Bruci Posted August 10, 2021 Share Posted August 10, 2021 https://www.genengnews.com/news/antidepressant-withdrawal-syndrome-linked-to-membrane-lipid-raft-signaling/ Link to paper in article. 1 1980s: First diagnosed with depression. Treated with a tricyclic. 1988: Switched to Prozac 20 mg. 1990s to 2010: On and off Prozac. Increased dose led to side effects. 2011: Put on Zyprexa. 2011: Work burnout and breakdown. Hospitalized for suicidal depression. Switched to Seroquel. Switched to Celexa 40 mg and lithium 300 mg. 2019: Stopped Seroquel. 2020 July: Decreased Celexa to 30 mg in attempt to alleviate sexual dysfunction. Worked somewhat. 2020 August: Decreased Celexa to 20 mg. Sexual function improved but w/d effects started. 2020 September: Maintaining Celexa at 20 mg. Experiencing w/d effects - fatigue, dysphoria, mood instability 2020 September 13: Increased Celexa to 30 mg due to w/d effects. Still on lithium 300 mg/day. 2020 October 3: Reduced Celexa to 27 mg. Started taper. 10% per month as recommended. 2020 October 18: Reduced to 24 mg. 2020 December 4: Reduced to 21 mg. 2020 December 23: Reduced to 20 mg (spacing out taper intervals due to persistent w/d effects) 2021 September 23: Several reductions over the past 9 months to 7.0 mg. Stressful life circumstances led me to feeling very depressed with suicidal feelings, so upped to the dose to 10 mg until I feel better. Link to comment Share on other sites More sharing options...
miomio Posted September 8, 2021 Share Posted September 8, 2021 https://www.genengnews.com/news/antidepressant-withdrawal-syndrome-linked-to-membrane-lipid-raft-signaling/ It's a kind of sad when someone like me struggles a lot after years of withdrawal and now they admit that the changes made are kind of persistent,I hope that doesn't mean recovery is just a coincidence I allready have a low motivational level. Started Venlafaxine around 2007-2008 for around 4,5-5 years 70mg ca .2012 Taper as doctors advise 2 weeks skip a day and stop 7 -8 later months total breakdown after sruggling a lot Hospitalized and started on Cipralex. Taper as doctors advise: Mai 2018 from 20 to 10 mg escitalopram to zero in one Month. supplements Magnesium citrate 600 mg Omega 3 2000 mg vitamin D3 sometimes Link to comment Share on other sites More sharing options...
Moderator Emeritus arbor Posted September 12, 2021 Moderator Emeritus Share Posted September 12, 2021 Hi @miomioIt's hard to keep the motivation going, I sure do know. It still seems likely that you will heal, and that with patience, time is your best healer (and mine as well), hard as it is. This study interests me because they're finally addressing our issues with these drugs. Also, the suggestion made here at SA to try fish oil in our diets, I think may be supported by this study. You have access to some of the best EPA fish oil in the world! I send you my best wishes for recovery--as we go through this unspeakable time🙏 Arbor Zoloft: 1995 - 2015 Prozac: 2015 - 2018 (tapered from 40mg x day on July 31 to 30mg on August 31 to 20mg on September 31 to 10mg October 31 to 0mg on December 15, 2018 Gabapentin: 2016 to 2019 (tapered from 300mg x day to 150mg on August 31, 2019 to 75mg on September 15 to 50mg on September 31 to 25ishmg on October 15 to 0mg on December 1, 2019 Enalapril: 2010 - 2019 Lipitor: 2017 -2017 Metformin: 2000 - 2020 Liothyronine: 2007 - 2019 Levothyroxine: 2000 - 2022 Link to comment Share on other sites More sharing options...
JesusSavemefromWD Posted September 13, 2021 Share Posted September 13, 2021 On 9/8/2021 at 8:45 AM, miomio said: https://www.genengnews.com/news/antidepressant-withdrawal-syndrome-linked-to-membrane-lipid-raft-signaling/ It's a kind of sad when someone like me struggles a lot after years of withdrawal and now they admit that the changes made are kind of persistent,I hope that doesn't mean recovery is just a coincidence I allready have a low motivational level. Although I don’t have access to full PDF of this paper, based on just its abstract i wouldn’t worry about it that much. First of all, the experiments were done in vitro (a cellular model set up outside the body) so ur not sure if this is really reflecting what happens to the actual human brain and secondly the authors mention “after 24hrs” in regards to changes remaining after antidepressant removal. It’s not like they did months or at least weeks to see if the changes persist long time. At least that’s my opinion as a neuroscientist who has worked years and years in experimental science and published several scientific papers. have u seen any improvements in ur symptoms lately? Aug. 16-17, 2020, cipralex: went CRAZY! Recovered in 24hrs Aug.28,2020; 3.5 weeks 25mg sertraline/4.5 weeks taper Oct. 25: Last dose (4mg) Symptoms while on zoloft DPDR/out of my body/soul despair/feeling dead; tinnitus/no appetite; fear, anxiety/panics 4 months OFF: soul despair, anxiety/fear, brain disconnection/ DPDR, brain feels swollen-numb/crazy/bedridden barely functioning, tinnitus, eye lid twitches; face spasms. Feeling slightly better after 10pm. - sleep & appetite are fine 9 months OFF: hell, no windows, same symptoms as above (only eye and face twitches have stopped) plus intense arm/shoulder pain and visual issues. Tinnitus replaced by head buzzing. 10 months-1 year: all above plus Insomnia (out of nowhere), depression, no peace of mind (mental Akathisia); 2.5mg melatonin 14months off: sleep resumed. All rest symptoms remain. Bedridden vegetable all day. DP is relentless. 1.5 years off: still severely disabled, not much changed except some improvement in vision. Link to comment Share on other sites More sharing options...
miomio Posted September 13, 2021 Share Posted September 13, 2021 Thanks both of u for the replay. Im am 3 years in withdrawal now, i am much better Physical but still have issues with low energie, fast heartbeat some times vision trouble, feelings i forehead, tinitus often, some time nervpain in the feets and clearly mental issues overthinking stuff and no positiv emotions, funny the anger works. Started Venlafaxine around 2007-2008 for around 4,5-5 years 70mg ca .2012 Taper as doctors advise 2 weeks skip a day and stop 7 -8 later months total breakdown after sruggling a lot Hospitalized and started on Cipralex. Taper as doctors advise: Mai 2018 from 20 to 10 mg escitalopram to zero in one Month. supplements Magnesium citrate 600 mg Omega 3 2000 mg vitamin D3 sometimes Link to comment Share on other sites More sharing options...
Administrator Altostrata Posted October 29, 2021 Administrator Share Posted October 29, 2021 Moved this because new topics in the Journals forum are only for citation of scientific articles, not articles about scientific papers. See This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment Share on other sites More sharing options...
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