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So I went cold turkey off of Effexor four months ago. I was prescribed Oxtellar XR (600 mg daily) because of two seizures I had while on it soon after/during cold turkey. The oxtellar seems to actually help but makes me slow and docile. Not long after that I was prescribed Buspar 15 daily. A month after that I started treatment with a psychiatrist for medicine management. He diagnosed me with OCD and has tried two different SSRI medications (Prozac and Lexapro). Each sent me into what felt like a mild psychosis within the first day with tremors, increased muscle spasms, hyperactive reflexes/thinking, motor function impairment (eyes, hands, etc.) I’m thinking my Effexor withdrawal has affected my serotonin sensitivity and I don’t need to be on any medications that affect it at the moment. I can’t seem to get any docs or people in my life to take this possibility seriously. If any more medication is thrown at me, I feel in-patient care at a mental health facility is inevitable. I don’t know what to do or who to talk to.

Edited by Gridley
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Welcome to SA, Nortonb13.


You are in withdrawal from the cold turkey of Effexor and as a result your central nervous system is very sensitized.  Your adverse reaction to the Prozac and Lexapro indicates you are not a good candidate for psychiatric drugs.  Adding more drugs to deal with withdrawal puts you on the drug merry-go-round, with more and more drugs being tried at random and your system becoming more and more sensitized.  You will heal (if they don't keep throwing drugs at you) but it will take some time. Time is the healer.  It is your body and you should be the one to decide what goes into it.  


By the way, doctors don't believe in the existence of withdrawal, which would explain your difficulty in getting them to see your point that you don't want any more drugs.  Drugs and more drugs is their stock in trade.


What are your current symptoms?  Are you still on the Buspar?


Here is some helpful information on withdrawal and the healing process.


What is withdrawal syndrome.


Daily Checklist of Antidepressant Withdrawal Symptoms (PDF) 


When we take psychiatric medications, the CNS (central nervous system) responds by making changes over the months and years we take the drug(s). When the medication is discontinued, the CNS has to undo all the changes it made. Rebuilding the neurotransmitter production and reactivating the receptor and transporter cells takes time -- during that rebuilding process symptoms occur.  


These explain the healing process really well:


Brain Remodelling 


Video:  Healing From Antidepressants - Patterns of Recovery


We don't recommend a lot of supplements on SA, as many members report being sensitive to them due to our over-reactive nervous systems, but two supplements that we do recommend are magnesium and omega 3 (fish oil). Many people find these to be calming to the nervous system. 


Magnesium, nature's calcium channel blocker 


Omega-3 fatty acids (fish oil) 


Add in one at a time and at a low dose in case you do experience problems.


This is your Introduction topic, where you can ask questions and connect with other members.  We're glad you found your way here.










Gridley Introduction


Lexapro 20 mg since 2004.  Begin Brassmonkey Slide Taper Jan. 2017.   

End 2017 year 1 of taper at 9.25mg 

End 2018 year 2 of taper at 4.1mg

End 2019 year 3 of taper at 1.0mg  

Oct. 30, 2020  Jump to zero from 0.025mg.  Current dose: 0.000mg

3 year, 10 month taper is 100% complete.


Ativan 1 mg to 1.875mg 1986-2020, two CT's and reinstatements

Nov. 2020, 7-week Ativan-Valium crossover to 18.75mg Valium

Feb. 2021, begin 10%/4 week taper of 18.75mg Valium  

End 2021  year 1 of taper at 6mg

End 2022 year 2 of taper at 2.75mg 

Current dose as of Feb. 25, 2023 2mg

Taper is 89% complete.


Imipramine 75 mg daily since 1986.  Jan-Sept 2016 tapered to 14.4mg  

March 22, 2022: Begin 10%/4 week taper

Aug. 5, 2022: hold at 9.5mg and shift to Valium taper

Taper is 87% complete.  


Supplements: omega-3, vitamins C, E and D3, magnesium glycinate, probiotic, zinc, melatonin .3mg

I am not a medical professional and this is not medical advice but simply information based on my own experience, as well as other members who have survived these drugs.

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