Iggy131313 validation is imminent

[Iggy131313]

Hi hon

 

my mum has been on seroxat (paxil) for 20 years......she also developed the intolerance to antihistamines, they increase serotonin and activate receptors so thats why, also as paxil directly acts on H1 inhibiting histamine....the brain of course will try to counter that by upregulating histamine receptors, as you taper and you have some receptor rebound and are not blocking those H1 receptors anymore, you are left with the new upregulated receptors and the old ones....thats why histamine issues could get worse... my mum has bad histamine issues that she never had before.....

 

you could try reducing histamine intake through your diet during pollen season etc, you might find it helps..theres alot of histamine intolerance stuff on here or you can join the facebook site the low histamine chef...xxx

 

cold and flu meds act BIG TIME on serotonin (5ht) receptors, should be avoided for sure, dangerous stuff...a cold will go away on its own, no need to medicate a cold....

[darktimes]

Hi iggy i drank a protein shake today and within an hour i got really spacey would you think the protein would have anythin to do with it ?

[Iggy131313]

Yes mate .... Its not the protien but they tryptophan content xx if it had whey in or tryptophan as an amino acid then it would activate your receptors...leave the protien shakes for now...perhaps in a year U could tolerate them x this reaction will wear off pretty fast...days...weeks at the most

 

That's my opionon anyway..i must always clarify that fact..but yes it was the shake

[darktimes]

Thanks iggy yeah it has tryptophan and lots of other amino acids will be more careful in future

[Djones1984]

Lot of interesting research you have done here. Any chance you can pm me your number? I would love to chat with you as I am going through the same ordeal.

[Iggy131313]

yes mate, Ill PM you tomorrow...hold on, Im in the UK you know...so its gonna cost you way too much, maybe skype

[Meimeiquest]

Thanks iggy yeah it has tryptophan and lots of other amino acids will be more careful in future

. I went off into extreme irritability with very high quality protein shake, which is "stage one" for me with anything that upsets my brain, stage 2 is the whirling thoughts,

[btdt]

I wasted 30 bucks on weigh powder once... never again. 

 

may have link for you think it is pot related 

http://www.autismone.org/content/important-new-scientific-paper-bradstreet-et-al

[Iggy131313]

yeah whey is packed full of tryptophan, as anythign that increases serotonin to the brain makes us worse, its a baaad idea, ive seen so many people react, same wit kefir and other high tryptophan things..I remember a gut contacting me saying he had drunk a gallon of milk and it had given him akathisia...he belived it was becasue it had acted a detox agent...nope tryptophan...

 

another guy who we are both friends with repeated the experiemnt (brave) he also got bad akathisia....(we all suffered akathisia anyway but it got far worse)

 

tryptophan#

 

thans for the link btdt, im not 100% sure of what its talking about....

 

I was layed in bed researching (got a list of topics I need to work on, at the moment its all about nM values and receptor occupancy, next its onto G protien uncoupling, phew!!)

 

Boyfriend said that I need to get out of the house, I agreed, went out for lunch which I was worried about as moving around makes me worse and eating DEFFO makes me worse.....ordered a glas of red wine and feltbetter for it, as always......its either gaba or its endorphins....anyway..

 

.it stayed quite mild.....went to boyfriends house and helped him clean for someone moving into his spare room....aka at bay...feeling kinda ok, not OK but ok

 

cleaned for 3 hours, the only times it revved up bad was when i smoked (i can always feel the cigerettes so much when im more severe...I guess its becasue ive had an upregulation and therefore am MORE sensitive)

 

went to the pub after 3 hours cleaning (around 7) and had another glass wine, played pool and had a good time...the distraction, the environment, the talking with people i dont know...all these things helped..in fact for the last 2 hours I had no symptoms at all....

 

went home at 10/11pm...once home i felt a TINY increase in sympoms as i started to think about them...had a bath and tried to relax....then STUPIDLY did 2 things at once......had a puff and had my dose...within 30 mins the aka got worse, and worse, and WORSE....it continued to get worse....at 4 hours after i was really very very bad......the night before i had no weed and also got worse and worse after my dose....perhaps not as bad as last night so i dont know

 

as usual sexual activity helped, but as soon as it stopped the aka was back.....after having an orgasm t styed away for a good 5 inutes and then hit me hard again....definitly dopamine

 

boyfriend was trying to comfort me....''its 4 hours after your dose, when its reached it max in the blood stream...and weeds making you worse, stop the weed''

 

hes right, but if i sop the weed for 4 weeks im gonna get the reaction.....maybe a week or 2 off would help....im not sure why weed would make me bad on smoking it....and only of course after the upregulation.....i will have to look further into it

 

but perhaps its my dose mainly as its basically like updosing, as more receptors are being activated as more have rebound....its a matter of waiting for either them to downregulate naturally or perhaps the small dose will eventually force them to

 

heres an interesting fact...we lose 18% of 5ht2a receptors per year until age 50........i wonder if that counts for someone who has a huge amount, percentage wise....i doubt it, as the woman who reacts to cold stuff who i asked if she hammered the XTC when she was younger hasnt touched it for over 20 years ....

 

god i want an assay done

 

so its day  of my cycle, its a bad one, this time last cycle i was heaving and retching ...it was either day 9, 10, and 11 that were the worst...OR it was days 10, 11, and 12

 

either way im around the very worst time....so watch this space

 

I have my son today, I will pick him up from school...i ordered him a new 100 quid scooter thats due to arrive today, cant wait to see his little face when i take it with me (of course, i have bonding issues AGGHHHHHHH)

 

and then Im going to TRY and do a school project with him, i wont be comfortable but ill try

 

i woke this morning with terror as usual, i can still feel it now, just sat in bed...when i get up to make a coffee in a sec it will get worse, i just hope that this cycle the symptoms are weaker than last cycle, im gonna do an experiement to see if my dose, the time of day or the weed is making me worse

 

serotonin is said to rise at 9, 10 and 11pm, its supopsed to be at its highest here.....also 5pm but the 5pm i saw in womans own magazine LOL...however I DO get worse at 5pm but as yet havent come across anything else that says it peaks at this time....

 

so it could be that from 9pm the stimulation of peaking serotonin is too much.....it lasts for 3 hours at a peak and then im over activated for the night

 

it could be that i take my dose at 9pm (although i took it later last night, when i got home)

 

or it could be thats whn ive been smoking some weed

 

so today....no weed, take my dose at 9pm see if i get worse after the dose.....

 

same again tomorrow

 

if I *do* get worse from 9......the day after I will take my dose at 6...I would like to move it to the morning but it will alter the levels too much so I would have to do that slowly....ill again monitor at 6pm for those 2 days.....if i *still* get worse at 9pm then i will know its the rising of serotonin thats doing it, and not the dose....

 

not that it matters i guess but i *do* like to know

 

ok, its 11.30 am and I just had a puff, (i kow i know) so lets see...oh its also worth mentioing that i had a puff in the pub last night with no bad effects, but I was occupueed and had alot of akathisia reliving things gong on...

[Iggy131313]

Interesting, smoked a few puffs today and akathisia not bad at all really.......that leadsme to think I am dealing with activation from my dose or from the time

 

HOWEVER I am developing eye floaters.......that happened during my last weed reaction, this time it could be to do with the upregulation from the missed dose...im not sure

 

I have come across a studie lnking ''impurities in the vitreous humor (eye floaters) being linked to upregulation of serotonin receptors, I dont have time to search now but will later.....for now there is this...

 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340756/

 

gotta run...got a little boy to make smile with a new scooter!!

[darktimes]

What part of uk you from iggy?

[Iggy131313]

I PMed you Mate

 

had an email from a well known withdrawal Dr, who has kindly sent me a few studies to look over..so will be running through those this eveing

 

had a slight flare of symtpoms around 5-6pm but not as bad as I have been...hangover/smoking weed...must be

 

be interesting to see what happens after my dose tonight

[Iggy131313]

Note to self...7.30pm and akathisia revved up quite bad......ate, but that was 40 minutes ago...so not sure why its bad now.....time of day?

 

http://www.ncbi.nlm.nih.gov/pubmed/19152552

[bluebalu86]

Iggy, I developed a huge amount of floaters when my withdrawal started on February 16th. Still experiencing them today. It would be interesting go know what causes them. They are very irritating and annoying. 

[Iggy131313]

hi Darling, its on my agenda, but im pretty sure its related to upregulation of 5ht receptors, I did alot of research on it last year when it was very bad, but all of that was lost on PP, and some links I just read and never posted anywhere, I should have kept all my info on one place.

 

Im not allowed to post anywhere but my own thread, but i have been keeping up to date with how you are doing...hang in there hon, things will get better I promise xx

[Iggy131313]

12.44pm

 

well im somewhat worse than yesterday, I guess thast to be expected as I dont have the hangover effect today, I had no booze yesterday...

 

ive had a little puff and thats helped some, but I can feel the akathisia and terror there...im still not as bad as I was this time in my last cycle so I guess I have to try and be grateful....

 

need to clean today and its gonna rev me, but i need to do it, and then this evening ill have a glass of red wine once Freddie is in bed so hopefully that will bring me some relief a bit tonight and also through tomorrow

 

the research continues, going to try and do a tiny bit this afternoon...if only compiling a list of things I need to print....god damn this akathisia....

 

Im looking towards the serotonin toxicity issues and leisons at the moment....Ive been there before but although its a factor for a while in withdrawal...its not the issue at hand as far as im concerned, we wont know until someone does a proper study using SPECT scans first on the brain and then after on receptors...not everyone has leisons, but they certainly happen in some...interestingly one of the most severe people I know had an MRI at 7 years off and there were no leisons....I wonder if there HAD been at an earlier point

 

Sunny had a SPECT and had restricted blood flow and signs of neurotoxicity....and leisons.....she is now healed, it would be very interesting to know if the SPECT scan would show any difference...but when your no longer having symptoms, why would you bother??? I wouldnt...thats why a study is called for...one with follow up SPECT scans at regular points (years apart) alongside receptor density assays...

 

people used to say to me on these forums...but uts not possible to see at receptor level unless the brain is removed sliced up and studied under a microscope...yes thats true of SEEING the receptors, but they can count the number and if there is a reduction or increase..using SPECT and binding lingands...

 

thats my aim...thats the end goal...to persuade SOMEONE, SOMEWHERE to do a small study, using SPECT , both on functional systems, blood flow, signs of neurotoxicity etc...and also receptor density and changes, on 5ht1a pre, 5ht1a post, 5ht2a and 5ht2c......even if it showed no change we would have one more answer than we had before

 

not looking forward to how the rest of today is going to go, hate this damn terror and akathisia

[Iggy131313]

Selma, it seems to me that your in a stable place to taper....stablity doesnt mean fine......make a small reduction, you may well find that it helps you.....good luck with your drop I will be thinking of you...

 

the fact that the pgad and aka are not happening and the emotional stuff is calming down is nothing short of a miracle....your doing great, and im so so proud of you xxx

 

Ive noticed that im waking with much nilder terror and dread...i havent had nausea since the last time I said I had nausea...either things are starting to settle or the weed has started to help again

 

yesterday AND the day before I have had a puff everytime i feel the aka kicking in, and it stops it.....its incredibly hard not to do that when i know I can function, I was explaining this to muddles yesterday, I was frozen to the living room chair, it was 5pm and a terrible time for aka, it was keeping me frozen with terror and agony, and then...I said oh F it....and i had a puff...the next minute im cooking Fredde his tea and cleaning with aka down from a 5 to a 1

 

but I think im improving from the setback...this time last month i wasnt able to do ANYTHING, just lay i bed and wail so im hvaing downregulation at last

 

im deffo DEFFO worse after my dose, but I need to let that settle some more before I drop.....Ill drop to 0.39 on the 11th May....if I feel its right at the time, otherwise I can put it off a few weeks or either a month...

 

cigs revving me uup this morning

[Iggy131313]

I learned SO much yeaterday, boyfrined is taking the micky out of me saying that Im a professor in biochemistry and being a bloomin pest...makes e laugh though.....I was trying to figure out what the HECK a G protien coupled receptor exactly is  and how that functions......

 

so if anyones interested...all of our serotonin receptors are G protien couples, apart from 5ht3....which is ion gated, the 5ht1a on the presynaptc side of a neuron is the autoreceptor...I learned nothing new reguarding symtpoms etc but its crucial i try to understand.......for my own sanity, it helps me, it cofrots me and knoweldge is power....if im wrong, and its quite possible I am...if we could find out for sure.....then at least it STILL brings us closer to an answer..by process of elimination

 

todays studys will consist of more reading about the strcture of serotonin nuerons, im getting there, neuron, axon, dendrites, synapse, pre synaptic and post synaptic and then the receptors on each side of the synapse......The mechanism each receptor uses and the second messenger reactions, im getting there, its a difficult concept but after alot of reading, drawing out diagrams for myself, watching videos and studying more and more Im getting somewhere.....this could take over a year until I know enough to wrote something decent, hope not...need to get something together asap

 

I have about 70 pages of studies and supporting evidence to print, highlight and file ready for referral...today Im working through a very long and VERY interesting document on serotonin syndrome that is printed (I have studies the MDNA study in MUCH detail) and also a 40 page book on serotonin receptors, but before I read that I need to understand cAMP a little more....once I grasp the function and mechanism of cAMP...then ill be ready to attempt the book on receptors.....

 

but to end on a high note, so yes, worst part of period, estrogen is high....i can tell and im no where near what I was before this setback.....but im functioning

 

ps - 3 sips of wine last night, not a big fan of drinking so ddidnt fancy it..not when my symptoms were not too bad

[Iggy131313]

quite truely.....if I can go from where I have been to this....there is hope for everyone...mine is because of the weed I know....but the fact is this.....even if its by finding the right supplliment or something, it doesnt have to stay acute and severe...3 years for me in a few weeks, and that it seems is enough time for me to have forgotten a previous life, as far as Im concerned my life has always been this, I became withdrawal for a looong time, i wasnt capable of anything else, too disabled, too much agony, going to places no human should ever go, where we are not equppied to survive....but slowly, slowly with the right approach....we will heal

 

and im gonna find some answers, even if its ONE small thing...i will not rest until I do

[Fizz]

Hi there Iggy, long time we've not spoken ay! I've just been muddling through, permanently exhausted. Unfortunately I'm now in a bad flare, haven't had one like this for ages. I was stupid enough to quit smoking and take up vaping around two weeks ago. Have had a real bad reaction to it, severe dizziness and other stuff I've not even experienced before. Of course I've stopped vaping but still feeling very ill, sleep has gone to nothing and all my cycling symptoms so much worse. I would love to get in contact with you for a quick chat, tell you how annoyed I am with this setback. Is there anyway I could get a phone number or I can try send you mine, would so much appreciate it. Xxxxxxxxxxxxxxx

[Iggy131313]

Ive replied to your PM hon, so good to hear from you, even though its with some bad news....im sure this reaction will pass quickly...you were brave to try the vaping...would scare me to death!!!

 

ive PMed you my number, lets talk soon ok? xx

[darktimes]

Im in the same situation regards cigs started vaping but i feel more spaced out but my body feels better no nervousness or anything ah just never figure this s### out

[Fizz]

That's interesting as after a few days I was getting more anxiety and adrenaline with vaping. Then on the Saturday night the magic roundabout started, spinning out. It's still coming and going, driving me mad. I did mix flavours though and the juice was a PG/VG mix, not sure what percentages. Also I vaped with no juice and got the burnt coil taste, it's made the inside of my nose and sinuses sore. Was a bad move.....

[darktimes]

I cant figure it out the last time i quit and start vaping i had a window for about a week i thought this is it the smoking was increasing my symptoms and im gona heal but think the vaping turned on me also just cant win

[WiggleIt]

Iggy, your signature says you haven't healed At all in three years, but just above you imply that you are doing better.

 

Can you explain? I also PMed you about some other stuff!

[Iggy131313]

Hi hon, I will reply to your PM...I mean I havent imrpoved naturaly....my improvemnts come from smoking weed....that treats my symptoms

[Fizz]

Thanks so much for talking Iggy, was very therapeutic, has helped a lot. You did wear me out though man, have hot ear syndrome aswell now, ha ha!

You've been so kind and helpful today, you don't know how much I appreciate it. Hope your evening goes as smoothly as poss. Lots of love xxxxxxxxxxxxxxx

[Dina]

Hi Iggy, we have met briefly on pp the last year - i wss at quite the start of wd, you were on a low dose of citalopram. I do remember you because i had lexapro wd, you - citalopram, these drugs are very related and i actually got pretty scared to read how horrible you felt 2 years in, what could i expect ? I'm glad i read you feel much better.

Anyway, i have also dramatically improved , i also found a remedy, but mine is ridiculously simple and cheap. Can tell what it is if you are interested .

I read a bit on your thread about your interest in explaining the wd in terms of neurobiology and pretty much of the stuff you conclude seems quite sound. I would very much agree on the serotonin receptor up regulation as major mechanism of wd, but do not underestimate inflammation , i have some reasons i believe it plays a huuuge role too.

I have a little boy of 15 months. Wd started at the end of my pregnancy so how i understand all these mums here.

So yeah, i decided to say hello, i post only occasionally cos my child us really active but i work part time so i read here whem om the bus to/from work.

dina xo

[Iggy131313]

Fizz xxxxx

 

Dina - im so glad your feeing better and congratulations on your baby, what a wonderful thing and a great age....its my greatest wish that one day I will be abe to have another child, they are the most wonderful and special gifts to us....without my son I would never have made it this far. I have PMed you x Also I would have imagined you would have recovered quite quickly, as it seems your drug history was straight forward...one drug, one dose, one brand....thats the ideal...however if you missed days at any point then you may have had some kindling,,,,,

 

so I continue to imrove....its one (or both) of 2 things....

 

1) since smoking a uff of weed in the MORNING, and not waiting to the evenings i have improved ALOT.....

 

2) time has at last caused some down reguation

 

I no longer seem to have the nausea, and im waking with only mild and transient terror...yesterday i became obsessed with TD as the night before i had a minor twitch in my lip....this led to stone cold fear running through me and an obsession that im developing TD.....i dont know if its a symptom or a somatic response but when i become osessed with TD i get this huge urge to twitch my face...i feel it in my nose and want to screw my face u...its happened a BILLION times in w/d but i dont know what comes first, the symptom or the obsessing about it....

 

so yesterday i sent the moring on the phone to the lovely muddles and fizz...then i went out with boyfriend....th TD symptoms rulling....that then changed when the aka kicked in....had bad aka from 3-4ish which felt better once we got to the pub that he was working in (as a plumber) I played some pool had a glass of wine and talked reassuringly to myself

 

stayed there most of the day, had 3 glasses of wine......had a puff of someones joint in the pub car park and was somewhat better....came home, watched some tv with a take away, took my dose and was somewhat revved up....came to bed

 

woke this morning at first with nothing but then a little terror and fear and akaanxiety kicked in (i say aka anxiety as it is the sensation which is aka on the way out, a severe terror) right now im sat in bed with a coffee and a cig and deciding what i am capable of doing today, not sure where I am in my cycle exactly but imagine its abround ovulation so at least I can cope with the knowledge that the next week should be better

 

it seems that its taken around 4 weeks for the upregulation to settle......that also fits in with the upregulation hypothisis....as im taking a dose still I would imagine that downregulation WOULD happen, as im telling the receptors thats what needs to happen by bombarding them with an agonist...and 4 weeks is about how long it takes when starting an ssri....

 

this is the conclusion I have come to about why we dont heal fast etc.....it seems clear to me (in my opinion only) that RECEPTORS dont communicate with EACHOTHER...they respond ONLY to what they are told individually.....they speak in the language of neurotransmitters....and addapt accordingly to those instructions.....they couldnt care LESS that there are more/less receptors as before, they dont look, they do not respond (or of they do then its in a much much slower way)

 

as we lose 18% of 5ht2a receptors per decade perhaps the improvements people see are due to time degrading those receptors.......or perhaps they do downregulate to a normal flow of serotonin, but its certainly not a drect order....the brain works in a negative feedback loop...we MUST speak to the brain in a language it understands, the language of neurotransmitter.........too much serotonin....DOWNREGULATE...not enough....UPREGULATE.....apart from the phenominon of functional selectivity which makes the serotonin system act in a different way....

 

in most other up/down regulations it seems we have to think counter intuitively...for example, those who have downregulation of 5ht1a autoreceptors....it seems alot of the PSSD boards use drugs like Buspar (and this is often successful) to bring back functioning, a partial agonist (same as weed) which by partially increasing serotonin to the autoreceptors, lessons the amount sent to the rest of the brain and in alot of pssd cases increases or resolves functioning.....and in my case eases akathisia and other related symptoms

 

it would be interesting if a trial was done on pssd....I mean firstly if a receptor lingand assay was done, to test the hypothisis of chronic downregulation of 5ht1a...iof this was proved to be correct, then working with the brains negative feedack loop, like computer coding we would theoretically need to work against the intuitive....and DECREASE serotonin to the 5ht1a receptor....this would instantly worsten symptoms..but by doing this we are saying to the brain...not enough serotonin here...UPREGULATE receptors....once that adaptation was made, (which again could be checked through spect lingand assays) either the antagonist could be stopped (we know that downregulation happens VERY slowly and only is response to being TOLD to downregulate) or if over time the receptors downregulated...then it would be about finding the correct level of upregulation needed...or the treatment could be repeated months/years later if downregulation happened again

 

HYPOTHISIS THEORY SPECULATION...but makes sense....and works with everything we KNOW happens to the brain in response to drugs

 

5ht2a receptor stop degrading by 18% per decade at age 50.......could this be why heay sees less healing in older people?

 

but if your over 50 and reading this, and belive my theory and get  upset DONT....becaue remember one thing....IF I am right....IF this is becasue 5ht2a is chronically upregulated in some (and id bet my health on it) then yes, recovery after 50 would be slower in terms of degrading those receptors BUT....older people also produce less transmitters and there also other factors....AND...if im right then that means there could well be treatment options.....

 

I can just see the future of mental health and neurology.....in my mind it will be JUST like computer programming.....the scans on receptor densisty will be mainstream and used all the time, just like an x ray.....people will poresent with mental health or damage or whatever....be scanned and told ''oh you have 40% less blahdy blah receptors...you have 20% more than average whatever receptors'' I belive at that point there will be drugs or even mechanisms (rife, lazer, etc etc) that can downregulate/destroy those receptors as easy as pie...increasing and decreasing receptor densitiy is the future of mental health treatment...becasue thats how it would be cured.....drs will learn so much once these types of scans are mainstream about how to manipulate specific receptors....you look at something called an irreversible antagonist.....http://en.wikipedia.org/wiki/Irreversible_antagonist

 

these literally KILL receptors..they DO NOT upregulate as its such a  rapid move from internalisation to downregulation to degredation) I want me a nice irreversible antagonist of 5ht2a please....I may then need a light dose of one at D3 in case i get some TD.....ahhhhh sweet normalcy....

 

ad its NOT IMPOSSIBLE.....the thing to keep in mind is this...even though no one is trying to help us (apart from ourselves, and we have dr healy who would but sady is chasing some red herrings around) there are howevere drs working tirlessly on the treatment of mental health, and im quite sure that GSK, and all the other murderers would GLADY help develop drugs that fixed those problems, so we, like scavengers, can sit around the table in the future and eat the leftovers as it were..of the metal health picnic...and as I also belive that this starts...continues....or at least has some basis in neurotoxicity..we look towards MS in the healing of leisons, remylination, etc...the answers will be out there, not tailor made for us, but we dont need that.....we can use what others have had done for them.

 

the future of mental health i think will be bright, and perhaps the only cases of it will be those who have had serious structural damage to the brain and therefore balance cannot be restored through receptor adaptation....who knows, will this be in 50 years? 60 years? 10? look how fast the ineternet happened, a concept that is STILL mind boggling, and yet it happened so fast (and thank god or we would all be in psyc wards) what im talking about is not a pipe dream...in fact as soon as any budding developer starts with a medical machine that tests receptors in a full way INVEST FOR YOUR LIVES!!!!!

 

Now some may say that they would NEVER touch another drug, etc etc NEVER work with GSK....well let me tell you, I would make love all night with the head honcho at GSK if it meant I could recover, have a life...but i dont mean  get to a livable point, thats NOT GOOD ENOUGH....I want ALL of my former life back...I want to be able to have an antibiotic at 7 years off without going back into severe withdrawal....I want to be able to have another child without the same thing happening, I want ALL my choices back as its my human right to have them....I want, if in the future, I develop a very serious health  issue like cancer, to be able to access treatment for that issue and not lay down and die which would now be my only choice.....

 

thats what I want, and I want it for every person on this forum, I demand my future back.....I will NEVER have the last 3 years back....my sons toddlerhood gone, my career over, but God damn it I will have my future back, and my choices and my life.....

 

I sound like spiderman or something lol

[Iggy131313]

very interested to know how you have got on today Fizz!!!

 

most of today has been grand, spent some lovely time talking to my gorgeous friend Muddles, what a star you are!! No boxes for you my dear, things are going to work out fine...

 

Just been to the supermarket and experienced the 5pm worsteing while there.....am going to have a smoke now and look at making something nice for tea...steak, salad and potatoes potato dauphinoise...

 

I was having a bath earlier and now I am thinking that there are (loads but i can identify 3).... 3 main categories of ssri damage...and the approach for each must be different

 

1) 5ht1a autoreceptor desensitisation (downregulation)

 

2) 5ht2a/c upregulation (all of this is explained in my previous posts)

 

3) excitotoxicity leading to methylation issues, detox issues etc..

 

 

we most likely all have 3..or did have, but it seems that in a few people they become so damn toxic that they even develop MCS, CFS etc etc.....this is very much in line with what I was talking about last year in regards to the toxic brain damage....sounds scarierthan it is...i think this is  definitly healable, but those who have alot of toxic build up need to address this..i also think there is something to be said about a NDMA antagonist preventing further damage....perhaps this is why some have found it helpful

[Fizz]

Well, picked the kids up from school and felt back to baseline for a few hours! Yes! Some discomfort and dizziness at the moment so of course I am not going to get too excited yet. My sensitivities are so severe that it is plain to see what happened re the vaping and air freshener. Extreme caution in all areas from now on. I expect things to be up and down for a while. Massive thanks to you Iggy for seeing me through this. Xxxxxxxxxxxxxxxxxx

[Altostrata]

To repeat: The staff of this site does not endorse Iggy's theories about 5ht1a autoreceptors, 5ht2a/c upregulation, excitotoxicity leading to methylation issues, detox issues etc.., and most certainly does not recommend anyone trying an NDMA antagonist without full caution.

[Iggy131313]

And I second that....this site has NOTHING to do with what im talking about, everything I talk about is speculation and hypothisis, gleaned through years of research.backed up through hundreds of studies, and supported by hundreds of anecdotal stories...but still hypothisis

 

I am NEVER recommending people DO anything, or TAKE anything, Im speaking theoretically.....just the same as everyone here...and my opinion is no more or no less valid...

 

I hope it is noticed I point this out in EVERY post I make about my theories, that it is a theory, that this is what *I* believe.not fact...when I speak to people here, on facebook or on the phone, I NEVER make recommendations to take drugs, to take suppliments, anything like that and never would...I speak about wha testing we could have, and very gentle coping techniques.....and of course how terrible it is that this has happened...and I ALWAYS say my thinking is only a theory....#

 

I am doing everything that has been asked of me, I dont post on any thread but my own, and contrary to the belief that I scare people...I speak only the truth about what I see and who I know, and in fact have been very supportive to others, but if I speak about people 10 years off and still severe, thats becasue there are people 10 years off and still severe...people who have done everything right...better? yes....totally disabled? yes....no one stops improving, and those people I know at 10 years off are STILL improving, healing never stops

 

I, however, feel I need to speculate and hypothisise, look into what has happened and how I can make it stop....becasue I dont have 10 years to spare in this suffering....and I dont belive this is a pipe dream.....I belive there IS a treatment that will make it stop.....and I CERTAINLY believe that the mechanism of ''withdrawal syndrome'' is to do with everything I have said...

 

all I want is to get my ideas and theories out there, and in the end, get someone to do a study, receptor assays, and then I will either be proved right, or proved wrong.....either way gets us a step towards anwers through the process of elimination....thats all I want

[Altostrata]

Iggy, your own blog is the best place for your ruminations. I'm getting more and more uncomfortable about your holding forth about your theories here.

[btdt]

zinc is listed as an NMDA antagonist... may be the least harmful.

http://en.wikipedia.org/wiki/Category:NMDA_receptor_antagonists

 

if your going to put this kind of information in your blog maybe you should put a  link to the blog in your history for anyone who wants to follow. 

peace

[Iggy131313]

terrible frantic panic and anxiety today....trying to stay calm...ovulating now so maybe its something to do woth it i dont know...I got obssed and upset about TD again last night, i was having that thing where as your about to fall asleep terrr floods through your vains and wakes you up heart racing...

 

today i was focused on TD alot but then i read an old jounal of mine tht upset me and now im frantic, feelings of unreality, panic, dread....playing xbox with freddie and on the edge

 

really scared and upset,