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How to make a liquid from tablets or capsules

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Adili13

Really? It seems like a lot of sediment to be all filler? I was thinking of getting Ora-Plus just to curb my ocd 

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Adili13

For anyone who feels their liquid is uneven and the pill just sinks to the bottom, Ora Plus works incredibly well at disbursing the pill evenly. I use 10 ml water and 10 ml Ora plus with my 20 mg of Paxil. I’m no longer worrying about it evenly dispersing. It’s clear as day that it works super well. 

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thecowisback

ii noticed i was low down in the jar of liquid this morning and it tasted more bitter than usual as there was more powder at the bottom. i wonder if any of the moderators would know more about how much of this powder is filler - i'm sure someone told me on here somewhere that all the medicine dissolves and the powder that's left is filler. i tried tagging some mods but it won't let me send the post with the tags in it for some reason. 

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Adili13

Do you make your own liquid or get it at a pharmacy? 

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thecowisback

i make my own. 

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Adili13

Me too. If you can afford the Ora plus and are stressing about dispersion, I highly recommend it. I have no idea if the sediment is filler or not, but the fact that it’s evenly mixed with the Ora eases my mind and is worth the money imo. 

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Adili13

I do half Ora 10 ml and half water. Being that the bottle contains over 400 ml, this will last me over 40 days. On amazon it’s like 25 bucks. Expensive, but not as much as paying like 250 a month for liquid paxil

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thecowisback
  • i'm trying to find a similar item in the uk but i think it must be called something different over here 😊

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Adili13

There’s gotta be. Go to a compounding pharmacy and see what they offer 

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thecowisback

we don't have one of those where i live 😑

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thecowisback

just double checking my dosage. i was making liquid from 1 x 20mg capsule in 20ml of water and taking 5ml a day - 5mg prozac. the mixture was running out quickly so today i used 3 x 20 mg capsules in 60ml of water so i still take 5 ml to equal 5mg prozac? i'm sure that 's right but needed to double check 😉 @ChessieCat

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thecowisback
On 5/2/2019 at 8:31 AM, thecowisback said:

just double checking my dosage. i was making liquid from 1 x 20mg capsule in 20ml of water and taking 5ml a day - 5mg prozac. the mixture was running out quickly so today i used 3 x 20 mg capsules in 60ml of water so i still take 5 ml to equal 5mg prozac? i'm sure that 's right but needed to double check 😉 @ChessieCat

@Altostrata

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Songbird
On 4/25/2019 at 7:09 AM, Adili13 said:

For anyone who feels their liquid is uneven and the pill just sinks to the bottom, Ora Plus works incredibly well at disbursing the pill evenly. I use 10 ml water and 10 ml Ora plus with my 20 mg of Paxil. I’m no longer worrying about it evenly dispersing. It’s clear as day that it works super well. 

 

This is what I've been doing as well, just in case there's any active ingredient stuck inside those tiny pill crumbs!  I also like that it makes a syrupy liquid rather than water, it seems easier to handle when measuring and when actually taking it.

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Altostrata
On 5/2/2019 at 12:31 AM, thecowisback said:

just double checking my dosage. i was making liquid from 1 x 20mg capsule in 20ml of water and taking 5ml a day - 5mg prozac. the mixture was running out quickly so today i used 3 x 20 mg capsules in 60ml of water so i still take 5 ml to equal 5mg prozac? i'm sure that 's right but needed to double check 😉 @ChessieCat

 

The 20mL lasted you 3-4 days, correct?

 

60mL might last you 11-12 days. I would not keep a do-it-yourself liquid for more than maybe 4 days, it might go bad, even in the refrigerator.

 

Your math is correct but your technique is not recommended.

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thecowisback

ok, thankyou ☺

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thecowisback

I'm still having trouble getting the last bit of compacted powder out of the capsules. I've tried using as toothpick to scrape out the last bits but some still remains. If I put the capsule into the water to wash it out some powder sticks to the capsule when I remove it. Would it be ok to leave the empty capsule in the solution for the duration of the use of the liquid? 

 

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TriD

I'm trying to take small amount of lexapro, i have 10mg tablet, but feel I only need a minute dose.

 

0.5mg or 0.2mg based on the attached PDF which i made, it would think a 10-20% 5-HTT block would be enough to treat my symptoms as i continue to taper.

 

i have a digital scale, so I am thinking of crushing the 10mg tablet to powder and weighing out what would be 0.5mg/0.2mg, which would be micro dosing.

 

then i will put the powder into 10ml of water and swallow that, in that i dont need to dissolve it, but rather mix it to a larger volume to allow for ingestion rather than putting powder in mouth which might have no effect.

 

thanks

Doc2.pdf

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brassmonkey

You would be working with a very tiny amount of powder and losing any of it would cause a large change in the strength of the dose.  If you try putting it into water there is a good chance that some will stick to the container and be lost.  There are several other ways that might work better.  Take a spoon of apple sauce or fruit jam and pour the powder on a pile on top of that and swallow it whole. Or take a very small piece of toilet tissue (single ply) and wrap the powder in that.  Make it into a tiny ball and swallow it whole with some water.

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TriD

nice thanks for the tip, i think i need a bit more paper in my diet so will take that option.

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swordiebrom

aren't you afraid of a relapse while you are tapering? i think i might have experienced a relapse of some sort or withdrawal,i  cant really tell, each relapse hurts my cognitive function

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Daffy

I was wondering if tap water was OK to use to make my liquid or do I need to buy distilled water?

 

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ChessieCat

I think tap water is okay.  However I think it would be better to use distilled water, bottled water or filtered water.

 

The unused portion needs to be refrigerated in a dark/tinted (preferably), covered container.

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Daffy

Ok. Thank-you!

 

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Raye
On 2/8/2014 at 1:50 PM, Ks1994 said:

I'd like to just add that if you switch from pill to liquid you likely should updose because your body will interpret it as a withdrawal. I could not stabilize on liquid and had to resort back to cutting/filing which is not as accurate unfortunately,

thats true. I was able to stabilize but I found that the dose changes depending on the kind of water you use. I noticed this with tap water vs filtered. I always used tap then the day I switched to filtered I went in withdrawal.. I think its because of the minerals in the water cause it to disperse differently

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beardsagain

Hey all, so I've started emptying my 20mg fluoxetine capsules into 200ml of filtered water, to see if there is any difference in effect when taking the capsule straight up. 

 

I can feel a difference. I found the potency of the drug to be much less than when I take it via the capsule. Is that crazy? Could there be some degradation happening? I try to take it as soon as possible after mixing and with food in the morning. I am wondering if there is just a small amount of degradation, or maybe small amounts that are lost when I open the capsule (sometimes a small amount of powder gets on my hands). Also there is a bit of residue on the glass. I fill my container back up repeatedly until the taste is gone to get as much of the residue. 

 

I am wondering if either of these factors are contributing to lower dosage, and therefore the feeling of reduced potency, or if it is all in my head. Or maybe I am just this sensitive to even the smallest amount of change to the medications.

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brassmonkey

You are correct Citalopram does not dissolve in water.  You have to do what is called a suspension, where you shake up the liquid every time just as you use it so the cloudy stuff is evenly distributed in the water.  You can also purchase a suspension medium, which is a thick syrup which holds the particles up so they don't settle out.  Or you could dissolve it in alcohol and then mix the alcohol with water. I think all three methods are discussed in this thread.

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bubbles

I have ordered Ora-Plus to make my own suspensions at home.

 

With 1x 50mg tablet and Ora-Plus to make a 1mg=1ml solution, that would make a batch that would cover about 17 days at my current dose. I see that the consensus here at SA seems to be to discard after a week or less. If I'm going to discard after a week, it will become an expensive exercise.

 

It looks as though, in my country, if a suspension is made up by a compounding pharmacy, it seems that a standard use by date may be 28 days. It's obviously hard to determine, but I have also heard from my local pharmacy that if they make me up a suspension, that they think the use by date is longer than that - for my particular drug and their particular suspension vehicle - I don't know what it is so, but it's definitely not Ora-Plus as that's not available here. (Mine is coming from the US.)

 

So, my 17 days' worth of suspension is obviously shorter than that 28 days. I'm wondering if it is worth an experiment on my part to push it a bit further, given that I'd be using the proprietary suspension formula, would disinfect everything I use, use cooled boiled water if I decide to dilute, can keep in the dark in the fridge etc.

 

Any thoughts? Do we know why the thought here at SA is to only keep home made suspensions for such a short time?

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Pokeshaw

Hi all - on my long slow micro taper I have  been having brand Lexapro compounded. The compounding pharmacy uses a slow release filler - Methocel E4M.  I am down to  0.1 mg and they cannot make capsules at lower doses. They offered an aliquot (10 caps of 0.01 mg ea) which I tried and my brain went sideways for months. I switched back to the individual capsules of 0.1 mg.  I have gained some stability but seem to be experiencing both w/drawal and side effect symptoms.  Over the yrs of my taper the side effect symptoms were always what prompted me to make a reduction.  And i feel i need to do that soon.

Unfortunately the filler Methocel E4M is not water soluble. it clumps up and really sticks to the side of the glass.  Very hard to make a suspension. it only dissolves in very hot water but I dont want to do that.

So I had the pharmacy make me 0.1mg caps in Methocrystalline cellulose which dissolves nicely in water but is fast release. I am trying to transition over by taking it (capsules for now with the idea of dissolving in water later) every 3 days but already feeling w/drawal aggravation.  Not sure how to do this?

Is there a way to make a suspension with the slow release Methocel E4M filler?

Or should I go more slowly with the transition from the slow release to fast release capsules?

Any ideas would be very helpful!

Thank you!

Poke

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lxjuice
On 3/31/2020 at 3:59 PM, Pokeshaw said:

Hi all - on my long slow micro taper I have  been having brand Lexapro compounded. The compounding pharmacy uses a slow release filler - Methocel E4M.  I am down to  0.1 mg and they cannot make capsules at lower doses. They offered an aliquot (10 caps of 0.01 mg ea) which I tried and my brain went sideways for months. I switched back to the individual capsules of 0.1 mg.  I have gained some stability but seem to be experiencing both w/drawal and side effect symptoms.  Over the yrs of my taper the side effect symptoms were always what prompted me to make a reduction.  And i feel i need to do that soon.

Unfortunately the filler Methocel E4M is not water soluble. it clumps up and really sticks to the side of the glass.  Very hard to make a suspension. it only dissolves in very hot water but I dont want to do that.

So I had the pharmacy make me 0.1mg caps in Methocrystalline cellulose which dissolves nicely in water but is fast release. I am trying to transition over by taking it (capsules for now with the idea of dissolving in water later) every 3 days but already feeling w/drawal aggravation.  Not sure how to do this?

Is there a way to make a suspension with the slow release Methocel E4M filler?

Or should I go more slowly with the transition from the slow release to fast release capsules?

Any ideas would be very helpful!

Thank you!

Poke

 

Escitalopram has a half life of somewhat over 24 hours, you could switch to twice a day liquid dosing to stabilize the blood concentrations more. You wouldn't have been able to make a liquid from the methocel E4M solution even if it hadn't clumped up because you would have lost the slow release.

The only way I can think you can transition from slow release to fast release is if you take the 0.01mg aliquots every 2.4 hours and then reduce the time between them until you are taking 10 aliquots at once, then you can direct swap to 0.1mg IR/liquid. You would have to set an alarm at night though. You could try taking them every 1.6 hours for the 16 hours you're awake but there will be a bigger immediate adjustment before you can shrink the schedule.

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Pokeshaw

Hi LX - Thanks for getting back to me.  I can't use the liquid since it only comes in generic and I had a bad reaction to it back a few yrs ago. I have been using brand Lexapro for the compounding. Also, I had tried the aliquot the pharmacy made for me over a year ago and was not able to stabilize on it so I went back to individual caps of 0.1 mg

 

Here's what I've been doing - and so far so good.

 

for a couple weeks I took the 0.1 mg fast release every 3 days and the other days I stayed with the 0.1 mg slow release. It was a bit bumpy as I mentioned in my post but then that passed. So I waited a few days and then I moved to every other day and that is where i am now. Doing OK 

Will stay here another week or so and then when I feel OK go to daily on the fast release. Will stay there until I feel pretty stable before starting to dissolve in water and do reductions.

One of the big 'side effect' issues for me that always indicated it was time to make a reduction is the 'lexapro clench'. Neck arms jaw and all the issues that ensue such as carpal tunnel, nerve pain and TMJ.  all stuff i suffered with along with constipation when I was on full dose of Lexapro and all went away when i stopped. unfortunately i stopped too fast and then went into a horror show of w/d. Then reinstated months later and have been on this seesaw of tapering and dealing with w/d and side effect symptoms for yrs. This final stretch is very hard! But good to have someplace to check in where people have a clue about this!

I have ordered a graduated cylinder and some oral syringes and have been reading about how to do it. But I'm sure I will post again once i get to the dilution phase.

Take good care and thank you again for responding!

Poke

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Johni
Posted (edited)

Don't you know that cipralex is soluble in water?

 

MOD NOTE:  This is incorrect.  Please see this post: 

 

 

Edited by ChessieCat
added mod note

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brassmonkey

Sorry Johni, but that isn't true.  According to rxlist.com 

 

 Escitalopram oxalate occurs as a fine, white to slightly-yellow powder and is freely soluble in methanol and dimethyl sulfoxide (DMSO), soluble in isotonic saline solution, sparingly soluble in water and ethanol, slightly soluble in ethyl acetate, and insoluble in heptane. (RED highlight added)

 

Your best bet would be to use a homemade isotonic saline solution (9% salt in water) as methanol is poisonous and DMSO is hard to get and hard to work with.

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