Administrator Altostrata Posted May 13, 2011 Administrator Share Posted May 13, 2011 Mol Brain. 2010 Mar 10;3:8. Depression research: where are we now? Lee S, Jeong J, Kwak Y, Park SK. Source Department of Life Science, Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, Republic of Korea. Free full text at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848031/?tool=pubmed and http://www.mediafire.com/?43a9sy6ekdocvgn Abstract at http://www.ncbi.nlm.nih.gov/pubmed/20219105 Abstract Extensive studies have led to a variety of hypotheses for the molecular basis of depression and related mood disorders, but a definite pathogenic mechanism has yet to be defined. The monoamine hypothesis, in conjunction with the efficacy of antidepressants targeting monoamine systems, has long been the central topic of depression research. While it is widely embraced that the initiation of antidepressant efficacy may involve acute changes in monoamine systems, apparently, the focus of current research is moving toward molecular mechanisms that underlie long-lasting downstream changes in the brain after chronic antidepressant treatment, thereby reaching for a detailed view of the pathophysiology of depression and related mood disorders. In this minireview, we briefly summarize major themes in current approaches to understanding mood disorders focusing on molecular views of depression and antidepressant action. This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment Share on other sites More sharing options...
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