Jump to content

Tips for tapering off mirtazapine (Remeron)


Altostrata

Recommended Posts

  • Administrator
On 1/19/2018 at 3:01 PM, Abilifyneedhelp88 said:

Hi Samantha,

 

I successfully tapered off Remeron 15mg three years ago. What i did was an olive oil base with pulverized remeron tablets.  The person I got info on for the recipe was Roy Katz who is a compound pharmacist.  I could not get a dr to agree with me to write the prescription for liquid so I made the liquid myself and decreased 1mg at  a time over several weeks. I think it took me a good 6 months to get off totally. But you should contact Roy and get the recipe for the liquid titration method. He is more than willing to talk with you about concocting your own. Google Roy Katz and give him a call to get the right amount of Remeron per mg of Olive oil. it is a liquid suspension and you can get an even amount of Remeron using a syringe. Hope this helps and Good luck with your taper. I do not suggest cutting them in half  or even cutting them at all. I got a pestle and bowl and pulverized them and then put them in the olive oil , then measured out the right mg with a syringe and took it that way. Do not try to get off this fast. Its a slow drawn out taper designed to give you as little side effects as possible..

 

On 1/19/2018 at 3:09 PM, samanthaelizabeth said:

How much Olive Oil?

 

 

On 1/19/2018 at 6:27 PM, Terry said:

 

People do just fine making a suspension with Remeron and water -- see the first post in this topic.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Link to post
Share on other sites
  • 5 months later...
  • Replies 130
  • Created
  • Last Reply

Top Posters In This Topic

  • Altostrata

    26

  • Pokey

    14

  • leahy

    10

  • ChessieCat

    9

Top Posters In This Topic

Popular Posts

I do not think it is worth wasting the mental energy trying to figure out how something "works" when it comes to psychiatric drugs but about what is happening to us by noticing the symptom pattern.  Y

Hello Everyone! I'm preparing myself for tapering off mirtazapine very soon. I have GEMINI-20 scale to weight my tablets, but I would rather prefer to use liquid mirtazapine and measure my doses with a syringe. I probably won't be able to get liquid mirtazapine from a pharmacy, so I have to make my own suspension. However, I'm little confused about that process. I have only orally disintegrating tablets. I want to make 15 ml suspension so that 1ml = 1mg. From what I understand I cannot dissolve the tablet only in water. Or can I? I need some suspending vehicle like Ora Plus https://www.amazon.com/PADDOCK-LABORATORIES-Ora-Plus-Suspending-Vehicle/dp/B000GGHSQM/ref=sr_1_1_a_it?ie=UTF8&qid=1545007008&sr=8-1&keywords=oraplus&fbclid=IwAR12cH9g3DPzRxU3iH3A5jPDsBQPmezkOt3tnG6sGUEosNJT4IID6uPGSFI.
So the process would look like this:
- I drop my tablet in the mixing tube then add 7.5 ml of water and shake it vigorously
- Then I add 7.5 ml. Ora Plus and shake it again
- I now have a 15 ml. solution. 1ml = 1mg of mirtazapine
- My first dose would be 13.5mg so I remove 1.5ml. of the solution with syringe 
- Drink the rest (13.5 ml. of the solution)

Do I have to crush the tablet into powder before dissolving them in water?
Has anyone used this method?
I'm still trying to figure out how to do it properly. Any advice would be greatly appreciated? Thank you.

December 2009 - February 2012:  Paroxetine (Seroxat), occasionally Clorazepate || February 2012 - November 2012: Escitalopram || November 2012 - May 2013: Venlafaxine, also benzodiazepines, mostly Xanax || June 2013 - December 2013: only benzodiazepines Xanax, I'm starting to become addicted to it. || December 2013 - March 2014: again Paroxetine, very often Xanax || March 2014 - June 2014Fluoxetine. Changed Paroxetine to Fluoxetine. I was practically addicted to Xanax at this point. || I had an unpleasant accident in June 2014. Abruptly Stopped taking SSRIs but was still addicted to benzos. || August 2014 I started taking Clomipramine and in September 2014 Mirtazapine 10 mg. This was the time I stopped taking benzos for good. The withdrawal was pretty hard for more than half a year.  || October 2014: Stopped Clomipramine and for month tried Sertraline

September 2014 to Present DayMirtazapine 15mg 
December 2014 to August 2018 I was on 30 mg Paroxetine.  Started tapering in January 2018
. Going twice from 30mg to 20mg in a matter of 2-3 days. Didn't work. Started again in February 2018.

Generally every 2 months I was making a big drop by 10mg in a matter of two weeks. I stopped taking it completely in August 11th, 2018.  My Symptoms include depression, anxiety, sleeping problems, apathy, anhedonia, photophobia, afterimages, other vision problems (hard to vocus my eyes), tinnitus, brain fog. The problems with my eyesight are especially annoying and scary.  After four months they have become more severe.

 

Currently: 15mg mirtazapine, 0 paroxetine

Link to post
Share on other sites
  • Administrator

Please always read these topics from the beginning. Likelihood is high your questions have been answered. See

 

 

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Link to post
Share on other sites
  • 9 months later...
On 4/10/2012 at 8:07 PM, Altostrata said:

Shelf-life after being opened is 6 weeks.

Hi Altostrata , does that mean when you open the pill container that mirtazapine caps should be discarded in 6 weeks? I have some from October. I have been discarding the liquid in 5 days. 

Pristiq 50 mg, 3 years, given mirtazapine 15 mg and lorazapam to help come off of pristiq, no longer taking mirtazapine.

April 2020, escitolopram 10 mg. Stopped after 2 months and put on pregabolin and sertraline...

May 2020,  sertraline 50 mg, pregabolin 100 mg. Pantoprazol 40 mg,  twice a day

Since then I have discontinued pantoprazoleDec. 2020 Sertraline 50 mg at 7 PM

Dec 2020 pre-Gabalin 110 mg, prescribed for depression.  I am presently tapering down on this. 10% a month

Nov 25 started three doses a day, they were 50/25/50. Before that 125 mg evening. Dec. 50/10/50 Dec 28 2020, STOPPED Gravol 50 ml. Jan. 3, 2021 stopped 2:00 p.m. pregabolin 10 ml. Liquid. And am taking 50 mg capsule at 8:00 AM and 8: p.m. February 24, taking pregabolin 25 mg.three times day, sertraliner 50 mg , March 21, calcium 325 mg. March 25th  pm pregabolin 25 mg to 25 ml, liquid 3Xday, March 28 pregabolin 22.4 ml x 3/day, calcium 650 mg.

 

 

 


 

 

Link to post
Share on other sites
  • Moderator
manymoretodays

Pens,

You could check the prescription label to see if there is an expiration date. 

I might check with the pharmacy/dispensary as well.  Ask them how long the capsules/tablets retain their potency.

Usually it's awhile......but Idk for sure.

 

I used oxcarbazepine caplets for quite some time, and they did not have an expiration date on the bottle.

 

Good question though.

I expect each medication and form, may have it's own expirary date.  Pharmacists are good resources for this type of information, or at least that's what I found.

Edited by manymoretodays

Started with psycho meds/psychiatric care circa 1988.  In retrospect, and on contemplation, situational overwhelm.

Rounding up to 30 years of medications(30 medication trials, poly-pharmacy maximum was 3 at one time).

5/28/2015-off Adderal salts 2.5mg. (I had been on that since hospital 10/2014)

12/2015---just holding, holding, holding, with trileptal/oxcarb at 75 mg. 1/2 tab at hs.  My last psycho med ever!  Tapered @ 10% every 4 weeks, sometimes 2 weeks to

2016 Dec 16 medication free!!

Longer signature post here, with current supplements.

Herb and alcohol free since 5/15/2016. 

None of my posts are intended as medical advice.  Please discuss any decisions about your medical care with a knowledgeable medical provider. manymoretodays

 

Link to post
Share on other sites
  • 1 month later...

Hi everyone... can anyone help please. I need to start tapering my Mirtazapine, but the tablet is coated with a pink film. Has anybody made a liquid from Mirtazapine in this form (i. e coated in pink film). On the packet it says do not crush or chew. I'm praying someone has successfully made a liquid out of a similar tablet, as its my only option. 

 

Aug 2004 - Dec 2006: Aropax ( 20mg - 30mg). Aug 2007: Fluoxetine (for 3 weeks).

Sept 07 - July 12: Lexapro ( 10mg - 20mg). Pooped out July 12. Titrated down off Lexapro over 3 weeks and switched to Paroxetine (with Xanax to cover switch for 2 weeks).

Aug 2012 - Aug 2019: Paroxetine (titrated up to 20mg in first few weeks,, dose reduced to 15mg . for 7 years until it 'pooped out'.

4th Aug 2019 - Reduced dose of paroxetine to 10mg (for 1 day) - under phychiatrists directions. Last dose of paroxetine.

5th Aug 2019 - Switch to 15mg Mirtazapine.

5th Aug - 15th Aug 2019 - 15mg Mirtazapine plus intermitent use of Lorazapm (0.25- 0.5 . Also used 12.5mg Quetiapine for 3 nights for sleep.

23rd Aug 2019 - Ended up in crisis team. Mirtazapine increased to 30mg. Diazapam 10mg twice daily.

30th Aug 2019 - Mirtazapine 30mg + Diazapam reduced to 7.5mg twice daily

6th Sept 2019 - Mirtazapine 30mg + Diazapam reduced to 5mg twice daily

13th Sept 2019 - Mirtazapine increased to 45mg. Diazapam increased back up to 10mg twice daily.

20th Sept - 29th Sept 2019: Mirtazapine 45mg. Diazapam being reduced from 10mg down to 0mg this week (in 2mg increments couple of days).

30th Sept - Thursday 3rd Oct 2019: Mirtazapine 45mg. WORST ANXIETY EVER. Akathisia. Couldn't stay still. Suicidal idealization.

Friday 4th October - present: Reduced from 45mg to 30mg (straight drop to alleviate akathisia - reduction definitely helped alot but still not gone completely)

 

 

, Vit B6, Curcumin, Magnesium (no adverse effects from adding these supplements - have helped akathisia somewhat).

* Everything done from 23rd August under care of outpatient crisis team management.

 

Untitled document.docx

Link to post
Share on other sites
  • Moderator Emeritus

Q:  What type/brand of mirtazapine are you using?

 

Q:  What dose are they?

 

Edited by ChessieCat

NEW!!!     INTERVIEW with Altostrata, SA's founder    NEW!!! 

 

Plodding along inch by inch:  12" = 1',  3' =  36 " or 1 yard,  1760 yards  = 63,360" or 1 mile

Current from 17 Apr 2021:  Pristiq 0.2665mg  now holding each dose for 3 weeks

ADs since ~1992:  25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq:  50mg 2012, 100mg beg 2013 (Serotonin Toxicity)  Tapering Oct 2015 

My tapering program   My Intro (goes to my tapering graph)  My website

PLEASE NOTE:  I am not a medical professional.  I provide information and make suggestions.

Link to post
Share on other sites
  • Moderator Emeritus

There are 7 pages of images here:  https://www.drugs.com/mirtazapine-images.html

NEW!!!     INTERVIEW with Altostrata, SA's founder    NEW!!! 

 

Plodding along inch by inch:  12" = 1',  3' =  36 " or 1 yard,  1760 yards  = 63,360" or 1 mile

Current from 17 Apr 2021:  Pristiq 0.2665mg  now holding each dose for 3 weeks

ADs since ~1992:  25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq:  50mg 2012, 100mg beg 2013 (Serotonin Toxicity)  Tapering Oct 2015 

My tapering program   My Intro (goes to my tapering graph)  My website

PLEASE NOTE:  I am not a medical professional.  I provide information and make suggestions.

Link to post
Share on other sites
On 7/23/2020 at 6:31 PM, ChessieCat said:

Q:  What type/brand of mirtazapine are you using?

 

Q:  What dose are they?

 

Hi @ChessieCat,

 

The box says APO-Mirtazapine (Apotex). 

 

They are 30mg

 

Aug 2004 - Dec 2006: Aropax ( 20mg - 30mg). Aug 2007: Fluoxetine (for 3 weeks).

Sept 07 - July 12: Lexapro ( 10mg - 20mg). Pooped out July 12. Titrated down off Lexapro over 3 weeks and switched to Paroxetine (with Xanax to cover switch for 2 weeks).

Aug 2012 - Aug 2019: Paroxetine (titrated up to 20mg in first few weeks,, dose reduced to 15mg . for 7 years until it 'pooped out'.

4th Aug 2019 - Reduced dose of paroxetine to 10mg (for 1 day) - under phychiatrists directions. Last dose of paroxetine.

5th Aug 2019 - Switch to 15mg Mirtazapine.

5th Aug - 15th Aug 2019 - 15mg Mirtazapine plus intermitent use of Lorazapm (0.25- 0.5 . Also used 12.5mg Quetiapine for 3 nights for sleep.

23rd Aug 2019 - Ended up in crisis team. Mirtazapine increased to 30mg. Diazapam 10mg twice daily.

30th Aug 2019 - Mirtazapine 30mg + Diazapam reduced to 7.5mg twice daily

6th Sept 2019 - Mirtazapine 30mg + Diazapam reduced to 5mg twice daily

13th Sept 2019 - Mirtazapine increased to 45mg. Diazapam increased back up to 10mg twice daily.

20th Sept - 29th Sept 2019: Mirtazapine 45mg. Diazapam being reduced from 10mg down to 0mg this week (in 2mg increments couple of days).

30th Sept - Thursday 3rd Oct 2019: Mirtazapine 45mg. WORST ANXIETY EVER. Akathisia. Couldn't stay still. Suicidal idealization.

Friday 4th October - present: Reduced from 45mg to 30mg (straight drop to alleviate akathisia - reduction definitely helped alot but still not gone completely)

 

 

, Vit B6, Curcumin, Magnesium (no adverse effects from adding these supplements - have helped akathisia somewhat).

* Everything done from 23rd August under care of outpatient crisis team management.

 

Untitled document.docx

Link to post
Share on other sites
  • Moderator Emeritus
1 hour ago, cathnz said:

The box says APO-Mirtazapine (Apotex). 

 

They are 30mg

 

https://www.drugs.com/imprints/apo-mi-30-11632.html

 

I suggest that you do a search for other members tapering mirtazapine and check out how they are getting their doses.

 

Use this as your search term in a search engine:  site:survivingantidepressants.org mirtazapine remeron mirt mirtazipine

NEW!!!     INTERVIEW with Altostrata, SA's founder    NEW!!! 

 

Plodding along inch by inch:  12" = 1',  3' =  36 " or 1 yard,  1760 yards  = 63,360" or 1 mile

Current from 17 Apr 2021:  Pristiq 0.2665mg  now holding each dose for 3 weeks

ADs since ~1992:  25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq:  50mg 2012, 100mg beg 2013 (Serotonin Toxicity)  Tapering Oct 2015 

My tapering program   My Intro (goes to my tapering graph)  My website

PLEASE NOTE:  I am not a medical professional.  I provide information and make suggestions.

Link to post
Share on other sites
  • Moderator Emeritus

@cathnz

 

If the tablet is scored then the tablet can be broken in half and then the coating isn't going to be "sealing" the tablet which means that the coating isn't actually there for any reason to do with absorption of the drug.

 

You will need to find out if the tablets are immediate release.  You can find this out by asking the pharmacist.  I've done a search online and I haven't been able to find out this information.

NEW!!!     INTERVIEW with Altostrata, SA's founder    NEW!!! 

 

Plodding along inch by inch:  12" = 1',  3' =  36 " or 1 yard,  1760 yards  = 63,360" or 1 mile

Current from 17 Apr 2021:  Pristiq 0.2665mg  now holding each dose for 3 weeks

ADs since ~1992:  25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq:  50mg 2012, 100mg beg 2013 (Serotonin Toxicity)  Tapering Oct 2015 

My tapering program   My Intro (goes to my tapering graph)  My website

PLEASE NOTE:  I am not a medical professional.  I provide information and make suggestions.

Link to post
Share on other sites
  • 2 weeks later...
Laurenjade08
On 7/24/2020 at 10:15 PM, cathnz said:

Hi @ChessieCat,

 

The box says APO-Mirtazapine (Apotex). 

 

They are 30mg

Hi,

are you unable to get the orodispersible form of tablet? They are available in most countries as far as I am aware. There was a national shortage of them but this should have been resolved by now.

 

Citalopram 2014 (1 wk)

sertraline 2015 (4 days)

Fluoxetine November 2018 - came off after 24 days due to severe side effects

 

Mirtazapine December 2018 (15mg)

Mirtazapine January 2019 (30mg x3 days)

Mirtazapine January-March 2019 (22.5mg)

 

Mirtazapine April 2019 tapered SLOW until July 2020 - Hit withdrawal wall at 10mg

 

Up dosed slowly up to 30mg. Stayed put for 14 weeks, since 14th December 2020 37.5mg (SEVERE symptoms including SI, depression, anxiety, vomiting, agitation, adrenaline rushes)

Decreased to 30MG 11th January... withdrawal ever since.. 

Link to post
Share on other sites

I've been on them for less than 2 weeks, 15 mg. Insomnia is my primary issue. Can I make the drop to 7.5 mg without the 10% tapering, with how short I've been on them? Thanks.

2020 July 28 - August 9: 15 mg Mirtazapine

Quit cold turkey. Experienced tiny brain zaps, dulled emotions, insomnia.

2020 September 2 - 4: reinstated with 7.5 mg Mirtazapine

2020 September 4 - 12: went back to 15 mg Mirtazapine

2020 September 13 - present: reduced to 7.5 mg Mirtazapine

Link to post
Share on other sites
  • Moderator

Hi @greyed,

 

You should first try a smaller drop, say 10-20%. Plasma levels will take around 5 days to stabilize, so I would avoid dropping again until you are sure symptoms are not too bad. Coming off these drugs needs to be done cautiously. People can have problems with very short term usage that lasts much longer than the time they were taking the meds.

 

Another thing is that you need to be especially careful with the last few milligrams. Often the biggest receptor occupancy drop occurs there. In fact, in many drugs the first 80% of the taper results in only a 10-20% drop in receptor occupancy, and then receptor occupancy falls off a cliff during the last few mg

 

Here is the full article by Horowitz and Taylor if you are interested: https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(19)30032-X/fulltext

 

Edit: here is a link to the topic on dose dependency curves.

 

 

Edited by DataGuy

Remeron - 2004-2005 (bad withdrawal)

Clonazepam - 2005-2018 (jumped around March)

Olanzapine - 2014- late 2017

Domperidone - 2008-2018

Many drugs in between including Lexapro, other benzos and z-drugs.

Still suffering post-withdrawal from Clonazepam (Klonopin), Olanzapine and Domperidone. 

Link to post
Share on other sites

I read that those at risk of withdrawal syndrome are people who had been on the medication for at least a month, so if true, isn't applicable to me. I'm very uncomfortable with exposing myself to the drug for any longer and cannot trust myself with the tapering. If that means some withdrawal symptoms temporarily, I think I will be okay.

2020 July 28 - August 9: 15 mg Mirtazapine

Quit cold turkey. Experienced tiny brain zaps, dulled emotions, insomnia.

2020 September 2 - 4: reinstated with 7.5 mg Mirtazapine

2020 September 4 - 12: went back to 15 mg Mirtazapine

2020 September 13 - present: reduced to 7.5 mg Mirtazapine

Link to post
Share on other sites
  • 5 months later...
Nomansland

Hello everyone,

 

i was asked by the mods to share some informations about making liquid out of the NORMAL mirtazapine/remeron tablet (NOT the SolTabs).

First, mirtazapine is only slighty solutable in water and always immediate release, which means you have to make a suspension out of it (via suspension addon "Ora-Plus" OR stirring it well enough before drawing up your dose, a magnetic stirrer on low speed may make it easier). Like Brassmonkey said its "powder hanging in water like a cloud".

 

I found some german documents that state that the normal mirtazapine/remeron tablets can be made into a suspension ("normally" for patients who are not able to swallow and need a stomach probe). So i will just share these documents with you.

 

NOTE: These documents are in german, if you want to translate them, use this easy google translator for pdfs: https://translate.google.com/?hl=de&sl=auto&tl=de&op=docs

 

 

1: Document from german pharma manufacturer "1 A Pharma" http://www.1a-files.de/pdf/sondenboegen/mirtazapin_122009.pdf

 

-> "The tablet disintegrates in 15 ml of water within 7 minutes. A finely divided suspension forms. Alternatively, grind the tablet in a mortar and disperse in 15 ml of water. The suspension with a syringe pick up and apply. Rinse the probe with 10 ml of water before and after application."

 

 

2: Document from hospital pharmacy of the university of basel: https://www.crit.cloud/uploads/2/7/6/1/27612891/zermoerserbarkeit_tabletten.pdf

 

-> search for "Remeron" and you will find the 30/45 mg normal tablets. There is a sign "Z / S", which means it can be crushed and suspended.

It will say the alternative to this would be to use "SolTabs", so we can be sure the normal tablets are meant in the table.

 

 

3: Document from the central pharmacy of St.-Johannes-Hospital Dortmund http://qz-chemnitz.de/Teilbarkeit/arzneimittelliste_sonde.pdf

 

-> search for "mirtazapin" (without "e" at the end) and you will find the normal, coated mirtazapine tablets. In the table you see a Z which means it can be crushed and an A which means it can be suspended. The X indicates its possible, while the o would mean its not.

 

In the end i want to say that in the german taper forum, nearly everyone uses normal tablets to make a suspension for tapering, not the SolTabs (they dont seem quite common here, but they are available). So i just wanted to share you these informations and say its very possible to make a suspension out of the normal mirtazapine tablets.

 

Greetings

 

Nomansland

IMPORTANT WITHDRAWAL PRINT-OUT: "Stopping Antidepressants" by Royal College of Psychiatrists

 

non-native speaker of english

3-March 2020 started Mirtazapine 15mg
3-March to 6-april aprx cutting to 0 mg
6-April to 20-April -> ~ 7,5 mg,

21-April to 31-April -> 15 mg,

1-May to 13-May -> ~ 10 mg (approx),

15-May to 19-July -> 15 mg (psychosomatic clinic)
started taper with scale and file: 19-July 2020 -> 14 mg (-6,6%), 08-August -> 12 mg (-14,3 %), 27-August -> 10 mg (-16,6 %), 15-September -> 8 mg (-20 %, bad idea, heavy WD) 23-September -> 10.2 mg (+20 %, 102 mgpw) from here windows and waves...holding

 

Supplements: 2 x 250 mg magnesiumbiglycinate daily, low histamin diet

Link to post
Share on other sites
Nomansland

Wrong thread, sorry. I deleted it and posted it in the scale thread. ( :

IMPORTANT WITHDRAWAL PRINT-OUT: "Stopping Antidepressants" by Royal College of Psychiatrists

 

non-native speaker of english

3-March 2020 started Mirtazapine 15mg
3-March to 6-april aprx cutting to 0 mg
6-April to 20-April -> ~ 7,5 mg,

21-April to 31-April -> 15 mg,

1-May to 13-May -> ~ 10 mg (approx),

15-May to 19-July -> 15 mg (psychosomatic clinic)
started taper with scale and file: 19-July 2020 -> 14 mg (-6,6%), 08-August -> 12 mg (-14,3 %), 27-August -> 10 mg (-16,6 %), 15-September -> 8 mg (-20 %, bad idea, heavy WD) 23-September -> 10.2 mg (+20 %, 102 mgpw) from here windows and waves...holding

 

Supplements: 2 x 250 mg magnesiumbiglycinate daily, low histamin diet

Link to post
Share on other sites
  • 1 month later...
AdviceNeeded

Looking at the binding profile of mirtazapine, would it be reasonable to say that once you get to the lower doses it largely becomes a (very) strong antihistamine? Or is my understanding way off? Just wondered what some more knowledgable minds think?

25/8/2020 - 15/9/2020 - 15mg mirtazapine

16/9/2020 - 30mg mirtazapine

17/9/2020 - 22/9/2020 - 7.5 mg mirtazapine

23/9/2020 - 6/10/2020 - 3.75mg mirtazapine

7/10/2020 - 15/10/2020 - 7.5 mg mirtazapine

16/10/2020 - 20/10/2020 - 15 mg mirtazapine

21/10/2020 - 22/10/2020 - 7.5 mg mirtazapine

23/10/202 - 26/11/2020 - 15 mg mirtazapine

27/11/2020 - 10/12/2020 -13.5 mg mirtazapine

11/12/2020 - 17/12/2020 - 12 mg mirtazapine

18/12/2020 - 26/12/2020 - 11.75 mg mirtazapine

 

Link to post
Share on other sites
  • Moderator Emeritus
ChessieCat

@AdviceNeeded

 

JanCarol is a moderator and has been a member since 2013.

  

On 9/17/2016 at 6:25 PM, JanCarol said:

 

Also, I wanted to let you know that mirtazapine was one of the drugs I have experience with - I was only on low dose amounts for sleep (at below 15-30 mg, mirtazapine acts more as an antihistamine, makes you sleepy.  Weirdly, the less you take, the sleepier you get!).  

 

 

On 3/7/2016 at 2:22 AM, JanCarol said:

 

Mirtazapine is a unique drug, in that the less of it you take, the more sedating it is.

 

7.5 mg is more sedating than 15, and 15 is more sedating than 30.  Also, it can be sedating at higher doses until you get used to it.  Then, as you acclimate, as Fresh said, it becomes more activating.  I think it is a receptor thing - at low doses 7.5-30 it hits this antihistamine channels, but 30 and higher it hits the neurotransmitters.  You are right on the line.  It could be sedating, it could be activating, it could be both.

 

 

NEW!!!     INTERVIEW with Altostrata, SA's founder    NEW!!! 

 

Plodding along inch by inch:  12" = 1',  3' =  36 " or 1 yard,  1760 yards  = 63,360" or 1 mile

Current from 17 Apr 2021:  Pristiq 0.2665mg  now holding each dose for 3 weeks

ADs since ~1992:  25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq:  50mg 2012, 100mg beg 2013 (Serotonin Toxicity)  Tapering Oct 2015 

My tapering program   My Intro (goes to my tapering graph)  My website

PLEASE NOTE:  I am not a medical professional.  I provide information and make suggestions.

Link to post
Share on other sites
AdviceNeeded

@ChessieCatthanks. That was pretty much my understanding.

 

So, as you taper down you’d effectively be going from withdrawing from an antidepressant (acting on serotonin and norepinephrine) to eventually withdrawing from something which is largely an antihistamine? I’m just speculating and very probably oversimplyfying.

25/8/2020 - 15/9/2020 - 15mg mirtazapine

16/9/2020 - 30mg mirtazapine

17/9/2020 - 22/9/2020 - 7.5 mg mirtazapine

23/9/2020 - 6/10/2020 - 3.75mg mirtazapine

7/10/2020 - 15/10/2020 - 7.5 mg mirtazapine

16/10/2020 - 20/10/2020 - 15 mg mirtazapine

21/10/2020 - 22/10/2020 - 7.5 mg mirtazapine

23/10/202 - 26/11/2020 - 15 mg mirtazapine

27/11/2020 - 10/12/2020 -13.5 mg mirtazapine

11/12/2020 - 17/12/2020 - 12 mg mirtazapine

18/12/2020 - 26/12/2020 - 11.75 mg mirtazapine

 

Link to post
Share on other sites
  • Moderator Emeritus
ChessieCat

I do not think it is worth wasting the mental energy trying to figure out how something "works" when it comes to psychiatric drugs but about what is happening to us by noticing the symptom pattern.  You are now aware that another member has experienced the drug causing sleepiness at lower doses so if a similar thing happens to you then you can assume that it is probably the drug causing it and not something else.

 

When we know about something then we are less likely to get stressed because of not knowing/understanding and we can often find ways to work around it and/or cope with it.

NEW!!!     INTERVIEW with Altostrata, SA's founder    NEW!!! 

 

Plodding along inch by inch:  12" = 1',  3' =  36 " or 1 yard,  1760 yards  = 63,360" or 1 mile

Current from 17 Apr 2021:  Pristiq 0.2665mg  now holding each dose for 3 weeks

ADs since ~1992:  25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq:  50mg 2012, 100mg beg 2013 (Serotonin Toxicity)  Tapering Oct 2015 

My tapering program   My Intro (goes to my tapering graph)  My website

PLEASE NOTE:  I am not a medical professional.  I provide information and make suggestions.

Link to post
Share on other sites
  • Moderator Emeritus
ChessieCat

@AdviceNeeded

 

See Post #1 of this topic.  There is a quote from a research paper regarding the drug being more sedating at lower doses.

 

Also note that mirtazapine has a long half life (also mentioned in Post #1) which means that it might take longer (7-10 days) for withdrawal symptoms to appear after making a reduction.

NEW!!!     INTERVIEW with Altostrata, SA's founder    NEW!!! 

 

Plodding along inch by inch:  12" = 1',  3' =  36 " or 1 yard,  1760 yards  = 63,360" or 1 mile

Current from 17 Apr 2021:  Pristiq 0.2665mg  now holding each dose for 3 weeks

ADs since ~1992:  25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq:  50mg 2012, 100mg beg 2013 (Serotonin Toxicity)  Tapering Oct 2015 

My tapering program   My Intro (goes to my tapering graph)  My website

PLEASE NOTE:  I am not a medical professional.  I provide information and make suggestions.

Link to post
Share on other sites
AdviceNeeded

@ChessieCat thanks again.

 
I’m definitely finding the lower the dose, the quicker it seems to induce sleep. Sleep is still fitful and I wake early feeling less than refreshed, but it does seem to have improved slightly as the dose has reduced.

25/8/2020 - 15/9/2020 - 15mg mirtazapine

16/9/2020 - 30mg mirtazapine

17/9/2020 - 22/9/2020 - 7.5 mg mirtazapine

23/9/2020 - 6/10/2020 - 3.75mg mirtazapine

7/10/2020 - 15/10/2020 - 7.5 mg mirtazapine

16/10/2020 - 20/10/2020 - 15 mg mirtazapine

21/10/2020 - 22/10/2020 - 7.5 mg mirtazapine

23/10/202 - 26/11/2020 - 15 mg mirtazapine

27/11/2020 - 10/12/2020 -13.5 mg mirtazapine

11/12/2020 - 17/12/2020 - 12 mg mirtazapine

18/12/2020 - 26/12/2020 - 11.75 mg mirtazapine

 

Link to post
Share on other sites

×
×
  • Create New...

Important Information

Terms of Use Privacy Policy