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Permanent brain alterations


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Can someone help me with one of my worst fear of SSRI having permanently alter my brains functioning?


i’m getting scared for this day by day.

2014-2020 Haloperidol
2017-2021 Zoloft
2018-2021 Issues zoloft so i decreased on both Haloperidol

November 2020 Taper down Haloperidol(barely any issues)
March 2021 taper down from zoloft(alot of issues)
Zoloft taperdown from march till late june
25mg was my dosage, may 10mg(from 10 too 5 was hard), 5mg in end of june every lowar dosage gave me alot of issues. clean in end of june.

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me too

many years ago given sinequan for depression bad reaction so tiny dose of meleril to balance... quit after a year or so c/t

years pass no drugs

reg doc had me try all of the  a/d bc of upset due to divorce.  couldn't handle any.  took klonopin to sleep .5 mg  2003

taper klonopin

hooked on tramadol accidentally. 2006-2008 husband had migraines and took them like candy. so i became dependent too.  c/t  2008

diagnosis of porphyria after years of symptoms,  then toxic event made me really ill.


gabapentin 300mg every 3 hours , 6x day.

propranolol   180 mg  6x / day

since 2012

clonazepam prescribed as 1 mg / day  but beginning to take more to deal with withdrawals and sleeplessness


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  • Moderator Emeritus

From a post made by Shep (admin):


Our brains are very neuroplastic. See:


Neuroplasticity video (2 minutes)


Healing from antidepressants. How to speed up the recovery process video (5 minutes)


While it can take a long time for this type of damage to heal, there are many ways of calming the nervous system and healthy and healing activities that can help the process along. See: 



Non-drug techniques to cope with emotional symptoms


Art, music, gentle stretching or yoga, journaling, walks in the sun, a healthy diet with plenty of water, etc. can help heal the brain and nervous system from hypersensitivity and kindling. And these are the skills, activities, and lifestyle that will keep you from feeling the need to reach for a drug to handle life after you're off these drugs. 


Healing takes time, but it does happen. 

Please DO NOT TAG me - thank you

PLEASE NOTE:  I am not a medical professional.  I provide information and make suggestions. 

  MISSION ACCOMPLISHED:    (6 year taper)      0mg Pristiq      on 13th November 2021

ADs since ~1992:  25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq:  50mg 2012, 100mg beg 2013 (Serotonin Toxicity)  Tapering from Oct 2015 - 13 Nov 2021   LAST DOSE 0.0025mg

Post 0 updates start here    My tapering program     My Intro (goes to tapering graph)

 VIDEO:   Antidepressant Withdrawal Syndrome and its Management

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  • Moderator

Think of healing......imagine it.  Don't spend too much time in the online trenches of suffering.

Here's a good article on Acute and Persistent WD Syndromes from some of the different classes of medications. 


and I don't know.......maybe just read the introduction, as they mention "reversible" a lot.  They don't mention numbers, and so don't assume you will be one of the hardest hit.

I don't know about you, but persistent or protracted WD sure is a bit lighter(in sound and understanding) than PERMANENT BRAIN ALTERATIONS.


Not all your drugs have been AD's.


I may still have some iatrogenic harms from my psychiatric career, yet they are always improving.  I no longer feel like it's WD at all, at all times.....  It's just something I get to deal with and find new ways to alter old patterns.


Be well, imagine it.  Let us know of improvements.......they usually are there if you focus on looking for them.


Be well, Love, peace, healing, and growth,




Edited by manymoretodays
additional, just language

2022 May- continuing with limited activity on site, just something I need to do right now

Started with psycho meds/psychiatric care circa 1988.  In retrospect, and on contemplation, situational overwhelm.

Rounding up to 30 years of medications(30 medication trials, poly-pharmacy maximum was 3 at one time).

5/28/2015-off Adderal salts 2.5mg. (I had been on that since hospital 10/2014)

12/2015---just holding, holding, holding, with trileptal/oxcarb at 75 mg. 1/2 tab at hs.  My last psycho med ever!  Tapered @ 10% every 4 weeks, sometimes 2 weeks to

2016 Dec 16 medication free!!

Longer signature post here, with current supplements.

Herb and alcohol free since 5/15/2016.  And.....I quit smoking 11/2021.  Can you say Hallelujah?(took me long enough)💜

None of my posts are intended as medical advice.  Please discuss any decisions about your medical care with a knowledgeable medical provider. manymoretodays


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