I took a risk knowingly with Wellbutrin because I had used it for such a short period of time and because of a liver interaction of the two drugs, it is not safe to taper Wellbutrin while still on Trintellix. Also, I did not want to prolong my usage of Werllbutrin by many multitudes by tapering Trintellix first. I have never before really used anything that affects noradrenaline and dopamine so intensely, so I did not want to create another downregulation of receptors by a long period of usage.