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Pedro: mirtazapine withdrawal


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So I've been on many meds for a long time (since 2004) for bipolar + addiction, and have been SLOWLY decreasing them because I had a complete panic attack inability to do anything after a too quick reduction in 2012.


I have been bipolar stable since 2005, when I stupidly stopped taking my Lithium.


2004 doses:

250 Lithium, three a day

600 Carbamazepine at night

60mg Mirtazapine at night


I started reducing Carbamazepine and Mirtazapine again in 2016 because I have two small children and I couldn't sleep as much as I used too, and had been stable for a long timer (all with my psychiatrist, who is really awesome). The goal was only the Lithium by the end of this summer (2019,  child 3 is on the way in September :). I don't really plan on ever stopping the Lithium.


As of January 2019, I was at 

250 Lithium, twice a day

100mg Carbamazepine

7.5 Remeron


I recently (3 weeks ago) went from 7.5 to no Mirtazapine and I can survive the psych and physical side effects--I have Xanax as needed, so I can force sleep when I need to (I've had the Rx for a while and don't take it every day and am intimately familiar with addiction from my life 1996-2004, so don't worry on that front) but have really annoying twitching in my right upper ab muscle. Has anyone else had this?


For me, 2 weeks and 4 weeks are always the sticking points. 


Thanks for the help!



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  • ChessieCat changed the title to Pedro: mirtazapine withdrawal
  • Administrator

Welcome, Pedro.


It sounds like your most recent drug change was going off mirtazapine 3 weeks ago and your sleep has been affected? What is your sleep pattern? How has it changed over the last 3 weeks?


Aside from that, the muscle twitching is your worst symptom? Has that changed over the last 3 weeks?


A lot of people find fish oil and magnesium supplements helpful, see


Try a little bit of one at a time to see how it affects you.


On 6/19/2019 at 8:13 AM, Pedro1933 said:

For me, 2 weeks and 4 weeks are always the sticking points. 

What does this mean?


To help us out, follow these instructions Please put your drug and withdrawal history in your signature You may need to use a computer to do this.

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Hi @Pedro1933 & Welcome to the Group!  Congratulations on tapering your Meds!  If you need any support, please don't hesitate to contact me, Good Luck - Laydefish

2 years Drug History Prior to Tapering:

Between 2011 & 2018 I had approximately 58 dose changes between the 4 main medications I took as well as 14 new medications add & taken away.

Prozac (Fluoxetine):(Aug 2016-Dec 2016: 60MG),(June 2017-Nov 2017: 60MG),(Dec 2017: 80MG),(June 2017-Sept 2 2018: 60MG),(Sept 3 2018-Sept 5 2018: 40MG),(Sept 6 2018-Sept 8 2018: 20MG),(Sept 9 2018: 0MG).

Cymbalta:(Jan 2017-May 2017: 60MG).

Cyclobenzaprine: (Aug 2016: 30MG,(Feb 2017: 30MG).

Diazepam (Valium):(Aug 2016-Sept 15 2016: 30MG),(Sept 16 2016-Oct 2017: 15MG),(Nov 2017-Aug 19 2018: 6MG),(Aug 20 2018: 0MG).

Gabapentin:(Aug 2016-Aug 3 2018: 2400MG),(Aug 4 2018-March 26 2019: 2000MG),(March 27 2019-March 30 2019: 1600MG),(May 1 2019: 2000MG)

Hydrocodone:(Aug 2016-Oct 2016: 10-325/4daily),(Nov 2016-Feb 2017: 10-325/3daily),(March 2017-April 2017: 5-325/4daily),(May 2017-April 2018: 10-325/3daily),(June 2018-Aug 25 2018: 10-325/5daily),(Aug 26 2018-Sept 2 2018: 4.5daily),(Sept 3 2018-Sept 10 2018: 10-325/4daily),(Sept 11 2018-Sept 18 2018: 10-325/3daily),(Sept 19 2018-May 1 2019: 10-325/3.5 daily).

Oxycodone: May 2018: 10-325MG/4daily). 

Please see my Intro for full drug history.

         **Forgive Yourself For Not Knowing What You Didn't Know Before You Knew It!  -Maya Angelou/

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  • Moderator Emeritus

Hi Pedro, 


How are you doing?💚

Been on APs, benzos, ADs and opiates, all for chronic pain. Had severe Akathisia in the past that made me suicidal. Still on Seroquel. 2019:➡️ March10=7.25mg ✔️April17=7.0✔️June5=6.75✔️ July14=6.50✔️Aug28=6.25✔️Oct10=6.20 ✔️ Oct21=6.0✔️Dec16=5.80 ✔️  2020➡️Jan 21=5.60✔️April2=5.40✔️May29=5.20✔️Aug14= 5.0 ✔️Sep29=4.80✔️2021➡️ Jan31=4.60 mg✔️April24=4.40mg✔️Jul17=4.30mg ✔️Aug 28=4.20✔️ Oct 11=4.15✔️Nov1=4.10✔️ Nov21= 4.05✔️ Dec13= 4mg✔️  2022➡️Jan8= 3.95 Jan 31=3.90✔️March2=3.85✔️ April4=3.80✔️June16=3.75✔️July26=3.70✔️Sep2=3.65✔️ Oct21=3.60✔️Dec8=3.55✔️ Jan 26=3.50✔️March 17=3.45✔️ THIS IS NOT MEDICAL ADVICE, consult a doctor.

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