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JMCA: Coming off Mertazapine


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I have been taking Mertazapine for 12 mths for anxiety and insomnia (got good results with sleep and was less anxious) and now things have levelled out some what in my life would like to stop taking it.  I am only just starting to reduce and after doing some reading I will be doing it slowly and see how my body reacts. Three days ago I reduced from 15mg to 7.5 (half tablet), have been feeling fine, sleep is OK but have read symptoms will set in after about 1 week.  Will see how it progresses.

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  • Moderator

Welcome to SA, JMCA.


You are tapering too fast.  We recommend tapering by no more than 10% of current dose every four weeks.  This link explains why.


Why taper by 10% of my dosage?


The link is specifically about tapering Mirtazapine, including how to obtain the small nonstandard doses you'll need for the 10% taper.


Tips for tapering off Remeron (mirtazapine)


Since it's only been three days, you can go back up to 15mg and taper at 10% from there.  That would be my recommendation.  If you choose to stay at 7.5mg, you should hold there for four weeks, then taper using the 10% taper.  It's especially important to go slowly at the lower doses.


This is your Introduction topic, where you can ask questions and connect with other members.  Again, welcome.







Gridley Introduction


Lexapro 20 mg since 2004.  Begin Brassmonkey Slide Taper Jan. 2017.   

End 2017 year 1 of taper at 9.25mg 

End 2018 year 2 of taper at 4.1mg

End 2019 year 3 of taper at 1.0mg  

Oct. 30, 2020  Jump to zero from 0.025mg.  Current dose: 0.000mg

3 year, 10 month taper is 100% complete.


Ativan 1 mg to 1.875mg 1986-2020, two CT's and reinstatements

Nov. 2020, 7-week Ativan-Valium crossover to 18.75mg Valium

Feb. 2021, begin 10%/4 week taper of 18.75mg Valium  

End 2021  year 1 of taper at 6mg

End 2022 year 2 of taper at 2.75mg 

Current dose as of Feb. 25, 2023 2mg

Taper is 89% complete.


Imipramine 75 mg daily since 1986.  Jan-Sept 2016 tapered to 14.4mg  

March 22, 2022: Begin 10%/4 week taper

Aug. 5, 2022: hold at 9.5mg and shift to Valium taper

Taper is 87% complete.  


Supplements: omega-3, vitamins C, E and D3, magnesium glycinate, probiotic, zinc, melatonin .3mg

I am not a medical professional and this is not medical advice but simply information based on my own experience, as well as other members who have survived these drugs.

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  • ChessieCat changed the title to JMCA: Coming off Mertazapine

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