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RollercoasterLife: New, and unsure what to do.


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Hello everyone,


I'm having a lot of issues from the fact my Prozac has quit out on me. I've tried twice in the past month to drop 3.85 mg of my 13.85mg dose and add in another AD(nortriptyline then Celexa) each time going back to my original dose after 3 to 4 days. I know this isn't good for my CNS, and I'm feeling it more so than I was feeling it before doing all that. I was going through withdrawal to begin with anyways but those two attempts to cross over definitely didn't help at all. I know I need to give more information, but atm my brain is frazzled so not sure as to what. I'm also unsure if I will ever stabilize, since I wasn't able to stabilize once Prozac stopped working.

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  • manymoretodays changed the title to RollercoasterLife: New, and unsure what to do.
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Welcome to SA, Rollercoasterlife.


Your Prozac stopping working is a common occurrence with psychiatric drugs.


Tachyphylaxis or As It’s Lovingly Known “Poopout”

When a drug poops out, it's time to taper off it.  However, your taper of 3.85mg was three times faster than what we recommend. This added to the withdrawal you were already experiencing due to the poopout.


What is withdrawal syndrome.


Daily Checklist of Antidepressant Withdrawal Symptoms (PDF) 


We are a site for going off drugs, and our approach when a drug poops out is to taper it down to zero.  We don't recommend adding other drugs to replace the original drug.  As you've seen, there's really no way to tell what effect a new drug will have.

Instead of adding new drugs, which is a hit-or-miss affair and puts one on the drug merry-go-round for many, many years, we recommend using non-drug techniques to cope with life.


Non-drug techniques to cope


When you're ready to taper the Prozac, we recommend tapering no more than 10% of your current dose every four weeks.


Why taper by 10% of my dosage?


This link is specifically about tapering Prozac, including how to get the non-standard doses you'll need for your 10% taper.


Tips for tapering off Prozac (fluoxetine)


We don't recommend a lot of supplements on SA, as many members report being sensitive to them due to our over-reactive nervous systems, but two supplements that we do recommend are magnesium (glycinate is a good form) and omega 3 (fish oil). Many people find these to be calming to the nervous system. 


Magnesium, nature's calcium channel blocker 


Omega-3 fatty acids (fish oil) 


Add in one at a time and at a low dose in case you do experience problems.


This is your Introduction topic, where you can ask questions and connect with other members.  We're glad you found your way here.













Gridley Introduction


Lexapro 20 mg since 2004.  Begin Brassmonkey Slide Taper Jan. 2017.   

End 2017 year 1 of taper at 9.25mg 

End 2018 year 2 of taper at 4.1mg

End 2019 year 3 of taper at 1.0mg  

Oct. 30, 2020  Jump to zero from 0.025mg.  Current dose: 0.000mg

3 year, 10 month taper is 100% complete.


Ativan 1 mg to 1.875mg 1986-2020, two CT's and reinstatements

Nov. 2020, 7-week Ativan-Valium crossover to 18.75mg Valium

Feb. 2021, begin 10%/4 week taper of 18.75mg Valium  

End 2021  year 1 of taper at 6mg

End 2022 year 2 of taper at 2.75mg 

Current dose as of Feb. 25, 2023 2mg

Taper is 89% complete.


Imipramine 75 mg daily since 1986.  Jan-Sept 2016 tapered to 14.4mg  

March 22, 2022: Begin 10%/4 week taper

Aug. 5, 2022: hold at 9.5mg and shift to Valium taper

Taper is 87% complete.  


Supplements: omega-3, vitamins C, E and D3, magnesium glycinate, probiotic, zinc, melatonin .3mg

I am not a medical professional and this is not medical advice but simply information based on my own experience, as well as other members who have survived these drugs.

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