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Tips for tapering off trazodone (Desyrel)

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Courageous
34 minutes ago, ChessieCat said:

 

I went to the Success Stories and typed trazadone in the search bar and clicked on Forum.  This is the link:

 

https://www.survivingantidepressants.org/search/?q=trazadone&type=forums_topic&nodes=28

 

Thank you.  I didn't think to try searching for that misspelling of 'Trazodone'.  Unfortunately the search results from your link are uninspiring—not a single success story as far as I can tell.  😞

 


  • 2019-01-16 50 mg of Trazodone 2x/week
  • 01-23 up to 100 mg, various frequencies and dosages
  • 05-03 100 mg
  • 05-10 90 mg
  • 05-16 Starting tapering by 2.5 mg/day
  • 05-30 50 mg
  • 05-31 65 mg
  • 06-07 75 mg
  • 06-15 67.5 mg
  • 06-17 75 mg

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ChessieCat

You could try searching for trazadone (try both spellings 😉) in the main Introduction forum and look for members who have a sun symbol ☼


Being very patient.  I'll get there - slowly.  ETA mid 2021

ADs:  25 years - 1 unknown, Prozac (caused muscle weakness), Zoloft/sertraline; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after)

Pristiq:  50mg 2012, 100mg beg 2013 (mild Serotonin Toxicity)

Began tapering Oct 2015  Current from 12 Sept 2020:  Pristiq 0.625 mg (compounded)

My tapering program

My Intro (goes to my tapering graph)

My website - includes my brief history + links to videos & information on the web

PLEASE NOTE:  I am not a medical professional.  I provide information and make suggestions.

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Courageous

Thanks for that tip!  After 20 minutes of searching I found two:

 

☼-sharkface-enduring-a-long-taper-hang-in-there

 

and

 

On 3/1/2016 at 11:01 AM, marie123 said:

Hi Sharkface,

 

I got off Trazadone 2 months ago with a nice slow taper of 11 months. I'm glad to rid of it.

 

Marie

 

marie123's Introduction topic

 

 

Edited by ChessieCat
fixed up links and added marie's intro topic link

  • 2019-01-16 50 mg of Trazodone 2x/week
  • 01-23 up to 100 mg, various frequencies and dosages
  • 05-03 100 mg
  • 05-10 90 mg
  • 05-16 Starting tapering by 2.5 mg/day
  • 05-30 50 mg
  • 05-31 65 mg
  • 06-07 75 mg
  • 06-15 67.5 mg
  • 06-17 75 mg

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Courageous

Has anyone figured out what the SERT transporter occupancy relationship is for Trazodone?  I've become curious after reading the table for Citalopram in the Horowitz paper.

 


  • 2019-01-16 50 mg of Trazodone 2x/week
  • 01-23 up to 100 mg, various frequencies and dosages
  • 05-03 100 mg
  • 05-10 90 mg
  • 05-16 Starting tapering by 2.5 mg/day
  • 05-30 50 mg
  • 05-31 65 mg
  • 06-07 75 mg
  • 06-15 67.5 mg
  • 06-17 75 mg

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brassmonkey

There is a lot more to trazodone than just SERT loading, but the following paper talks a lot about it around page 26.

 

https://kclpure.kcl.ac.uk/portal/files/92011077/Evaluating_the_dose_dependent_SETTIMO_Published15January2018_GREEN_AAM.pdf


20 years on Paxil starting at 20mg and working up to 40mg. Sept 2011 started 10% every 6 weeks taper (2.5% every week for 4 weeks then hold for 2 additional weeks), currently at 7.9mg. Oct 2011 CTed 15oz vodka a night, to only drinking 2 beers most nights, totally sober Feb 2013.

Since I wrote this I have continued to decrease my dose by 10% every 6 weeks (2.5% every week for 4 weeks and then hold for an additional 2 weeks). I added in an extra 6 week hold when I hit 10mg to let things settle out even more. When I hit 3mgpw it became hard to split the drop into 4 parts so I switched to dropping 1mgpw (pill weight) every week for 3 weeks and then holding for another 3 weeks.  The 3 + 3 schedule turned out to be too harsh so I cut back to dropping 1mgpw every 4 weeks which is working better.

Current dose 0.000mg 04-15-2017

 

"It's also important not to become angry, no matter how difficult life is, because you can loose all hope if you can't laugh at yourself and at life in general."  Stephen Hawking

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Altostrata

The Horowitz SERT occupancy theory can be taken as a metaphor for all psychopharmacological relationships being hyperbolic; the techique of exponential reduction is likely to apply to any target no matter what it is.


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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Courageous
On 6/15/2019 at 3:44 PM, brassmonkey said:

There is a lot more to trazodone than just SERT loading, but the following paper talks a lot about it around page 26.

 

https://kclpure.kcl.ac.uk/portal/files/92011077/Evaluating_the_dose_dependent_SETTIMO_Published15January2018_GREEN_AAM.pdf

 

Thank you!

 


  • 2019-01-16 50 mg of Trazodone 2x/week
  • 01-23 up to 100 mg, various frequencies and dosages
  • 05-03 100 mg
  • 05-10 90 mg
  • 05-16 Starting tapering by 2.5 mg/day
  • 05-30 50 mg
  • 05-31 65 mg
  • 06-07 75 mg
  • 06-15 67.5 mg
  • 06-17 75 mg

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Shashal

So this is why I experienced some severe muscle symptoms during my last benzo tapering procedure even after I had jumped benzo! I reported to different doctors about this life-threatening event and they said “Don’t worry, it’s just because you are too anxious “🙄

 

On 7/20/2012 at 12:40 PM, Altostrata said:

Unnecessary polypharmacy
If your doctor has given you a benzo to help with adverse effects caused by trazodone, mCPP, or drug interactions, you are taking two medications to counter the adverse effects of another drug: Trazodone to counter insomnia from the antidepressant and a benzo to counter the effects of trazodone.

 

Edited by ChessieCat
removed blasphemy

Dependence of 0.4mg Xanax night dose only within 8 weeks, felt unreasonable anxieties in afternoon. Tried twice C/T and failed with severe symptoms then reinstated and up-dosed then switched to 7.14mg Valium 6.27 7.14mg 7.4 5.92mg felt much better and got some windows  7.11 4.74mg 7.18 3.79mg 7.25 2.93mg got harder and slowed down a little 8.1 2.14mg felt good then speeded up 8.8 1.32mg speeded up too much now holding at 1.25mg felt bad but not bad as C/T  8.15 1.25mg felt a little improvement will try to continue my progress 8.22 0.79mg 8.28 0.5mg 8.29 Jumped (Never thought AD WD is a big deal so didn’t record the dosage for Trazodone )

 

9.12 Still on 100mg Zoloft prescribed by doctor who denied I was in benzo withdrawal but only anxiety from June / 25mg-50mg Trazodone on and off for sleep 9.15 Stop taking Trazodone symptoms not steady  9.16 50mg Zoloft before bed 75mg Zoloft in the morning up-dosed 25mg Zoloft to see if can replace the Trazodone  9.17 Failed, back to 100mg Zoloft in the morning, 20mg Trazodone before sleep 9.22 Got little stabilized90mg Zoloft in the morning, 18mg Trazodone + reinstated 1mg Valium for sleep 9.29 80mg Zoloft + 18mg Trazodone + 0.9mg Valium, stabilized 10.6 72mg Zoloft + 18mg Trazodone + 0.8 Valium 10.13 64mg Zoloft + 18mg Trazodone + 0.7mg Valium, blood test got positive result of D-dimer, made extra test for blood clot but nothing found, don’t know if it’s Zoloft related 10.20 Zoloft 56mg + 16.5mg Trazodone + 0.7mg Valium, only little symptoms of tinnitus, wake up early, fatigue and muscle pain. 10.27 Zoloft 48mg + 16.5mg Trazodone + 0.7mg Valium 11.3 41mg Zoloft + 16.5mg Trazodone, stopped taking Valium 11.10 36mg Zoloft + 16mg Trazodone 11.17 29mg Zoloft + 16mg Trazodone 11.24 22mg Zoloft +15mg Trazodone, D-dimer level went to normal 

12.1 15mg Zoloft + 15mg Trazodone 12.8 10mg Zoloft + 15mg Trazodone 

 

2019.12.15 Jumped Zoloft at 4mg 2020.1.4 Jumped Trazodone at 5mg  

6.1 95% healed! 

 

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lxjuice

Trazodone is only available as a capsule in the UK. It was easy to empty the capsule into water and pull it up with an oral syringe. The fact it is sparingly soluble means it has to be shaken before you take it and also stirred before you draw it up for the first time after emptying the cap. This avoids issues like crushing tablets and losing 10% of it or more to waste.


Dx: complex PTSD

Discontinuation/taper history: sertraline, trazodone, prazosin, mirtazapine, diazepam

Took 200mg quetiapine for 0.5 years and 150mg for 1.5 years until 01/2020. Now microtapering daily at an overall rate of 12.5mg/month.

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Altostrata

Thanks, @lxjuice , for that useful information.


This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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drugged
17 hours ago, lxjuice said:

Trazodone is only available as a capsule in the UK. It was easy to empty the capsule into water and pull it up with an oral syringe. The fact it is sparingly soluble means it has to be shaken before you take it and also stirred before you draw it up for the first time after emptying the cap. This avoids issues like crushing tablets and losing 10% of it or more to waste.

Thanks @lxjuice

 

I've got lots and lots of 100 mg tablets since I've never taken more than half the prescribed amount. Even using a slow taper I'm going to have tabs leftover so ... but thanks.

 

I'll probably just take the dry powder and wash it down with water rather than make a suspension unless there's a reason I shouldn't do it that way.  These are immediate release tabs so no coatings.  


1994  Venlafaxine XR 300mg, 2003 tapered, 2004 off briefly back to 37.5 then 75mg, held, June 2019 up to  150mg, Aug.12 tapered down to 112.5mgs, Oct. 21, 2019 96mg;  Dec. 8, 2019  90mg, Jan. 8 2020 81mg, Feb. 4, 75mg;

2003/2004? Diazepam 10mg/bedtime

2013 Lyrica 300mg to 25mg; April 6, 2020 17mg; April 28, <5mg; May 7, 2020 Lyrica 0 mg!

2013 Tramadol 50mg tablets, 200mg/day divided

2005? Trazodone 50mg bedtime, Feb. 12, 2020 40mg, March 7, 25mg

2009? Zolpidem 5mg at bedtime. Nov. 9, 2019 Zolpidem 0 mg! 

1990? Omeprazole 20mg in morning.

2010? Levothyroxine 75mcg morning

2011? Liothyronine 5mcg morning

1999? Buspirone 30mg twice a day  August 2019 15mg once a day,  Oct.21, 2019 2.5mg evening  Oct. 25, 2019 Buspirone 0 mg!

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