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Cortisol adverse interaction


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mickde1

Hi all i have learned that for us older males on the recovery path that excess cortisol peak that's tied in with anxiety us sufferers experience in the early mornings has a detrimental effect on  prostate health there is a strong correlation with cortisol  elevated PSA levels that invariably can lead to prostate cancer not good news as i fall in this category and am effected with this, it now has prompted me to search for ways to minimise this predisposition,  here is a clinical link for those that may need to know https://www.researchgate.net/publication/49717938_Life_events_cortisol_and_levels_of_prostate_specific_antigen_A_story_of_synergism 

hoping you all a shorten  journey to your recovery 

 

 

I've been medication free for 65 months and a half months as posted of May 30th 2021 , stopped   med's December 14th 2015,  history  20 years on  Prozac 80mg & Moclobemide 150 mg  per day,  stopped  Moclobemide sometime in 2012 then about a year later lowered Prozac  dose to 20mg  per day, then changed to Paroxetine, then change to a Mirtazapine,  then change to Lexapro,  then changed to Brintellix,  then changed to Edronax  all at 10mgs or less  over a period of about  year,   Edronax tapered 4mg to 2mg over  10 weeks, 2 mg for 8 weeks 1 mg for 10 weeks  stopped all meds completely 14 December 2015  3 months later all HELL broke loose 

18 Jan 2019 reinstated Prozac  .25 mg then ceased 8/8/20

 

 

 

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Venlafckcine
On 6/11/2021 at 1:04 AM, mickde1 said:

Hi all i have learned that for us older males on the recovery path that excess cortisol peak that's tied in with anxiety us sufferers experience in the early mornings has a detrimental effect on  prostate health there is a strong correlation with cortisol  elevated PSA levels that invariably can lead to prostate cancer not good news as i fall in this category and am effected with this, it now has prompted me to search for ways to minimise this predisposition,  here is a clinical link for those that may need to know https://www.researchgate.net/publication/49717938_Life_events_cortisol_and_levels_of_prostate_specific_antigen_A_story_of_synergism 

hoping you all a shorten  journey to your recovery 

Hi Mickde1,

This study examined the relationship between stressful life events, PSA levels and cortisol. They refer to Holmes and Rahe questionnaire about stressful life events during the past 1-5 years. I don't know if what you mention is listed in this questionnaire as a stressful life event.

Moreover cortisol levels are changing naturally. Did you get your cortisol levels checked? Are you sure that there is excess cortisol?

Furthermore this study states only that there might be a possible cancer risk, where the hypothalamic pituitary adrenal axis may moderate stress-cancer risk associations.

Besides the sample size used in this study is very small. And it says nothing about the medical relevance of it's results. 

Evidence is something else. ;)

When you worry about your cancer risk I guess it would be best to speak to your healthcare provider first.

Ven

 

2014 – 2020: Venlafaxine (extended release) in doses from 37,5 – 300 mg

2017: Venlafaxine - started tapering off after discontinuation had failed

12-15-2019: Venlafaxine 2,64 mg (8 beads) = 4 weeks

01-15-2020: Venlafaxine 1,32 mg (4 beads)] = 6 weeks || 02-29: 1,98 mg (6 beads) = 6 weeks || 04-15: 1,65 mg (5 beads) ≈ 14 weeks = 3,5 month || 07-25: 1,98 mg (6 beads) = 1 day || 07-26: 1,65 mg (5 beads) ≈ 2 weeks || 08-10: 1,98 mg (6 beads) = 4 days || 08-14: 1,65 mg (5 beads) = 4 days || 08-18: 0,99 mg (3 beads) = 6 days || 08-24: (0 mg)

08-2020 – 03-2021: Diazepam occasionally in doses from 2,5 – 5 mg

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mickde1

Hi Ven

Its a known fact that this condition exist with sufferers of WD symptoms ( elevated cortisol leveis ) you'll find evidence of cases on this site  and inforamtion on ways to try to manage cortisol spikes  i disagree with your view that you seem to dispel that sufferes of WD symptoms don't live a stressful existence for me, personally my 5 and a half year journey in sufferance has been the most stressful on going existence  encountered its been epic to say the least and yes professioal people i consult with have diagnosed this state.

It's not a myth 

 

 

I've been medication free for 65 months and a half months as posted of May 30th 2021 , stopped   med's December 14th 2015,  history  20 years on  Prozac 80mg & Moclobemide 150 mg  per day,  stopped  Moclobemide sometime in 2012 then about a year later lowered Prozac  dose to 20mg  per day, then changed to Paroxetine, then change to a Mirtazapine,  then change to Lexapro,  then changed to Brintellix,  then changed to Edronax  all at 10mgs or less  over a period of about  year,   Edronax tapered 4mg to 2mg over  10 weeks, 2 mg for 8 weeks 1 mg for 10 weeks  stopped all meds completely 14 December 2015  3 months later all HELL broke loose 

18 Jan 2019 reinstated Prozac  .25 mg then ceased 8/8/20

 

 

 

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mickde1

Furthermore its only one of many studies that conclude this finding 

 

 

I've been medication free for 65 months and a half months as posted of May 30th 2021 , stopped   med's December 14th 2015,  history  20 years on  Prozac 80mg & Moclobemide 150 mg  per day,  stopped  Moclobemide sometime in 2012 then about a year later lowered Prozac  dose to 20mg  per day, then changed to Paroxetine, then change to a Mirtazapine,  then change to Lexapro,  then changed to Brintellix,  then changed to Edronax  all at 10mgs or less  over a period of about  year,   Edronax tapered 4mg to 2mg over  10 weeks, 2 mg for 8 weeks 1 mg for 10 weeks  stopped all meds completely 14 December 2015  3 months later all HELL broke loose 

18 Jan 2019 reinstated Prozac  .25 mg then ceased 8/8/20

 

 

 

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Venlafckcine
10 minutes ago, mickde1 said:

Hi Ven

Its a known fact that this condition exist with sufferers of WD symptoms ( elevated cortisol leveis ) you'll find evidence of cases on this site  and inforamtion on ways to try to manage cortisol spikes  i disagree with your view that you seem to dispel that sufferes of WD symptoms don't live a stressful existence for me, personally my 5 and a half year journey in sufferance has been the most stressful on going existence  encountered its been epic to say the least and yes professioal people i consult with have diagnosed this state.

It's not a myth 

Hi Mickde1,

 

I don't doubt your suffering by any means. The study that you mention is most likely not suitable for laymen to join dots that are simply not there as what they might see as a critcal factor simply was not part of the study. The clincal relevance of the results of such studies also needs to be proven seperately before jumping to conclusions that might not exist.
When you need interpretation of the study results in respect to your symptoms, it's probably best when you speak to your healthcare provider about it.

Ven 

 

2014 – 2020: Venlafaxine (extended release) in doses from 37,5 – 300 mg

2017: Venlafaxine - started tapering off after discontinuation had failed

12-15-2019: Venlafaxine 2,64 mg (8 beads) = 4 weeks

01-15-2020: Venlafaxine 1,32 mg (4 beads)] = 6 weeks || 02-29: 1,98 mg (6 beads) = 6 weeks || 04-15: 1,65 mg (5 beads) ≈ 14 weeks = 3,5 month || 07-25: 1,98 mg (6 beads) = 1 day || 07-26: 1,65 mg (5 beads) ≈ 2 weeks || 08-10: 1,98 mg (6 beads) = 4 days || 08-14: 1,65 mg (5 beads) = 4 days || 08-18: 0,99 mg (3 beads) = 6 days || 08-24: (0 mg)

08-2020 – 03-2021: Diazepam occasionally in doses from 2,5 – 5 mg

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mickde1

With all due respect Ven i have drawn plenty of validity  in several studies and findings that conclude the same result chemicals hormones and pathways and interactions im not going to spell out the process it's relent and  exist, all the lovely people that are the constituent of this great resourceful site that that look out for each other have express their short comings after being on antidepressants they know to well of the morning cortisol spike and yes Dr Micheal Woodbridge of Nutritional & Environmental Medicine Queensland ...FACEM FRACGP MB CHB DIP MSM DIP B SC

acknowledging this condition in myself this is the case and may well be for others as i first stated in my first post so be it end of story

have great day Ven

 

 

I've been medication free for 65 months and a half months as posted of May 30th 2021 , stopped   med's December 14th 2015,  history  20 years on  Prozac 80mg & Moclobemide 150 mg  per day,  stopped  Moclobemide sometime in 2012 then about a year later lowered Prozac  dose to 20mg  per day, then changed to Paroxetine, then change to a Mirtazapine,  then change to Lexapro,  then changed to Brintellix,  then changed to Edronax  all at 10mgs or less  over a period of about  year,   Edronax tapered 4mg to 2mg over  10 weeks, 2 mg for 8 weeks 1 mg for 10 weeks  stopped all meds completely 14 December 2015  3 months later all HELL broke loose 

18 Jan 2019 reinstated Prozac  .25 mg then ceased 8/8/20

 

 

 

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Venlafckcine

Hi Mickde1,

 

Again - please don't get me wrong - I don't doubt any of your conditions. When you have high cortisol or abnormal cortisol levels you have them. No doubt. What I say is that one has to be careful about the conclusions one draws from a study like this. The reasons why I say this pls see my other posts on this issue. If you want to believe something else you're free to do so. There is no need to argue that.

The cirtical factors in respect to cancer of this study are: "age, body mass index and the ratio of triglycerides to HDL cholesterol". If you want to lower your risk to cancer you may want to address these parameters first. This means: healthy, anti inflamatory and plant based nutrition, no alcohol, no smoking, no refined sugars, suitable expercise, etc. But these are all things that one should discuss with his healthcare provider.

To your health!
Ven



 

 

2014 – 2020: Venlafaxine (extended release) in doses from 37,5 – 300 mg

2017: Venlafaxine - started tapering off after discontinuation had failed

12-15-2019: Venlafaxine 2,64 mg (8 beads) = 4 weeks

01-15-2020: Venlafaxine 1,32 mg (4 beads)] = 6 weeks || 02-29: 1,98 mg (6 beads) = 6 weeks || 04-15: 1,65 mg (5 beads) ≈ 14 weeks = 3,5 month || 07-25: 1,98 mg (6 beads) = 1 day || 07-26: 1,65 mg (5 beads) ≈ 2 weeks || 08-10: 1,98 mg (6 beads) = 4 days || 08-14: 1,65 mg (5 beads) = 4 days || 08-18: 0,99 mg (3 beads) = 6 days || 08-24: (0 mg)

08-2020 – 03-2021: Diazepam occasionally in doses from 2,5 – 5 mg

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