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Glycine for sleep?


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DruggedinJapan

Great to know there are alternatives to meds for sleeping.

 

I'm like a kid in a toy store in this forum - constantly stumbling across new and exciting things!

 

Wish I knew these things years ago.

Jan 2004 - 2008 25-50mg of Zoloft. 2008 - 2011 - Effexor ( sorry, forgot dosage)
March 2011 2 week taper and stop all meds.June 2011 start etizolum (3mg per day ) + mirtazapine 15mg
Sep. 2011 increase mirtazapine to 30mg per day , start cimbalta 20mg
2012 increase cymbalta to 40mg. Etizolam to 4-5 mg + add 5mg ambien
Aug 2012. Taper off ADs over 2 months. Stop. Taking 1mg etizolam and 5 mg ambien
May 2013. Start mirtapine 15 mg & cymbalta 20mg. Increase etizolum to 4-5mg
Jan 2014 double ADs.March 2014. Start 15mg of Valium to Stop alcohol . 2-3mg etizolum. Same ADs.
2weeks later stop etizolam and Valium . Stop ambien.

Currently I take 2 x 20mg cymbalta in the morning.

0.5mg of lorazepam 3 times a day - occasionally 5mg of Valium when I have an exceptionally bad night at home. April 22 take 1 epizolam.
2 x 15mg of mirtazapine in the evening.
Roserem 8mg sleeping tablet for one week. April 19 take Zopiclone instead. 20th half ambien (no sleep) April 21st Roserem. April22 half roserem.

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Keeping cool aids sleep.

 

The body naturally cools down at night, but it sounds like your temperature regulation is off, cw.

 

I take magnesium glycinate in doses of about 130mg each. I take 1 mag glycinate plus 81mg aspirin and 1 fish oil capsule every time I wake at night, which is usually at least once. The glycinate in the magnesium does not seem to affect the amount of glycine I can handle. It seems my tolerance for glycine has changed, it doesn't upset my stomach any more.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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Hi-

For extra help with keeping cool I go to bed some night with those refreezable ice cube things that you find for coolers. I get the ones that are kind of flexible. I stick them in a sock & put one behind my neck & one under each shoulder. It really helps me fall asleep.

 

Jan. 1994 Pamelor

2000 switched to Zoloft 

2011 Zoloft pooped out- Dr. switched me directly to Lexapro15mg -had a horrible 6mths

2013 upped Lexapro to 20 mgs-pooped out

June 2013 Dr. added 150 Wellbutrin to Lexapro.

July 2013 Switched back to Zoloft 100mgs.Was still taking Wellbutrin. Lots of anxiety from the Wellbutrin

July 2013 Started to wean Wellbutrin- off by Sept.

Oct. 2013 added 400 mgs of Neurotin to the Zoloft

Jan 2014 Tapered off of the Zoloft and onto Prozac 30 mgs. Also still taking 400 mgs Neurotin

Feb 2014 Reduced Prozac to 13 mgs. Still taking 400 mgs Neurotin

Aug. 2014 Prozac 13 mgs. Finished with Neurotin. .7 Risperadol

 

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cymbaltawithdrawal5600

And the way I sense ambient temps is way off too but not as bad as it was. My mother nearly froze when we had abnormally cold temps this winter because I didn't realize it was too cold in the house and neglected to turn the heat on at night. I'd get up and be burning up inside yet my skin felt cold. The thermostat said 62 degrees and I'd be surprised because I because I used to get cold easily before WD.

 

I take mag citrate, it is the only thing keeping my tendon sheaths in the backs of my knees (and now the crooks of my elbows) from screaming in agony due to my reduction in activity. 400-600 mg during the day. I think I'll keep it and just try adding some glycine powder. I'm afraid to reduce the mag. The citrate doesn't bother my stomach and keeps water in my stools. The 'Calm' powder gave me the runs.

 

The constant feeling of unwellness is wearing me down terribly. Thanks for answering, Alto.

What happened and how I arrived here: http://survivingantidepressants.org/index.php?/topic/4243-cymbaltawithdrawal5600-introduction/#entry50878

 

July 2016 I have decided to leave my story here at SA unfinished. I have left my contact information in my profile for anyone who wishes to talk to me. I have a posting history spanning nearly 4 years and 3000+ posts all over the site.

 

Thank you to all who participated in my recovery. I'll miss talking to you but know that I'll be cheering you on from the sidelines, suffering and rejoicing with you in spirit, as you go on in your journey.

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Hang in there, cw.

 

Great idea, Zoe!

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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  • 3 weeks later...
  • Administrator
Altostrata

Taking glycine with melatonin was making me sleep too heavily and waking me up with a paradoxical reaction. I now take 500mg glycine when I wake up in the middle of the night. So far, seems to help.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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I have now tried glycine for a week. I seem to stomach it OK. I sleep longer before waking but its harder to get back to sleep when i do wake. Tried 3 grams for two nights. Worked less good and i got seriously cranky/irritable during the day. Reduced to 1.5 grams and the crankiness went away. Hard to get correct dose. Will continue to supplement.

2010: Mirtazapine 30mg followed by Zopiclone 7.5 mg for sleep post surgery due to pain.
2012-> Tapering Mirtazapine and Zopiclone at different rates unsuccessfully.
2013: Hospitalized 10 days due to complete Insomnia. Forced back up to 45mg Mirtazapine, 7.5 mg Zopiclone and also Theralene 1 ml.
2013-03: Lab showed Vitamin D deficient. Found the vitamin d and insomnia connection. Supplementing vitamin d. Sleep improved by 1-2 hours
2013-04: Dropped mirtazapine to 30 due to severe side effects. Quit Theralene. Zopiclone 7.5.
2013-05 - 2013-11: Mirtazapine taper monthly 25 20 15 11 8 4 2.5 mg
2013-12 Holding M at 2.5. Need to taper Zopiclone due to daytime nausea and vomiting. Taper zopiclone 1/4 red every 5 d. Last Z 2013-12-19
2013-12-31 M:2.5. Reinstated Zopiclone 3.75 due to Insomnia
2014-01-06 M:2.5. Taper Z 1.9 ... 2014-01-14 M:2.5. Z 1 mg.
Jumped of Zopiclone 01-20. Jumped mirtazapine 02-16.

Theralene: 10mg 02-09. 8mg 03-09. 5mg 03-15. 4mg 03-24. 3mg 04-08. Jumped 04-21.
Zopiclone free for 251 days. Mirtazapine free for 224 days.

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  • 5 months later...

Oddly I have been waking up for years at 4am and this is the first time I have heard of glycine. 

I did a google search before coming here and found this link

from a chat if anyone is interested One person said it made them fat... something to do with liver glucagon was suspected... but not really followed up

http://www.reddit.com/r/Supplements/comments/1a899m/what_do_people_think_of_glycine/

 

thinking of trying it after more reading maybe

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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I take glycine daily. I am taking it for liver benefits. I also am taking 3mg a day. Ideally I am supposed to take 1mg in the morning and 2mg at bed, which I've not been doing but spacing it 3x daily between meals. After reading this I will try to take a more concentrated dose at bedtime to see if I get a sleep benefit.

What were you hoping glycine would help in your liver Alex?  I have a sleep pattern like you often up all night and see the sun before I sleep have had years of this.. sleep 4-7 or it switches around... all over the place for a bit.  I can't get a pattern that sticks. 

My body temp has been low for years even when I was having the hot flashes and night sweats when I am ill I rarely reach normal body temp and have not had an actual fever that registered on a thermometer in over 10 years tho I have been sick plenty of times with infections one would expect to bring a temp pneumonia for example.  

I almost always sleep with a heat source in the cold weather and can't tolerate heat in the summer.

I am thinking lowering my body temp even more may be a bad idea... any thoughts on this? 

 

I sure would like to not feel tired all day. 

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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At first search it appears no store so far has ever heard of glycine.  Guess I won't be trying it. 

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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  • 3 weeks later...

I get my glycine from gelatin. Great Lakes makes a gelatin free of dyes and sugars and the amino acid profile is impressive. It is most high in glycine and has 11g of protein in one tablespoon.

 

I put a few tablespoons of this in my evening tea before bed along with Mg.

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How did it work, Luna?

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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  • 2 months later...

Did anyone try to take glycine during the day? 

1st short round: from 2012 april ~ july 

Sertraline 50mg with 1mg Larazepam fast wd few problems

 

2013 may - 2014 january:  75mg Effexor XR +  1mg Rivotril + 10mg Ambien(zolpidem)

2014 january ~ june :        150mg Effexor XR +  2mg Rivotril    cold turkeyed both almost at the same time (crazy wd of course)

 

two days after cold turkey of Effexor I started 10mg of Lexapro for around a month then did a fast taper (for some days took little Ambien to combat wd)

 

Reinstated to 1mg of Klonopin on 2015.04.23  took the 1mg total for 10 days.  I did in three divided doses 0.25 morning + 0.25 afternoon + 0.5 before sleep.  

Now: 1 mgs total K, divided into .75 night .25 day

 

Started taking 3mg Lamictal on 05.07...... Slowly tiltrated up to 6mg....

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  • 1 year later...
  • Moderator Emeritus

After struggling with sleeping for over 5 months I decided to try out glycine. Here is my experience.

 

Briefly: I've only taken it for two nights before sleep. First night at 2 grams and the second at 3. The positive effect on sleeping was noticeable: the first night I got 4 hours of uninterrupted sleep in the first half of the night. Unfortunately anxiety during the day was also noticeable.

 

The second night after 3 grams

I felt sleepy even when I woke up in the middle of the night but anxiety upon waking up was brutal. It stayed on a high level throughout the day.

 

No glycine for me tonight. I will maybe try again at a lower dose.

Current: Xanax 0.26 (down from 2 mg in 2013), Lexapro 2.85 mg (down from 5 mg 2013)

Amitriptyline (tricyclic AD) and clonazepam for 3 months to treat headache in 1996 
1999. - present Xanax prn up to 3 mg.
2000-2005 Prozac CT twice, 2005-2010 Zoloft CT 3 times, 2010-2013 Escitalopram 10 mg
went from 2.5 to zero on 7 Aug 2013, bad crash 40 days after
reinstated to 5 mg Escitalopram 4Oct 2013 and holding liquid Xanax every 5 hours
28 Jan 2014 Xanax 1.9, 18 Apr  2015 1 mg,  25 June 2015 Lex 4.8, 6 Aug Lexapro 4.6, 1 Jan 2016 0.64  Xanax     9 month hold

24 Sept 2016 4.5 Lex, 17 Oct 4.4 Lex (Nov 0.63 Xanax, Dec 0.625 Xanax), 1 Jan 2017 4.3 Lex, 24 Jan 4.2, 5 Feb 4.1, 24 Mar 4 mg, 10 Apr 3.9 mg, May 3.85, June 3.8, July 3.75, 22 July 3.7, 15 Aug 3.65, 17 Sept 3.6, 1 Jan 2018 3.55, 19 Jan 3.5, 16 Mar 3.4, 14 Apr 3.3, 23 May 3.2, 16 June 3.15, 15 Jul 3.1, 31 Jul 3, 21 Aug 2.9 26 Sept 2.85, 14 Nov Xan 0.61, 1 Dec 0.59, 19 Dec 0.58, 4 Jan 0.565, 6 Feb 0.55, 20 Feb 0.535, 1 Mar 0.505, 10 Mar 0.475, 14 Mar 0.45, 4 Apr 0.415, 13 Apr 0.37, 21 Apr 0.33, 29 Apr 0.29, 10 May 0.27, 17 May 0.25, 28 May 0.22, 19 June 0.22, 21 Jun updose to 0.24, 24 Jun updose to 0.26

Supplements: Omega 3 + Vit E, Vit C, D, magnesium, Taurine, probiotic 

I'm not a medical professional. Any advice I give is based on my own experience and reading. 

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  • 4 months later...

I take glycine daily. I am taking it for liver benefits. I also am taking 3mg a day. Ideally I am supposed to take 1mg in the morning and 2mg at bed, which I've not been doing but spacing it 3x daily between meals. After reading this I will try to take a more concentrated dose at bedtime to see if I get a sleep benefit.

If your still around could you please tell me how glycine benefits the liver?  I know I want to be spoon fed... I could look it up. 

 

Odd short story about glycine... I could not find it when I first went looking.  Then I got his movement disorder and started being a true supplement shopper... ( like my life depended on it) I had a store order it in for me.  A lady who had MCS (multiple chemical sensitivities) which is what I seem to have now... suggested using it to help with reactions.  The idea according to her was it helped to push thing thru the liver and out of the body faster.. it and a few more things.  

ALA +glycine+ NAC = glutothione... glutothione is used to detox the body... something like that... is what I read ... 

 

I started taking the glycine with vit C glutathione and ALA to get out of a reaction to chemicals faster... when it did not work fast I would bump up the glycine first as it tastes best...often this was enough to stop the numb face spinning head brain fog pick a symptom.... 

 

I started to sleep better... after being on all of the above... truth is I started taking glutathione first as it was the master detoxer and then learned taking it too much can cause your body not to make enough... so then I saved it for bad reactions and take the precursors for maintenance.

 

I started with magnesium calm at 1/4 t a night as I have reacted to it for a years and built up to 1 t.  I stay there.

 

I have not tried glycine with magnesium before bed for sleep but I have taken it to stop the jerking when jerking wakes me up it seems to help for that.

 

Here is a bit about all that if anyone thinks better than I do and some of you must..

 "

Effect of single and combined supply of glutamine, glycine, N-acetylcysteine, and R,S-alpha-lipoic acid on glutathione content of myelomonocytic cells.
Abstract
BACKGROUND & AIMS:

Several diseases are characterised by decreased glutathione (GSH) levels due to an enhanced formation of oxygen radicals. To increase GSH levels, the additional supply of GSH precursors was suggested. In this study we evaluated the potency of a single and combined administration of the GSH modulating substances glutamine (GLN), N-acetylcysteine (NAC), and glycine (GLY) as well as R,S-alpha-lipoic acid (LA) to enhance intracellular GSH content in a well-defined model system.

RESULTS:

Exposure of myelomonocytic U937 cells for 24 h to GLN revealed a 1.5-fold enhancement of GSH levels with a concomitant decrease in the formation of reactive oxygen species and lipid peroxidation. Addition of NAC stimulated GSH formation only at subphysiological GLN levels. GLY enhanced GSH levels under GLN starvation, but caused a diminution of GSH content under optimal GLN supply. LA in combination with 2 mmol/l GLN evoked a 3.6-fold enhancement of GSH content compared to GLN starved cells.

CONCLUSION:

These results demonstrate that the GSH content of U937 cells is dependent on the supply of GLN, NAC, LA, and GLY. Combinations of the single substances can enhance but also decrease the intracellular GSH content, which is of clinical importance when supplying GSH-modulating substances to patients.

PMID:   14613752
[PubMed - indexed for MEDLINE]"  

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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From thorne research 

 

inhibitory neurotransmitter and detoxification factor*

  • promotes relaxation for healthy stress management*
  • necessary for detoxification*
  • helps modulate cytokines in the body associated with obesity*???? whatever that is....

Glycine is an important amino acid for relaxation, detoxification, and normal muscle function.* Glycine plays a key role in maintaining healthy function of the central nervous system (CNS).* Along with GABA, glycine is considered one of the most important inhibitory neurotransmitters in the CNS, particularly in the brainstem and spinal cord.*

Studies show glycine may help improve memory retrieval in individuals with a wide variety of sleep-depriving conditions, including jet lag and overwork.*

The benefits of glycine are not just limited to the CNS. Glycine plays a key role in phase II liver detoxification by direct effect on toxin elimination or via its effect on increasing glutathione, which is composed of three amino acids – cysteine, glycine, and glutamic acid.*

In addition, glycine is necessary for the production of healthy DNA and RNA, and therefore plays an important role in ensuring healthy cell function throughout the body.* Glycine is one of three amino acids (along with arginine and methionine) needed for the synthesis of creatine, which in turn supplies energy to muscle and nerve cells.* High concentrations of glycine are found in the muscles, the skin, and other connective tissues. Approximately 30 percent of collagen is composed of glycine.

Glycine plays an important role in supporting a healthy digestive system by helping regulate the synthesis of the bile acid that digests fats.* Glycine also regulates glucose utilization for energy.*

 

I find all I wanted and can't process it I have hit my "wall" but I will be back

peace all

 

WARNING THIS WILL BE LONG
Had a car accident in 85
Codeine was the pain med when I was release from hosp continuous use till 89
Given PROZAC by a specialist to help with nerve pain in my leg 89-90 not sure which year
Was not told a thing about it being a psych med thought it was a pain killer no info about psych side effects I went nuts had hallucinations. As I had a head injury and was diagnosed with a concussion in 85 I was sent to a head injury clinic in 1990 five years after the accident. I don't think they knew I had been on prozac I did not think it a big deal and never did finish the bottle of pills. I had tests of course lots of them. Was put into a pain clinic and given amitriptyline which stopped the withdrawal but had many side effects. But I could sleep something I had not done in a very long time the pain lessened. My mother got cancer in 94 they switched my meds to Zoloft to help deal with this pressure as I was her main care giver she died in 96. I stopped zoloft in 96 had withdrawal was put on paxil went nutty quit it ct put on resperidol quit it ct had withdrawal was put on Effexor... 2years later celexa was added 20mg then increased to 40mg huge personality change went wild. Did too fast taper off Celexa 05 as I felt unwell for a long time prior... quit Effexor 150mg ct 07 found ****** 8 months into withdrawal learned some things was banned from there in 08 have kept learning since. there is really not enough room here to put my history but I have a lot of opinions about a lot of things especially any of the drugs mentioned above.
One thing I would like to add here is this tidbit ALL OPIATES INCREASE SEROTONIN it is not a huge jump to being in chronic pain to being put on an ssri/snri and opiates will affect your antidepressants and your thinking.

As I do not update much I will put my quit date Nov. 17 2007 I quit Effexor cold turkey. 

http://survivingantidepressants.org/index.php?/topic/1096-introducing-myself-btdt/

There is a crack in everything ..That's how the light gets in :)

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  • 2 months later...

Has anybody found glycine to help with anxiety?

Main thread: http://survivingantidepressants.org/index.php?/topic/14472-shakeyjerr-say-hello/

History: Prozac & Lithium from 1999 to 2003. Ended up back on after 4 months because taking a beta-blocker caused immediate depression (just 2 doses - turned out I didn't even need it; I had no other withdrawal symptoms - I might have ended up med and withdrawal-free otherwise :(). - Switched to Effexor (75mg 3/day) and Seroquel (50mg 3/day) in 2010. - Did a self-taper during 2016. - Developed Discontinuation Syndrome 02/17.

Supplements: Magnesium-Glycinate 400mg split into 4 100mg doses throughout the day. Vitamin C 500mg - once per day. Fish Oil 1360 mg (950 mg Active Omega-3) - twice per day.

I'm not a doctor. I use the internet, experience, and trial & error. Seek medical advice if necessary.

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I started taking glycine this past week or so and it def helps me with anxiety

 

I started off with half a capsule (500mgs) and worked up slowly to a full capsule at night and one in the morning.

 

I don't know if it helps with sleep but it does help me relax so my sleep seems deeper and more refreshing.

I did have a few nights with poor sleep since taking it, but with no increase in anxiety.

 

I increased the dose last night to 2 capsules (1000mgs each) and had a very good night.

 

My question is: has anyone had a stable dose of glycine go "paradoxical" ?

I plan to stay on the 2 capsules at night and one in the morning, but am wondering if I should be watching for an possible opposite reaction of increased anxiety, the longer I take it?

do you think I should take a break from it from time to time, or lower the dose at least, to prevent a possible paradoxical reaction?

I don't know how many ppl use glycine so I don't know if there's enough experience out there to be able to say how it works for ppl in WD

 

but I hope someone with experience can chime in.

thanks

  • pysch med history: 1974 @ age 18 to Oct 2017 (approx 43 yrs total)
  •  Drug list: stelazine, haldol, elavil, lithium, zoloft, celexa, lexapro(doses as high as 40mgs), klonopin, ambien, seroquel(high doses), depakote, zyprexa, lamictal- plus brief trials of dozens of other psych meds over the years
  • started lexapro 2002, dose varied from 20mgs to 40mgs. I tried to get off it several times. WD symptoms were mistaken for "relapse". 
  •  2013 too fast taper down to 5mg but WD forced me back to 20mgs
  •  June of 2105, tapered again too rapidly to 2.5mgs by Dec 2015. Found SA, held at 2.5 mgs til May 2016 when I foolishly "jumped off". Crashed in Sept, reinstated at 0.3mgs in Oct. 2106
  • Tapered off to zero by  Oct. 2017 Doing very well
  • Nov. 2018 feel 95% healed, current age 63 
  • Jan. 2020 feel 100% healed, peaceful and content 
  • Nov. 2020, loving life ❤️ 
 
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I started taking glycine this past week or so and it def helps me with anxiety

 

I started off with half a capsule (500mgs) and worked up slowly to a full capsule at night and one in the morning.

 

I don't know if it helps with sleep but it does help me relax so my sleep seems deeper and more refreshing.

I did have a few nights with poor sleep since taking it, but with no increase in anxiety.

 

I increased the dose last night to 2 capsules (1000mgs each) and had a very good night.

 

My question is: has anyone had a stable dose of glycine go "paradoxical" ?

I plan to stay on the 2 capsules at night and one in the morning, but am wondering if I should be watching for an possible opposite reaction of increased anxiety, the longer I take it?

do you think I should take a break from it from time to time, or lower the dose at least, to prevent a possible paradoxical reaction?

 

I don't know how many ppl use glycine so I don't know if there's enough experience out there to be able to say how it works for ppl in WD

 

but I hope someone with experience can chime in.

thanks

 

Can we get a glycine update, catnapt? How is it working for morning/day time anxiety?

 

SJ

Main thread: http://survivingantidepressants.org/index.php?/topic/14472-shakeyjerr-say-hello/

History: Prozac & Lithium from 1999 to 2003. Ended up back on after 4 months because taking a beta-blocker caused immediate depression (just 2 doses - turned out I didn't even need it; I had no other withdrawal symptoms - I might have ended up med and withdrawal-free otherwise :(). - Switched to Effexor (75mg 3/day) and Seroquel (50mg 3/day) in 2010. - Did a self-taper during 2016. - Developed Discontinuation Syndrome 02/17.

Supplements: Magnesium-Glycinate 400mg split into 4 100mg doses throughout the day. Vitamin C 500mg - once per day. Fish Oil 1360 mg (950 mg Active Omega-3) - twice per day.

I'm not a doctor. I use the internet, experience, and trial & error. Seek medical advice if necessary.

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  • 3 weeks later...

Hi everybody!

 

I have also taken glycine for sleep for many months to its relaxing effect on the CNS and it has helped me a lot, I get restful sleeps and I get sleeped after few minutes I lay on bed even if a I have anxiety all day long. I take it together with a infusion of chamomile, passionflower and meliss. However, even if I sleep very well, the moment I open my eyes I get all my anxiety back.

I use the Glycinate powder of Now food I find on iherb which I think it is excellent, i take 3/4 teaspoon as indicated on the product

 

I have never used it during the day, so I am waiting for catnap opinion as well.

 

Is glycine safe to bu used for many months or may it be creating an addiction/dependency? Should I suspend it from time to time or it is not necessary so far I get relief from it?

Valium: 1 year approx. - begun at the end of 2010 and tapered off at the end of 2011

Rivotril: 3 years approx.- begun at the end of 2011 tapered off at the end of 2014

Gabapentin: 9 months approx., begun in March 2011 tapered off at the end of 2011

Laroxyl (amitriptyline)- 1,5 years, begun at the end of 2011 and tapered off in April of 2013 and then changed to 

Cymbalta - 1,8 years (up to 90mg), begun in April 2013 and tapered off in 6-8 weeks from 90 mg to 0 mg at the beginning of 2015.

When tapering off Cymbalta all these symptoms of anxiety began:

Physically: Inner tremor, craneal and ear ringing, tingling, continuous tension and fatigue, inner agitation, nausea in the morning and mentally: obsessive thoughts, suicidal thoughts when I fell very bad and much hypocondrya. 

Bromazepam- 1,5 month 1-2 capsules/day of 1,5 mg, begun in March 2015 and tapered off in May 2015. As symptoms continued my doctor put me on

Lyrica - 8 months, (up to 75mg/day), begun in June 2015 and then tapered off gradually (25 mg off each month) in February 2016

My symptoms of anxiety went away thanks to Lyrica but went back before beginning to taper it off at the end of November 2015 so I went back to 

Bromazepam- 3 months 1-2 capsules/day of 1,5 mg, begun in November 2015 and tapered off in March 2016.

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  • 7 months later...

tried glycine last night, this is what happened

 

took around 300mg of glycine at 8pm and was asleep for just before 9pm which is my usual sleeping time, I then woke just before 12pm for the toilet so got 3 solid hours which is nothing special as I often get over 3 solid hours, the 3 hours I got though was very deep sleep, I knew it was deep when i woke from it and looking at my fitbit data this morning shows that I got 1 and half hours deep sleep within those 3 hours, usually my fitbit data shows I only get 1 and half hours and often a lot less for the whole night of sometimes up to 8 hours , so getting this much deep sleep in just 3 hours shows that the glycine had a big effect on my deep sleep,

 

unfortunately though I could not get back to sleep after I woke, I can usually get back to sleep very fast usually within a minute or 2 if I wake any time before 2.30pm, any time waking after 2.30pm usually takes a while to get back to sleep,

 

so it got to around 1pm and i decided to take another 300mg of glycine, this did nothing and it got to 2am and I knew I was getting no more sleep unless I took a sleep aid so I took 1 tylenol pm which I have just imported from the USA, this worked and I was back asleep just before 3am, ended up getting around another 3 hours sleep waking once in between,

 

I have probably chose a bad time to try glycine as the last few days I have a cold and really sore throat and sleep is always worse when I have a cold etc,

 

I am going to experiment some more with glycine, maybe I did not take enough to keep me asleep longer than the 3 hours as it does say on the bottle to take up to 3 capsules before bed which is 3000mg where I just took 1/10 of that at only 300mg,

 

I will likely try taking it next when wake in the early morning and see what effect that has and then do some further experimenting when my cold and sore throat has fully gone

2001 - 2005 prozac,  2001 - 2017 various benzos, mainly diazapem and zanex,  2002 - 2017 olanzapine or seroquel,  2002 -2017 propanolol, 2005 - 2009 venlafaxine 75mg , forced to go cold turkey off venlafaxine as moved Thailand, doctor cut me off and couldn't get it there, severely ill for over 2 years, countered withdrawals with more zanex and seroquel

2014 returned to UK, mainly to get treatment getting off meds

doctor advised to taper seroquel over a few weeks, severely ill and bed bed-bound so reinstated it, 2015 tapered seroquel myself slower over a few months, was off it 2 months and was too ill so went on olanzapine, became zombie and too tired to get out of bed, went back on seroquel, very depressed so went back on venlafaxine, didnt work  so doctor swapped to zoloft became very agitated so back on venlafaxine

June 2016 - felt strong enough to begin tapering again, started what I thought was a slow taper of all meds,  2016 July Not had any alcoholic drink since this date, 

2016 October completely off diazepem, 2017 Feb completely off seroquel, 2017 March completely off proponanlol, 2017 April (day before birthday) completely off venlafaxine, OFF ALL MEDS 11/4/2017, was fine for nearly 3 months and then delayed withdrawal hit,

supplements taking: turmeric capsules, NiaCel (nicotinamide riboside), Vit B12 sublingual, Vit B3, Vit B6, Vit B1, apple cider vinegar, manuka umf 10 honey, camu camu powder,  melatonin when needed, epsom salt baths, juices, smoothies, 

Intro: http://survivingantidepressants.org/topic/15175-dj2010-off-all-meds-for-3-months-and-been-fine-now-bad-insomnia/

 

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  • 2 years later...

I was reading through this post about Glycine because I was considering adding into my sleep tool kit while I'm tapering from Clonazepam.

 

Currently I take between .25 and .50 of Melatonin though I will take breaks from it for 3 or 4 days.  I also take between 1 and 2 Magnesium Gylcinate tablets totalling about 200mgs.  

 

From what I have read here, adding the gylcinate and starting at a low dose doesn't seem to cause issues. Ans it seems to be okay taking with the Magnesium Gylcinate.

 

Is anyone still using it or trying it?

 

I'm getting between 4-6 hours of broken sleep.  Very light and takes me a long time to fall asleep.  

 Sept 2013-Apr 2014:  After death of my mom put on as series of meds. Zoloft 6 days, Lexapro1 day, Nortriptyline 10 days, Liquid Prozac 1 week, Cymbalta 1 week.

Got off Clonzapam: 1/2014-9/2014. After given Lamictal, stopped Clonzapam at .125mgs

Completed Remeron taper: 41.25 -0.025mgs  1/2015-4 2017. 

Completed Lamictal Taper: 200mgs-0.05 mgs 7/ 2015-11/2018. 

Clonazapam  December 2018. 0.625 Had paradoxical reaction to Lamictal wd, broke my heart to take a benzo but wasn't sleeping and not thinking straight. 28 March, 2019  4% taper Total: .625mgai   26 May, 2019  4% taper Total: .575 mgai,   24 June, 2019 2.5 % taper  10 Clonzapam tablets weigh1.999 mgpw  Average  200 mgpw.  0.0073mgai 9AM, 0.0073mgai 3PM, .415mgai, Total: 561mgai,  10 July, 2019 (Compounded pills) .0073mgai 9AM,.0073mgai 3PM, .415mgai,

Total .561mgai   26 August, 2019 (Back to regular pills due to bad reaction) .0078mgai 9AM, .01075mgai 3PM, .360mgai PM, Total: .545mgai   26 Sept. 2019 .0775mgai 9AM, .1mgai 3PM, 0.350mgai PM: Total: .5275mgai   31 Oct, 2019 .0750mgai 9AM, .0925mgai 3PM, 0.340mgai 930PM, Total: .5075mgai,   30 Nov. 2019 .0775mgai 9AM, .0825mgai 3PM, .3325mgai 9:30PM, Total:.490mgai   31 Dec. 2019 .0775mgai 9AM,  .080mgai 3PM, .3225mgai 9:30PM,  Total: .4775mgai   31 Jan. 2020 .0725mgai 9AM, .0750mgai 3pm, .315mgai 9:30PM, Total: .4625mgai    29 Feb. 2020  .0675mgai 9AM, .0675 3PM, .305 mgai 9PM Total: .440mgai 31 March 2020 .065mgai 9AM,  .065mgai 3PM, .2925mgai 10PM, Total: 4225mgai  30 April 2020 .0625mgai 9AM, .0625mgai 3PM, .2775mgai 10PM  Total: .4025mgai 31 May 2020 .0625mgai 9AM, .0625 mgai 3PM, .2526 mgai 10PM, Total: .3775mgai  30 June 2020 .0625mgai 9AM, .0625mgai 3PM  .2175 mgai 10PM Total .3425mgai.   31 July 2020 .0575 mgai 9AM .0550 mgai 3PM .180mgai 10PM Total .2925mgai  31 August 2020 .0475mgai 9AM, 0.045mgai 3PM, .01475mgai 10PM Total: .2375mgai  30 September 2020 0.0375mgai 9AM 0.035mgai 3PM 0.110mgai 10PM  Total: .1825mgai 31 October 2020 .0325mgai 9AM .0350mgai 3PM  .0725mgai 9PM

Total: .14mgai  30 Nov. 2020 .03mgai 9AM  .0276mgai 3PM 0.450mgai 9PM Total: .1025mgai 31 Dec. 2020 .02mgai 9AM .02mgai 3PM .02mgai 9PM Total: .06mgai  5 February, 2021 .0150mgai Stepped off of Clonzapam, Benzo Free

 

Additional Support:  Armour Thyroid 75mgs,  Vitamin D, Vitamin C, Magnesium Glycinate

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  • 3 months later...

I'm currently using glycine at around 500mg before sleep, and 500mg after early wake-up.   The growth hormone release could partly be why it works so well for sleep.  One might consider ornithine (most effective for me) and/or lysine for sleep as well.   I've been taking all three for a couple weeks.  They also cause the release of growth hormone, and I find their effect on my sleep more consistent than just  glycine.  

1997-2019 Prozac, Zoloft, Paxil, Celexa, Effexor, Serzone, Wellbutrin, Amitryptiline, Mirtazapine, Lexapro (mostly, 10-20mg)

Jan 16-Feb 2019 Fast tapered Lexapro after spontaneous kundalini syndrome 

Feb-Jul Used various herbs to deal with severe anxiety (bacopa, gotu kola)

Sept 2019 Developed histamine intolerance and daily panic

Currently taking high DHA fish oil, magnesium.  Occasionally l-ornithine, l-lysine, l-glycine, melatonin for sleep.  Dayvigo for sleep, and l-thp or seroquel (haven't settled on dose) for sleep when in sleep deprivation crisis

 

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  • 9 months later...
rapunzel2

Im looking for supplements to take for sleep and thinking about glycine. however, I found that it messes with serotonin and this makes me afraid to try it. we should avoid serotonin things, right?

 

https://www.psychologytoday.com/us/blog/sleep-newzzz/201902/4-sleep-benefits-glycine

In particular, glycine helps the body make serotonin, a hormone and neurotransmitter that has significant effects on sleep and mood.

in 2002- 0,5 tablet cipramil for half a year, ended it uneventfully. in 2006 - citalopram for half a year, ended in horrific state, ditched the drugs CT. 2007-2008 not feeling well but drug free. in 2008 prozac 20mg + quetiapine 25mg. 2009 tried to stop, ended up in hole after couple of months, started zoloft. 2009-2011 zoloft 50mg. went to 25mg in 2011 summer, it resulted in half a year horrible suffering. reinstated, changed drugs, nothing happened. by 2012 beginning suddenly felt great and CT meds. after 4 months came suddenly most horrible human suffering that's possible. was started on prozac and questiapine. started tapering slowly, GFCF diet and Hardy Nutritionals vitamins in 2013 summer. 

current medications: 1) fluoxetine and quetiapine since Aug 2012; 2) Daily Essential Nutrients by Hardy Nutritionals 7 capsules / since May 2013 + omega3; 3) Gluten-free-casein-free diet since june 2013

 

Started withdrawing slowly since april 2013. Mostly around 10% cuts. 

April'13 - March'14: fluoxetine 40mg -> 19,5mg; quetiapine 50mg -> 40mg
April'14-March'15: fluoxetine 19,5mg -> 14,4mg; quetiapine 40mg -> 22mg

April'15-March'16: fluoxetine 14,4mg -> 7,4mg; quetiapine 22mg -> 15mg

April'16-March'17: fluoxetine 7,4mg -> 5,0mg; quetiapine 15mg -> 7,25mg

April'17-March'18: fluoxetine 5,0mg -> 4,0mg; quetiapine 7,25mg -> 0 (as of 1st Feb 2018)!!!!

April´18-March´19: fluoxetine 4,0mg - > 2,3mg. Jumped off fluoxetine 1,4mg due to pregnancy in July 2019. Oct 2019 severe withdrawal syndrome started.

Took mistakenly a complex for hormonal support that included pregnenolone dec2019-april2020. Stopped it april 2020 and immediately severe akathisia started. Have had life threatening akathisia since, 100% disabled, suicidal, very hard to hold on. 

 

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  • Moderator Emeritus
ChessieCat
9 hours ago, rapunzel2 said:

glycine helps the body make serotonin

 

And serotonin is a precursor to melatonin which is why it might help some people.  However, as you have most probably seen happen with other members of SA since you became a member back in 2013, things that "other people" are okay taking (those who have not taken psychiatric drugs), members might have issues with.

 

And as we always suggest to members, if you try anything new only start with a small amount and only make one change at a time.

NEW!!!     INTERVIEW with Altostrata, SA's founder    NEW!!! 

 

Plodding along inch by inch:  12" = 1',  3' =  36 " or 1 yard,  1760 yards  = 63,360" or 1 mile

Current from 27 Mar 2021:  Pristiq 0.295 mg

ADs since ~1992:  25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq:  50mg 2012, 100mg beg 2013 (Serotonin Toxicity)  Tapering Oct 2015 

My tapering program   My Intro (goes to my tapering graph)  My website

PLEASE NOTE:  I am not a medical professional.  I provide information and make suggestions.

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lucidity
20 hours ago, rapunzel2 said:

Im looking for supplements to take for sleep and thinking about glycine. however, I found that it messes with serotonin and this makes me afraid to try it. we should avoid serotonin things, right?

 

https://www.psychologytoday.com/us/blog/sleep-newzzz/201902/4-sleep-benefits-glycine

In particular, glycine helps the body make serotonin, a hormone and neurotransmitter that has significant effects on sleep and mood.

 

You know what else affects serotonin? Almost all (if not all, albeit indirectly) vitamins, amino acids, and electrolytes, carbohydrates, fats, etc. In other words, about anything you put into your body.  Personally, I had more success with ornithine and lysine (they helped for about a year, then ornithine went paradoxical on me and lysine stopped doing anything noticable) but glycine did help some too. I did have to keep the dose lower than what is normally recommended for sleep with glycine

1997-2019 Prozac, Zoloft, Paxil, Celexa, Effexor, Serzone, Wellbutrin, Amitryptiline, Mirtazapine, Lexapro (mostly, 10-20mg)

Jan 16-Feb 2019 Fast tapered Lexapro after spontaneous kundalini syndrome 

Feb-Jul Used various herbs to deal with severe anxiety (bacopa, gotu kola)

Sept 2019 Developed histamine intolerance and daily panic

Currently taking high DHA fish oil, magnesium.  Occasionally l-ornithine, l-lysine, l-glycine, melatonin for sleep.  Dayvigo for sleep, and l-thp or seroquel (haven't settled on dose) for sleep when in sleep deprivation crisis

 

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  • Administrator
Altostrata

Correct, the reference to serotonin is baloney, as it usually is.

 

Glycine may be helpful, but we don't know why.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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