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Antidepressant Withdrawal Syndrome Linked to Membrane Lipid Raft Signaling


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Interesting!!!!!

 

https://www.genengnews.com/news/antidepressant-withdrawal-syndrome-linked-to-membrane-lipid-raft-signaling/
 

(In the article there is the link of the paper)

Studies by researchers at the University of Illinois Chicago (UIC) offer up new insights into the molecular and cellular mechanisms that underpin the unpleasant symptoms associated with withdrawing from antidepressant therapy.

06/2012 - 02/2015 CIPRALEX 10 mg (given by GP motivation: I developed left abdomen pain for ca. 2 yr probably due to MD stress) - prior to this NOT any significant episode of anxiety/depression - on medication: emotional-sexual numbness, total inability to cry, +8 kg even with going to the gym, mild fatigue -> abdominal pain gone

02/2015 - 1/04/2015 tapering from 10 mg to 0 mg because I had enough of the numbness following GP advise

05/05/2015 SUDDENLY never-had-before huge anxiety, burning skin sensation, panic, fear, not able to cry again, never-had-before insomnia, totally lost appetite, little loss of vision in one eye, sweating, chest pain, short breath, restlessness, accelerated heartbeat 

30/05/2015 reinstated 8mg (I was suggested 5 mg here, but I had a fight with my GP that he knows better...last time I gave him credibility -__- )

middle 07/2015 general improving

09/2015 quite stable 10/2015 start tapering 7mg  11/2015 6mg  12/2015 5mg 1/2016 4mg  2/2016 4mg  3/2016 3mg ->FAIL back to 4mg AGAIN.... 8/2016 3mg 8/2017 2mg  (had a very short wave in summer '17) 8/2018 2mg stable  8/2019 1mg  1/2020 tried  ~0.6 mg 1/4/2020 0mg FREE!

7/2020 till end 9/2020 MILD WD (mostly anxiety, poor sleep)

11/6/2021 13 MONTHS OFF FULL WD WAVE (anxiety, severe insomnia, total loss of appetite, deep depression, internal restlessness, sexuality gone) trying to resist 😫

SUPPLEMENTS 2021 0.5g melatonin, magnesium, eating a lot of fish + exercise, no alcol, very low caffeine, low carb

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