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lplp: Withdrawing from benadryl


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I took 100 mg of benadryl an SSRI for 30 years for sleep. Then had a seizure at age 60 i had to quit work and slowly taper over 2.5 years and at 3mg i went ct and stopped. The wd r debilitating. Fatique dizzy brain fog headaches.  Iam a walking zombie. Not sure how long this will last. 

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  • manymoretodays changed the title to lplp: Withdrawing from benadryl
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Welcome to lplp.


Benadryl is an antihistamine, not an SSRI antidepressant.  Were you also on an SSRI? If so, which one and at what dosage?


When did you stop the Benadryl and, if you were on an SSRI, when did you stop it and at what dosage?


The following link gives excellent information about benadryl withdrawal, especially the posts by cymbaltawithdrawal5600.

Fuhgetabouddit: I need help! - Surviving Antidepressants

This is your Introduction topic, where you can answer my questions, ask your own and connect with other members.

Edited by Gridley

Gridley Introduction


Lexapro 20 mg since 2004.  Begin Brassmonkey Slide Taper Jan. 2017.   

End 2017 year 1 of taper at 9.25mg 

End 2018 year 2 of taper at 4.1mg

End 2019 year 3 of taper at 1.0mg  

Oct. 30, 2020  Jump to zero from 0.025mg.  Current dose: 0.000mg

3 year, 10 month taper is 100% complete.


Ativan 1 mg to 1.875mg 1986-2020, two CT's and reinstatements

Nov. 2020, 7-week Ativan-Valium crossover to 18.75mg Valium

Feb. 2021, begin 10%/4 week taper of 18.75mg Valium  

End 2021  year 1 of taper at 6mg

End 2022 year 2 of taper at 2.75mg 

Current dose as of Feb. 25, 2023 2mg

Taper is 89% complete.


Imipramine 75 mg daily since 1986.  Jan-Sept 2016 tapered to 14.4mg  

March 22, 2022: Begin 10%/4 week taper

Aug. 5, 2022: hold at 9.5mg and shift to Valium taper

Taper is 87% complete.  


Supplements: omega-3, vitamins C, E and D3, magnesium glycinate, probiotic, zinc, melatonin .3mg

I am not a medical professional and this is not medical advice but simply information based on my own experience, as well as other members who have survived these drugs.

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In reading about benadryl aka diphenhydramine for the past 5 years it was used before prozac came along from 1940 to 1970 as a mild ssri. Then prozac came along and all hell broke loose. No im not taking anything else except Icelandic astaxathin 12mg this is helping with mood and fatique. I wish everyone a good recovery. Each day is different good and bad. There is a light.

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  • 3 months later...

Hi lplp.  I too have been withdrawing from Benadryl for the past eight months and it is been horrible.  And I know what withdrawal feels like since I had a withdrawal from Effexor over 10 years ago.  Benadryl is an anticholinergetic and a antihistamine and from what I have researched is that it has five different chemicals in it that can affect our brains, not just one or two. I know many people don't think Benadryl can cause these symptoms but I'm here to say that it has caused severe withdrawal for me.  We all have a different chemical and dna makeup and we can react to things differently.  I just want you to know that you are not alone.   

Effexor for one year in either 2004 or 2005- Quit cold turkey- Doctor said I don't need to taper! Then quit on my own in 4 weeks- still cold turkey

Adrenal Glandulars mixed with rhodiola and aswaganda - one year 2014-2015

Benadryl for 8 years- Off completely in July 2019

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Yes it has been going on 3 years with my wds. It has been my worse mistake ever taking them. I had purchased them at the $ store thinking it was innocuous.  I was soooo wrong. Mine have turned into barometric vascular migraines each time the weather changes which is a lot. Never had a headache prior to benadryl. I had read benadryl is used for headaches.  I had botox injections for migraines. My second biggest mistake. It changes the pain fibers towards depression each time the weather changes. I wish u all the luck in your recovery. Lplp

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