Jump to content
BfromNJ

How does being a rapid or ultrarapid metabolizer affect tapering or withdrawal?

Recommended Posts

BfromNJ

So I am an ultrarapid metabolizer on the CYP450.  I had the genomind test done.  So it turned out the mirtazapine is one of the drugs that was in my "use with caution" column.   Basically I guess I metabolize this drug quicker and I am supposed to use caution when this drug is taken "in the presence of inducers" (ie other drugs in the CYP450). It can make the drug less effective.  With that being said, does anyone know that being I am an ultrarapid metabolizer , will this affect my taper/withdraw? 

 

My doctor had indicated when I started the med that this really just meant that the mirt. would be less effective when I take another med that is an inducer or drink coffee, smoke, etc.  

 

 

Share this post


Link to post
Share on other sites
Altostrata

What this means is you might have to take higher doses to get an effect from mirtazapine when you're taking it. If you also ingest an inducer (could be a drug, a supplement, or even a food) of the same liver enzyme, your metabolization of the original drug will be speeded up even more, to the point you might experience withdrawal symptoms.

 

The danger for rapid metabolizers is that they can handle such high doses of drugs without side effects, doctors may overlook the risk of gradual organ damage over time.

 

You are not taking a particularly high dose of mirtazapine.

 

This doesn't mean anything for tapering. You taper to the rate you can tolerate. If you get withdrawal symptoms, you taper more gradually.

 

Generally, these genetic tests are useful only to identify potential drug-drug interactions for drugs that you are considering taking or already taking. They don't indicate anything about withdrawal.

Share this post


Link to post
Share on other sites
Vonnegutjunky

Also it depends on if the drug your taken is converted to its active form via cyp450.

 

if it is converted to its active form via cyp450,  you can get too much of the active drug into your system at once, and the rest of the enzymatic pathway doesn’t clear it, meaning a low dose can feel like an overdose. 

 

Here is is a nice little chart. 

 

https://selfhacked.com/blog/cyp-enzymes-interact-supplements-related-genes/

Share this post


Link to post
Share on other sites
BfromNJ

Thanks.  Very useful.  So basically im screwed coming and going.  Lol.  🙄😂

Share this post


Link to post
Share on other sites
Rachellynn

Is there somewhere to run raw data from 23andme through to find this information out? I too suspect liver issues with/from these drugs🙄

 

ive been told I’m a slow oxidizer but not sure if that’s the same thing. 

 

Thanks!

Share this post


Link to post
Share on other sites
Vonnegutjunky
4 hours ago, BfromNJ said:

Thanks.  Very useful.  So basically im screwed coming and going.  Lol.  🙄😂

 

Lol,I think we all are! Regardless of metabolic issues 😂😂😂

 

honestly, just becuse you have the gene doesn’t mean it’s turned on. It could be, mine actually turned on, and now I know why I had such an extremely adverse reaction to a once previously well tolerated medication. 

 

But becuse you are susceptible, I would say just go slower with your taper than what’s suggested, and you will probably have more intesne waves than others, if your gene has expressed. Also take this advice as a grain of salt becuse I am only speaking from my personal experience and I am in way an expert. (Mod Note:  I think member meant to say "I am in no way an expert".) Just my own research from what happened to me. 

 

 

Edited by ChessieCat
added mod note

Share this post


Link to post
Share on other sites
Vonnegutjunky
13 minutes ago, Rachellynn said:

Is there somewhere to run raw data from 23andme through to find this information out? I too suspect liver issues with/from these drugs🙄

 

ive been told I’m a slow oxidizer but not sure if that’s the same thing. 

 

Thanks!

The only place I know of that will do it online is through selfhacked, it’s called selfdecode, it’s on their site, I don’t know what the charge is. 

Share this post


Link to post
Share on other sites
ChessieCat
4 hours ago, Vonnegutjunky said:

I am only speaking from my personal experience and I am in way an expert. (Mod Note:  I think member meant to say "I am in no way an expert".) Just my own research from what happened to me. 

 

Made the above correction to this post about what I think Vonnegutjunky really meant.

Share this post


Link to post
Share on other sites
BfromNJ

my doctor ordered it through genomind.

Share this post


Link to post
Share on other sites
Vonnegutjunky

Hers was done through 23 and me, she has raw data, it’s different and needs to be decoded. 

 

Yes Chessie! Thank you! 

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

×