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Singulair aka Montelukast asthma/allergy drug


ShiningLight

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  • Mentor

I was recently prescribed this drug. Thankfully I am not going to take it.

 

Posting to share info. I found this drug to have an alarming safety record according to FDA adverse events web site reports. Reports of suicides, depression, agitation (akathisia???) and serious side effects. Black box warning. 

 

☠️ ☣️

Now: 100 mg Zoloft am, 50 mg Trazodone.  Daily drug burden decreased from 2050 in 2018 mg to 150 mg 🐢🐢

Zoloft: 1/24/23 increased to 100 mg after suicide attempt 9/17/22 cut 6 mg, 8/14/22 cut 6.5 mg, 5/7/22 cut 12.5 mg 3/20/22 cut 12.5 mg 10/26/21 cut 6 mg 10/17/21 cut 5 mg, 9/17/21 Cut 3 mg,  9/13/21 cut 4 mg, 8/29/21 Cut 2 mg 8/8/21 Cut 3 mg  7/30/21 Zoloft: Converted 25 mg to liquid. Also take 100 mg pill & 25 mg pill=150 mg total
🌞 Feb 28, 2021 0 mg Gapapentin 2021 Gaba each dose 4x/day: Feb 27 7 mg (one dose only), Feb 10, 7 mg, Jan 14 10 mg 2020 Current taper schedule from Aug 30-present: drop 8 mg every 2-3 weeks. Aug 20 31 mg, Aug 18, 33 mg, July 29, 35 mg, July 23 38 mg, July 22 40 mg Jun 24 42 mg, Jun 15 44 mg, Jun 9 48 mg, May 22 50 mg, May 14 54 mg, May 7 56 mg, Apr 16 58 mg, Mar 28 60 mg, Mar 18 62 mg. Feb 26 64 mg. Feb 19, 66 mg. Jan 23, 70 mg. 2019 Dec 19, 72 mg. Nov 14 ,76 mg. Aug 8, 80 mg. Aug 6, 85 mg. Jul 26, 90 mg. Jul 11, 95 mg.

Jul 16 trazodone from 100 to 50 mg.

Jun 17-July 10 Slowly changed gab fr pill to liquid at same dose 100 mg 4x/d.

Apr 24 Stopped klon!!! 🌞 Apr 4  Decreased gaba to 400 mg (100 mg 4x/day)-Apr 4, 2019   0.25 klon March 11  Klonopin .5 mg twice daily, varied dose til Apr 15. Started Klon fast taper 25%, short use

Mar 16, 450 mg gaba 3x/day cut 600 mg--not exact!--updose after learning w/d

Feb 20, 2019 1800 mg gabapentin; MD taper; off 3 days=mvt disorder & autonomic instability. July 2018 temazepam 15 mg 1-2; prn several x/wk til Jan/Feb 2019 when cold turkey, flu illness for months

July 2018 started gabapentin 100 3x/day; titrated up to 1800 mg (600 3x/day)

Buspar, I forget how much, 2 pills a day Jan 2017-July 2018 cold turkey. On Zoloft since maybe 2004? After trying many.

*I speak from my experience. Nothing I say is medical advice. I'm not a doctor.

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  • 3 weeks later...

I've taken it a couple of times for bronchial hyperreactivity that asthma inhalers weren't completely addressing, with good results. Based on my experience I think anyone with a history of mental health issues should probably avoid it. It is notorious for producing nightmares, but that's an oversimplification. I'd say it is more like a dream intensifier, sometimes good, sometimes bad. First night I ever took it I had a classic someone-aiming-a-gun-at-me nightmare, but I suspect I had sort of programmed myself for that after reading about the side effects. A year or so later, first night of a new course resulted in a wonderful visionary dream. Both times, the dream intensity settled down after a few days, but I had the feeling that the med was altering sleep cycles resulting in some reduced quality of sleep. I had zero problem stopping it, though I did finish the course at a half dose for maybe a week.

Amitriptyline: prescribed 10 mg/day in mid-August 2022

  • Began fairly quick taper 18 October 2022 to 3 mg by 9 November (no withdrawal symptoms)
  • Reinstated at 10 mg on 9 November leading to some serious sleep disturbance
    • 10–17 November, tried 8 or 9 mg
    • 18 November, 10 mg
    • 19–22 November, 3.5 mg after advice to drop back to taper level
    • 23 November – 14 Dec., 3 mg
    • 15–22 Dec., 2.7 mg
    • 23 Dec. 2022 to 3/15/2023, ranged from 2.5 mg up to 3 mg w/partial reinstatement after bad crash provoked by CBD/THC gummy, then slowly back down to 2.5 with long hold in March
    • from 15 March 2023, continued slow taper (Brassmonkey slide, 2.5% week + 2 week hold every 4 weeks) to 1.2 mg as of 1/1/24. Increased tapering speed to 20% in 6 weeks, probably bad idea.

Other medications: albuterol inhaler as needed, acetaminophen as needed

Supplements: daily multivitamin, magnesium glycinate 400 mg/day PRN, probiotics
Caffeine: Max 1 cup coffee/day or 2 cups of tea

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im in wd but this is about my 6 year old daughter who at the time was 4 , her doctor gave her this rx for asthma and the first time i gave it to her was at night and she feel asleep about 30 minutes later i noticed her hair all curly from her sweating so bad her head was wet , i knew something was wrong with this medicine ugh , im so glade i never gave it to her again , my poor baby , 

2021:  started celexa 10mg feb 2nd 

feb 25th took my last 10g; feb 26th 5mg; feb 27th 5mg; feb 28th 2021 cold turkey 

currently taking mag

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  • Mentor

There's a whole Facebook group for Singulair/Montelukast survivors. 

I finally got an rx for atrovent, but there have been long delays and I still don't have it yet.

Now: 100 mg Zoloft am, 50 mg Trazodone.  Daily drug burden decreased from 2050 in 2018 mg to 150 mg 🐢🐢

Zoloft: 1/24/23 increased to 100 mg after suicide attempt 9/17/22 cut 6 mg, 8/14/22 cut 6.5 mg, 5/7/22 cut 12.5 mg 3/20/22 cut 12.5 mg 10/26/21 cut 6 mg 10/17/21 cut 5 mg, 9/17/21 Cut 3 mg,  9/13/21 cut 4 mg, 8/29/21 Cut 2 mg 8/8/21 Cut 3 mg  7/30/21 Zoloft: Converted 25 mg to liquid. Also take 100 mg pill & 25 mg pill=150 mg total
🌞 Feb 28, 2021 0 mg Gapapentin 2021 Gaba each dose 4x/day: Feb 27 7 mg (one dose only), Feb 10, 7 mg, Jan 14 10 mg 2020 Current taper schedule from Aug 30-present: drop 8 mg every 2-3 weeks. Aug 20 31 mg, Aug 18, 33 mg, July 29, 35 mg, July 23 38 mg, July 22 40 mg Jun 24 42 mg, Jun 15 44 mg, Jun 9 48 mg, May 22 50 mg, May 14 54 mg, May 7 56 mg, Apr 16 58 mg, Mar 28 60 mg, Mar 18 62 mg. Feb 26 64 mg. Feb 19, 66 mg. Jan 23, 70 mg. 2019 Dec 19, 72 mg. Nov 14 ,76 mg. Aug 8, 80 mg. Aug 6, 85 mg. Jul 26, 90 mg. Jul 11, 95 mg.

Jul 16 trazodone from 100 to 50 mg.

Jun 17-July 10 Slowly changed gab fr pill to liquid at same dose 100 mg 4x/d.

Apr 24 Stopped klon!!! 🌞 Apr 4  Decreased gaba to 400 mg (100 mg 4x/day)-Apr 4, 2019   0.25 klon March 11  Klonopin .5 mg twice daily, varied dose til Apr 15. Started Klon fast taper 25%, short use

Mar 16, 450 mg gaba 3x/day cut 600 mg--not exact!--updose after learning w/d

Feb 20, 2019 1800 mg gabapentin; MD taper; off 3 days=mvt disorder & autonomic instability. July 2018 temazepam 15 mg 1-2; prn several x/wk til Jan/Feb 2019 when cold turkey, flu illness for months

July 2018 started gabapentin 100 3x/day; titrated up to 1800 mg (600 3x/day)

Buspar, I forget how much, 2 pills a day Jan 2017-July 2018 cold turkey. On Zoloft since maybe 2004? After trying many.

*I speak from my experience. Nothing I say is medical advice. I'm not a doctor.

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  • 6 months later...

Hello! Has anyone here tapered off montelukast and want to share their story and method?

 

2002-2021: 19 yrs on/off psychotropics

2/2022: Wellbutrin 150mg, Lexapro 20mg  3/22: Wellbutrin 150mg xl, Lexapro 10mg    4/22: Wellbutrin 150xl, Lexapro 5mg 

4/2022: Lexa 7.5mg total, Wellbutrin 150mg    5/2022: Wellb 112.5mg xl, Lexa 7.5mg (Stopped Clonazepam & Hydroxyzine- didn't take often)

6/2022: Welbutrin 111mg xl, Lexa 6.8mg          8/2022: Wellbutrin 100mg xl, Lexa 6.8mg            10/9/22: Wellbutrin 100 mg IR, Lexa 6.5 mg

11/3/22: Wellbutrin 96 mg IR, Lexa 6.5 mg       11/30/22: Wellbutrin 96 mg IR, Lexa 6 mg

3/15/23: Wellbutrin 96 mg IR, Lexa 6.2 mg???

Other Daily Meds: Singulair 10mg, Zyrtec 10mg, Spiriva Respimat inhaler.  Rarely taking: OTC pain relievers, Diclofenac, Cyclobenzaprine, anti acids

SupplementsFish oil 1300mg, Nigella oil, Mag Glycinate 200mg, Probiotics 30 billion, 1/5 dose prenatals, Melatonin .38mg, (Reishi, Lion's Mane & psilocybin microdosing by cycles)

 

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I tapered off by splitting 10 mg tablets and taking 5 mg for a few days, then stopping. Zero discontinuation symptoms. But that doesn't mean that everyone will have the same experience. I don't know whether it would work to make a liquid solution or suspension of the tablets for slower tapering--pill splitting/weighing might be best. If there are support groups for montelukast users, probably that's the place to look for more information.

Amitriptyline: prescribed 10 mg/day in mid-August 2022

  • Began fairly quick taper 18 October 2022 to 3 mg by 9 November (no withdrawal symptoms)
  • Reinstated at 10 mg on 9 November leading to some serious sleep disturbance
    • 10–17 November, tried 8 or 9 mg
    • 18 November, 10 mg
    • 19–22 November, 3.5 mg after advice to drop back to taper level
    • 23 November – 14 Dec., 3 mg
    • 15–22 Dec., 2.7 mg
    • 23 Dec. 2022 to 3/15/2023, ranged from 2.5 mg up to 3 mg w/partial reinstatement after bad crash provoked by CBD/THC gummy, then slowly back down to 2.5 with long hold in March
    • from 15 March 2023, continued slow taper (Brassmonkey slide, 2.5% week + 2 week hold every 4 weeks) to 1.2 mg as of 1/1/24. Increased tapering speed to 20% in 6 weeks, probably bad idea.

Other medications: albuterol inhaler as needed, acetaminophen as needed

Supplements: daily multivitamin, magnesium glycinate 400 mg/day PRN, probiotics
Caffeine: Max 1 cup coffee/day or 2 cups of tea

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