sunnysideup69

 

Thank you for  asking . 
Not good I’m afraid Don’t know what I’ve done to myself but symptoms getting progressively worse . Prob trying to taper two meds and destabilised . Lyrica such a small dose thought it wasn’t doing anything anyway. I found out it works like a Benzo and from the symptoms I’m getting and checking my diary over this period  my guess is it’s that and not the accidental double dose Of Paxil the one day. im holding at my current doses until things settle . 
 

[sunnysideup69]

Aah, sorry to hear that @Longroadhome....yes, even tiny doses can make an impact. Incredible, isn't it? I think you're right to hold and stabilise. Hang in there ❤️

[Longroadhome]

@Altostrata

 

I am currently on 4.8mg Paxil and 25mg pregabalin . As the Lowest dose of  pregabalin Is a 25mg tablet I mix this with 2.5mg mL of water*. I use a syringe to take 1.25mg morning and the same of an evening. The Paxil is liquid form. 

 

*

25 minutes ago, Longroadhome said:

Sorry when mixing with water should have wrote ml not mg 

 

each day I take 

 

4.8mg Paxil at                    8.30am

12.5mg pregabalin at       10am

12.5mg pregabalin at        4pm 

as I intend to hold for an extended period would you say those times apart work . I’ve done it this way for a while through tapering but as I’m holding and now at lower doses I was wondering if timing was still ok or whether I would benefit by spreading the times out more or even taking the one 25mg pregabalin tablet once a day ? 
 

your advice would be greatly appreciated 

 

thanks Alto. 

 

 

 

Edited September 17, 2020 by ChessieCat
made correct mg to mL

[Longroadhome]

1 hour ago, Longroadhome said:

@Altostrata

 

I am currently on 4.8mg Paxil and 25mg pregabalin . As the Lowest dose of  pregabalin Is a 25mg tablet I mix this with 2.5mg of water. I use a syringe to take 1.25mg morning and the same of an evening. The Paxil is liquid form. 

each day I take 

 

4.8mg Paxil at                    8.30am

12.5mg pregabalin at       10am

12.5mg pregabalin at        4pm 

as I intend to hold for an extended period would you say those times apart work . I’ve done it this way for a while through tapering but as I’m holding and now at lower doses I was wondering if timing was still ok or whether I would benefit by spreading the times out more or even taking the one 25mg pregabalin tablet once a day ? 
 

your advice would be greatly appreciated 

 

thanks Alto. 

 

 

Sorry when mixing with water should have wrote ml not mg 

[Altostrata]

As we discussed, when you taper two drugs at once, it makes it very difficult to interpret your symptom pattern. I have no idea what's going on.

 

Paxil is very difficult to taper on its own.

 

I suppose it would make more sense to take the pregabalin doses 12 hours apart. 25mg pregabalin is not a small dose.

 

I don't know if this will help. You'll probably have to hold a long while to get to a baseline.

[Longroadhome]

@Altostrata

 

thank you 

 

so what times would you take the pregabalin ?
for example 10am and 10pm  Or earlier 7am and 7pm ?  
 

and is the Paxil dose ok staying at 8:30am each morning ? 
 

my intention is to hold for a long time

 

Thank  you for your support Alt I really appreciate  

[Erell]

Hello dear,

 

How are you feeling these days ?

 

3 hours ago, Longroadhome said:

 

so what times would you take the pregabalin ?
for example 10am and 10pm  Or earlier 7am and 7pm ?  
 

and is the Paxil dose ok staying at 8:30am each morning ? 

 

- do you feel like Pregabalin has a soothing effect on you ?

In that case it might be interesting to take it close to bedtime.

 

- I don't see why taking Paxil at 8.30am would be an issue. What makes you think that?

 

Take care, you're halfway home ☀️😊

[Longroadhome]

Hi Erell 

thank you for your reply 

at the moment I’m getting lots of symptoms down to destabilising 

trying to taper both meds . Not a good idea and I’m paying for it since beginning of August . 
 I have severe symptoms some days  and bearable symptoms other days. 
When I am calmer I don’t notice it tying in with taking meds it seems to come randomly.
for instance yesterday I felt calm from 1pm onwards meds were taken at 8.30am Paxil

And 10am pregabalin  
regarding Paxil it’s not an issue with the time I take it I was just wondering if changing the time for pregabalin would make a difference to the time I take Paxil . 
 

Alto has mentioned about leaving 12 hrs between pregabalin doses and I’m wondering how that looks regarding times?  Maybe keep the first dose the same at 10am then start to alter the timing of the second dose to 10pm. 
At the moment I take it at 4pm so to

alter to 10pm would it be a good idea to change by one hour each day going forward ? 
 

im going to hold until I even out 

 

hope you are having a good day today 😊 

[Longroadhome]

Hi @Altostrata

 

would it be ok to alter my dose of pregabalin to 7:30am and then 7:30pm of an evening ? 
 

I take 12.5mg at 10am and 12.5mg at 4pm at the moment . 
 

If so what is the best way to do this would I alter the morning one first my one hour over three days and then alter the evening one by one hour over the next three days ? 
 

I take my dose of Paxil at 8:30am each morning 

 

thanks Alto enjoy yr weekend 

[Altostrata]

You'll want to take pregabalin some hours separate from Paxil, in divided doses 12 hours apart. You pick the schedule.

 

[Longroadhome]

Ok thanks Alt 

 

[Longroadhome]

@Altostrata

 

The half life for  Lyrica is 5 to 7 hours So is it ok to take 12 hours apart ?

 

I’m slowly moving it to be 7am morning and 7pm evening 

And Paxil st 8:30am 

this all sound ok ? 
 

After research on this site I suspect the Lyrica taper has caused my problem and not Paxil because of the nature of the symptoms I am experiencing . I do not want to re instate any but the symptoms seem to be getting worse even though it’s been two months since the reduction. Is it normal to experience more intense muscle spasms and dizziness two months after holding taper?  And if so why ? 
 

Thanks  Alt I do appreciate your support very much even though you’re  angry (Hopefully not as angry..)  at me for tapering two meds. 

[Altostrata]

Most likely, it's mainly Paxil withdrawal.

 

On 9/19/2020 at 11:04 AM, Altostrata said:

You'll want to take pregabalin some hours separate from Paxil, in divided doses 12 hours apart. You pick the schedule.

 

 

We need to see the effects of the new schedule. Please keep daily notes of times of day you take your drugs, their dosages, and your symptoms throughout the day. Post 24 hours of notes at a time in this topic, in a simple list format with time of day on the left and notation (symptom or drug and dosage) on the right. This can show if your symptoms are adverse effects from one of your drugs.

[Longroadhome]

Will do Alt as from tomorrow 

many  thanks 
 

[Longroadhome]

@Altostrata

 

23rd Sep

 

2:45am       Woke up to Mild whole body tremor 
                     And face tics

                     Dozed until 6:45am anxiety high

                     Neck muscles in a spasm 

7am.            Walked dog 

8:15.            12.5mg. Pregabalin 

8.45am .     4.8mg Paxil 
9am.            Work / breakfast 

                     Anxiety very high coordination poor

10:10am.    Came over sweaty and panicky 

                     Calmed after 10 mins

12:15.          Skin became tingly all over I felt 

                     Like I was going to fit lasted for 

                     2 hours varying intensity
                     Muscles felt wired like a current 

                     Running through them 

1pm.           Lunch at home walked dog back to 

                    Work 

managed to work through and finished at 6pm
with small anxiety spikes 

 

6:15pm.      12.5mg pregabalin 

7pm.            Sisters for dinner . Calmer but new 

                     Symptom came on . Weird and hard to 

                      Explain like feeling you get in tummy on 

                     Fairground ride / butterflies feeling 
                     Kept reoccurring on and off all night 

11pm.          Bed

no alcohol no supplements no other meds decaf 

drinks 

    

 

for the record 

each day all day I have anxiety varying degrees from small spikes to sweaty and panicky. Small reprieves in between. Have to keep moving foot as sometimes it goes like akathesia 

I have continuous floaty boat feeling and neck muscle spasms at the slightest provocation 
 

all these symptoms came on after double dose of Paxil on 15th July . They cane on slowly and have got progressively worse over two months 
I was also decreasing pregabalin at the time inbetween Paxil taper . I can give you dates of decreases etc if it will help ?

 

thanks Alto please let me know if this is ok or you require further info ?

 

im not a person to panic but these symptoms are severe and extremely uncomfortable. It feels unlike anything I’ve experienced so far in WD almost like My system is now reacting adversely to either Paxil or Lyrica  

 

 

 

 

                    

                     

 

 

[Altostrata]

13 hours ago, Longroadhome said:

8:15.            12.5mg. Pregabalin 

8.45am .     4.8mg Paxil 

 

Do you feel better or worse after you take these 2 drugs in the morning?

 

You are taking the drugs at almost the same time. It would be best if you separated them by some hours, while taking the pregabalin doses 12 hours apart.

 

Since you were changing dosages of 2 drugs at once, we will not be able to interpret your history of drug changes.

[Longroadhome]

Hi Alto

posting timetable shortly 
 

just to say I’m in the process of moving pregabalin times so that was why on that day they were taken close together 

 

as from today  the times will be 

 

7am.           12.5mg pregabalin 

8:30am.       4.8mg. Paxil 

7pm.          12.5mg pregabalin 

do you think it would be ok to move the Paxil from 8:30am  to 10am leaving a gap of 3 hours between pregabalin and paxil doses of a morning? 
 

From my double dose error I feel worse taking these two drugs. There is no relief. 
it feels like my body is rejecting them hence the very intense symptoms. Can this happen ? 
 

Thank you 

 

[Longroadhome]

@Altostrata

 

24th September 

 

2:30am        woke to cortisol spike mild whole  body 

                      tremor. Dozed on and off thereafter 

7:10am.       Walked dog panic feeling and sweaty

                      Butterfly feeling in tummy horrible 

                     Feeling From tummy to knees

7:45am.       12.5mg pregabalin 
8:30am.      4.8mg paxil

9.30am.      Work. Have breakfast . Off balance 

                     Strong floaty boat feeling 

11.45am.    Whole body tremors start with anxiety 
                     Spike and funny butterfly tummy . When

                    This happens I have to keep tapping my 

                     foot

12 noon.     Lunch 

1pm.           Home to let dog out . Floaty boat 

                     Feeling   Is less 
3pm.            Floaty boat off balance feeling  strong
                     anxiety and neck muscle Spasms
5pm.           Meeting at work. Symptoms still

                     Strong as above 

6.30pm.      At sisters house symptoms lighter

7pm.            12.5mg pregabalin 

8.05pm.      Symptoms light 

11pm.          Bed 

 

[Longroadhome]

For the record 

having these funny turns that make me feel like I’m going to fit reminded me of a few years ago I think about 10 years ago. I wanted to come off Paxil and was on 20mg at the time . My doctor told me to alternate days . One day 20mg the next 10mg and so on . I did this for a few weeks.
went to Rome with my hubby. Fist night there the most scary thing happened to me . I started to feel strange can’t describe it. Like I was looking in on myself from the outside. Just so hard to describe  I fell to the ground couldn’t move my arms or legs . Husband called for an ambulance . I also felt like I was going to lose consciousness but I didn’t . 
paramedics came took me to hospital . I recovered but felt really trembly for hours  . After tests they could find nothing wrong and I was discharged  . 
I put it down to a severe anxiety attack . But. Now I’m wondering if it was a seizure/fit due to alternating my daily dose of Paxil . 
 After that day I upped my dose back to 20mg every day as the episode brought on anxiety . 
never happened again . 
 

funny always considered myself a good girl . Never did drugs never smoked always against anything that could be addictive  Yet all along  unbeknown  to me I was screwing  myself over by taking that little white pill every day ... for years. 

 

[sunnysideup69]

Hey @Longroadhome,

Catching up on your thread. Am hoping you are getting some symptom relief, however small xxx

[Longroadhome]

Aaah thank you @sunnysideup69

im afraid there’s no let up at the moment hoping to catch a break soon ! Though some evenings are better! 
would be interesting to find out if anyone has symptoms that gradually  get worse and more intense over a period of time . Majority I read seems the intense symptoms are there at the start but mine come on and then gradually intensify. 
 

How are you Sunny and how’s work  ? 

[sunnysideup69]

I'm doing okay. Still seem to have cycles of waves within the month, almost feels like PMT except I went through menopause four years ago now. But, thankfully, the waves are really pretty mild now and I'm pretty stable. Often in a good mood. Work is okay but tiring and weird at times...we are all segmented off into 'bubbles' which is bizarre...

Sorry to read there's not much let up, at the moment. You know it will change, but it's tough to cope with for sure. Really hoping you get some relief sooner rather than later x

[Longroadhome]

3 minutes ago, sunnysideup69 said:

I'm doing okay. Still seem to have cycles of waves within the month, almost feels like PMT except I went through menopause four years ago now. But, thankfully, the waves are really pretty mild now and I'm pretty stable. Often in a good mood. Work is okay but tiring and weird at times...we are all segmented off into 'bubbles' which is bizarre...

Sorry to read there's not much let up, at the moment. You know it will change, but it's tough to cope with for sure. Really hoping you get some relief sooner rather than later x

Thank you 

are the bubbles working as in keeping you isolated from others ? 
it’s almost impossible at nursery. For instance children have to pass through one classroom to get to theirs.  
though children have their set times to use the playground inevitably children from one area are leaving the playground as others arrive and there’s only one entry/exit. 

we are giving set times for parents to arrive at the setting but some choose to ignore and totally ignore social distancing rules. 
 
It’s a nightmare !!