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Tips for tapering off trazodone (Desyrel)


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Aka Oleptro, Beneficat, Deprax, Desirel, Molipaxin, Thombran, Trazorel, Trialodine, Trittico, and Mesyrel

Trazodone (trazodone hydrochloride) is a nasty drug often added to antidepressants and other "activating" drugs to aid sleep.

It's nasty because it has an evil active metabolite, meta-Chlorophenylpiperazine (mCPP), and a huge number of interactions with other drugs that can make you feel very sick.

First, carefully read the below to see if you have any adverse effects from trazodone.

Trazodone's evil byproduct, mCPP
Trazodone's active metabolite, mCPP, does the opposite of aiding sleep -- it's very, very activating, often in an unpleasant way.

Wikipedia on mCPP http://en.wikipedia.org/wiki/Meta-Chlorophenylpiperazine

 

Quote

Meta-chlorophenylpiperazine is a major metabolite of the psychotropic drug trazodone, and may be responsible for some of its side-effects, such as headaches and migraines induced many hours after initial consumption.


per Wikipedia http://en.wikipedia.org/wiki/Trazodone

Quote

The mean blood elimination half-life is biphasic: the first phase's half-life is 3–6 hours, and the following phase's half-life is 5–9 hours. The drug is extensively metabolized with 3 or 4 major metabolites having been identified in the human body, particularly mCPP,[39] which may contribute to the side effect profile of trazodone.

....mCPP, a non-selective serotonin receptor agonist and serotonin releasing agent, is an active metabolite of trazodone and has been suggested to possibly play a role in its therapeutic benefits.[31][32][33] However, scientific research has not supported this hypothesis, and mCPP may actually antagonize trazodone's efficacy as well as produce additional side effects....

 

Half-lives
trazodone (8-15 hrs) ---> mCPP (2-6 hrs) ---> other metabolites (inactive)

 

The metabolism of trazodone is highly variable among individuals. mCPP can be produced during the initial 8-15 hours; its clearance from the body can be blocked by other drugs (see explanation below).
 

mCPP is used to induce anxiety for study in the laboratory, e.g. http://www.ncbi.nlm.nih.gov/pubmed/20828578

For some people, mCPP produces not only anxiety but headaches and a hallucinatory effect. So while trazodone may help you sleep at night, mCPP might make you feel sick, anxious, and out of control during the day.
 
http://www.ncbi.nlm.nih.gov/pubmed/19384678

Quote

World J Biol Psychiatry. 2009;10(4 Pt 2):682-5. doi: 10.1080/15622970902836022.
Trazodone generates m-CPP: in 2008 risks from m-CPP might outweigh benefits of trazodone.
Kast RE.

Source
Department of Psychiatry, University of Vermont, Burlington, VT 05401, USA. rekast at email.com

Abstract
Since deleterious effects of m-CPP, the primary catabolic metabolite of trazodone, were last reviewed 2 years ago, research data continue to accrue showing that clinically significant levels of m-CPP (a) are generated in patients using trazodone for sleep and ( B) are present 24 h a day and © have potentially serious ill effects. This commentary argues that the documented potential for harm and multiple risks of m-CPP outweigh potential benefits of trazodone, given the development and marketing of many safer alternatives since trazodone's introduction in the 1980s.

 

Traffic jams with antidepressants in the liver
While trazodone is metabolized by liver enzyme P450 cyp 3A4 http://www.ncbi.nlm.nih.gov/pubmed/9616194

mCPP requires enzyme cyp 2D6 to leave your body Example: http://www.ncbi.nlm.nih.gov/pubmed/9836023

Liver enzyme enzyme cyp 2D6 also is necessary for metabolization of most antidepressants, such as Prozac and Paxil, and all tricyclic antidepressants.
 

If two or more drugs try to use cyp 2D6 in the liver, a "traffic jam" occurs and one or both of the drugs backs up, causing adverse reactions and possibly liver damage.

 

Additionally, about 10% of the population are cyp 2D6 "poor metabolizers" and particularly prone to this type of adverse reaction.

When trazodone is taken with another drug utilizing liver enzyme CYP2D6, the "traffic jam" in the liver can cause increased levels of mCPP, the other drug, or both in the blood stream, increasing the incidence of adverse events.

Special problems with Abilify (aripiprazole)
Abilify conflicts with trazodone via two liver pathways, cyp 3A4 and cyp 2D6. See https://www.pharmgkb.org/label/PA166104839

 

This can cause 1) delay of trazodone metabolism via cyp 3A4 and a backup of trazodone, increasing side effects or 2) delay of mCPP metabolism via cyp 2D6 and a backup of mCPP, or 3) both.

 

Huge number of drug interactions with trazodone
Major drug interactions with trazodone http://www.drugs.com/drug-interactions/trazodone.html
include:

5-HTP (5-hydroxytryptophan)
amitriptyline
BuSpar (buspirone)
Celexa (citalopram)
Cymbalta (duloxetine)
doxepin
Lexapro (escitalopram)
lithium
Luvox (fluvoxamine)
mirtazapine
Nardil (phenelzine)
nefazodone
nortriptyline
Prozac (fluoxetine)
Savella (milnacipran)
Wellbutrin (bupropion)
Zoloft (sertraline)
and on for 138 drugs, and that's just the major interactions.

Danger of serotonin syndrome
Trazodone and mCPP are serotonergics. Taking trazodone with antidepressants can cause serotonin overload or serotonin syndrome.

At the extreme, serotonin syndrome is a life-threatening condition. But even an increased serotonin level of serotonin in the bloodstream can be dangerous.

Unnecessary polypharmacy
If your doctor has given you a benzo to help with adverse effects caused by trazodone, mCPP, or drug interactions, you are taking two medications to counter the adverse effects of another drug: Trazodone to counter insomnia from the antidepressant and a benzo to counter the effects of trazodone.

Should I go off trazodone first?
If you are having any of the above adverse effects of trazodone, you might consider reducing trazodone first.

BUT -- if you're taking trazodone because your antidepressant keeps you awake, what should you do?

You might reduce the antidepressant first, part way. If it's interacting with trazodone, this may enable the trazodone and mCPP to be metabolized faster, and reduce the adverse effects of trazodone.

To see if reducing your antidepressant (or other medication) will help reduce adverse effects of trazodone, look here to see if your antidepressant is a substrate or inhibitor of cyp 3A4 or cyp 2D6, the liver enzymes needed to metabolize trazodone and mCPP.

Trazodone tablet dosages
Official FDA information (with NDC codes for ordering): http://www.drugs.com/pro/trazodone.html
 

Quote

Trazodone HCl is supplied for oral administration in 50 mg, 100 mg and 150 mg tablets.

....
Peak plasma levels occur approximately one hour after dosing when Trazodone hydrochloride is taken on an empty stomach or two hours after dosing when taken with food.

 

Reduce trazodone by 10% per month to start
The 10% rule holds for trazodone, just like other antidepressants: Reduce by 10% per month, calculated on the last dosage. (The amount of the reduction gets progressively smaller.)

See Why taper by 10% of my dosage?

Cutting up tablets to taper
If you're taking more than 50mg trazodone, you might ask your doctor or pharmacy to fill your prescription with 50mg tablets (i.e. instead of 30 100mg tablets, 60 50mg tablets per month).

Then you can cut a piece from a 50mg tablet to reduce your dosage by 10%.

Weighing your tablets with a digital scale will enable accurate dosage.

Get trazodone oral solution from the pharmacy
In the UK, trazodone is available in liquid form, each 5ml containing 50mg trazodone.

Use an oral syringe for dosing.

Order a liquid from a compounding pharmacy
Compounding pharmacies can make a liquid from medications that do not have special extended-release coatings or Cymbalta.

Your doctor will have to write a prescription specifying how the drug is to be compounded.

Use an oral syringe for dosing.

Dissolving trazodone in water to make a liquid
According to the US National Library of Medicine http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=42836232-a71f-4e4b-8060-2bdbd853398a#nlm34089-3
 

Quote

It is a white to off-white crystalline powder which is sparingly soluble in chloroform and in water.

On the other hand, according to this Material Safety Data Sheet (pdf) from ScienceLab, it may be "partially soluble in cold water."

Our member Rhi has made suspensions from drugs that are technically insoluble in water, see http://survivingantidepressants.org/index.php?/topic/2883-tips-for-tapering-off-trazodone-desyrel/page__view__findpost__p__45161

I haven't personally done this and I don't know of anyone who has, so if you do it, please post your experience in this topic.

Also see How to make a liquid from tablets or capsules

Use an oral syringe for dosing.

 

Using a combination of tablets or capsules and liquid

Rather than switch directly to an all-liquid dose, you may wish to take part of your dose in liquid and part in lower-dose tablets or capsules, gradually converting to all liquid as you get to lower dosages. This can be very convenient and reduce any problems switching from one form of the drug to another.

 

If your doctor prescribes liquid and tablets or capsules at the same time, most likely he or she will have to indicate "divided doses" in the prescriptions to get the drugs covered by insurance.

 

Going off trazodone CR or extended-release

Trazodone immediate-release has a half-life of about 7 hours. The extended-release form has a half-life of 10 hours. That is not a big difference.

 

If you cut an extended-release tablet, a piece probably will act like immediate-release trazodone. Lots of people take immediate-release trazodone. You may or may not feel the difference.

 

Depending on the dosage you're taking, you may wish to gradually transition to immediate-release trazodone in order to use a liquid in the last phase of your taper. You won't be able to make a liquid from a CR or extended-release tablet, they contain glue that becomes gummy mixed with water.

Edited by manymoretodays
updated, added link to Flockhart table-TM, in section on Should I go off trazodone first

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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  • 6 months later...

Hi Alto

 

After seeing my doctor today and discussing some problems with her regarding trazodone, we both decided that it would be best for me to take 75mgs every 6 hours instead of the 100mgs every 8 hours, because 100mgs started to make me feel zombied and didn't seem to last until my next dose was due.

 

As we know, tablets don't come in 75mgs only 150, 100 and 50, and my doctor said she was unable to prescribe me a liquid version because of the cost, and the liquids were only reserved for people with feeding tubes or otherwise unable to take a tablet.

 

My intention was to make 100mg : 100ml solution and draw off 25mgs leaving me with 75mgs each dose time.

When I went back to my jar of trazodone solution, however, it looked uneven, as if something had not dissolved. The water was cloudy and there seemed a deposit on the bottom.

Whilst doing a google search to see how to get around this problem, I came up with this link which says trazodone is insoluble.

http://www.sigmaaldrich.com/united-kingdom.html

 

I went and spoke to a pharmacist at our local chemists, and she advised me not to try to get 75mg trazodone from a 100mg capsule as capsules were not designed to be tampered with, and there was a high chance I would not be giving my self the correct dose, because of the uneven distribution of the trazodone in the liquid.

She never said anything about solubility or insolubility.

She was really helpful and phoned my surgery and got a doctor to issue me with 150mg pills, as I can split them into 75mg pieces.

 

It seems opinions on trazodones solubility is divided, as I read another post from a trazodone user who also said it did not dissolve, but they were not scientifically qualified.

pregan taper 600mg down to 240mg, daily cuts since xmas

valium, just over 75mg, tapering 0.1 a day, will keep this more udated, cos amounts going down

i have borderline personality, chronic ptsd, and suspected adhd and substance misuse as a symptom, which i am addressing with help of medical staff, drugs agencies & mh sta

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primrose, if you want to take 75mg trazodone, splitting a 150mg tablet seems as good a way as any.

 

Apparently trazodone is "sparingly soluble" in water, meaning not so much. The FDA info I had from drugs.com was incorrect. I've corrected post #1.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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Hi Alto and thanks.

 

What does sparingly soluble mean please?

pregan taper 600mg down to 240mg, daily cuts since xmas

valium, just over 75mg, tapering 0.1 a day, will keep this more udated, cos amounts going down

i have borderline personality, chronic ptsd, and suspected adhd and substance misuse as a symptom, which i am addressing with help of medical staff, drugs agencies & mh sta

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Slightly soluble.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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Doc told me the other day Traz comes in a powder. Don't know what that would be measured with but I'll find out next visit..

C/T Celexa and Trazadone on Jan.29th 2014
Prescribed 1mg of Klonopin every 6 hours on Jan.29th
Began tapering Klonopin April 18th..stretching time between doses...at first one hour for 2 weeks then a half hour for app.10 days then another half hour 10days later.
Presently at .25 three times a day..6 2 and 10pm. Trying to stabilize.
Also still taking gabapentin 300mgs 2xs a day..

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Hi Alto and flower, that would be useful to know.

 

Luckily, my 150mg tablets were ready to pick up yesterday, so I am now on two of them a day (chopping them up to make 75mgs 4 x a day)

 

This link seems to suggest that light degrades trazodone and to keep in a light sensitive container http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=33648

It's relevant for me because I have my pills split in half so the powder is exposed.

pregan taper 600mg down to 240mg, daily cuts since xmas

valium, just over 75mg, tapering 0.1 a day, will keep this more udated, cos amounts going down

i have borderline personality, chronic ptsd, and suspected adhd and substance misuse as a symptom, which i am addressing with help of medical staff, drugs agencies & mh sta

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Hi Alto and flower, that would be useful to know.

 

Luckily, my 150mg tablets were ready to pick up yesterday, so I am now on two of them a day (chopping them up to make 75mgs 4 x a day)

 

This link seems to suggest that light degrades trazodone and to keep in a light sensitive container http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=33648

It's relevant for me because I have my pills split in half so the powder is exposed.

 

that's good to know, are you preparing to taper?

C/T Celexa and Trazadone on Jan.29th 2014
Prescribed 1mg of Klonopin every 6 hours on Jan.29th
Began tapering Klonopin April 18th..stretching time between doses...at first one hour for 2 weeks then a half hour for app.10 days then another half hour 10days later.
Presently at .25 three times a day..6 2 and 10pm. Trying to stabilize.
Also still taking gabapentin 300mgs 2xs a day..

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Hi Alto and flower, that would be useful to know.

 

Luckily, my 150mg tablets were ready to pick up yesterday, so I am now on two of them a day (chopping them up to make 75mgs 4 x a day)

 

This link seems to suggest that light degrades trazodone and to keep in a light sensitive container http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=33648

It's relevant for me because I have my pills split in half so the powder is exposed.

 

that's good to know, are you preparing to taper?

 

Not yet Flower

 

I was tapering my valium and held the taper due to symptoms. When things got better, I cut 112.5mg off my seroquel last week, so am holding things again at the moment.

I will then taper my valium again.

 

Not looking forward to the traz taper. Beleiving it to be water soluble, I thought there would not be a problem, but discovered that it is not fully water soluble.

pregan taper 600mg down to 240mg, daily cuts since xmas

valium, just over 75mg, tapering 0.1 a day, will keep this more udated, cos amounts going down

i have borderline personality, chronic ptsd, and suspected adhd and substance misuse as a symptom, which i am addressing with help of medical staff, drugs agencies & mh sta

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As near as I can tell, trazodone powder is available only for experimental purposes. If you find you can get it by prescription, please let us know.

 

From Children’s Hospitals and Clinics of Minnesota http://www.childrensmn.org/manuals/pfs/med/018920.pdf

 

Trazodone comes in pill form. It can also be

made into liquid by your pharmacist.

 

Give it at regular times, to keep a steady

level in the bloodstream. It may take 1-4

weeks for effects to be seen.

 

If using the liquid form, shake well right

before using. ....

 

For children who cannot swallow pills:

 

• Crush it between 2 spoons or crush it

inside a plastic bag or in folded paper.

 

• Mix the powder with a very small

amount (about 1 teaspoon) of soft food,

such as applesauce, chocolate syrup, ice

cream, jelly, or yogurt. Make sure your

child takes all of the mixture.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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*Woops* I made a mistake above

 

I cut from 112.5mg seroquel to 100mgs, sorry for the confusion.

pregan taper 600mg down to 240mg, daily cuts since xmas

valium, just over 75mg, tapering 0.1 a day, will keep this more udated, cos amounts going down

i have borderline personality, chronic ptsd, and suspected adhd and substance misuse as a symptom, which i am addressing with help of medical staff, drugs agencies & mh sta

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  • 4 weeks later...
  • Administrator

About solubility or insolubility, Rhi has made many, many homemade liquids:

 

I'm kind of out of it right now and need to go to bed, but I just wanted to toss in my usual bit on the subject of making preparations for liquid tapering, which is: I personally don't worry about solubility.

 

None of the meds I'm tapering are actually soluble in water. But the pills dissolve into small enough particles that I can stir them up and keep them suspended in water while I measure them out, and that seems to work for me. I stir well before I measure, I stir a little while pipetting them up; I dissolve the pills in glass and pipette out of glass so that I can see visually how evenly everything is suspended, and that's good enough for me.

 

I use water as a medium because I like it that I can easily see for myself how evenly the little particles are suspended or if they seem to be settling out. Also because it's handy and cheap and I don't have to carry it with me if I travel.

 

Mostly I would just say, I don't think it really matters if the medication is soluble in whatever vehicle you're using, as long as it can be evenly distributed. What really matters is that it be evenly distributed and that your method be repeatable and consistent.

 

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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That is encouraging thankyou.

pregan taper 600mg down to 240mg, daily cuts since xmas

valium, just over 75mg, tapering 0.1 a day, will keep this more udated, cos amounts going down

i have borderline personality, chronic ptsd, and suspected adhd and substance misuse as a symptom, which i am addressing with help of medical staff, drugs agencies & mh sta

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  • 1 month later...

I am on trazodone 50 mg and want to come off

can somebody suggest the best way to taper

each time i try i hit total sleeplessness

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If you figure this out Sassy let me know..I too take 75mgs.. How long have you taken it? I will watch your progress.

C/T Celexa and Trazadone on Jan.29th 2014
Prescribed 1mg of Klonopin every 6 hours on Jan.29th
Began tapering Klonopin April 18th..stretching time between doses...at first one hour for 2 weeks then a half hour for app.10 days then another half hour 10days later.
Presently at .25 three times a day..6 2 and 10pm. Trying to stabilize.
Also still taking gabapentin 300mgs 2xs a day..

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the general rule... 10% of current dose tapers...every 2 to 4 weeks... I've seen work just fine...

 

also it seems, in general, that most people have less problems with trazadone causing other symptoms besides insomnia...so just going really slow and easy, allowing the body to adapt to the change, seems to work quite well.

Everything Matters: Beyond Meds 

https://beyondmeds.com/

withdrawn from a cocktail of 6 psychiatric drugs that included every class of psych drug.
 

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  • 5 months later...

I apologize if this was addressed in a previous post but I can't seem to find it.

 

I was thinking of using a mg scale to measure my Trazadone reductions but not sure if it makes sense: are medications assigned a mg based on the weight of the pill or the amount of active medication? In other words, can I use a pill cutter to weigh 20mg traz, etc.

 

Thank you!

 

Anna

-1/10-Rxed 50mg Zoloft & .5mg Klonopin daily after a death in the family

- 2/2012 Successfully micro tapered off .5mg of Klonopin after being on daily for 2 years. Started 100mg of Trazadone for sleep slowly tapered to 25mg w/ out issues.

- 2/2012-7/2013Symptom free not an ounce of anxiety or depression. 

- July 2013- Stopped trazadone for 5 days and immediately reinstated. 3 weeks started having severe withdrawal episodes that mimicked benzo w/d. 

- Oct 2013- Quickly tapered off 25mg of trazadone. Bad idea! But finally trazadone free. 

- July 2015- present Became very ill with lyme like sxs

-August 2018-present. Started micro taper off 50mg of Zoloft via liquid titration  ... 

- July 2021- down to 3mg.. had digestive issues so got an endoscopy and started experiencing major depression anxiety, weakness, near fainting, loss of appetite etc updosed to 10mg experienced akathisia -August 2021- present. Holding at 6mg. Unable to stabilize.  Experiencing near fainting, agitation, major depressive episodes. Had to quit job. Feeling hopeless. 

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Hi Anna,

 

Here is the information about using a scale for measuring medication:

 

http://survivingantidepressants.org/index.php?/topic/1596-using-a-digital-scale-to-measure-doses/#entry13379

 

scroll down to post #8 for an answer to your question.

 

 

I'm not a doctor.  My comments are not medical advise. These are my opinions based on my own experience and what I've learned. Please discuss your situation with a medical practitioner who has knowledge of tapering and withdrawal...if you are lucky enough to find one.

My Introduction Thread

Full Drug and Withdrawal History

Brief Summary

Several SSRIs for 13 years starting 1997 (for mild to moderate partly situational anxiety) Xanax PRN ~ Various other drugs over the years for side effects

2 month 'taper' off Lexapro 2010

Short acute withdrawal, followed by 2 -3 months of improvement then delayed protracted withdrawal

DX ADHD followed by several years of stimulants and other drugs trying to manage increasing symptoms

Failed reinstatement of Lexapro and trial of Prozac (became suicidal)

May 2013 Found SA, learned about withdrawal, stopped taking drugs...healing begins.

Protracted withdrawal, with a very sensitized nervous system, slowly recovering as time passes

Supplements which have helped: Vitamin C, Magnesium, Taurine

Bad reactions: Many supplements but mostly fish oil and Vitamin D

June 2016 - Started daily juicing, mostly vegetables and lots of greens.

Aug 2016 - Oct 2016 Best window ever, felt almost completely recovered

Oct 2016 -Symptoms returned - bad days and less bad days.

April 2018 - No windows, but significant improvement, it feels like permanent full recovery is close.

VIDEO: Where did the chemical imbalance theory come from?



VIDEO: How are psychiatric diagnoses made?



VIDEO: Why do psychiatric drugs have withdrawal syndromes?



VIDEO: Can psychiatric drugs cause long-lasting negative effects?

VIDEO: Dr. Claire Weekes

 

 

 

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  • 1 year later...

I updosed last night to 50 mgs and will stay there for a few months, not going to make the same mistake twice (made a 20% cut and had horrible withdrawal sx) 
But I would like to read other people's experiences and get as much information as possible.

Several ssri's, antipsychotics, opiads and benzo's since 2003.

Flurazepam: rapid taper after 6 weeks usage in beginning of march 2015

Trazodone: rapid taper from 50ms to 0mgs end of july 2015

Current medication:12 mgs seroquel (from 25mgs)

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I had no problem cutting from 150 mg --> 50 --> 25 but I made the mistake of going from 25 to 0. The withdrawal took a couple of days to hit but was quite pronounced when it did come. Tremors, confusion, akathisia, ataxia and lots of aches and pains. I went back to 25 mg but it did not help so I tried going back to 50 mg and the relief was almost immediate, I could not believe the difference.

 

So I started over a couple of months later and I am back down to 25 mg where I will hold for at least 2 months before making about a 10% reduction this time. I made the mistaken assumption that Trazodone would be easier to stop than my other meds, maybe the initial cuts were far easier but CT from 25 mg was just as bad as other things I have stopped.

 

BTW I also had a severe psychotic reaction within a couple of hours of taking 50 mg of Trazodone after cutting Zopiclone by 50% based on my doctor's recommendation.

Cymbalta - 90 mg
Risperidone - 5 mg
Ativan - 3-5 mg (3mg tablets, 2 mg sub-lingual)
* Zopiclone - 7.5 mg (down from 15 mg)
* Trazodone - 25 mg (down from150 mg)
Tegretol - 900 mg
Baclofen - 30 mg
Inderal - 40 mg

My Introduction Page

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Hi,

I was put on trazodone 3 weeks ago 50mg. I tried to cut a quarter off to taper and felt horrible the next day. I  had to go back to 50mg. I'm going to get a pill cutter and just take a little off. I don't want to be on something that causes so much pain when you don't take it.

I have been on Lexapro for 10 years

I have tried to get off many many times. 

Right now I am at the max dose of 20mg.

I also take Trazodone 50mg to help me sleep. 

 

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  • 2 weeks later...

I get the 10% taper, but specifically what would be the tapering amounts for tapering off 300mg of Trazodone. I can't figure out the math and the other posts were about 50 or 150 Trazodone. Thanks for any specific advice or maybe there is someone on this forum that helps people with their tapers?

Trazodone 150-300 nightly

Ambien CR. 3-5 times a week

Taking Klonopin crossing over to Valium started 6-25-15

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  • 2 weeks later...

300-->270-->243-->218.7-->196.8-->177.2-->159.4-->143.5-->129.1-->116.2-->104.6-->94.2-->84.7-->76.3-->68.6-->61.8-->55.6-->50-->45-->

 

40.5-->36.4-->32.8-->29.5-->26.5-->23.9-->21.5-->19.3-->17.4-->15.7-->14.1-->13.0-->11.7-->10.5-->9.5-->8.5-->7.7-->6.9-->6.2-->5.6-->5-->

 

4.5-->4.1-->3.7-->3.3-->3-->2.7-->2.4-->2.2-->2-->1.8-->1.6-->1.5-->1.3-->1.2-->1.1-->1

 

Numbers are less accurate the smaller they get but this should still be a good guideline.

Cymbalta - 90 mg
Risperidone - 5 mg
Ativan - 3-5 mg (3mg tablets, 2 mg sub-lingual)
* Zopiclone - 7.5 mg (down from 15 mg)
* Trazodone - 25 mg (down from150 mg)
Tegretol - 900 mg
Baclofen - 30 mg
Inderal - 40 mg

My Introduction Page

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If you get really pronounced symptoms, do you need to updose or wait it out? I'm confused about this. 

Several ssri's, antipsychotics, opiads and benzo's since 2003.

Flurazepam: rapid taper after 6 weeks usage in beginning of march 2015

Trazodone: rapid taper from 50ms to 0mgs end of july 2015

Current medication:12 mgs seroquel (from 25mgs)

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Thank you, Amygdala.

 

lanah, if you get really pronounced withdrawal symptoms, you are tapering too fast. If you have been reducing by more than 10% for a while, thus risking withdrawal symptoms, you may need to updose.

 

If you have just made a 10% decrease and experience really pronounced withdrawal symptoms for the first time, you might try waiting it out and make a smaller decrease the next time. There's no way to predict if waiting it out will work. It's up to you if you want to go back to the previous dose at which you were stable.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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  • 1 year later...

Does Trazadone ( a non-Ssri) have the same risks of causing The protracted withdrawal syndrome caused by SSRI's, when it is discontinued at a slow taper?

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We have people here who have had problems going off trazodone and took quite a while to recover. It's difficult to tell if the risk of withdrawal syndrome is the same as the SSRIs, trazodone isn't prescribed as often.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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  • 2 months later...

My GP handed me a prescription for Trazadone a year ago for sleep issues. I used to work swing shift and had many sleep issues. He knew I was already on Zoloft but handed them out to me anyway. He said "It probably will even help with your depression"....Ugh!! Of course at that time I didn't know any better and used them on a as needed basis. So basically popping a 20mg pill once or twice a week when my bad sleep periods would hit. I used them like sleeping pills because I didn't know any better. I quit using them months ago but never tapered, just CT'd. I haven't experienced anything negative after quitting. That may be due to the short sporadic time I was using them. I know better now. The complete ignorance that some doctors have is very disturbing to me. It's hard for me to have trust in doctors anymore.

April 26th - 36.5>32.8mg Z.

Feb 4th - 40.5>36.5mg Zoloft.

Jan 5th - 45>40.5mg Zoloft.

Dec 6th - 50>45mg Zoloft.

Nov 1st - 53>50.0mg Zoloft. Sep 22/17 - 50.0>53.0mg Zoloft. Sep 18/17 - 59.0>50.0mg Zoloft.

Aug 7/17 - 65.6>59.0mg  July 18/17 - 72.9>65.6mg. June 18/17 - 81>72.9mg 

May 28/17 - 90>81mg.  May 8/17:  Started my taper. 100>90mg

1995 to May 8/17:  100mg Zoloft/day.  Working well but suspecting some signs of Tolerance this past year.

4/5/17:  Started Testosterone Replacement Therapy via T pellet insertion.  Diagnosed with Secondary Hypogonadism.

Supplements:  1000mg fish oil, 10,000iu Vit D3 with K2, 400mg Magnesium.

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Yes, sporadic use may not cause the neurological adaptation that leads to withdrawal syndrome.

 

The combination of trazodone with an SSRI like Zoloft is common but often leads to drug-drug conflicts, see https://www.drugs.com/drug-interactions/trazodone-with-zoloft-2228-0-2057-1348.html

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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  • 1 month later...

Trazodone and Zoloft is also the combination that is the bane of my existence..... 

2000: Paxil, low dose. 2001: Paxil, quickly tapered off. 2006: Zoloft, 25mg. 2007: Wellbutrin, low dose, discontinued after a week or a month. 2007-2009: Zoloft, increasing dose (up to 75mg). 2009-2011: Zoloft, failed withdrawal attempts (cold-turkey; fast tapering). 2009-2011: Trying out Cymbalta, Celexa, Prozac, Lexapro, Ambien, Ativan, and Xanax. 2012-2015: Zoloft, 100mg to 200mg. 2013: Trazadone for Zoloft-induced insomnia, 25mg to 50mg.  2015: Trileptal, dose?, withdrew; Bupropion, up to 200mg. 2016: Zoloft, 137mg, Bupropion, 150mg, Trazodone, 25mg.

05/21/16: Began Zoloft taper - 10% from 150mg - 137ish mg

06/23/16: Zoloft taper - 125mg

08/03/16: Bupropion XL taper - cut 150mg pill in crude half (mistake)

10/31: Zoloft successfully down to 100mg. Staying on 100mg for 2-3 months to let my brain rest.

11/09: Wellbutrin SR prescribed, 150mg once a day, for withdrawal.

12/11: Wellbutrin SR, twice daily - minus 18ishmg = 112.50mg

09/30/17: Off Wellbutrin SR successfully. Zoloft taper: 90ish mg (shaving it off). Trazodone: still at 50mg.

June 2018: Zoloft: 80ish (shaving off). Trazodone: 6mg. End of 2018: Off Trazodone.

01/20: Zoloft: 70ish?

08/20: Still around 80 or 70. Tapering by only 15 shaves each month.

04/2021: 50mg!

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  • 1 year later...

I've been on Trazodone for 4 months and most of that was only 2x/week.

 

I just started tapering 10% from my (now) nightly 100 mg.

 

Because I haven't been on it very long I'm intending to try tapering 10% every week for 6 months, which will get me down to 5 mg before jumping off.  I know that everyone reacts differently but does this sound ballpark reasonable?

  • 2019-01-16 50 mg of Trazodone 2x/week
  • 01-23 up to 100 mg, various frequencies and dosages
  • 05-03 100 mg
  • 05-10 90 mg
  • 05-16 Starting tapering by 2.5 mg/day
  • 05-30 50 mg
  • 05-31 65 mg
  • 06-07 75 mg
  • 06-15 67.5 mg
  • 06-17 75 mg
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  • 4 weeks later...

It's been a difficult emotional journey for me, accepting that I'm dependent on Trazodone.  I know that personal stories belong in another location on the forum.

 

Here I am looking for motivational support.  It would help me enormously to read about a Trazodone success story but I'm having trouble finding any with the search function.  Can anyone point me to Trazodone success stories?

 

Many thanks,

Courageous

 

  • 2019-01-16 50 mg of Trazodone 2x/week
  • 01-23 up to 100 mg, various frequencies and dosages
  • 05-03 100 mg
  • 05-10 90 mg
  • 05-16 Starting tapering by 2.5 mg/day
  • 05-30 50 mg
  • 05-31 65 mg
  • 06-07 75 mg
  • 06-15 67.5 mg
  • 06-17 75 mg
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12 minutes ago, Courageous said:

It's been a difficult emotional journey for me, accepting that I'm dependent on Trazodone.  I know that personal stories belong in another location on the forum.

 

Here I am looking for motivational support.  It would help me enormously to read about a Trazodone success story but I'm having trouble finding any with the search function.  Can anyone point me to Trazodone success stories?

 

Many thanks,

Courageous

 

I was on trazodone a few years ago for about 6 months as an attempt at a sleep aid. It never worked. I tapered off of it without much trouble. I'm sure others have tapered it successfully, too. People just naturally tend to post when they're having trouble.

 

MN

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Thank you, MN!  You just made my day!

 

May I ask how long your taper took and whether you needed to use a compounding pharmacy/liquids, etc., or just cut 50 mg tablets?

 

  • 2019-01-16 50 mg of Trazodone 2x/week
  • 01-23 up to 100 mg, various frequencies and dosages
  • 05-03 100 mg
  • 05-10 90 mg
  • 05-16 Starting tapering by 2.5 mg/day
  • 05-30 50 mg
  • 05-31 65 mg
  • 06-07 75 mg
  • 06-15 67.5 mg
  • 06-17 75 mg
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  • Moderator Emeritus
7 hours ago, Courageous said:

It would help me enormously to read about a Trazodone success story but I'm having trouble finding any with the search function.  Can anyone point me to Trazodone success stories?

 

I went to the Success Stories and typed trazadone in the search bar and clicked on Forum.  This is the link:

 

https://www.survivingantidepressants.org/search/?q=trazadone&type=forums_topic&nodes=28

 MISSION ACCOMPLISHED:    13 November 2021 -  0mg Pristiq      

Woohoo!!!  Finally off Pristiq   

ADs since ~1992:  25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq:  50mg 2012, 100mg beg 2013 (Serotonin Toxicity)  Tapering from Oct 2015 - 13 Nov 2021   LAST DOSE 0.0025mg

My full tapering program     My Intro (goes to my tapering graph)    My website

PLEASE NOTE:  I am not a medical professional.  I provide information and make suggestions.  I do not provide tapering advice via PM.  Please post questions in your Introduction topic.  Please do not tag me for any reason.  I am an unpaid volunteer and assist members if I am able to and when I have the time.  Thank you for your understanding.

Mid Nov 2021 changed to low carb diet due to diabetes & cholesterol.  Lost 1/16 body weight, BP has reduced a lot. 

Links to my exercises and weights.  I also do 3 x 5.5 min with HIIT on exercise bike with 20 secs/min as fast as I can cycle.

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