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Goss: Zyban


Goss

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Goss

 

I need tapering help for zyban 150mg extended release which I take in the UK for depression. Thanks.

Edited by Gridley
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  • Moderator

Welcome to SA, Goss.

 

We recommend tapering by no more than 10% of your current dose every four weeks.

 

Why taper by 10% of my dosage?

 

The following link gives very specific instructions about tapering Zyban (Wellbutrin).  Please read it carefully,

 

 

Tips for tapering off Wellbutrin, SR, XR, XL (buproprion)

 

The link contains instructions on how to taper SR.  

 

We don't recommend a lot of supplements on SA, as many members report being sensitive to them due to our over-reactive nervous systems, but two supplements that we do recommend are magnesium (glycinate is a good form) and omega 3 (fish oil). Many people find these to be calming to the nervous system. 

 

Magnesium, nature's calcium channel blocker 

 

Omega-3 fatty acids (fish oil) 

 

Add in one at a time and at a low dose in case you do experience problems.

 

This is your Introduction topic, where you can ask questions and connect with other members.  We're glad you found your way here.

 

 

 

Edited by Gridley

Gridley Introduction

 

Lexapro 20 mg since 2004.  Begin Brassmonkey Slide Taper Jan. 2017.   

End 2017 year 1 of taper at 9.25mg 

End 2018 year 2 of taper at 4.1mg

End 2019 year 3 of taper at 1.0mg  

Oct. 30, 2020  Jump to zero from 0.025mg.  Current dose: 0.000mg

3 year, 10 month taper is 100% complete.

 

Ativan 1 mg to 1.875mg 1986-2020, two CT's and reinstatements

Nov. 2020, 7-week Ativan-Valium crossover to 18.75mg Valium

Feb. 2021, begin 10%/4 week taper.  Current Valium dose as of Feb 22, 2022: 4.8mg 

March 22, 2022: hold at 4.8 and shift to Imipramine taper

Taper is 74% complete.

 

Imipramine 75 mg daily since 1986.  Jan-Sept 2016 tapered to 16mg.  

Held until Aug 2021, tapered for 4 weeks to 14.4mg

March 22, 2022: Begin 10%/4 week taper.  Current dose as of May 17: 10.5mg 

Taper is 86% complete.  

  

Supplements: omega-3, vitamins C, E and D3, magnesium glycinate, probiotic, zinc, melatonin .3mg


I am not a medical professional and this is not medical advice, but simply information based on my own experience, as well as other members who have survived these drugs.

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  • Moderator

  @Goss

 

The following link gives specific instructions about tapering Zyban (Wellbutrin).  Please read it carefully,

 

Tips for tapering off Wellbutrin, SR, XR, XL (buproprion)

 

The link contains instructions on how to taper SR.  From the link:

 

How to taper off bupropion SR (sustained release)
From FDA information: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b5d286ce-e23f-4dde-b400-cb4832172ece
- Available as brand-name or generic in 100 mg, 150 mg, 200 mg sustained-release tablets
- To be taken twice daily, "at least 8 hours between successive doses." (This is equivalent to 3-times daily immediate-release bupropion.)

According to Merck http://www.merckmanuals.com/professional/print/lexicomp/bupropion.html
 

  Quote

"Data from the manufacturer states that dividing Wellbutrin SR® tablets resulted in an increased rate of release at 15 minutes: “However, the divided tablet retained its sustained-release characteristics with similar increases of released bupropion at each sampling point beyond 15 minutes when compared to the intact Wellbutrin SR® tablet...” Bupropion is hydroscopic and therefore should be stored in a dry place. Splitting of large quantities in advance of administration is not advised since loss of potency may result. If necessary, splitting should be done cleanly without crushing."

 
In the name-brand Wellbutrin SR, the sustained-release quality is in the binder, the glue that holds the tablet together. Generic versions (which would be called bupropion SR, not Wellbutrin SR) may be made differently. Contact the manufacturer to find out exactly how the tablet is formulated, or talk to a pharmacist specializing in psychopharmacology.
 
I personally found you CAN cut Wellbutrin SR (sustained release) tablets up -- the timed-release mechanism is mixed in with the drug. Put the pieces in a water-tight container and use them up within 24 hours because the time-release binder can absorb humidity and degrade.

For a short time, I cut up generic 100mg bupropion SR and took 50mg in the morning, Wellbutrin XL 150mg a couple of hours later, and another SR 50mg in the early evening for a total of 250mg/day. (I never tolerated Wellbutrin very well.)

To taper, convert your dosage to 100mg SR tablets, cut up the 100mg tablets, make reductions by 25mg or less, take 2 times a day.
 
(Note: If you cut an SR tablet in very small fragments or crush it, it won't to continue to be sustained-release -- the binder is extensively damaged. Take in divided doses as though it was immediate-release.)

Taper with a mix of sustained-release (SR) and immediate-release (IR) tablets
As immediate-release tablets come in the smallest dosage of 75mg, which can be quartered into pieces of 18.75mg, you might want to convert part of your daily dose to IR tablets.

This will enable you to taper by 18.75mg at a time.

You might be able to get by with taking the SR tablet in the morning and the IR tablet at night.
 

 

 

Edited by Gridley

Gridley Introduction

 

Lexapro 20 mg since 2004.  Begin Brassmonkey Slide Taper Jan. 2017.   

End 2017 year 1 of taper at 9.25mg 

End 2018 year 2 of taper at 4.1mg

End 2019 year 3 of taper at 1.0mg  

Oct. 30, 2020  Jump to zero from 0.025mg.  Current dose: 0.000mg

3 year, 10 month taper is 100% complete.

 

Ativan 1 mg to 1.875mg 1986-2020, two CT's and reinstatements

Nov. 2020, 7-week Ativan-Valium crossover to 18.75mg Valium

Feb. 2021, begin 10%/4 week taper.  Current Valium dose as of Feb 22, 2022: 4.8mg 

March 22, 2022: hold at 4.8 and shift to Imipramine taper

Taper is 74% complete.

 

Imipramine 75 mg daily since 1986.  Jan-Sept 2016 tapered to 16mg.  

Held until Aug 2021, tapered for 4 weeks to 14.4mg

March 22, 2022: Begin 10%/4 week taper.  Current dose as of May 17: 10.5mg 

Taper is 86% complete.  

  

Supplements: omega-3, vitamins C, E and D3, magnesium glycinate, probiotic, zinc, melatonin .3mg


I am not a medical professional and this is not medical advice, but simply information based on my own experience, as well as other members who have survived these drugs.

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Admin:   I need information on how to safely stop taking Zyban 150mg?   The manufacturer says not to cut the pill so I can't do the 10% tapering.  Advise please.

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  • ChessieCat changed the title to Goss: Zyban
  • Moderator Emeritus

Hi Goss,

 

I've moved your new post to your Introduction topic.  Gridley has provided the link to tapering Zyban which is also known as Wellbutrin  The common drug name is bupropion.

 

Please ask questions about your own specific situation here in your Introduction topic.

 * * * * * *   PLEASE WATCH THIS VIDEO   * * * * * *

Antidepressant Withdrawal Syndrome and its Management

 

MISSION ACCOMPLISHED:    (6 year taper)      0mg Pristiq      on 13th November 2021

Woohoo!!!  Finally off Pristiq    Post 0 updates start here

ADs since ~1992:  25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq:  50mg 2012, 100mg beg 2013 (Serotonin Toxicity)  Tapering from Oct 2015 - 13 Nov 2021   LAST DOSE 0.0025mg

My full tapering program     My Intro (goes to my tapering graph)    My website

PLEASE NOTE:  I am not a medical professional.  I provide information and make suggestions. 

Please DO NOT TAG me - thank you.

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