Jump to content
Sign in to follow this  
Healing

NSAIDs interfere with SSRIs

Recommended Posts

Healing

The Wall Street Journal

26 Apr 11

by Shirley S. Wang

 

....Researchers found that painkillers such as aspirin and ibuprofen appear to decrease the effectiveness of a popular class of antidepressants that includes Prozac and Celexa.

 

The finding, published Monday, may help explain why even the most effective antidepressants don't work for everyone. At best only about two-thirds of patients respond effectively to Celexa and other selective serotonin reuptake inhibitors, or SSRIs....

 

It isn't clear from the study whether taking ibuprofen for an occasional headache is enough to blunt the effect of an antidepressant or whether it takes long-term use for a condition such as arthritis for there to be an inhibitory effect.....

 

Antidepressants, the bulk of which are SSRIs, were the second most popular drug class prescribed in the U.S. last year, netting $11.6 billion in sales, according to IMS Health, which tracks pharmaceutical sales.....

 

There were 253 million prescriptions for antidepressants in the U.S. in 2010.

 

The Rockefeller researchers initially looked at changes of a biochemical marker of depression in mice when the animals were consistently given an SSRI, an anti-inflammatory or both medicines.

 

They figured if there was any effect from combining the two, it would have been to improve depressive symptoms since inflammation, an immune system response to infection, it thought to worsen or even cause depression in some people, Dr. Warner-Schmidt said.

 

Instead, they found that mice given a combination regimen had a dampened response—and sometimes no response—to the antidepressant compared to the group that got the SSRI alone. Mice who received just the anti-inflammatory didn't show any change in the protein marker, called p11.

 

The researchers then looked to see if there was any evidence of this effect in humans. By examining data from an already-completed 4,000-patient large clinical trial of depressed patients known as STAR*D, they found that there was indeed a significant difference. Depressive symptoms—such as feeling down, crying more frequently than usual or having decreased appetite—in patients who took Celexa went away 55% of the time, but that rate dropped to 45% in individuals who reported they also had taken an anti-inflammatory.

 

Madhukar Trivedi, who co-led the STAR*D trial and wasn't involved in the new study, called the mouse data "clearly compelling" and the STAR*D analysis "very fascinating" but in need of follow-up.....

 

It isn't clear why NSAIDs suppress the effect of SSRIs, but it could be simply an interaction between the drugs where NSAIDs prevent SSRIs from reaching the brain, the researchers said.....

 

Write to Shirley S. Wang at shirley.wang@wsj.com

 

http://online.wsj.com/article/SB10001424052748704132204576285183033104082.html

Share this post


Link to post
Share on other sites
Healing

So many opportunities to use the :blink: emoticon here!

Share this post


Link to post
Share on other sites
Altostrata

I wish I had one for being speechless.

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
Sign in to follow this  

×
×
  • Create New...

Important Information

Terms of Use Privacy Policy