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SonSetFree: Starting my journey of healing (Wellbutrin, Cymbalta, Trazodone)


SonSetFree

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Hi All,

 

I have been following this site for a couple of months now as I have been going through major AD withdraw for last 6 weeks and looking at reinstatement options.  It is amazing what the site is doing and I am so thankful I found you.  Here is a brief history of most recent meds;

 

1995 Start Effexor
2001 Stop Effexor (fast taper), Start Wellbutrin, Start Celexa
2009 Start Trazodone
2010 Stop Celexa (fast taper), Start Cymbalta
2014, 2016 Reductions in Dosages Cymbalta and Wellbutrin
2018 Started Slow Taper of Cymbalta from 30mg

2021 May Dropped Trazodone from 75mg to 50mg

2021 May Started Chiropractor

**Started Muscle Twitching and Spasms thought it was due to chiropractor but later realize after reading this site that it was must likely the Trazodone drop**
2021 July Stopped Cymbalta After Long Taper (down to 4 flakes)
2021 July Stopped Wellbutrin Fast Taper (alternating dose 100mg SR)

**Stopped Wellbutrin because noticed after reducing a dose it helped my muscle spasms**

10 days after stopping Wellbutrin and Cymbalta, started Severe Anxiety, Depression, Insomnia, No Appetite, Major Stomach Issues and Still Occasional Muscle Spasms but not as bad as on Wellbutrin
2021 Psych advised Start Remeron - 7.5mg to help with sleep and appetite and overall anxiety.  Did Help Sleep and Appetite and maybe eased Anxiety some


I am now 6 weeks since stopping Wellbutrin and 2 weeks into starting Remeron, while also continuing my Trazodone.  I am worse off now than before I dropped Wellbutrin and looking for any advice on reinstatement of Wellbutrin and/or Cymbalta or possibly even Trazodone (3 months since i dropped from 75mg to 50mg).  My last dosage of Wellbutrin was 100mg SR on alternating days and Cymbalta 4 flakes or 0.6mg.  Which reinstatement would you recommend and what dosage?  I suspect the Wellbutrin, but how much?  Of course my psych wants me to increase Remeron Dosage.

 

So grateful for you and this site - 

 

I am not seeing WD fro

Edited by manymoretodays
name to title

1995 - 2001 Wellbutrin & Effexor, 2001 Stop Effexor (CT), Start Celexa. 2009 Start Trazodone, 2010 Stop Celexa (fast taper), Start Cymbalta. 2014, 2016 Reductions in Dosages Cymbalta and Wellbutrin
2018 Started Slow Taper of Cymbalta from 30mg

2021 May Trazodone Dose drop from 75 to 50 - Started Muscle Cramping and Spasms
2021 July 5th Stopped Cymbalta After 3 YR Taper (No method, I removed beads based on how I was feeling.  Got down to 4 beads, or about 0.4mg before stopping)
2021 July 5th Stopped Wellbutrin cold turkey (was taking 75mg.  Over last week on Wellbutrin, I skipped days taking 100mg SR every other day).  Took last dose of Wellbutrin July 5th.  Severe WD Started July 17th.
2021 Aug 3rd:  Start Remeron 7.5mg at Night 

2021 Aug 23rd: Reinstated Wellbutrin 10mg AM / 10 mg PM, Stopped Remeron

2021 Aug 30th: Changed WB Dosing to 10mg AM / 5mg Mid Day / 8mg Early Evening

2021 Sept 1st: Reinstated Remeron 7.5mg for sleep

2021 Sept 14th: Changed WB to 10mg AM / 6mg Mid day / 6mg Early Evening, Jan 24: Changed WB to 9mg AM / 6mg Mid Day / 6mg PM

2021 Sept 21: Re-instated Cymbalta at 1 bead 2X a day, Oct 12:  Updosed to 2 beads AM, 1 bead PM, March 11:  Updosed 2 beads AM, 2 beads PM
Currently on Trazodone 50mg and Remeron 7.5mg.  Cymbalta 2 Beads (0.1mg) 2X Day 7AM and 6PM.  Wellbutrin 9mg AM / 6mg Mid day / 6mg Early Evening

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  • manymoretodays changed the title to SonSetFree: Starting my journey of healing (Wellbutrin, Cymbalta, Trazodone)
  • Moderator

Hi SonSet Free,

 

Welcome to this support site. Before we can answer your questions, please give us more information first. Good that you came here. There is a lot of knowledge to be found and shared here. Also the members can support each other here.

 

Reading your story it seems to me that you suffer mainly from fast tapering Wellbutrin. For a lot of people Wellbutrin is quite easy to taper, but for others it can be extremely difficult.

 

It becomes an extra problem when Wellbutrin is tapered when taking other meds that are metabolized slower because of taking Wellbutrin. Because Wellbutrin slowers down the metabolism of all drugs that are metabolized by the CYP2D6 enzym.

 

Also Trazodone (and Cymbalta and Remeron) are metabolized by this enzym. This means effectively that when one tapers Wellbutrin the metabolism of the other drugs increases. And this gives the same effect as tapering all taken med at the same time!

 

Since you tapered Cymbalta to zero before fast tapering the Wellbutrin, I guess there was no effect. But with the Trazodone there will have been interaction nearly for sure. 

 

So this may have worsened the withdrawal effect as a whole. I know from experience how heavy Wellbutrin withdrawal can be (in combination with Lexapro (escitalopram) and Prozac (fluoxetine). 

 

As far as I know there is not much experience with reinstating Wellbutrin in very low dosages. But it might be worthwhile trying. I would advise to take a real low dosage first and to see if that helps. Reinstating high dosages is not recommended!

 

https://www.survivingantidepressants.org/topic/7562-about-reinstating-and-stabilizing-to-reduce-withdrawal-symptoms/?tab=comments#comment-33809

 

I read you have been tapering the Wellbutrin by altering a daily dose of 100mg. Many of us have made this mistake. Please read why you should not do so again:

https://www.survivingantidepressants.org/topic/22958-never-skip-doses-to-taper/

 

 

- Could you specify more exactly when you started taking Wellbutrin.

- What dosage changes did you make over time (when and how much).

- When exactly did you start tapering and what dosage were you taking before you started tapering?

- What dosages have you been taking during the tapering process (describe your tapering process as much as possible in detail with dates and dosages.

 

Not really sure how much to reinstate yet. Probably between 5 or 15 mg, depending on your answers of these questions.

1993    Anafranil (Clomipramine) for a few months. Later in 1993 Paxil for a few months 1993- 2006      No medication

2006   Effexor, Cymbalta, some Benzo’s. All for short periods. Later in 2006 Lexapro (escitalopram) 10 mg and shortly after Wellbutrin XR 150mg, against side effects Lexapro 

Since 2006 until end of 2015: Several times on and off Lexapro and Wellbutrin and several slight dosage changes. Mostly taken dosages: 5mg Lexapro and 150mg Wellbutrin

2016  Dosage change Lexapro from 5mg to 2,5 mg. Wellbutrin stayed om 150mg

November 2016 – April 2017 Down from 2,5mg to 0,6mg Lexapro (in steps) without much problems. Wellbutrin down from 150mg to 66mg. Also without much problems.

April 2017 – March 2019       Lexapro 0,6 mg        April 2017 - August 2018       Wellbutrin in small steps down from 66mg in to 37,5 mg . Quite heavy WD after each step.

March 2019 – May 2019 Lexapro down from 0,6 to 0,3mg then Prozac to 0,6 mg switch because severe discontinuation effects (may also have been from Wellbutrin..)    

Wellbutrin down from 37,5mg to 35,3mg 

October 2019        Seroquel 12,5 mg for 4 weeks because of extreme sleeping problems, then weaning off in 2 weeks       Prozac up dosage to 1,2 mg

March 2020     Wellbutrin in 2 steps down from 35,3mg to 33,3mg   Extreme withdrawal affects during 8 months. Stopped tapering Wellbutrin  until total off Prozac. 

February 2020 – November 2020   Prozac down in steps from 1,2mg to 0,57mg. 

Jan 2021  Prozac down to:  0,55> 0,53>0,51mg,   Feb 0,47mg ,  Mar 0,42mg,   Apr 0,37, longer hold because of WD symptoms July 0,36 and hold again, Sept 19 0,35, Sept 26 0,34mg, Oct 3 0,33mg  

January 20, 2022:  Wellbutrin from 33,3 to 32,3mg

March 22, 2022 Prozac down from 0,33mg to: 0,30mg, Apr 0,29, May 0,28, 0,27, June 0,26, 0,25, July 0,24, 0,23, 0,22, 0,21, Aug 0,20

 

Supplements: Fish Oil (3000mg), Magnesium 100 mg, 2 drops of Lavender Oil when feeling anxiety. 50mg of L-Theanine when severe discontinuation effects caused by Wellbutrin

 

Please note this is NOT a medical advice. Discuss all your medical issues with a doctor who understands psychical drugs and really knows how to withdraw from them. I wish that you will find one.

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Hi Go2Zero, @Go2zero

 

Thank you for your reply!  It is so encouraging hearing from someone that understands what I'm going through.

 

I just realized my signature says I started started Wellbutrin in 2001, it was actually in 1996.  My dose has gone up and down between 300mg and 150mg over the many years.  Then about 5 years ago lowered dose to 100SR, then down to 75mg starting 2 years ago. Then stayed on 75 mg for 2 years until this past July when I started 100SR and taking 3 times on every other day over a period of 5 days.  My last dose was July 5.  By the way, I wanted to get off Wellbutrin because I started having muscle spasms, twitching and pain about 2 months earlier and Wellbutrin seemed to be causing it.  However in retrospect, the muscle spasms may have been due to my lowering Trazodone in May (75mg to 50mg).

 

Thanks, I'm looking forward to getting started on the reinstatement and will wait to hear back from you.  I was thinking around 10 mg twice a day.  Also, since I am only 2.5 weeks into starting Remeron at 7.5mg, do you think I'm better off just discontinuing before I become dependant?

 

thanks again and hope you are well on your journey!

1995 - 2001 Wellbutrin & Effexor, 2001 Stop Effexor (CT), Start Celexa. 2009 Start Trazodone, 2010 Stop Celexa (fast taper), Start Cymbalta. 2014, 2016 Reductions in Dosages Cymbalta and Wellbutrin
2018 Started Slow Taper of Cymbalta from 30mg

2021 May Trazodone Dose drop from 75 to 50 - Started Muscle Cramping and Spasms
2021 July 5th Stopped Cymbalta After 3 YR Taper (No method, I removed beads based on how I was feeling.  Got down to 4 beads, or about 0.4mg before stopping)
2021 July 5th Stopped Wellbutrin cold turkey (was taking 75mg.  Over last week on Wellbutrin, I skipped days taking 100mg SR every other day).  Took last dose of Wellbutrin July 5th.  Severe WD Started July 17th.
2021 Aug 3rd:  Start Remeron 7.5mg at Night 

2021 Aug 23rd: Reinstated Wellbutrin 10mg AM / 10 mg PM, Stopped Remeron

2021 Aug 30th: Changed WB Dosing to 10mg AM / 5mg Mid Day / 8mg Early Evening

2021 Sept 1st: Reinstated Remeron 7.5mg for sleep

2021 Sept 14th: Changed WB to 10mg AM / 6mg Mid day / 6mg Early Evening, Jan 24: Changed WB to 9mg AM / 6mg Mid Day / 6mg PM

2021 Sept 21: Re-instated Cymbalta at 1 bead 2X a day, Oct 12:  Updosed to 2 beads AM, 1 bead PM, March 11:  Updosed 2 beads AM, 2 beads PM
Currently on Trazodone 50mg and Remeron 7.5mg.  Cymbalta 2 Beads (0.1mg) 2X Day 7AM and 6PM.  Wellbutrin 9mg AM / 6mg Mid day / 6mg Early Evening

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  • Moderator
8 hours ago, SonSetFree said:

Then stayed on 75 mg for 2 years until this past July when I started 100SR and taking 3 times on every other day over a period of 5 days.  My last dose was July 5.

 

Just to understand right; you took 75 mg daily for 2 years until july this year. Then you up dosed to 3 times 100mg every other day? That would mean an average of 150 mg daily? While tapering? I am correct? Please explain what you did. 

 

Do I understand that you stopped Wellbutrin over a period of only 5 days ? That would be about the same as cold turkey. Please explain as well so that I can understand fully what you did.

 

The symptoms you are experiencing right now will be most probably of too fast stopping wellbutrin and of tapering Trazadon indirectly because of the increased metabolism.

 

Very important that you will stabilize after reinstatement. This reinstatement will again influence (slower now) the metabolism of Trazodone. So also there your body and nervous system need to find balance again....

 

Before being more clear about the reinstatement dose, I would like to see your answers again to the above questions.

 

Small reinstatement are most often better than bigger ones. 

1993    Anafranil (Clomipramine) for a few months. Later in 1993 Paxil for a few months 1993- 2006      No medication

2006   Effexor, Cymbalta, some Benzo’s. All for short periods. Later in 2006 Lexapro (escitalopram) 10 mg and shortly after Wellbutrin XR 150mg, against side effects Lexapro 

Since 2006 until end of 2015: Several times on and off Lexapro and Wellbutrin and several slight dosage changes. Mostly taken dosages: 5mg Lexapro and 150mg Wellbutrin

2016  Dosage change Lexapro from 5mg to 2,5 mg. Wellbutrin stayed om 150mg

November 2016 – April 2017 Down from 2,5mg to 0,6mg Lexapro (in steps) without much problems. Wellbutrin down from 150mg to 66mg. Also without much problems.

April 2017 – March 2019       Lexapro 0,6 mg        April 2017 - August 2018       Wellbutrin in small steps down from 66mg in to 37,5 mg . Quite heavy WD after each step.

March 2019 – May 2019 Lexapro down from 0,6 to 0,3mg then Prozac to 0,6 mg switch because severe discontinuation effects (may also have been from Wellbutrin..)    

Wellbutrin down from 37,5mg to 35,3mg 

October 2019        Seroquel 12,5 mg for 4 weeks because of extreme sleeping problems, then weaning off in 2 weeks       Prozac up dosage to 1,2 mg

March 2020     Wellbutrin in 2 steps down from 35,3mg to 33,3mg   Extreme withdrawal affects during 8 months. Stopped tapering Wellbutrin  until total off Prozac. 

February 2020 – November 2020   Prozac down in steps from 1,2mg to 0,57mg. 

Jan 2021  Prozac down to:  0,55> 0,53>0,51mg,   Feb 0,47mg ,  Mar 0,42mg,   Apr 0,37, longer hold because of WD symptoms July 0,36 and hold again, Sept 19 0,35, Sept 26 0,34mg, Oct 3 0,33mg  

January 20, 2022:  Wellbutrin from 33,3 to 32,3mg

March 22, 2022 Prozac down from 0,33mg to: 0,30mg, Apr 0,29, May 0,28, 0,27, June 0,26, 0,25, July 0,24, 0,23, 0,22, 0,21, Aug 0,20

 

Supplements: Fish Oil (3000mg), Magnesium 100 mg, 2 drops of Lavender Oil when feeling anxiety. 50mg of L-Theanine when severe discontinuation effects caused by Wellbutrin

 

Please note this is NOT a medical advice. Discuss all your medical issues with a doctor who understands psychical drugs and really knows how to withdraw from them. I wish that you will find one.

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  • Moderator
9 hours ago, SonSetFree said:

Also, since I am only 2.5 weeks into starting Remeron at 7.5mg, do you think I'm better off just discontinuing before I become dependant?

If you want to stop Remeron, I think this would be a good moment! You only used it for 2,5 weeks, so it should be possible without too much problems. After 4 weeks it often becomes much more difficult. But your nervous system seems to be sensitized, so you may have some extra WD symptoms for a while. This will settle. 

1993    Anafranil (Clomipramine) for a few months. Later in 1993 Paxil for a few months 1993- 2006      No medication

2006   Effexor, Cymbalta, some Benzo’s. All for short periods. Later in 2006 Lexapro (escitalopram) 10 mg and shortly after Wellbutrin XR 150mg, against side effects Lexapro 

Since 2006 until end of 2015: Several times on and off Lexapro and Wellbutrin and several slight dosage changes. Mostly taken dosages: 5mg Lexapro and 150mg Wellbutrin

2016  Dosage change Lexapro from 5mg to 2,5 mg. Wellbutrin stayed om 150mg

November 2016 – April 2017 Down from 2,5mg to 0,6mg Lexapro (in steps) without much problems. Wellbutrin down from 150mg to 66mg. Also without much problems.

April 2017 – March 2019       Lexapro 0,6 mg        April 2017 - August 2018       Wellbutrin in small steps down from 66mg in to 37,5 mg . Quite heavy WD after each step.

March 2019 – May 2019 Lexapro down from 0,6 to 0,3mg then Prozac to 0,6 mg switch because severe discontinuation effects (may also have been from Wellbutrin..)    

Wellbutrin down from 37,5mg to 35,3mg 

October 2019        Seroquel 12,5 mg for 4 weeks because of extreme sleeping problems, then weaning off in 2 weeks       Prozac up dosage to 1,2 mg

March 2020     Wellbutrin in 2 steps down from 35,3mg to 33,3mg   Extreme withdrawal affects during 8 months. Stopped tapering Wellbutrin  until total off Prozac. 

February 2020 – November 2020   Prozac down in steps from 1,2mg to 0,57mg. 

Jan 2021  Prozac down to:  0,55> 0,53>0,51mg,   Feb 0,47mg ,  Mar 0,42mg,   Apr 0,37, longer hold because of WD symptoms July 0,36 and hold again, Sept 19 0,35, Sept 26 0,34mg, Oct 3 0,33mg  

January 20, 2022:  Wellbutrin from 33,3 to 32,3mg

March 22, 2022 Prozac down from 0,33mg to: 0,30mg, Apr 0,29, May 0,28, 0,27, June 0,26, 0,25, July 0,24, 0,23, 0,22, 0,21, Aug 0,20

 

Supplements: Fish Oil (3000mg), Magnesium 100 mg, 2 drops of Lavender Oil when feeling anxiety. 50mg of L-Theanine when severe discontinuation effects caused by Wellbutrin

 

Please note this is NOT a medical advice. Discuss all your medical issues with a doctor who understands psychical drugs and really knows how to withdraw from them. I wish that you will find one.

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Hi Go2Zero, @Go2zero

 

I was on 75 mg for 2 years, then starting July 1st took one 100SR, July 2nd skipped, July 3rd took one 100SR, July 4th skipped, and July 5th took one 100 SR then stopped.  So I too 300mg over 5 days, which works out to 60mg a day.

 

For Remeron, should I quit CT even through I'm reintroducing at the same time?  I would like to start reintroducing today if possible by the way the WD is hard to bare right now.  

 

Thank you and hope you are well

1995 - 2001 Wellbutrin & Effexor, 2001 Stop Effexor (CT), Start Celexa. 2009 Start Trazodone, 2010 Stop Celexa (fast taper), Start Cymbalta. 2014, 2016 Reductions in Dosages Cymbalta and Wellbutrin
2018 Started Slow Taper of Cymbalta from 30mg

2021 May Trazodone Dose drop from 75 to 50 - Started Muscle Cramping and Spasms
2021 July 5th Stopped Cymbalta After 3 YR Taper (No method, I removed beads based on how I was feeling.  Got down to 4 beads, or about 0.4mg before stopping)
2021 July 5th Stopped Wellbutrin cold turkey (was taking 75mg.  Over last week on Wellbutrin, I skipped days taking 100mg SR every other day).  Took last dose of Wellbutrin July 5th.  Severe WD Started July 17th.
2021 Aug 3rd:  Start Remeron 7.5mg at Night 

2021 Aug 23rd: Reinstated Wellbutrin 10mg AM / 10 mg PM, Stopped Remeron

2021 Aug 30th: Changed WB Dosing to 10mg AM / 5mg Mid Day / 8mg Early Evening

2021 Sept 1st: Reinstated Remeron 7.5mg for sleep

2021 Sept 14th: Changed WB to 10mg AM / 6mg Mid day / 6mg Early Evening, Jan 24: Changed WB to 9mg AM / 6mg Mid Day / 6mg PM

2021 Sept 21: Re-instated Cymbalta at 1 bead 2X a day, Oct 12:  Updosed to 2 beads AM, 1 bead PM, March 11:  Updosed 2 beads AM, 2 beads PM
Currently on Trazodone 50mg and Remeron 7.5mg.  Cymbalta 2 Beads (0.1mg) 2X Day 7AM and 6PM.  Wellbutrin 9mg AM / 6mg Mid day / 6mg Early Evening

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  • Moderator
1 hour ago, SonSetFree said:

For Remeron, should I quit CT even through I'm reintroducing at the same time?  I would like to start reintroducing today if possible by the way the WD is hard to bare right now.  

 

It is a bit of a dilemma. But you do not have to much choice I guess. For being in time to reinstate Wellbutrin you should not wait. But for stopping Remeron you should not wait either. Since the Wellbutrin also has effect on both Remeron and the Trazodone you might even have worse WD symptoms for a while. But when you stabilize over a longer period this will settle. It may be a bumpy ride, but you can be lucky that is is not so bad.

 

We all react differently. I hope you understand the interactions I described in metabolism? This explains why everything will be quite out of balance right now...

 

So, if I were you I would stop the Remeron and start the reinstatement of the Wellbutrin. Why don't you try with a dose of 10 mg in the morning and 5 mg later in the afternoon. Would be great if you would only have to reinstate 15mg. It will be try and error and not so easy to say what is going on during the coming weeks, because of what I have explained. Everything needs to settle and stabilize. This may take time!

1993    Anafranil (Clomipramine) for a few months. Later in 1993 Paxil for a few months 1993- 2006      No medication

2006   Effexor, Cymbalta, some Benzo’s. All for short periods. Later in 2006 Lexapro (escitalopram) 10 mg and shortly after Wellbutrin XR 150mg, against side effects Lexapro 

Since 2006 until end of 2015: Several times on and off Lexapro and Wellbutrin and several slight dosage changes. Mostly taken dosages: 5mg Lexapro and 150mg Wellbutrin

2016  Dosage change Lexapro from 5mg to 2,5 mg. Wellbutrin stayed om 150mg

November 2016 – April 2017 Down from 2,5mg to 0,6mg Lexapro (in steps) without much problems. Wellbutrin down from 150mg to 66mg. Also without much problems.

April 2017 – March 2019       Lexapro 0,6 mg        April 2017 - August 2018       Wellbutrin in small steps down from 66mg in to 37,5 mg . Quite heavy WD after each step.

March 2019 – May 2019 Lexapro down from 0,6 to 0,3mg then Prozac to 0,6 mg switch because severe discontinuation effects (may also have been from Wellbutrin..)    

Wellbutrin down from 37,5mg to 35,3mg 

October 2019        Seroquel 12,5 mg for 4 weeks because of extreme sleeping problems, then weaning off in 2 weeks       Prozac up dosage to 1,2 mg

March 2020     Wellbutrin in 2 steps down from 35,3mg to 33,3mg   Extreme withdrawal affects during 8 months. Stopped tapering Wellbutrin  until total off Prozac. 

February 2020 – November 2020   Prozac down in steps from 1,2mg to 0,57mg. 

Jan 2021  Prozac down to:  0,55> 0,53>0,51mg,   Feb 0,47mg ,  Mar 0,42mg,   Apr 0,37, longer hold because of WD symptoms July 0,36 and hold again, Sept 19 0,35, Sept 26 0,34mg, Oct 3 0,33mg  

January 20, 2022:  Wellbutrin from 33,3 to 32,3mg

March 22, 2022 Prozac down from 0,33mg to: 0,30mg, Apr 0,29, May 0,28, 0,27, June 0,26, 0,25, July 0,24, 0,23, 0,22, 0,21, Aug 0,20

 

Supplements: Fish Oil (3000mg), Magnesium 100 mg, 2 drops of Lavender Oil when feeling anxiety. 50mg of L-Theanine when severe discontinuation effects caused by Wellbutrin

 

Please note this is NOT a medical advice. Discuss all your medical issues with a doctor who understands psychical drugs and really knows how to withdraw from them. I wish that you will find one.

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Thank you so much for your quick reply! I  took the 10mg 2 hours ago and will take another 5mg tonight.  I’m feeling better and so far no bad muscle cramping which was my biggest concern getting back on Wellbutrin.
 

I do understand your explanation of the effect taking Wellbutrin has on the metabolism of the other medications that use the same liver enzyme.  Thanks for sharing that does make sense.  That may explain a lot of what I’ve experienced the past weeks.  Not sure how to explain why I was seeing bad muscle cramps while taking Wellbutrin at full 75mg dose but it started around the same time I lowered my Trazodone dose.  
 

I am nervous about stopping the Remeron but agree now’s the time to do it.  Ok thanks again I’ll check back in later tonight.  

1995 - 2001 Wellbutrin & Effexor, 2001 Stop Effexor (CT), Start Celexa. 2009 Start Trazodone, 2010 Stop Celexa (fast taper), Start Cymbalta. 2014, 2016 Reductions in Dosages Cymbalta and Wellbutrin
2018 Started Slow Taper of Cymbalta from 30mg

2021 May Trazodone Dose drop from 75 to 50 - Started Muscle Cramping and Spasms
2021 July 5th Stopped Cymbalta After 3 YR Taper (No method, I removed beads based on how I was feeling.  Got down to 4 beads, or about 0.4mg before stopping)
2021 July 5th Stopped Wellbutrin cold turkey (was taking 75mg.  Over last week on Wellbutrin, I skipped days taking 100mg SR every other day).  Took last dose of Wellbutrin July 5th.  Severe WD Started July 17th.
2021 Aug 3rd:  Start Remeron 7.5mg at Night 

2021 Aug 23rd: Reinstated Wellbutrin 10mg AM / 10 mg PM, Stopped Remeron

2021 Aug 30th: Changed WB Dosing to 10mg AM / 5mg Mid Day / 8mg Early Evening

2021 Sept 1st: Reinstated Remeron 7.5mg for sleep

2021 Sept 14th: Changed WB to 10mg AM / 6mg Mid day / 6mg Early Evening, Jan 24: Changed WB to 9mg AM / 6mg Mid Day / 6mg PM

2021 Sept 21: Re-instated Cymbalta at 1 bead 2X a day, Oct 12:  Updosed to 2 beads AM, 1 bead PM, March 11:  Updosed 2 beads AM, 2 beads PM
Currently on Trazodone 50mg and Remeron 7.5mg.  Cymbalta 2 Beads (0.1mg) 2X Day 7AM and 6PM.  Wellbutrin 9mg AM / 6mg Mid day / 6mg Early Evening

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Hi Go2Zero, checking back in.  I am on day 4 of reintroducing Wellbutrin at a low dose, after 6 weeks from stopping 75mg cold turkey.  I am also day 4 on stopping Remeron after 2.5 weeks of taking 7.5mg. 

 

On day 1, started feeling the anxiety relieve some.  Still have the crying spells other WD symptoms.  Insomnia was worse, didn’t sleep but 1-2 hrs all night…as expected going off of Remeron. 

 

Day 2, about the same. Started to see some muscle twitching and spasms come back but not as bad as when I was on full Wellbutrin at 75mg which was discouraging.  That is why I stopped taking the Wellbutrin in the first place they had gotten so bad (although I don’t think Wellbutrin caused the muscle issues, just makes them worse.  Likely cause was an adverse reaction to Bentyl or when I dropped Trazodone dose from 75mg to 50mg 3 months ago). 

 

Day 3 and 4, starting to feel flu like, nausea and weakness.  Suspect this is the Remeron WD kicking in. 

 

Question @Go2zero on the flu like symptoms, any thoughts on on is this WD from Remeron or Adverse Reaction to Wellbutrin reinstatement?  I would assume it's Remeron since I didn't feel this immediately upon reinstatement.  

 

Thanks - Hope you are well

1995 - 2001 Wellbutrin & Effexor, 2001 Stop Effexor (CT), Start Celexa. 2009 Start Trazodone, 2010 Stop Celexa (fast taper), Start Cymbalta. 2014, 2016 Reductions in Dosages Cymbalta and Wellbutrin
2018 Started Slow Taper of Cymbalta from 30mg

2021 May Trazodone Dose drop from 75 to 50 - Started Muscle Cramping and Spasms
2021 July 5th Stopped Cymbalta After 3 YR Taper (No method, I removed beads based on how I was feeling.  Got down to 4 beads, or about 0.4mg before stopping)
2021 July 5th Stopped Wellbutrin cold turkey (was taking 75mg.  Over last week on Wellbutrin, I skipped days taking 100mg SR every other day).  Took last dose of Wellbutrin July 5th.  Severe WD Started July 17th.
2021 Aug 3rd:  Start Remeron 7.5mg at Night 

2021 Aug 23rd: Reinstated Wellbutrin 10mg AM / 10 mg PM, Stopped Remeron

2021 Aug 30th: Changed WB Dosing to 10mg AM / 5mg Mid Day / 8mg Early Evening

2021 Sept 1st: Reinstated Remeron 7.5mg for sleep

2021 Sept 14th: Changed WB to 10mg AM / 6mg Mid day / 6mg Early Evening, Jan 24: Changed WB to 9mg AM / 6mg Mid Day / 6mg PM

2021 Sept 21: Re-instated Cymbalta at 1 bead 2X a day, Oct 12:  Updosed to 2 beads AM, 1 bead PM, March 11:  Updosed 2 beads AM, 2 beads PM
Currently on Trazodone 50mg and Remeron 7.5mg.  Cymbalta 2 Beads (0.1mg) 2X Day 7AM and 6PM.  Wellbutrin 9mg AM / 6mg Mid day / 6mg Early Evening

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  • Moderator
2 hours ago, SonSetFree said:

Question @Go2zero on the flu like symptoms, any thoughts on on is this WD from Remeron or Adverse Reaction to Wellbutrin reinstatement?  I would assume it's Remeron since I didn't feel this immediately upon reinstatement.  

 

This question is very hard to answer. Since your system has been so shocked probably by all changes and the interaction in the metabolism of all these meds as well. This needs to settle. It can not be said now what is causing what. Therefor we always suggest to taper only 1 drug at a time. Then is often more clear what is causing symptoms.

 

But you did not know about the increased metabolism of all other meds that started after stopping Wellbutrin. So don't blame yourself for it. Be kind to yourself and give attention to your stabilizing. Take time for it! It will settle. And yes you may have quite some symptoms during this process. But it will get less and less. Not in one line, but most often in waves and windows.

 

https://www.survivingantidepressants.org/topic/82-the-windows-and-waves-pattern-of-stabilization/

 

1993    Anafranil (Clomipramine) for a few months. Later in 1993 Paxil for a few months 1993- 2006      No medication

2006   Effexor, Cymbalta, some Benzo’s. All for short periods. Later in 2006 Lexapro (escitalopram) 10 mg and shortly after Wellbutrin XR 150mg, against side effects Lexapro 

Since 2006 until end of 2015: Several times on and off Lexapro and Wellbutrin and several slight dosage changes. Mostly taken dosages: 5mg Lexapro and 150mg Wellbutrin

2016  Dosage change Lexapro from 5mg to 2,5 mg. Wellbutrin stayed om 150mg

November 2016 – April 2017 Down from 2,5mg to 0,6mg Lexapro (in steps) without much problems. Wellbutrin down from 150mg to 66mg. Also without much problems.

April 2017 – March 2019       Lexapro 0,6 mg        April 2017 - August 2018       Wellbutrin in small steps down from 66mg in to 37,5 mg . Quite heavy WD after each step.

March 2019 – May 2019 Lexapro down from 0,6 to 0,3mg then Prozac to 0,6 mg switch because severe discontinuation effects (may also have been from Wellbutrin..)    

Wellbutrin down from 37,5mg to 35,3mg 

October 2019        Seroquel 12,5 mg for 4 weeks because of extreme sleeping problems, then weaning off in 2 weeks       Prozac up dosage to 1,2 mg

March 2020     Wellbutrin in 2 steps down from 35,3mg to 33,3mg   Extreme withdrawal affects during 8 months. Stopped tapering Wellbutrin  until total off Prozac. 

February 2020 – November 2020   Prozac down in steps from 1,2mg to 0,57mg. 

Jan 2021  Prozac down to:  0,55> 0,53>0,51mg,   Feb 0,47mg ,  Mar 0,42mg,   Apr 0,37, longer hold because of WD symptoms July 0,36 and hold again, Sept 19 0,35, Sept 26 0,34mg, Oct 3 0,33mg  

January 20, 2022:  Wellbutrin from 33,3 to 32,3mg

March 22, 2022 Prozac down from 0,33mg to: 0,30mg, Apr 0,29, May 0,28, 0,27, June 0,26, 0,25, July 0,24, 0,23, 0,22, 0,21, Aug 0,20

 

Supplements: Fish Oil (3000mg), Magnesium 100 mg, 2 drops of Lavender Oil when feeling anxiety. 50mg of L-Theanine when severe discontinuation effects caused by Wellbutrin

 

Please note this is NOT a medical advice. Discuss all your medical issues with a doctor who understands psychical drugs and really knows how to withdraw from them. I wish that you will find one.

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@Go2zero,

 

Thanks for your encouragement and advice. It occurred to me also based on the logic that the Wellbutrin effects my Trazadone metabolism and that I may be experiencing withdrawal from it that I should try bumping up the dose slightly there as well to help offset the effect.  Let me know your thoughts.  

1995 - 2001 Wellbutrin & Effexor, 2001 Stop Effexor (CT), Start Celexa. 2009 Start Trazodone, 2010 Stop Celexa (fast taper), Start Cymbalta. 2014, 2016 Reductions in Dosages Cymbalta and Wellbutrin
2018 Started Slow Taper of Cymbalta from 30mg

2021 May Trazodone Dose drop from 75 to 50 - Started Muscle Cramping and Spasms
2021 July 5th Stopped Cymbalta After 3 YR Taper (No method, I removed beads based on how I was feeling.  Got down to 4 beads, or about 0.4mg before stopping)
2021 July 5th Stopped Wellbutrin cold turkey (was taking 75mg.  Over last week on Wellbutrin, I skipped days taking 100mg SR every other day).  Took last dose of Wellbutrin July 5th.  Severe WD Started July 17th.
2021 Aug 3rd:  Start Remeron 7.5mg at Night 

2021 Aug 23rd: Reinstated Wellbutrin 10mg AM / 10 mg PM, Stopped Remeron

2021 Aug 30th: Changed WB Dosing to 10mg AM / 5mg Mid Day / 8mg Early Evening

2021 Sept 1st: Reinstated Remeron 7.5mg for sleep

2021 Sept 14th: Changed WB to 10mg AM / 6mg Mid day / 6mg Early Evening, Jan 24: Changed WB to 9mg AM / 6mg Mid Day / 6mg PM

2021 Sept 21: Re-instated Cymbalta at 1 bead 2X a day, Oct 12:  Updosed to 2 beads AM, 1 bead PM, March 11:  Updosed 2 beads AM, 2 beads PM
Currently on Trazodone 50mg and Remeron 7.5mg.  Cymbalta 2 Beads (0.1mg) 2X Day 7AM and 6PM.  Wellbutrin 9mg AM / 6mg Mid day / 6mg Early Evening

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  • Moderator

Indirectly you tapered Trazodone because of increasing the metabolism when stopping Wellbutrin. Now with reinstating a low dose of Wellbutrin you decrease the metabolism of the Trazodone and updose the trazodone indirectly (not real but in effect).

 

I would not mess around with other meds when reinstating. The stopping of the remeron is also going on. I would say that is enough to handle....

1993    Anafranil (Clomipramine) for a few months. Later in 1993 Paxil for a few months 1993- 2006      No medication

2006   Effexor, Cymbalta, some Benzo’s. All for short periods. Later in 2006 Lexapro (escitalopram) 10 mg and shortly after Wellbutrin XR 150mg, against side effects Lexapro 

Since 2006 until end of 2015: Several times on and off Lexapro and Wellbutrin and several slight dosage changes. Mostly taken dosages: 5mg Lexapro and 150mg Wellbutrin

2016  Dosage change Lexapro from 5mg to 2,5 mg. Wellbutrin stayed om 150mg

November 2016 – April 2017 Down from 2,5mg to 0,6mg Lexapro (in steps) without much problems. Wellbutrin down from 150mg to 66mg. Also without much problems.

April 2017 – March 2019       Lexapro 0,6 mg        April 2017 - August 2018       Wellbutrin in small steps down from 66mg in to 37,5 mg . Quite heavy WD after each step.

March 2019 – May 2019 Lexapro down from 0,6 to 0,3mg then Prozac to 0,6 mg switch because severe discontinuation effects (may also have been from Wellbutrin..)    

Wellbutrin down from 37,5mg to 35,3mg 

October 2019        Seroquel 12,5 mg for 4 weeks because of extreme sleeping problems, then weaning off in 2 weeks       Prozac up dosage to 1,2 mg

March 2020     Wellbutrin in 2 steps down from 35,3mg to 33,3mg   Extreme withdrawal affects during 8 months. Stopped tapering Wellbutrin  until total off Prozac. 

February 2020 – November 2020   Prozac down in steps from 1,2mg to 0,57mg. 

Jan 2021  Prozac down to:  0,55> 0,53>0,51mg,   Feb 0,47mg ,  Mar 0,42mg,   Apr 0,37, longer hold because of WD symptoms July 0,36 and hold again, Sept 19 0,35, Sept 26 0,34mg, Oct 3 0,33mg  

January 20, 2022:  Wellbutrin from 33,3 to 32,3mg

March 22, 2022 Prozac down from 0,33mg to: 0,30mg, Apr 0,29, May 0,28, 0,27, June 0,26, 0,25, July 0,24, 0,23, 0,22, 0,21, Aug 0,20

 

Supplements: Fish Oil (3000mg), Magnesium 100 mg, 2 drops of Lavender Oil when feeling anxiety. 50mg of L-Theanine when severe discontinuation effects caused by Wellbutrin

 

Please note this is NOT a medical advice. Discuss all your medical issues with a doctor who understands psychical drugs and really knows how to withdraw from them. I wish that you will find one.

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  • Moderator

Could you please update your signature with the latest changes?  Please do so every time when you make changes in meds or dosages. Thanks!

1993    Anafranil (Clomipramine) for a few months. Later in 1993 Paxil for a few months 1993- 2006      No medication

2006   Effexor, Cymbalta, some Benzo’s. All for short periods. Later in 2006 Lexapro (escitalopram) 10 mg and shortly after Wellbutrin XR 150mg, against side effects Lexapro 

Since 2006 until end of 2015: Several times on and off Lexapro and Wellbutrin and several slight dosage changes. Mostly taken dosages: 5mg Lexapro and 150mg Wellbutrin

2016  Dosage change Lexapro from 5mg to 2,5 mg. Wellbutrin stayed om 150mg

November 2016 – April 2017 Down from 2,5mg to 0,6mg Lexapro (in steps) without much problems. Wellbutrin down from 150mg to 66mg. Also without much problems.

April 2017 – March 2019       Lexapro 0,6 mg        April 2017 - August 2018       Wellbutrin in small steps down from 66mg in to 37,5 mg . Quite heavy WD after each step.

March 2019 – May 2019 Lexapro down from 0,6 to 0,3mg then Prozac to 0,6 mg switch because severe discontinuation effects (may also have been from Wellbutrin..)    

Wellbutrin down from 37,5mg to 35,3mg 

October 2019        Seroquel 12,5 mg for 4 weeks because of extreme sleeping problems, then weaning off in 2 weeks       Prozac up dosage to 1,2 mg

March 2020     Wellbutrin in 2 steps down from 35,3mg to 33,3mg   Extreme withdrawal affects during 8 months. Stopped tapering Wellbutrin  until total off Prozac. 

February 2020 – November 2020   Prozac down in steps from 1,2mg to 0,57mg. 

Jan 2021  Prozac down to:  0,55> 0,53>0,51mg,   Feb 0,47mg ,  Mar 0,42mg,   Apr 0,37, longer hold because of WD symptoms July 0,36 and hold again, Sept 19 0,35, Sept 26 0,34mg, Oct 3 0,33mg  

January 20, 2022:  Wellbutrin from 33,3 to 32,3mg

March 22, 2022 Prozac down from 0,33mg to: 0,30mg, Apr 0,29, May 0,28, 0,27, June 0,26, 0,25, July 0,24, 0,23, 0,22, 0,21, Aug 0,20

 

Supplements: Fish Oil (3000mg), Magnesium 100 mg, 2 drops of Lavender Oil when feeling anxiety. 50mg of L-Theanine when severe discontinuation effects caused by Wellbutrin

 

Please note this is NOT a medical advice. Discuss all your medical issues with a doctor who understands psychical drugs and really knows how to withdraw from them. I wish that you will find one.

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Thanks Go2Zero, Ok I've updated my signature.  

1995 - 2001 Wellbutrin & Effexor, 2001 Stop Effexor (CT), Start Celexa. 2009 Start Trazodone, 2010 Stop Celexa (fast taper), Start Cymbalta. 2014, 2016 Reductions in Dosages Cymbalta and Wellbutrin
2018 Started Slow Taper of Cymbalta from 30mg

2021 May Trazodone Dose drop from 75 to 50 - Started Muscle Cramping and Spasms
2021 July 5th Stopped Cymbalta After 3 YR Taper (No method, I removed beads based on how I was feeling.  Got down to 4 beads, or about 0.4mg before stopping)
2021 July 5th Stopped Wellbutrin cold turkey (was taking 75mg.  Over last week on Wellbutrin, I skipped days taking 100mg SR every other day).  Took last dose of Wellbutrin July 5th.  Severe WD Started July 17th.
2021 Aug 3rd:  Start Remeron 7.5mg at Night 

2021 Aug 23rd: Reinstated Wellbutrin 10mg AM / 10 mg PM, Stopped Remeron

2021 Aug 30th: Changed WB Dosing to 10mg AM / 5mg Mid Day / 8mg Early Evening

2021 Sept 1st: Reinstated Remeron 7.5mg for sleep

2021 Sept 14th: Changed WB to 10mg AM / 6mg Mid day / 6mg Early Evening, Jan 24: Changed WB to 9mg AM / 6mg Mid Day / 6mg PM

2021 Sept 21: Re-instated Cymbalta at 1 bead 2X a day, Oct 12:  Updosed to 2 beads AM, 1 bead PM, March 11:  Updosed 2 beads AM, 2 beads PM
Currently on Trazodone 50mg and Remeron 7.5mg.  Cymbalta 2 Beads (0.1mg) 2X Day 7AM and 6PM.  Wellbutrin 9mg AM / 6mg Mid day / 6mg Early Evening

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Hi Go2Zero,

 

Hope you are well.  Today is day 12 since reintroducing Wellbutrin at very low dose, (10mg) morning and evening.  Overall I feel like reinstatement has helped slightly, but I am not back to normal by any means yet.  Still having major bouts of anxiety, crying and depression on top of some physical symptoms.  The insomnia is worse on WB too.  

 

Also, because of my dosing of WB being low and spaced apart, I have symptoms (agitation and stomach) 1 hour after WB that subsides after an hour or so, then the symptoms will come on again as I am coming off of Wellbutrin around 6 hours later like a bad hangover.  I figured this would settle down once I've been on WB for a while and it's built up in my system but it hasn't yet.  So I have changed my dosing some.

 

I was taking 10mg morning and 10 mg night.  Now I am spreading this out over 3 doses and making my last dose no later than 4:00 PM to help with sleep.  So now I'm doing 7:00AM: 10mg, 12:00PM: 5mg, 4:00PM: 8mg.

 

I wish it were possible to do sustained release at a low dose but that is not possible.  I've been researching the thread on here on Wellbutrin Tapering and a lot of people have a hard time switching from SR to IR for the same reason.  I've even considered going 4 or 5 doses a day at a smaller dose to minimize the up and down effect.  

 

Any thoughts on the dosing schedule?  I read on here that you can cut a WB 100SR and it will retain some of its sustained effect.  Also, do you still think I will stabilize and improve over time?  I still have the Remeron factor as you may recall I quit it at the same time as reinstating WB, so it is hard to say what is what, as you have said.  I guess I am looking to see if you think I am still on the best track.  It's hard making it through the days...

 

Sonsetfree

1995 - 2001 Wellbutrin & Effexor, 2001 Stop Effexor (CT), Start Celexa. 2009 Start Trazodone, 2010 Stop Celexa (fast taper), Start Cymbalta. 2014, 2016 Reductions in Dosages Cymbalta and Wellbutrin
2018 Started Slow Taper of Cymbalta from 30mg

2021 May Trazodone Dose drop from 75 to 50 - Started Muscle Cramping and Spasms
2021 July 5th Stopped Cymbalta After 3 YR Taper (No method, I removed beads based on how I was feeling.  Got down to 4 beads, or about 0.4mg before stopping)
2021 July 5th Stopped Wellbutrin cold turkey (was taking 75mg.  Over last week on Wellbutrin, I skipped days taking 100mg SR every other day).  Took last dose of Wellbutrin July 5th.  Severe WD Started July 17th.
2021 Aug 3rd:  Start Remeron 7.5mg at Night 

2021 Aug 23rd: Reinstated Wellbutrin 10mg AM / 10 mg PM, Stopped Remeron

2021 Aug 30th: Changed WB Dosing to 10mg AM / 5mg Mid Day / 8mg Early Evening

2021 Sept 1st: Reinstated Remeron 7.5mg for sleep

2021 Sept 14th: Changed WB to 10mg AM / 6mg Mid day / 6mg Early Evening, Jan 24: Changed WB to 9mg AM / 6mg Mid Day / 6mg PM

2021 Sept 21: Re-instated Cymbalta at 1 bead 2X a day, Oct 12:  Updosed to 2 beads AM, 1 bead PM, March 11:  Updosed 2 beads AM, 2 beads PM
Currently on Trazodone 50mg and Remeron 7.5mg.  Cymbalta 2 Beads (0.1mg) 2X Day 7AM and 6PM.  Wellbutrin 9mg AM / 6mg Mid day / 6mg Early Evening

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@Altostrata,  

 

Hi sorry to bug you, but I read you have some personal experience on this.  I have the generic version of Wellbutrin 100 SR from Solco Healthcare.  Is that the one you used?  Have you or anyone looked into it's sustained properties when divided to see if similar to Wellbutrin properties?

 

Thanks

1995 - 2001 Wellbutrin & Effexor, 2001 Stop Effexor (CT), Start Celexa. 2009 Start Trazodone, 2010 Stop Celexa (fast taper), Start Cymbalta. 2014, 2016 Reductions in Dosages Cymbalta and Wellbutrin
2018 Started Slow Taper of Cymbalta from 30mg

2021 May Trazodone Dose drop from 75 to 50 - Started Muscle Cramping and Spasms
2021 July 5th Stopped Cymbalta After 3 YR Taper (No method, I removed beads based on how I was feeling.  Got down to 4 beads, or about 0.4mg before stopping)
2021 July 5th Stopped Wellbutrin cold turkey (was taking 75mg.  Over last week on Wellbutrin, I skipped days taking 100mg SR every other day).  Took last dose of Wellbutrin July 5th.  Severe WD Started July 17th.
2021 Aug 3rd:  Start Remeron 7.5mg at Night 

2021 Aug 23rd: Reinstated Wellbutrin 10mg AM / 10 mg PM, Stopped Remeron

2021 Aug 30th: Changed WB Dosing to 10mg AM / 5mg Mid Day / 8mg Early Evening

2021 Sept 1st: Reinstated Remeron 7.5mg for sleep

2021 Sept 14th: Changed WB to 10mg AM / 6mg Mid day / 6mg Early Evening, Jan 24: Changed WB to 9mg AM / 6mg Mid Day / 6mg PM

2021 Sept 21: Re-instated Cymbalta at 1 bead 2X a day, Oct 12:  Updosed to 2 beads AM, 1 bead PM, March 11:  Updosed 2 beads AM, 2 beads PM
Currently on Trazodone 50mg and Remeron 7.5mg.  Cymbalta 2 Beads (0.1mg) 2X Day 7AM and 6PM.  Wellbutrin 9mg AM / 6mg Mid day / 6mg Early Evening

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  • Moderator
5 hours ago, SonSetFree said:

I was taking 10mg morning and 10 mg night.  Now I am spreading this out over 3 doses and making my last dose no later than 4:00 PM to help with sleep.  So now I'm doing 7:00AM: 10mg, 12:00PM: 5mg, 4:00PM: 8mg.

 

I would think that taking 3 dosages per day is OK. But maybe better a bit more at 12PM and a bit less at 4PM. This may better for sleeping. The IR  version also gives much more short after taking it (in the morning) and less and less in the afternoon and evening.

 

Are you taking the same brand bupropion as the one before you reinstated? I understand you take generic bupropion and not Wellbutrin (which is a brandname of the original).

5 hours ago, SonSetFree said:

Today is day 12 since reintroducing Wellbutrin at very low dose, (10mg) morning and evening.  Overall I feel like reinstatement has helped slightly, but I am not back to normal by any means yet.  Still having major bouts of anxiety, crying and depression on top of some physical symptoms.  The insomnia is worse on WB too.  

Full effect of reinstatement may need more time. If not enough effect after some more time, you could try if a small up-dose would give better result.

 

How did you sleep before you stopped bupropion in July?

1993    Anafranil (Clomipramine) for a few months. Later in 1993 Paxil for a few months 1993- 2006      No medication

2006   Effexor, Cymbalta, some Benzo’s. All for short periods. Later in 2006 Lexapro (escitalopram) 10 mg and shortly after Wellbutrin XR 150mg, against side effects Lexapro 

Since 2006 until end of 2015: Several times on and off Lexapro and Wellbutrin and several slight dosage changes. Mostly taken dosages: 5mg Lexapro and 150mg Wellbutrin

2016  Dosage change Lexapro from 5mg to 2,5 mg. Wellbutrin stayed om 150mg

November 2016 – April 2017 Down from 2,5mg to 0,6mg Lexapro (in steps) without much problems. Wellbutrin down from 150mg to 66mg. Also without much problems.

April 2017 – March 2019       Lexapro 0,6 mg        April 2017 - August 2018       Wellbutrin in small steps down from 66mg in to 37,5 mg . Quite heavy WD after each step.

March 2019 – May 2019 Lexapro down from 0,6 to 0,3mg then Prozac to 0,6 mg switch because severe discontinuation effects (may also have been from Wellbutrin..)    

Wellbutrin down from 37,5mg to 35,3mg 

October 2019        Seroquel 12,5 mg for 4 weeks because of extreme sleeping problems, then weaning off in 2 weeks       Prozac up dosage to 1,2 mg

March 2020     Wellbutrin in 2 steps down from 35,3mg to 33,3mg   Extreme withdrawal affects during 8 months. Stopped tapering Wellbutrin  until total off Prozac. 

February 2020 – November 2020   Prozac down in steps from 1,2mg to 0,57mg. 

Jan 2021  Prozac down to:  0,55> 0,53>0,51mg,   Feb 0,47mg ,  Mar 0,42mg,   Apr 0,37, longer hold because of WD symptoms July 0,36 and hold again, Sept 19 0,35, Sept 26 0,34mg, Oct 3 0,33mg  

January 20, 2022:  Wellbutrin from 33,3 to 32,3mg

March 22, 2022 Prozac down from 0,33mg to: 0,30mg, Apr 0,29, May 0,28, 0,27, June 0,26, 0,25, July 0,24, 0,23, 0,22, 0,21, Aug 0,20

 

Supplements: Fish Oil (3000mg), Magnesium 100 mg, 2 drops of Lavender Oil when feeling anxiety. 50mg of L-Theanine when severe discontinuation effects caused by Wellbutrin

 

Please note this is NOT a medical advice. Discuss all your medical issues with a doctor who understands psychical drugs and really knows how to withdraw from them. I wish that you will find one.

Link to comment
25 minutes ago, Go2zero said:

Are you taking the same brand bupropion as the one before you reinstated?

I was on 75mg IR for 2 years but due to muscle cramps switched to 100mg SR but for only 3 or 4 doses to see if it improved.  It didn’t improve so I quit taking.  I reintroduced on the 75mg pill (same manufacturer as before).  

 

28 minutes ago, Go2zero said:

How did you sleep before you stopped bupropion in July?

Had trouble which is why I took trazadone. It was intermittent but I at least got 8 hrs asleep before.  Now I get 3. 

1995 - 2001 Wellbutrin & Effexor, 2001 Stop Effexor (CT), Start Celexa. 2009 Start Trazodone, 2010 Stop Celexa (fast taper), Start Cymbalta. 2014, 2016 Reductions in Dosages Cymbalta and Wellbutrin
2018 Started Slow Taper of Cymbalta from 30mg

2021 May Trazodone Dose drop from 75 to 50 - Started Muscle Cramping and Spasms
2021 July 5th Stopped Cymbalta After 3 YR Taper (No method, I removed beads based on how I was feeling.  Got down to 4 beads, or about 0.4mg before stopping)
2021 July 5th Stopped Wellbutrin cold turkey (was taking 75mg.  Over last week on Wellbutrin, I skipped days taking 100mg SR every other day).  Took last dose of Wellbutrin July 5th.  Severe WD Started July 17th.
2021 Aug 3rd:  Start Remeron 7.5mg at Night 

2021 Aug 23rd: Reinstated Wellbutrin 10mg AM / 10 mg PM, Stopped Remeron

2021 Aug 30th: Changed WB Dosing to 10mg AM / 5mg Mid Day / 8mg Early Evening

2021 Sept 1st: Reinstated Remeron 7.5mg for sleep

2021 Sept 14th: Changed WB to 10mg AM / 6mg Mid day / 6mg Early Evening, Jan 24: Changed WB to 9mg AM / 6mg Mid Day / 6mg PM

2021 Sept 21: Re-instated Cymbalta at 1 bead 2X a day, Oct 12:  Updosed to 2 beads AM, 1 bead PM, March 11:  Updosed 2 beads AM, 2 beads PM
Currently on Trazodone 50mg and Remeron 7.5mg.  Cymbalta 2 Beads (0.1mg) 2X Day 7AM and 6PM.  Wellbutrin 9mg AM / 6mg Mid day / 6mg Early Evening

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  • Moderator
14 hours ago, SonSetFree said:

was on 75mg IR for 2 years but due to muscle cramps switched to 100mg SR but for only 3 or 4 doses to see if it improved.  It didn’t improve so I quit taking.  I reintroduced on the 75mg pill (same manufacturer as before).  

 

OK, good to know. That should not be the problem then. Because changing brands can also lead to problems.

 

14 hours ago, SonSetFree said:

Had trouble which is why I took trazadone. It was intermittent but I at least got 8 hrs asleep before.  Now I get 3. 

We see quite often that insomnia starts after a large dosage drop or stopping and it can stay quite a while also after reinstating..... This can take months for some. It will get better, but be patient....

1993    Anafranil (Clomipramine) for a few months. Later in 1993 Paxil for a few months 1993- 2006      No medication

2006   Effexor, Cymbalta, some Benzo’s. All for short periods. Later in 2006 Lexapro (escitalopram) 10 mg and shortly after Wellbutrin XR 150mg, against side effects Lexapro 

Since 2006 until end of 2015: Several times on and off Lexapro and Wellbutrin and several slight dosage changes. Mostly taken dosages: 5mg Lexapro and 150mg Wellbutrin

2016  Dosage change Lexapro from 5mg to 2,5 mg. Wellbutrin stayed om 150mg

November 2016 – April 2017 Down from 2,5mg to 0,6mg Lexapro (in steps) without much problems. Wellbutrin down from 150mg to 66mg. Also without much problems.

April 2017 – March 2019       Lexapro 0,6 mg        April 2017 - August 2018       Wellbutrin in small steps down from 66mg in to 37,5 mg . Quite heavy WD after each step.

March 2019 – May 2019 Lexapro down from 0,6 to 0,3mg then Prozac to 0,6 mg switch because severe discontinuation effects (may also have been from Wellbutrin..)    

Wellbutrin down from 37,5mg to 35,3mg 

October 2019        Seroquel 12,5 mg for 4 weeks because of extreme sleeping problems, then weaning off in 2 weeks       Prozac up dosage to 1,2 mg

March 2020     Wellbutrin in 2 steps down from 35,3mg to 33,3mg   Extreme withdrawal affects during 8 months. Stopped tapering Wellbutrin  until total off Prozac. 

February 2020 – November 2020   Prozac down in steps from 1,2mg to 0,57mg. 

Jan 2021  Prozac down to:  0,55> 0,53>0,51mg,   Feb 0,47mg ,  Mar 0,42mg,   Apr 0,37, longer hold because of WD symptoms July 0,36 and hold again, Sept 19 0,35, Sept 26 0,34mg, Oct 3 0,33mg  

January 20, 2022:  Wellbutrin from 33,3 to 32,3mg

March 22, 2022 Prozac down from 0,33mg to: 0,30mg, Apr 0,29, May 0,28, 0,27, June 0,26, 0,25, July 0,24, 0,23, 0,22, 0,21, Aug 0,20

 

Supplements: Fish Oil (3000mg), Magnesium 100 mg, 2 drops of Lavender Oil when feeling anxiety. 50mg of L-Theanine when severe discontinuation effects caused by Wellbutrin

 

Please note this is NOT a medical advice. Discuss all your medical issues with a doctor who understands psychical drugs and really knows how to withdraw from them. I wish that you will find one.

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Thanks Go2Zero,

 

I will give it time.  Also been wondering lately about my Cymbalta discontinuation which I also stopped at the same time as the Wellbutrin.  Although it was only 4 beads (0.6mg), Wellbutrin was in the mix so may have been the equivalent of taking 2-5x Cymbalta given they share the same liver enzyme metabolizer.  It will be 2 months this weekend since I stopped.  It will also be 2 weeks since I reinstated.  Wonder if I should consider a small reinstatement of Cymbalta with the Wellbutrin.  Maybe that should be another option if I don’t see marked improvement in another week or so. Don’t want to wait until it’s too late.  
 

Pray you are well!

1995 - 2001 Wellbutrin & Effexor, 2001 Stop Effexor (CT), Start Celexa. 2009 Start Trazodone, 2010 Stop Celexa (fast taper), Start Cymbalta. 2014, 2016 Reductions in Dosages Cymbalta and Wellbutrin
2018 Started Slow Taper of Cymbalta from 30mg

2021 May Trazodone Dose drop from 75 to 50 - Started Muscle Cramping and Spasms
2021 July 5th Stopped Cymbalta After 3 YR Taper (No method, I removed beads based on how I was feeling.  Got down to 4 beads, or about 0.4mg before stopping)
2021 July 5th Stopped Wellbutrin cold turkey (was taking 75mg.  Over last week on Wellbutrin, I skipped days taking 100mg SR every other day).  Took last dose of Wellbutrin July 5th.  Severe WD Started July 17th.
2021 Aug 3rd:  Start Remeron 7.5mg at Night 

2021 Aug 23rd: Reinstated Wellbutrin 10mg AM / 10 mg PM, Stopped Remeron

2021 Aug 30th: Changed WB Dosing to 10mg AM / 5mg Mid Day / 8mg Early Evening

2021 Sept 1st: Reinstated Remeron 7.5mg for sleep

2021 Sept 14th: Changed WB to 10mg AM / 6mg Mid day / 6mg Early Evening, Jan 24: Changed WB to 9mg AM / 6mg Mid Day / 6mg PM

2021 Sept 21: Re-instated Cymbalta at 1 bead 2X a day, Oct 12:  Updosed to 2 beads AM, 1 bead PM, March 11:  Updosed 2 beads AM, 2 beads PM
Currently on Trazodone 50mg and Remeron 7.5mg.  Cymbalta 2 Beads (0.1mg) 2X Day 7AM and 6PM.  Wellbutrin 9mg AM / 6mg Mid day / 6mg Early Evening

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Hi Go2Zero,

 

Well I managed to scrape by after reintroducing Wellbutrin for a while and then hit a major wall.  I suspected the Remeron WD was to blame (As you may recall I quit the 7.5mg Remeron CT after being on for 2.5 weeks the same time I reintroduced WB).  I new I was in for a bumpy ride but I just couldn’t cope so I started back on the Remeron to lessen the misery (don’t judge).  It gave me a bit of relief the first couple of days (was able to sleep 4-5 hrs and fewer episodes of intense anxiety and depression).  Now I am on day 4 and the insomnia is back and starting to see some more episodes again.  I’m thinking it is messing with my WB daily dosing balance (morning, noon, late afternoon).  I may have to spread the dosing further apart again (6 hrs apart instead of 5 hours apart because I am metabolizing slower).  How have you been?

 

- Sonsetfree

1995 - 2001 Wellbutrin & Effexor, 2001 Stop Effexor (CT), Start Celexa. 2009 Start Trazodone, 2010 Stop Celexa (fast taper), Start Cymbalta. 2014, 2016 Reductions in Dosages Cymbalta and Wellbutrin
2018 Started Slow Taper of Cymbalta from 30mg

2021 May Trazodone Dose drop from 75 to 50 - Started Muscle Cramping and Spasms
2021 July 5th Stopped Cymbalta After 3 YR Taper (No method, I removed beads based on how I was feeling.  Got down to 4 beads, or about 0.4mg before stopping)
2021 July 5th Stopped Wellbutrin cold turkey (was taking 75mg.  Over last week on Wellbutrin, I skipped days taking 100mg SR every other day).  Took last dose of Wellbutrin July 5th.  Severe WD Started July 17th.
2021 Aug 3rd:  Start Remeron 7.5mg at Night 

2021 Aug 23rd: Reinstated Wellbutrin 10mg AM / 10 mg PM, Stopped Remeron

2021 Aug 30th: Changed WB Dosing to 10mg AM / 5mg Mid Day / 8mg Early Evening

2021 Sept 1st: Reinstated Remeron 7.5mg for sleep

2021 Sept 14th: Changed WB to 10mg AM / 6mg Mid day / 6mg Early Evening, Jan 24: Changed WB to 9mg AM / 6mg Mid Day / 6mg PM

2021 Sept 21: Re-instated Cymbalta at 1 bead 2X a day, Oct 12:  Updosed to 2 beads AM, 1 bead PM, March 11:  Updosed 2 beads AM, 2 beads PM
Currently on Trazodone 50mg and Remeron 7.5mg.  Cymbalta 2 Beads (0.1mg) 2X Day 7AM and 6PM.  Wellbutrin 9mg AM / 6mg Mid day / 6mg Early Evening

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  • Moderator
13 hours ago, SonSetFree said:

I new I was in for a bumpy ride but I just couldn’t cope so I started back on the Remeron to lessen the misery (don’t judge).  It gave me a bit of relief the first couple of days (was able to sleep 4-5 hrs and fewer episodes of intense anxiety and depression).  Now I am on day 4 and the insomnia is back and starting to see some more episodes again.

 

I don't judge. We all tried things to find relief. Sometimes it works, often doesn't...  

 

If it does not help with sleep I would rather stop the Remeron. How much mg did you take and at what moment of the day?

 

WD from Wellbutrin can take quite a while for some (in my case 8 months after a small change in dosage). You might try to take 25 mg Wellbutrin and see if that helps. 15 mg AM and 10 mg PM. Not sure if it helps, but you could give it a try for 1 week or so. 

 

1993    Anafranil (Clomipramine) for a few months. Later in 1993 Paxil for a few months 1993- 2006      No medication

2006   Effexor, Cymbalta, some Benzo’s. All for short periods. Later in 2006 Lexapro (escitalopram) 10 mg and shortly after Wellbutrin XR 150mg, against side effects Lexapro 

Since 2006 until end of 2015: Several times on and off Lexapro and Wellbutrin and several slight dosage changes. Mostly taken dosages: 5mg Lexapro and 150mg Wellbutrin

2016  Dosage change Lexapro from 5mg to 2,5 mg. Wellbutrin stayed om 150mg

November 2016 – April 2017 Down from 2,5mg to 0,6mg Lexapro (in steps) without much problems. Wellbutrin down from 150mg to 66mg. Also without much problems.

April 2017 – March 2019       Lexapro 0,6 mg        April 2017 - August 2018       Wellbutrin in small steps down from 66mg in to 37,5 mg . Quite heavy WD after each step.

March 2019 – May 2019 Lexapro down from 0,6 to 0,3mg then Prozac to 0,6 mg switch because severe discontinuation effects (may also have been from Wellbutrin..)    

Wellbutrin down from 37,5mg to 35,3mg 

October 2019        Seroquel 12,5 mg for 4 weeks because of extreme sleeping problems, then weaning off in 2 weeks       Prozac up dosage to 1,2 mg

March 2020     Wellbutrin in 2 steps down from 35,3mg to 33,3mg   Extreme withdrawal affects during 8 months. Stopped tapering Wellbutrin  until total off Prozac. 

February 2020 – November 2020   Prozac down in steps from 1,2mg to 0,57mg. 

Jan 2021  Prozac down to:  0,55> 0,53>0,51mg,   Feb 0,47mg ,  Mar 0,42mg,   Apr 0,37, longer hold because of WD symptoms July 0,36 and hold again, Sept 19 0,35, Sept 26 0,34mg, Oct 3 0,33mg  

January 20, 2022:  Wellbutrin from 33,3 to 32,3mg

March 22, 2022 Prozac down from 0,33mg to: 0,30mg, Apr 0,29, May 0,28, 0,27, June 0,26, 0,25, July 0,24, 0,23, 0,22, 0,21, Aug 0,20

 

Supplements: Fish Oil (3000mg), Magnesium 100 mg, 2 drops of Lavender Oil when feeling anxiety. 50mg of L-Theanine when severe discontinuation effects caused by Wellbutrin

 

Please note this is NOT a medical advice. Discuss all your medical issues with a doctor who understands psychical drugs and really knows how to withdraw from them. I wish that you will find one.

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Hi Go2Zero,

 

Thank you so much for your response.  I hope that your tapering is going well.  Sorry to hear you suffered for so long.  What were the main symptoms and did all the symptoms last the entire 8 months?

 

I am taking Remeron 7.5mg at bed time along with the 50mg of Trazadone I was already taking for insomnia.

I am currently taking Wellbutrin in 3 doses;  10mg morning (7:00 AM), 5mg mid day (12:00 PM), and 8mg early evening (5:00 PM).  

 

I am sleeping better most nights.  Days am suffering from stomach pain, severe fatigue and severe depression. Crying a lot and can't engage in simple activities, like watching TV or reading a book.  But still, it is better than the severe anxiety I was having.  

 

I agree with trying WB updose.  I hope 5mg is enough.  

 

Thanks again.

 

  

 

 

 

 

 

1995 - 2001 Wellbutrin & Effexor, 2001 Stop Effexor (CT), Start Celexa. 2009 Start Trazodone, 2010 Stop Celexa (fast taper), Start Cymbalta. 2014, 2016 Reductions in Dosages Cymbalta and Wellbutrin
2018 Started Slow Taper of Cymbalta from 30mg

2021 May Trazodone Dose drop from 75 to 50 - Started Muscle Cramping and Spasms
2021 July 5th Stopped Cymbalta After 3 YR Taper (No method, I removed beads based on how I was feeling.  Got down to 4 beads, or about 0.4mg before stopping)
2021 July 5th Stopped Wellbutrin cold turkey (was taking 75mg.  Over last week on Wellbutrin, I skipped days taking 100mg SR every other day).  Took last dose of Wellbutrin July 5th.  Severe WD Started July 17th.
2021 Aug 3rd:  Start Remeron 7.5mg at Night 

2021 Aug 23rd: Reinstated Wellbutrin 10mg AM / 10 mg PM, Stopped Remeron

2021 Aug 30th: Changed WB Dosing to 10mg AM / 5mg Mid Day / 8mg Early Evening

2021 Sept 1st: Reinstated Remeron 7.5mg for sleep

2021 Sept 14th: Changed WB to 10mg AM / 6mg Mid day / 6mg Early Evening, Jan 24: Changed WB to 9mg AM / 6mg Mid Day / 6mg PM

2021 Sept 21: Re-instated Cymbalta at 1 bead 2X a day, Oct 12:  Updosed to 2 beads AM, 1 bead PM, March 11:  Updosed 2 beads AM, 2 beads PM
Currently on Trazodone 50mg and Remeron 7.5mg.  Cymbalta 2 Beads (0.1mg) 2X Day 7AM and 6PM.  Wellbutrin 9mg AM / 6mg Mid day / 6mg Early Evening

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5 hours ago, SonSetFree said:

What were the main symptoms and did all the symptoms last the entire 8 months?

The list of symptoms is too long. Symptoms came and others went. They went and others cams (back again), etc.

Extreme depresed, very very tired, headaches, suicidal thoughts, heavy concentration problems, heavy memory problems, paresthesia (burning feeling on inside skin), extreme sweating in bed, feeling sad, nervous and anvious, no energy and no lust to do anything, etc. 

 

As said, all these symptoms came, went, came back etc. And it took 8 months before it really got better. I have not reduced my dose since then, since I need to get off the prozac first. Since the metabolism of the prozac is slowed down by the bupropion. I can only hope that tapering the rest of my bupropion dose (33,3mg) will be easier after being off the prozac. With the tapering of prozac I am on hold now for almost 6 months, since WD symptoms started to be alarming (heavy insomnia and paresthesia). It is slowly getting better. Hope to resume tapering prozac soon.

 

5 hours ago, SonSetFree said:

I agree with trying WB updose.  I hope 5mg is enough.  

 

Let me know if it helps. Give it at least 1-2 weeks

1993    Anafranil (Clomipramine) for a few months. Later in 1993 Paxil for a few months 1993- 2006      No medication

2006   Effexor, Cymbalta, some Benzo’s. All for short periods. Later in 2006 Lexapro (escitalopram) 10 mg and shortly after Wellbutrin XR 150mg, against side effects Lexapro 

Since 2006 until end of 2015: Several times on and off Lexapro and Wellbutrin and several slight dosage changes. Mostly taken dosages: 5mg Lexapro and 150mg Wellbutrin

2016  Dosage change Lexapro from 5mg to 2,5 mg. Wellbutrin stayed om 150mg

November 2016 – April 2017 Down from 2,5mg to 0,6mg Lexapro (in steps) without much problems. Wellbutrin down from 150mg to 66mg. Also without much problems.

April 2017 – March 2019       Lexapro 0,6 mg        April 2017 - August 2018       Wellbutrin in small steps down from 66mg in to 37,5 mg . Quite heavy WD after each step.

March 2019 – May 2019 Lexapro down from 0,6 to 0,3mg then Prozac to 0,6 mg switch because severe discontinuation effects (may also have been from Wellbutrin..)    

Wellbutrin down from 37,5mg to 35,3mg 

October 2019        Seroquel 12,5 mg for 4 weeks because of extreme sleeping problems, then weaning off in 2 weeks       Prozac up dosage to 1,2 mg

March 2020     Wellbutrin in 2 steps down from 35,3mg to 33,3mg   Extreme withdrawal affects during 8 months. Stopped tapering Wellbutrin  until total off Prozac. 

February 2020 – November 2020   Prozac down in steps from 1,2mg to 0,57mg. 

Jan 2021  Prozac down to:  0,55> 0,53>0,51mg,   Feb 0,47mg ,  Mar 0,42mg,   Apr 0,37, longer hold because of WD symptoms July 0,36 and hold again, Sept 19 0,35, Sept 26 0,34mg, Oct 3 0,33mg  

January 20, 2022:  Wellbutrin from 33,3 to 32,3mg

March 22, 2022 Prozac down from 0,33mg to: 0,30mg, Apr 0,29, May 0,28, 0,27, June 0,26, 0,25, July 0,24, 0,23, 0,22, 0,21, Aug 0,20

 

Supplements: Fish Oil (3000mg), Magnesium 100 mg, 2 drops of Lavender Oil when feeling anxiety. 50mg of L-Theanine when severe discontinuation effects caused by Wellbutrin

 

Please note this is NOT a medical advice. Discuss all your medical issues with a doctor who understands psychical drugs and really knows how to withdraw from them. I wish that you will find one.

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Hi Son!

 

I see your trying to find the right Wellbutrin level.

It has a very decent half life, so you should not need to dose it more than 2 times a day.

Too many dosages of differing amounts during the day can delay stabilization since getting the right dose evened out is just as important as what amount.

You shouldn't be getting interdose wd from Wellbutrin at 2 times a day.

 

Also, now that you've added the Remeron back in, it's another change that can delay everything else settling down.

But don't panic, you will get there!

 

I did as you, cutting the 75 mg pills in quarters.

Eventually I ended up getting it compounded by a pharmacy for the rest of my taper off of it.

 

I would give it a good 2 weeks and see how you feel.

As mentioned even tiny dose changes are a change, and it can take time for everything to settle.

Have a great weekend!

 

 Starting ds 2 (12.5 CR'S) = 25 MG PAXIL CR 1/21/15: 1 Pill + 10mg liquid (2 weeks) 2/4: 1 Pill + 9mg Lq (3 weeks) 2/25: 1 Pill + 8 mg lq (1 week) 3/4: 1 Pill + 6 mg lq (2 weeks) 3/18/15 1 Pill + 4 mg lq (2 weeks) 4/1/15 1 Pill + 3 mg lq (2 weeks) 4/14/15 1 Pill + 2 mg lq (2 weeks) 4/29/15 1Pill + 1 mg lq (16 days) 5/15/15 1 12.5 mg Pill ONLY (9 days) 5/24/15 12 mgs liquid (8 days) 6/1/15 11mg lq (12 days) 6/13/15 10 mg.  12/3/15 Drop from 8mg to 7.6 (24 days to) 12/27/15 7.2mgs 8/4/16 6.8mgs,  11/1/16 6.4mgs, 2/5/17 6 mgs  4/3/17 5.6mgs, 4/24/17 5.2mg, 6/13/17 4.8mgs, 9/20/17 4.4mgS, 11/23/17 4 mgs, 1/1/18 3.6 mgs, 2/15/18 3.2 mgs. 4/13/18 2.8mgs, 5/11/18 2.4mgs, 6/10/18 2.0 mgs, 8/4/18 1.6mgs,  9/27/18 1.2mgs, 12/24/18 0.8mg, 3/24/19 0.64 mg,(syringe change issue date?) 4/22/19 0.60 mg, 5/24/19 0.60 mg, 7/7/19 0.52 mgs, 8/4/19 0.44mgs, 11/4/19 0.36mgs, 2/1/20 0.28mgs, 3/1/20 0.24mgs (crash April 6) Compound started 6/28/21: 0.24mgs, 8/29/21: 0.22mgs, 10/31/21: 0.20mgs, 1/03/22: 0.18mgs, 3/5/22: 0.16mgs, 5/5/22: 0.14mgs.

 

Original Wellbutrin Dose: 6 months from 9/14 to 3/2015, 300 XL 3/15/15: Half to 150 XL ( severe symptoms started on day 12) 4/16/15: 125mg   for 20 days to: 5/6/15:   100mg  for  15 days to: 5/21/15    75mg  for  10 days to: 6/1/15:  56.25mg      13 days to: 6/13/15: 37.25mg    7 days to: 6/20/15  28.12mg   14 days to: 7/4/15  18.75mg, 7 days to: 7/11/15; RAISE BACK TO: 28.12 to 8/14/15: 18.75mg  20 days to :9/3/15 : 12.5mg, 8/4/16 9mg 1/9/17: 8.5mg 2/8/17 8mg, 3/9/17: 7.6  4/9/17  7.2  5/27/17 6.4 6/24/17 5.8, 8/1/17 5.0, 8/29/17 4.2mgs, 10/2/17 3.5mgs, 12/28/17 2.5mgs, 2/27/18 1.7mgs,  4/19/18 0.8 mgs, LAST DOSE: 6/11/18:  3 YEARS, 2 MONTHS, 27 DAYS...

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22 hours ago, Colonial said:

stabilization since getting the right dose evened out is just as important as what amount.

Hi Colonial!  I’ve read several of your posts. So grateful you’ve reached out.  So you are saying you think I would get stable sooner if I take 2 equal doses a day?    
 

As I’ve shared I reinstated 1.5 months after going CT from 75mg a day.  Like you severe WD hit around day 12.  What type of symptoms did you have?  Reinstating so far hasn’t knocked out my WD but may have taken the edge off the severe anxiety and depression.  The downside is I have had regular stomach pain and hot flashes since reinstatement that I didn’t have before reinstatement.  I thought these new symptoms would have gone away by now.  Maybe it hasn’t because I have updosed slightly and added Remeron to the mix (I had to the insomnia was horrible).  
 

I noticed you tapered Paxil all the way down to less than 0.12mg.  I discontinued Cymbalta at 0.6mg the same day I discontinued WB.  I wonder sometimes if the Cymbalta withdrawal is what I’m dealing with.  I have considered reinstatement of Cymbalta as well.  Any thoughts?
 

So glad to see you are free from Wellbutrin!  It brings me hope.  

1995 - 2001 Wellbutrin & Effexor, 2001 Stop Effexor (CT), Start Celexa. 2009 Start Trazodone, 2010 Stop Celexa (fast taper), Start Cymbalta. 2014, 2016 Reductions in Dosages Cymbalta and Wellbutrin
2018 Started Slow Taper of Cymbalta from 30mg

2021 May Trazodone Dose drop from 75 to 50 - Started Muscle Cramping and Spasms
2021 July 5th Stopped Cymbalta After 3 YR Taper (No method, I removed beads based on how I was feeling.  Got down to 4 beads, or about 0.4mg before stopping)
2021 July 5th Stopped Wellbutrin cold turkey (was taking 75mg.  Over last week on Wellbutrin, I skipped days taking 100mg SR every other day).  Took last dose of Wellbutrin July 5th.  Severe WD Started July 17th.
2021 Aug 3rd:  Start Remeron 7.5mg at Night 

2021 Aug 23rd: Reinstated Wellbutrin 10mg AM / 10 mg PM, Stopped Remeron

2021 Aug 30th: Changed WB Dosing to 10mg AM / 5mg Mid Day / 8mg Early Evening

2021 Sept 1st: Reinstated Remeron 7.5mg for sleep

2021 Sept 14th: Changed WB to 10mg AM / 6mg Mid day / 6mg Early Evening, Jan 24: Changed WB to 9mg AM / 6mg Mid Day / 6mg PM

2021 Sept 21: Re-instated Cymbalta at 1 bead 2X a day, Oct 12:  Updosed to 2 beads AM, 1 bead PM, March 11:  Updosed 2 beads AM, 2 beads PM
Currently on Trazodone 50mg and Remeron 7.5mg.  Cymbalta 2 Beads (0.1mg) 2X Day 7AM and 6PM.  Wellbutrin 9mg AM / 6mg Mid day / 6mg Early Evening

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Wellbutrin has a pretty long half life, 33 to 37 hours.

I've never seen someone split doing it before.

For meds with shorter than 24 hours it's a good step but I think if you took it all at once or  half your dose close to every 12 hours you should be fine.

 

The more times you dose, the more chances you have to make a mistake, if your weighing and making your own dosages.

When I had my end levels compounded at the pharmacy I took it once a day and within a few weeks I started to level out since the dose was now  exact.

 

So, not trying to give you something else to worry about but if each dose is off a tiny bit, your daily dose is off more than dosing all at one time.

So when I say it's important to get the right dose evened out, you want to try to avoid unnecessary dosing errors by unnecessary extra dosages.

 

I know you thought a certain symptom was coming right at the end of a Wellbutrin dose but in all honesty I think it was something else.

It was likely just the time of day that symptom came for you, this is why good symptom notes over time are important

Even if you were a fast metabolizer your Wellbutrin half life is not less than 28 hours.

 

1 hour ago, SonSetFree said:

 I discontinued Cymbalta at 0.6mg the same day I discontinued WB.  I wonder sometimes if the Cymbalta withdrawal is what I’m dealing with.  I have considered reinstatement of Cymbalta as well. 

 

You may likely be in wd from both drugs.

I realize you may think the Cymbalta was a "long" taper but in truth it was at most 3 years.

And It really depends on how "slow" your final few mgs were, that's what most doctors don't realize.

I was 18 months dropping the last 9 of 300 mgs of Wellbutrin.

 

Your signature needs your wellbutrin taper speed the last 6 months to have an idea if 25mgs is going to be enough of a reinstatement.

 

You also dropped the Trazadone by a hefty amount just before stopping both anti depressants and now on again off again Remeron.

 

Your signature is missing the actual DAYS of the end of the Wellbutrin, and the dates and dosages of the reinstatements at which dosages.

Also, it needs the dates and dosages of the Remeron.

 

Months by themselves are ok for drugs more than 2 years ago but to give advice on current issues months along leave too large of a gap.

Also, the day of your last Cymbalta, or as close as you can remember it, a 30 day window is large when discussing a reinstatement dose.

If you can give some idea of your last 6 months of the cymbalta dosage wise, that would be good to look at that as well.

Reinstatement dosages are nt just about how long since your last dose, but how fast your taper was.

 

It's better to have a plan for each med all at once and stick to it.

Constantly changing dosages, even a little, can prolong stabilization and make you think you need higher amount than you do.

 

 

 

Edited by Colonial

 Starting ds 2 (12.5 CR'S) = 25 MG PAXIL CR 1/21/15: 1 Pill + 10mg liquid (2 weeks) 2/4: 1 Pill + 9mg Lq (3 weeks) 2/25: 1 Pill + 8 mg lq (1 week) 3/4: 1 Pill + 6 mg lq (2 weeks) 3/18/15 1 Pill + 4 mg lq (2 weeks) 4/1/15 1 Pill + 3 mg lq (2 weeks) 4/14/15 1 Pill + 2 mg lq (2 weeks) 4/29/15 1Pill + 1 mg lq (16 days) 5/15/15 1 12.5 mg Pill ONLY (9 days) 5/24/15 12 mgs liquid (8 days) 6/1/15 11mg lq (12 days) 6/13/15 10 mg.  12/3/15 Drop from 8mg to 7.6 (24 days to) 12/27/15 7.2mgs 8/4/16 6.8mgs,  11/1/16 6.4mgs, 2/5/17 6 mgs  4/3/17 5.6mgs, 4/24/17 5.2mg, 6/13/17 4.8mgs, 9/20/17 4.4mgS, 11/23/17 4 mgs, 1/1/18 3.6 mgs, 2/15/18 3.2 mgs. 4/13/18 2.8mgs, 5/11/18 2.4mgs, 6/10/18 2.0 mgs, 8/4/18 1.6mgs,  9/27/18 1.2mgs, 12/24/18 0.8mg, 3/24/19 0.64 mg,(syringe change issue date?) 4/22/19 0.60 mg, 5/24/19 0.60 mg, 7/7/19 0.52 mgs, 8/4/19 0.44mgs, 11/4/19 0.36mgs, 2/1/20 0.28mgs, 3/1/20 0.24mgs (crash April 6) Compound started 6/28/21: 0.24mgs, 8/29/21: 0.22mgs, 10/31/21: 0.20mgs, 1/03/22: 0.18mgs, 3/5/22: 0.16mgs, 5/5/22: 0.14mgs.

 

Original Wellbutrin Dose: 6 months from 9/14 to 3/2015, 300 XL 3/15/15: Half to 150 XL ( severe symptoms started on day 12) 4/16/15: 125mg   for 20 days to: 5/6/15:   100mg  for  15 days to: 5/21/15    75mg  for  10 days to: 6/1/15:  56.25mg      13 days to: 6/13/15: 37.25mg    7 days to: 6/20/15  28.12mg   14 days to: 7/4/15  18.75mg, 7 days to: 7/11/15; RAISE BACK TO: 28.12 to 8/14/15: 18.75mg  20 days to :9/3/15 : 12.5mg, 8/4/16 9mg 1/9/17: 8.5mg 2/8/17 8mg, 3/9/17: 7.6  4/9/17  7.2  5/27/17 6.4 6/24/17 5.8, 8/1/17 5.0, 8/29/17 4.2mgs, 10/2/17 3.5mgs, 12/28/17 2.5mgs, 2/27/18 1.7mgs,  4/19/18 0.8 mgs, LAST DOSE: 6/11/18:  3 YEARS, 2 MONTHS, 27 DAYS...

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On 9/2/2021 at 12:19 PM, SonSetFree said:

@Altostrata,  

 

Hi sorry to bug you, but I read you have some personal experience on this.  I have the generic version of Wellbutrin 100 SR from Solco Healthcare.  Is that the one you used?  Have you or anyone looked into it's sustained properties when divided to see if similar to Wellbutrin properties?

 

Thanks

 

Please read 

 

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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4 hours ago, Colonial said:

The more times you dose, the more chances you have to make a mistake, if your weighing and making your own dosages.

When I had my end levels compounded at the pharmacy I took it once a day and within a few weeks I started to level out since the dose was now  exact.

 

So, not trying to give you something else to worry about but if each dose is off a tiny bit, your daily dose is off more than dosing all at one time.

These are great points...I see what you are saying now.  You may be right on the daily fluctuation of symptoms I was seeing not being related, but I was having episodes at 1:30 and 5:30 pretty consistently which is 1 hr after my WB doses.    

 

4 hours ago, Colonial said:

If you can give some idea of your last 6 months of the cymbalta dosage wise, that would be good to look at that as well.

When I started tapering close to 3 years ago, initially I would take 6-10 pellets out of 120 total pellets in a 20mg capsule.  Toward the last 6 months I slowed down to about 3 flakes per drop every 4 weeks, which in retrospect probably wasn't slow enough.  So if I had to guess, 6 months ago I was somewhere around 20 pellets out of 120, so that's 20/120*20mg=3.3mg.  So 3.3mg down to 0.67mg over 6months.  That is almost a 25% taper so too fast now that I know the 10%, non-linear rule.  One of the reasons I didn't think it was cymbalta is I would have the brain zaps when I tried to drop to fast, and I would see the symptoms come one pretty quickly after the taper.  After the last dose I took, I didn't have the brain zaps and felt fine for 12 days or so.  I don't want to rule out cymbalta withdrawal as a possibility so I am curious what type of reinstatement recommendation you would have.  It has been 2.5 months since stopping cymbalta so time is ticking.  I have updated my signature per your request.  Hope you are well and thanks so much for taking the time Colonial!

1995 - 2001 Wellbutrin & Effexor, 2001 Stop Effexor (CT), Start Celexa. 2009 Start Trazodone, 2010 Stop Celexa (fast taper), Start Cymbalta. 2014, 2016 Reductions in Dosages Cymbalta and Wellbutrin
2018 Started Slow Taper of Cymbalta from 30mg

2021 May Trazodone Dose drop from 75 to 50 - Started Muscle Cramping and Spasms
2021 July 5th Stopped Cymbalta After 3 YR Taper (No method, I removed beads based on how I was feeling.  Got down to 4 beads, or about 0.4mg before stopping)
2021 July 5th Stopped Wellbutrin cold turkey (was taking 75mg.  Over last week on Wellbutrin, I skipped days taking 100mg SR every other day).  Took last dose of Wellbutrin July 5th.  Severe WD Started July 17th.
2021 Aug 3rd:  Start Remeron 7.5mg at Night 

2021 Aug 23rd: Reinstated Wellbutrin 10mg AM / 10 mg PM, Stopped Remeron

2021 Aug 30th: Changed WB Dosing to 10mg AM / 5mg Mid Day / 8mg Early Evening

2021 Sept 1st: Reinstated Remeron 7.5mg for sleep

2021 Sept 14th: Changed WB to 10mg AM / 6mg Mid day / 6mg Early Evening, Jan 24: Changed WB to 9mg AM / 6mg Mid Day / 6mg PM

2021 Sept 21: Re-instated Cymbalta at 1 bead 2X a day, Oct 12:  Updosed to 2 beads AM, 1 bead PM, March 11:  Updosed 2 beads AM, 2 beads PM
Currently on Trazodone 50mg and Remeron 7.5mg.  Cymbalta 2 Beads (0.1mg) 2X Day 7AM and 6PM.  Wellbutrin 9mg AM / 6mg Mid day / 6mg Early Evening

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What is the difference between a Cymbalta "bead" and a "flake"?

 Starting ds 2 (12.5 CR'S) = 25 MG PAXIL CR 1/21/15: 1 Pill + 10mg liquid (2 weeks) 2/4: 1 Pill + 9mg Lq (3 weeks) 2/25: 1 Pill + 8 mg lq (1 week) 3/4: 1 Pill + 6 mg lq (2 weeks) 3/18/15 1 Pill + 4 mg lq (2 weeks) 4/1/15 1 Pill + 3 mg lq (2 weeks) 4/14/15 1 Pill + 2 mg lq (2 weeks) 4/29/15 1Pill + 1 mg lq (16 days) 5/15/15 1 12.5 mg Pill ONLY (9 days) 5/24/15 12 mgs liquid (8 days) 6/1/15 11mg lq (12 days) 6/13/15 10 mg.  12/3/15 Drop from 8mg to 7.6 (24 days to) 12/27/15 7.2mgs 8/4/16 6.8mgs,  11/1/16 6.4mgs, 2/5/17 6 mgs  4/3/17 5.6mgs, 4/24/17 5.2mg, 6/13/17 4.8mgs, 9/20/17 4.4mgS, 11/23/17 4 mgs, 1/1/18 3.6 mgs, 2/15/18 3.2 mgs. 4/13/18 2.8mgs, 5/11/18 2.4mgs, 6/10/18 2.0 mgs, 8/4/18 1.6mgs,  9/27/18 1.2mgs, 12/24/18 0.8mg, 3/24/19 0.64 mg,(syringe change issue date?) 4/22/19 0.60 mg, 5/24/19 0.60 mg, 7/7/19 0.52 mgs, 8/4/19 0.44mgs, 11/4/19 0.36mgs, 2/1/20 0.28mgs, 3/1/20 0.24mgs (crash April 6) Compound started 6/28/21: 0.24mgs, 8/29/21: 0.22mgs, 10/31/21: 0.20mgs, 1/03/22: 0.18mgs, 3/5/22: 0.16mgs, 5/5/22: 0.14mgs.

 

Original Wellbutrin Dose: 6 months from 9/14 to 3/2015, 300 XL 3/15/15: Half to 150 XL ( severe symptoms started on day 12) 4/16/15: 125mg   for 20 days to: 5/6/15:   100mg  for  15 days to: 5/21/15    75mg  for  10 days to: 6/1/15:  56.25mg      13 days to: 6/13/15: 37.25mg    7 days to: 6/20/15  28.12mg   14 days to: 7/4/15  18.75mg, 7 days to: 7/11/15; RAISE BACK TO: 28.12 to 8/14/15: 18.75mg  20 days to :9/3/15 : 12.5mg, 8/4/16 9mg 1/9/17: 8.5mg 2/8/17 8mg, 3/9/17: 7.6  4/9/17  7.2  5/27/17 6.4 6/24/17 5.8, 8/1/17 5.0, 8/29/17 4.2mgs, 10/2/17 3.5mgs, 12/28/17 2.5mgs, 2/27/18 1.7mgs,  4/19/18 0.8 mgs, LAST DOSE: 6/11/18:  3 YEARS, 2 MONTHS, 27 DAYS...

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No difference they are referring to the same thing.  The little pieces inside the capsule.  

1995 - 2001 Wellbutrin & Effexor, 2001 Stop Effexor (CT), Start Celexa. 2009 Start Trazodone, 2010 Stop Celexa (fast taper), Start Cymbalta. 2014, 2016 Reductions in Dosages Cymbalta and Wellbutrin
2018 Started Slow Taper of Cymbalta from 30mg

2021 May Trazodone Dose drop from 75 to 50 - Started Muscle Cramping and Spasms
2021 July 5th Stopped Cymbalta After 3 YR Taper (No method, I removed beads based on how I was feeling.  Got down to 4 beads, or about 0.4mg before stopping)
2021 July 5th Stopped Wellbutrin cold turkey (was taking 75mg.  Over last week on Wellbutrin, I skipped days taking 100mg SR every other day).  Took last dose of Wellbutrin July 5th.  Severe WD Started July 17th.
2021 Aug 3rd:  Start Remeron 7.5mg at Night 

2021 Aug 23rd: Reinstated Wellbutrin 10mg AM / 10 mg PM, Stopped Remeron

2021 Aug 30th: Changed WB Dosing to 10mg AM / 5mg Mid Day / 8mg Early Evening

2021 Sept 1st: Reinstated Remeron 7.5mg for sleep

2021 Sept 14th: Changed WB to 10mg AM / 6mg Mid day / 6mg Early Evening, Jan 24: Changed WB to 9mg AM / 6mg Mid Day / 6mg PM

2021 Sept 21: Re-instated Cymbalta at 1 bead 2X a day, Oct 12:  Updosed to 2 beads AM, 1 bead PM, March 11:  Updosed 2 beads AM, 2 beads PM
Currently on Trazodone 50mg and Remeron 7.5mg.  Cymbalta 2 Beads (0.1mg) 2X Day 7AM and 6PM.  Wellbutrin 9mg AM / 6mg Mid day / 6mg Early Evening

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On 9/2/2021 at 3:16 PM, SonSetFree said:

Also, because of my dosing of WB being low and spaced apart, I have symptoms (agitation and stomach) 1 hour after WB that subsides after an hour or so, then the symptoms will come on again as I am coming off of Wellbutrin around 6 hours later like a bad hangover.  I figured this would settle down once I've been on WB for a while and it's built up in my system but it hasn't yet.  So I have changed my dosing some.

 

Ok, this is 2 different issues.

I was referring to the fact that:  " the symptoms will come on again as I am coming off of Wellbutrin around 6 hours later".

 

I took that to mean you thought the Wellbutrin was leaving your system so fast that you were taking more doses a day because you felt it was a WD symptom.  Those are the symptoms I was referring to that I did not think were Inter dose WD or Wellbutrin related.

 

However, you are also reporting "activating" symptoms an hour after you take it.

Do you have those symptoms after all 3 dosages?  If not after which specific ones?

As the link Alto gave, Wellbutrin is a stimulant, so agitation would be possible.

Did you notice these agitating symptoms when you were originally on the Wellbutrin or just now after reinstating?

 Starting ds 2 (12.5 CR'S) = 25 MG PAXIL CR 1/21/15: 1 Pill + 10mg liquid (2 weeks) 2/4: 1 Pill + 9mg Lq (3 weeks) 2/25: 1 Pill + 8 mg lq (1 week) 3/4: 1 Pill + 6 mg lq (2 weeks) 3/18/15 1 Pill + 4 mg lq (2 weeks) 4/1/15 1 Pill + 3 mg lq (2 weeks) 4/14/15 1 Pill + 2 mg lq (2 weeks) 4/29/15 1Pill + 1 mg lq (16 days) 5/15/15 1 12.5 mg Pill ONLY (9 days) 5/24/15 12 mgs liquid (8 days) 6/1/15 11mg lq (12 days) 6/13/15 10 mg.  12/3/15 Drop from 8mg to 7.6 (24 days to) 12/27/15 7.2mgs 8/4/16 6.8mgs,  11/1/16 6.4mgs, 2/5/17 6 mgs  4/3/17 5.6mgs, 4/24/17 5.2mg, 6/13/17 4.8mgs, 9/20/17 4.4mgS, 11/23/17 4 mgs, 1/1/18 3.6 mgs, 2/15/18 3.2 mgs. 4/13/18 2.8mgs, 5/11/18 2.4mgs, 6/10/18 2.0 mgs, 8/4/18 1.6mgs,  9/27/18 1.2mgs, 12/24/18 0.8mg, 3/24/19 0.64 mg,(syringe change issue date?) 4/22/19 0.60 mg, 5/24/19 0.60 mg, 7/7/19 0.52 mgs, 8/4/19 0.44mgs, 11/4/19 0.36mgs, 2/1/20 0.28mgs, 3/1/20 0.24mgs (crash April 6) Compound started 6/28/21: 0.24mgs, 8/29/21: 0.22mgs, 10/31/21: 0.20mgs, 1/03/22: 0.18mgs, 3/5/22: 0.16mgs, 5/5/22: 0.14mgs.

 

Original Wellbutrin Dose: 6 months from 9/14 to 3/2015, 300 XL 3/15/15: Half to 150 XL ( severe symptoms started on day 12) 4/16/15: 125mg   for 20 days to: 5/6/15:   100mg  for  15 days to: 5/21/15    75mg  for  10 days to: 6/1/15:  56.25mg      13 days to: 6/13/15: 37.25mg    7 days to: 6/20/15  28.12mg   14 days to: 7/4/15  18.75mg, 7 days to: 7/11/15; RAISE BACK TO: 28.12 to 8/14/15: 18.75mg  20 days to :9/3/15 : 12.5mg, 8/4/16 9mg 1/9/17: 8.5mg 2/8/17 8mg, 3/9/17: 7.6  4/9/17  7.2  5/27/17 6.4 6/24/17 5.8, 8/1/17 5.0, 8/29/17 4.2mgs, 10/2/17 3.5mgs, 12/28/17 2.5mgs, 2/27/18 1.7mgs,  4/19/18 0.8 mgs, LAST DOSE: 6/11/18:  3 YEARS, 2 MONTHS, 27 DAYS...

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Yes you’re right, two different issues.  Sorry to confuse.  When I first started reintroduction I took a 7:00 AM and 4:00 PM dose.  Around mid day I would start feeling bad.  I chalked this up to “coming off my morning WB dose”.  So I added a 3rd dose at mid day and the problem seemed to go away.  As a separate issue, when I initially added the 3rd dose I was taking the first two doses too close together, 4 hours apart, and  I would start feeling bad within an hour after the second dose.  Once I spaced the 2nd dose out more, about 5.5 hours, I no longer had the problem.  

1995 - 2001 Wellbutrin & Effexor, 2001 Stop Effexor (CT), Start Celexa. 2009 Start Trazodone, 2010 Stop Celexa (fast taper), Start Cymbalta. 2014, 2016 Reductions in Dosages Cymbalta and Wellbutrin
2018 Started Slow Taper of Cymbalta from 30mg

2021 May Trazodone Dose drop from 75 to 50 - Started Muscle Cramping and Spasms
2021 July 5th Stopped Cymbalta After 3 YR Taper (No method, I removed beads based on how I was feeling.  Got down to 4 beads, or about 0.4mg before stopping)
2021 July 5th Stopped Wellbutrin cold turkey (was taking 75mg.  Over last week on Wellbutrin, I skipped days taking 100mg SR every other day).  Took last dose of Wellbutrin July 5th.  Severe WD Started July 17th.
2021 Aug 3rd:  Start Remeron 7.5mg at Night 

2021 Aug 23rd: Reinstated Wellbutrin 10mg AM / 10 mg PM, Stopped Remeron

2021 Aug 30th: Changed WB Dosing to 10mg AM / 5mg Mid Day / 8mg Early Evening

2021 Sept 1st: Reinstated Remeron 7.5mg for sleep

2021 Sept 14th: Changed WB to 10mg AM / 6mg Mid day / 6mg Early Evening, Jan 24: Changed WB to 9mg AM / 6mg Mid Day / 6mg PM

2021 Sept 21: Re-instated Cymbalta at 1 bead 2X a day, Oct 12:  Updosed to 2 beads AM, 1 bead PM, March 11:  Updosed 2 beads AM, 2 beads PM
Currently on Trazodone 50mg and Remeron 7.5mg.  Cymbalta 2 Beads (0.1mg) 2X Day 7AM and 6PM.  Wellbutrin 9mg AM / 6mg Mid day / 6mg Early Evening

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The stomach pain hangs around most of the day.  The episodes I would have when I take a 2nd dose too soon we’re anxiety and crying spells.  No I didn’t experience these symptoms while previously on WB.  

1995 - 2001 Wellbutrin & Effexor, 2001 Stop Effexor (CT), Start Celexa. 2009 Start Trazodone, 2010 Stop Celexa (fast taper), Start Cymbalta. 2014, 2016 Reductions in Dosages Cymbalta and Wellbutrin
2018 Started Slow Taper of Cymbalta from 30mg

2021 May Trazodone Dose drop from 75 to 50 - Started Muscle Cramping and Spasms
2021 July 5th Stopped Cymbalta After 3 YR Taper (No method, I removed beads based on how I was feeling.  Got down to 4 beads, or about 0.4mg before stopping)
2021 July 5th Stopped Wellbutrin cold turkey (was taking 75mg.  Over last week on Wellbutrin, I skipped days taking 100mg SR every other day).  Took last dose of Wellbutrin July 5th.  Severe WD Started July 17th.
2021 Aug 3rd:  Start Remeron 7.5mg at Night 

2021 Aug 23rd: Reinstated Wellbutrin 10mg AM / 10 mg PM, Stopped Remeron

2021 Aug 30th: Changed WB Dosing to 10mg AM / 5mg Mid Day / 8mg Early Evening

2021 Sept 1st: Reinstated Remeron 7.5mg for sleep

2021 Sept 14th: Changed WB to 10mg AM / 6mg Mid day / 6mg Early Evening, Jan 24: Changed WB to 9mg AM / 6mg Mid Day / 6mg PM

2021 Sept 21: Re-instated Cymbalta at 1 bead 2X a day, Oct 12:  Updosed to 2 beads AM, 1 bead PM, March 11:  Updosed 2 beads AM, 2 beads PM
Currently on Trazodone 50mg and Remeron 7.5mg.  Cymbalta 2 Beads (0.1mg) 2X Day 7AM and 6PM.  Wellbutrin 9mg AM / 6mg Mid day / 6mg Early Evening

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1 hour ago, SonSetFree said:

So if I had to guess, 6 months ago I was somewhere around 20 pellets out of 120, so that's 20/120*20mg=3.3mg.  So 3.3mg down to 0.67mg over 6months. 

 

So you estimate that 6 months ago, around mid April, you were around 3.3mgs

And from mid April to July 5th you went down to 0.67mgs, about a 75% decrease in just under 3 months?

 

From mid April to mid September, the drop should not have averaged more than around 50%, so in theory you should still be taking around 1.15mgs.

I would not want to reinstate higher than where you should have been, and even lower(about half) since your brain has made changes.

 

This is a med that does have a short half life of about 12 hours, so this med you would need to dose 2 times a day

Since these beads are not the same weight, you would need a scale to weigh a bunch out, crush them and then make up dosages, I assume like your doing now with the Wellbutrin. 

 

For an educated guess, I would shoot for HALF of where you would be if tapered correctly, which is probably near what you jumped off at.

About 0.30mgs 2 times a day for a daily total of 0.60mgs. 

Since the entire end taper was too fast, it is hard to say, but I think that may not give you a negative reaction by itself.

If  it would need to be adjusted higher to 1mg total over time I can't say but you first do not want to do any harm adding too much back in.

 

 

For the Wellbutrin:

(When I first started reintroduction I took a 7:00 AM and 4:00 PM dose.  Around mid day I would start feeling bad.  I chalked this up to “coming off my morning WB dose”.  So I added a 3rd dose at mid day and the problem seemed to go away.  As a separate issue, when I initially added the 3rd dose I was taking the first two doses too close together, 4 hours apart, and  I would start feeling bad within an hour after the second dose.  Once I spaced the 2nd dose out more, about 5.5 hours, I no longer had the problem.) 

 

Ok, so it seems you had some "activation" symptoms from reinstating over the 10mgs dose to the 22mgs, since the anxiety did not hit until you started taking the second dose of the day. If that has passed, the anxiety and crying spells, and your on 22mgs, that seems good. I think by the time you added the 3rd dose, your body had just become adjusted to reinstatement at that point, I don't think it was the spacing. If not you may wish to drop it a few mgs.

 

FIRST: I would call your pharmacy and confirm with them the half life of your particular brand.

If it is more than 24 hours you can dose yourself once a day, if you are on a brand that is less than that, then go to twice a day

 

I think your stomach pain may be a side effect of the Remeron more than the Wellbutrin reinstatement.

 

Did your stomach hurt in between Aug. 3rd when you started the Remeron and Aug. 23rd when you reinstated the Wellbutrin?

Did it stop the week of Aug. 23rd and Sept. 1st when you went off of it?

.

2021 July 5th Stopped Wellbutrin cold turkey
2021 Aug 3rd:  Start Remeron 7.5mg at Night 

2021 Aug 23rd: Reinstated Wellbutrin 10mg AM / 10 mg PM, Stopped Remeron

2021 Sept 1st: Reinstated Remeron 7.5mg for sleep

 

 

Edited by Colonial

 Starting ds 2 (12.5 CR'S) = 25 MG PAXIL CR 1/21/15: 1 Pill + 10mg liquid (2 weeks) 2/4: 1 Pill + 9mg Lq (3 weeks) 2/25: 1 Pill + 8 mg lq (1 week) 3/4: 1 Pill + 6 mg lq (2 weeks) 3/18/15 1 Pill + 4 mg lq (2 weeks) 4/1/15 1 Pill + 3 mg lq (2 weeks) 4/14/15 1 Pill + 2 mg lq (2 weeks) 4/29/15 1Pill + 1 mg lq (16 days) 5/15/15 1 12.5 mg Pill ONLY (9 days) 5/24/15 12 mgs liquid (8 days) 6/1/15 11mg lq (12 days) 6/13/15 10 mg.  12/3/15 Drop from 8mg to 7.6 (24 days to) 12/27/15 7.2mgs 8/4/16 6.8mgs,  11/1/16 6.4mgs, 2/5/17 6 mgs  4/3/17 5.6mgs, 4/24/17 5.2mg, 6/13/17 4.8mgs, 9/20/17 4.4mgS, 11/23/17 4 mgs, 1/1/18 3.6 mgs, 2/15/18 3.2 mgs. 4/13/18 2.8mgs, 5/11/18 2.4mgs, 6/10/18 2.0 mgs, 8/4/18 1.6mgs,  9/27/18 1.2mgs, 12/24/18 0.8mg, 3/24/19 0.64 mg,(syringe change issue date?) 4/22/19 0.60 mg, 5/24/19 0.60 mg, 7/7/19 0.52 mgs, 8/4/19 0.44mgs, 11/4/19 0.36mgs, 2/1/20 0.28mgs, 3/1/20 0.24mgs (crash April 6) Compound started 6/28/21: 0.24mgs, 8/29/21: 0.22mgs, 10/31/21: 0.20mgs, 1/03/22: 0.18mgs, 3/5/22: 0.16mgs, 5/5/22: 0.14mgs.

 

Original Wellbutrin Dose: 6 months from 9/14 to 3/2015, 300 XL 3/15/15: Half to 150 XL ( severe symptoms started on day 12) 4/16/15: 125mg   for 20 days to: 5/6/15:   100mg  for  15 days to: 5/21/15    75mg  for  10 days to: 6/1/15:  56.25mg      13 days to: 6/13/15: 37.25mg    7 days to: 6/20/15  28.12mg   14 days to: 7/4/15  18.75mg, 7 days to: 7/11/15; RAISE BACK TO: 28.12 to 8/14/15: 18.75mg  20 days to :9/3/15 : 12.5mg, 8/4/16 9mg 1/9/17: 8.5mg 2/8/17 8mg, 3/9/17: 7.6  4/9/17  7.2  5/27/17 6.4 6/24/17 5.8, 8/1/17 5.0, 8/29/17 4.2mgs, 10/2/17 3.5mgs, 12/28/17 2.5mgs, 2/27/18 1.7mgs,  4/19/18 0.8 mgs, LAST DOSE: 6/11/18:  3 YEARS, 2 MONTHS, 27 DAYS...

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18 minutes ago, Colonial said:

So you estimate that 6 months ago, around mid April, you were around 3.3mgs

And from mid April to July 5th you went down to 0.67mgs, about a 75% decrease in just under 3 months

Not 6 months ago, but 6 months prior to my last dose of Cymbalta.  So say January I was at 3.3mg and was down to 0.67 in July when I quit.  Based on that what dose would you reinstate?

 

I will check on the Wellbutrin half life and work towards adjusting my dosing.  Note: I stopped seeing the anxiety and crying spells at that particular time of the day with the doses.  But I still have these episodes 2-3 times a day (sometimes more) at random times.  I believe this is the general discontinuation of the original Wellbutrin/Cymbalta.  

 

Let me confirm from my Journal on the stomach pain prior to starting WB and get back on that one.  
 

 

1995 - 2001 Wellbutrin & Effexor, 2001 Stop Effexor (CT), Start Celexa. 2009 Start Trazodone, 2010 Stop Celexa (fast taper), Start Cymbalta. 2014, 2016 Reductions in Dosages Cymbalta and Wellbutrin
2018 Started Slow Taper of Cymbalta from 30mg

2021 May Trazodone Dose drop from 75 to 50 - Started Muscle Cramping and Spasms
2021 July 5th Stopped Cymbalta After 3 YR Taper (No method, I removed beads based on how I was feeling.  Got down to 4 beads, or about 0.4mg before stopping)
2021 July 5th Stopped Wellbutrin cold turkey (was taking 75mg.  Over last week on Wellbutrin, I skipped days taking 100mg SR every other day).  Took last dose of Wellbutrin July 5th.  Severe WD Started July 17th.
2021 Aug 3rd:  Start Remeron 7.5mg at Night 

2021 Aug 23rd: Reinstated Wellbutrin 10mg AM / 10 mg PM, Stopped Remeron

2021 Aug 30th: Changed WB Dosing to 10mg AM / 5mg Mid Day / 8mg Early Evening

2021 Sept 1st: Reinstated Remeron 7.5mg for sleep

2021 Sept 14th: Changed WB to 10mg AM / 6mg Mid day / 6mg Early Evening, Jan 24: Changed WB to 9mg AM / 6mg Mid Day / 6mg PM

2021 Sept 21: Re-instated Cymbalta at 1 bead 2X a day, Oct 12:  Updosed to 2 beads AM, 1 bead PM, March 11:  Updosed 2 beads AM, 2 beads PM
Currently on Trazodone 50mg and Remeron 7.5mg.  Cymbalta 2 Beads (0.1mg) 2X Day 7AM and 6PM.  Wellbutrin 9mg AM / 6mg Mid day / 6mg Early Evening

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