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Lewis: Four research papers I wish my GP had read before prescribing antidepressants


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Lewis S. Four research papers I wish my GP had read before prescribing antidepressants. Br J Gen Pract. 2021 Jun 24;71(708):316-317. doi: 10.3399/bjgp21X716321. PMID: 34319885; PMCID: PMC8249025.

1980s: First diagnosed with depression. Treated with a tricyclic. 1988: Switched to Prozac 20 mg.  1990s to 2010: On and off Prozac. Increased dose led to side effects. 2011: Put on Zyprexa. 2011: Work burnout and breakdown. Hospitalized for suicidal depression. Switched to Seroquel. Switched to Celexa 40 mg and lithium 300 mg. 2019: Stopped Seroquel. 

2020 July: Decreased Celexa to 30 mg in attempt to alleviate sexual dysfunction. Worked somewhat.

2020 August: Decreased Celexa to 20 mg. Sexual function improved but w/d effects started. 

2020 September: Maintaining Celexa at 20 mg. Experiencing w/d effects - fatigue, dysphoria, mood instability

2020 September 13: Increased Celexa to 30 mg due to w/d effects. Still on lithium 300 mg/day.

2020 October 3: Reduced Celexa to 27 mg. Started taper. 10% per month as recommended.

2020 October 18: Reduced to 24 mg.

2020 December 4: Reduced to 21 mg.

2020 December 23: Reduced to 20 mg (spacing out taper intervals due to persistent w/d effects)

2021 September 23: Several reductions over the past 9 months to 7.0 mg. Stressful life circumstances led me to feeling very depressed with suicidal feelings, so upped to the dose to 10 mg until I feel better. 

 

 

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