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Update on milk peptides (Lactium) for sleep


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  • Administrator
Altostrata

Bioactive milk peptides can be beneficial for sleep, according to a somewhat breathless recent article published by the Life Extension Foundation, a source for reliably good-quality supplements. The milk peptide formulation described is known by the trade name Lactium, made by a French company called Ingredia.

 

I have used this off and on for several years, and I have friends who swear by it. It is very, very mild but may be just the thing for people who are hypersensitive. I take it in the middle of the night when I wake up, to get back to sleep. It doesn't always work, but sometimes it seems to help.

 

I found the best value to be the oddly named Swanson Ultra Women's Anti-Stress Formula, containing 167mg Lactium per capsule (no other active ingredients) at about $.33 per capsule.

 

(All of the "milk protein hydrolysate" products claiming sleep benefits -- Immunotec Research PNT-200, Atrium Pro Calm, Symbiotics Tryptozen, Promedis Prozen, Biozen Relax, Point of Return Relax -- contain the same active ingredient, Lactium, in varying amounts. All of these manufacturers are purchasing from the same single source for Lactium, Ingredia.)

 

The Life Extension Foundation article, excerpted below, has a large set of citations -- the numbers in the text refer to citations.

 

Bioactive Milk Peptides: A Natural Sedative?

 

from April 2011 Life Extension Magazine http://tinyurl.com/3q9djoo

 

For generations, mothers have given their children a warm glass of milk before bed as a way to help them fall asleep. ...In 1997, pediatric researchers added to the evidence by demonstrating that newborns given an infant formula containing milk fell asleep not solely due to nursing and being held, but owing specifically to something in milk itself.12

 

In 2000,13 researchers identified what that “something” was. It turns out that nutrients found in cow’s milk called bioactive peptides (chains of amino acids) exert a sedative effect on the brain and induce sustained sleep patterns.

 

These bioactive milk peptides have since been shown to act on the brain’s GABA-A receptors,14 the same mechanism of action that makes the class of sedatives known as benzodiazepines so effective.15 The advantage of milk peptides, of course, is that they induce relaxation and sleep without the side effects associated with long-term benzodiazepine use.

 

In pre-clinical models, milk peptides15,16 markedly reduce anxiety and improve sleep in animals subjected to chronic stress.17

 

In human studies, a proprietary bioactive milk peptide compound used widely in Europe has been shown to effectively induce relaxation, leading not only to deeper, more restorative sleep, but also to substantial improvements across a wide range of stress markers.

 

Bioactive Milk Peptides: Reducing Stress, Restoring Sleep

When given this proprietary bioactive milk peptide compound, aging individuals suffering from stress-related symptoms and chronic insomnia consistently exhibit substantial reductions in biomarkers associated with the stress response. These stress response biomarkers include elevated cortisol, heart rate, and blood pressure, along with physical and psychological symptoms.

 

In a number of especially noteworthy published studies, the improvements in stress-related markers proved to be both significant and system-wide.

 

....

Cortisol Levels Slashed in Human Study

In a double-blind study involving over 40 healthy male subjects,19 two groups were subjected to psychological and physical stress tests, with cortisol concentrations, heart rate, and blood pressure levels measured at specific intervals.

 

Each of these three stress response markers were substantially lowered in the group taking the proprietary bioactive milk peptide compared to controls.19

 

Cortisol levels in the placebo group—measured before and after administration of stress testing—saw a net change of only -3.39%. This means that the harmful spike in cortisol typically caused by stressful situations was almost entirely unaffected in the group that did not receive treatment. By comparison, the milk peptide group experienced a net reduction in cortisol of -20.69%. In other words, the release of cortisol was kept under control by the milk peptides, limiting its detrimental effects.19

 

....

Human Studies Verify Sleep Efficacy

Recent studies validate milk peptides’ capacity to restore more restful sleep patterns while enhancing daytime performance and cognition.

 

In a placebo-controlled study of 165 healthy adults with a history of insomnia, participants were given 150 mg of milk peptides or placebo each day for one month.

 

Changes in their ability to relax and fall asleep were evaluated using established diagnostic tools that measure 27 individual indicators of sleep disorders and insomnia-related problems (including daytime cognition and overall function).20

 

The proprietary milk peptide yielded positive outcomes in nearly all indicators measured, for both men and women.20 Sleep quality, sleep efficiency, sleep disturbances, and daytime dysfunction were all improved, especially in individuals who suffered from moderate symptoms of anxiety or depression.

 

These results were confirmed by yet another clinical analysis of bioactive milk peptides in adults suffering from pronounced sleep disturbances.

 

Thirty-two healthy men and women suffering from insomnia during the preceding six months took a 150 mg capsule of patented milk bioactive peptide one hour before bedtime—or placebo—for a month.21

 

After two weeks, the bioactive milk peptide group experienced a 50% improvement in sleep quality. At four weeks, they needed 30% less time to fall asleep and experienced improvements in daytime alertness and function.21

 

....

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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  • 8 months later...

Hello!

 

Can Swanson Ultra Women's Anti-Stress Formula only be bought online or does anyone know of a pharmacy/store that sells it over the counter?

My husband tried CVS when he was in the States with no luck.

 

Bless you all,

Mrs Green

(Germany)

June 2009 - September 2010 25mg Amitriptyline

Tapered 0,2mg every few days.

Speeded up (too fast) until I was left with 4mg mid December 2010.

Severe Insomnia set in.

Always had trouble sleeping but not like this.

Kept reducing by 0.2mg every so often.

26 March 2011: 0mg.

Insomnia slowly getting better, still in need of help on 2 out of 7 days.

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  • Administrator

The Swanson product contains only Lactium, which is manufactured in France. You might be able to find it under other brand names in Europe. See if you can find any of these products in Germany http://www.lactium.com/uk/right-menu/find-lactium-natural-cure.html?zone=0

 

If it's available in stores in the US, they would probably be "alternative" health food stores or supplement stores. The most convenient way to find it is to order it online.

 

Here are the products containing Lactium available in the U.S. (most contain other herbs and supplements in addition to Lactium):

 

• PROCALM

• TRYPTOZEN

• PROZEN

• DE STRESS

• PNT 200

• DREAMERZ

• ANTI-STRESS WOMAN FORMULA (Swanson's, contains only Lactium)

• ULTIMATE STRESS

• BIOZEN Relax

• BENESOM

• LUMINA

 

I looked at most of them and found the Swanson's product was the best value.

 

I do not recommend supplements with mixed ingredients because if you have a bad reaction, you don't know which ingredient caused it.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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Thank you!

 

In this case I think I will go along with Swanson's - as I am sensitive to little things.

I will try to get some info from the company themselves and will post it here for information.

 

MrsGreen

June 2009 - September 2010 25mg Amitriptyline

Tapered 0,2mg every few days.

Speeded up (too fast) until I was left with 4mg mid December 2010.

Severe Insomnia set in.

Always had trouble sleeping but not like this.

Kept reducing by 0.2mg every so often.

26 March 2011: 0mg.

Insomnia slowly getting better, still in need of help on 2 out of 7 days.

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  • 4 months later...

I know this post is a bit old, but it looks interesting. I just ordered the Swansons, and am looking forward to trying it. I guess I will start with one and see what happens. Anyone having success with this? Any ideas on a good dose?

Approximately 18 years on Effexor. Tapered for more than two years. Totally off of Effexor since late Oct. 2010.

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  • Administrator
Altostrata

It helped me for a long time. I used to take 1-2 capsules.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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Ok Alto, thanks for the info!

Approximately 18 years on Effexor. Tapered for more than two years. Totally off of Effexor since late Oct. 2010.

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  • Moderator Emeritus

So--can't we just drink warm milk? Those of us who are lactose tolerant, anyway. What's the advantage of this refined form? I'm thinking of trying it, but I already drink kefir and milk and prefer whole foods when possible.

Started on Prozac and Xanax in 1992 for PTSD after an assault. One drug led to more, the usual story. Got sicker and sicker, but believed I needed the drugs for my "underlying disease". Long story...lost everything. Life savings, home, physical and mental health, relationships, friendships, ability to work, everything. Amitryptiline, Prozac, bupropion, buspirone, flurazepam, diazepam, alprazolam, Paxil, citalopram, lamotrigine, gabapentin...probably more I've forgotten. 

Started multidrug taper in Feb 2010.  Doing a very slow microtaper, down to low doses now and feeling SO much better, getting my old personality and my brain back! Able to work full time, have a full social life, and cope with stress better than ever. Not perfect, but much better. After 23 lost years. Big Pharma has a lot to answer for. And "medicine for profit" is just not a great idea.

 

Feb 15 2010:  300 mg Neurontin  200 Lamictal   10 Celexa      0.65 Xanax   and 5 mg Ambien 

Feb 10 2014:   62 Lamictal    1.1 Celexa         0.135 Xanax    1.8 Valium

Feb 10 2015:   50 Lamictal      0.875 Celexa    0.11 Xanax      1.5 Valium

Feb 15 2016:   47.5 Lamictal   0.75 Celexa      0.0875 Xanax    1.42 Valium    

2/12/20             12                       0.045               0.007                   1 

 

I'm not a doctor. Any advice I give is just my civilian opinion.

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it's a peptide..a piece of casein...casomorphin...and that is all it is...it's got no lactose or other parts of casein.

 

so no, it's not the same as milk...but if warm milk works for you that's fine.

Everything Matters: Beyond Meds 

https://beyondmeds.com/

withdrawn from a cocktail of 6 psychiatric drugs that included every class of psych drug.
 

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  • Moderator Emeritus

it's a peptide..a piece of casein...casomorphin...and that is all it is...it's got no lactose or other parts of casein.

 

so no, it's not the same as milk...but if warm milk works for you that's fine.

 

Hm, maybe I'll try it...Is there a hangover effect, has anyone noticed?

Started on Prozac and Xanax in 1992 for PTSD after an assault. One drug led to more, the usual story. Got sicker and sicker, but believed I needed the drugs for my "underlying disease". Long story...lost everything. Life savings, home, physical and mental health, relationships, friendships, ability to work, everything. Amitryptiline, Prozac, bupropion, buspirone, flurazepam, diazepam, alprazolam, Paxil, citalopram, lamotrigine, gabapentin...probably more I've forgotten. 

Started multidrug taper in Feb 2010.  Doing a very slow microtaper, down to low doses now and feeling SO much better, getting my old personality and my brain back! Able to work full time, have a full social life, and cope with stress better than ever. Not perfect, but much better. After 23 lost years. Big Pharma has a lot to answer for. And "medicine for profit" is just not a great idea.

 

Feb 15 2010:  300 mg Neurontin  200 Lamictal   10 Celexa      0.65 Xanax   and 5 mg Ambien 

Feb 10 2014:   62 Lamictal    1.1 Celexa         0.135 Xanax    1.8 Valium

Feb 10 2015:   50 Lamictal      0.875 Celexa    0.11 Xanax      1.5 Valium

Feb 15 2016:   47.5 Lamictal   0.75 Celexa      0.0875 Xanax    1.42 Valium    

2/12/20             12                       0.045               0.007                   1 

 

I'm not a doctor. Any advice I give is just my civilian opinion.

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much to my amazement after much experimentation I'm clearly intolerant of milk....and it's NOT a lactose issue...it's a casein issue

 

casein acts on the opiate receptors and it messes with me...

 

I'm trying to get off lactium now...it saved me for a while...I was beyond desperate for sleep, but my milk intolerance (to casein/casomorphin) is causing a lot of pain...seems to exacerbate inflammation for me

 

So I'm tapering off it now...yup...and I do feel it...but it's not like a psych med...

 

see this:

 

http://www.yumuniverse.com/2011/04/25/dr-jenna-taylor-addiction-to-cheese-is-real-thanks-to-casomorphins/

 

When I went off milk (over a year ago now) I went through a radically intense withdrawal...I was completely SHOCKED. And it was like an opiate...cravings like you wouldn't believe...way worse than any psych drug...I did that cold turkey though...

 

I'm doing the lactium slowly...

 

anyway...people really aren't aware of how milk works in our bodies...I sure as heck wasn't.

 

If you do dairy though, taking lactium isn't gonna make the situation any worse in my opinion...but now that I've had such a radical (and shocking) experience with milk withdrawal I suggest everyone rule out issues with milk.

Everything Matters: Beyond Meds 

https://beyondmeds.com/

withdrawn from a cocktail of 6 psychiatric drugs that included every class of psych drug.
 

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  • Administrator
Altostrata

No, no hangover effect. I used it for quite a while and had no bad reactions.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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  • Moderator Emeritus

Do you have to take it all the time? I ordered some to experiment with during the times I'm desperate for sleep. But that's not all the time. I have spells of being able to sleep okay. I'd like to only take it when I need it.

 

Oh well, guess I'll be experimenting with it...not ready to give up my homemade kefir yet, so I'll be using milk products anyway.

Started on Prozac and Xanax in 1992 for PTSD after an assault. One drug led to more, the usual story. Got sicker and sicker, but believed I needed the drugs for my "underlying disease". Long story...lost everything. Life savings, home, physical and mental health, relationships, friendships, ability to work, everything. Amitryptiline, Prozac, bupropion, buspirone, flurazepam, diazepam, alprazolam, Paxil, citalopram, lamotrigine, gabapentin...probably more I've forgotten. 

Started multidrug taper in Feb 2010.  Doing a very slow microtaper, down to low doses now and feeling SO much better, getting my old personality and my brain back! Able to work full time, have a full social life, and cope with stress better than ever. Not perfect, but much better. After 23 lost years. Big Pharma has a lot to answer for. And "medicine for profit" is just not a great idea.

 

Feb 15 2010:  300 mg Neurontin  200 Lamictal   10 Celexa      0.65 Xanax   and 5 mg Ambien 

Feb 10 2014:   62 Lamictal    1.1 Celexa         0.135 Xanax    1.8 Valium

Feb 10 2015:   50 Lamictal      0.875 Celexa    0.11 Xanax      1.5 Valium

Feb 15 2016:   47.5 Lamictal   0.75 Celexa      0.0875 Xanax    1.42 Valium    

2/12/20             12                       0.045               0.007                   1 

 

I'm not a doctor. Any advice I give is just my civilian opinion.

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Altostrata

No, you can take it as needed. It's very mild. You can take it during the day if you feel edgy.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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  • 2 months later...
  • Administrator

Bumping -- many people find milk peptides supplements helpful.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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  • Moderator Emeritus

Just a note, I bought two bottles and then it turned out they give me headaches the next day. Just get one bottle if you're going to try them. :-)

Started on Prozac and Xanax in 1992 for PTSD after an assault. One drug led to more, the usual story. Got sicker and sicker, but believed I needed the drugs for my "underlying disease". Long story...lost everything. Life savings, home, physical and mental health, relationships, friendships, ability to work, everything. Amitryptiline, Prozac, bupropion, buspirone, flurazepam, diazepam, alprazolam, Paxil, citalopram, lamotrigine, gabapentin...probably more I've forgotten. 

Started multidrug taper in Feb 2010.  Doing a very slow microtaper, down to low doses now and feeling SO much better, getting my old personality and my brain back! Able to work full time, have a full social life, and cope with stress better than ever. Not perfect, but much better. After 23 lost years. Big Pharma has a lot to answer for. And "medicine for profit" is just not a great idea.

 

Feb 15 2010:  300 mg Neurontin  200 Lamictal   10 Celexa      0.65 Xanax   and 5 mg Ambien 

Feb 10 2014:   62 Lamictal    1.1 Celexa         0.135 Xanax    1.8 Valium

Feb 10 2015:   50 Lamictal      0.875 Celexa    0.11 Xanax      1.5 Valium

Feb 15 2016:   47.5 Lamictal   0.75 Celexa      0.0875 Xanax    1.42 Valium    

2/12/20             12                       0.045               0.007                   1 

 

I'm not a doctor. Any advice I give is just my civilian opinion.

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Rhi, by sheer coincidence, I'm trying to figure out whether the dairy products that got me through recovering from paxil w/d so far, might have become a problem for me without my realizing it.

 

As you know, I'm six years off paxil and still on the 0.5 mg. clonazepam I was on prior to taking paxil. (Oops, I never got around to creating a signature. Hope I can make even the highlights fit into one web page lol :wacko:. Horrified at realizing how many meds I've been on over the years. Can't even remember all of them.)

 

I've never tried milk peptides, but I'm wondering whether the fact that:

 

These bioactive milk peptides have since been shown to act on the brain’s GABA-A receptors,14 the same mechanism of action that makes the class of sedatives known as benzodiazepines so effective.15 The advantage of milk peptides, of course, is that they induce relaxation and sleep without the side effects associated with long-term benzodiazepine use.

might cause it to displace benzos in receptor sites. I know a lot of people find them helpful in benzo tapering, but different supplements seem to act differently at different stages of w/d from various kinds of meds, I've observed in my years of reading on w/d groups.

 

I tried googling briefly just now and didn't find anything relevant, but in w/d anything's possible. I don't know how long you tried the peptides - some supplements can cause unpleasant reactions briefly, but it certainly may not be right for your particular needs.

 

(I hope if you can't use them you can return them and get a refund. Swanson's is great about refunds if you need to order online - they don't carry everything but have a good selection of products, and they take returns no questions asked for a year and even pay for return shipping. I have absolutely NO association with them other than being an occasional customer, but thought I'd pass along the tip.)

I was "TryingToGetWell" (aka TTGW) on paxilprogress. I also was one of the original members here on Surviving Antidepressants

 

I had horrific and protracted withdrawal from paxil, but now am back to enjoying life with enthusiasm to the max, some residual physical symptoms continued but largely improve. The horror, severe derealization, anhedonia, akathisia, and so much more, are long over.

 

My signature is a temporary scribble from year 2013. I'll rewrite it when I can.

 

If you want to read it, click on http://survivingantidepressants.org/index.php?/topic/209-brandy-anyone/?p=110343

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  • Administrator

In 2007, did one of my investigative projects on that claim about milk peptides having a "benzodiazepine-like" effect on GABA receptors:

 

Okay, this is probably the source of the (questionable) comparison of milk peptides to benzodiazepines:

 

Characterization of a-casozepine, a tryptic peptide from bovine a-casein with benzodiazepine-like activity

 

http://www.fasebj.org/cgi/reprint/00-0685fjev1.pdf

 

Abstract

 

"Caseins are a known source of biologically active peptides. In this study, we have shown evidence of a novel anxiolytic activity in a tryptic hydrolysate of bovine as1-casein. Injection of 3 mg/kg of this hydrolysate significantly reduced the epileptic symptoms caused by pentylenetetrazole in rats. Anxiety reduction was also observed when the hydrolysate was tested in the elevated plus-maze and in the conditioned defensive burying rat models. Peptides isolated from the hydrolysate were examined for their affinity for the ?-amino-butyric acid (GABA) type A receptor. Only one peptide, named a-casozepine, corresponding to the 91ñ100 fragment from bovine as1-casein, expressed affinity for GABAA receptor. In vitro, the peptide had 10,000 less affinity for the benzodiazepine site of the GABAA than did diazepam. However, in the conditioned defensive burying paradigm it was 10-fold more efficient than diazepam. The difference observed between the in vitro and in vivo activity of a-casozepine could not been explained by an action via the peripheral-type benzodiazepine receptor; a-casozepine had no affinity for this receptor. The a-casozepine amino acid sequence could be related to the carboxy-terminal sequence of the polypeptide diazepam binding inhibitor, an endogenous ligand of the central GABAA and peripheral-type benzodiazepine receptors...."

 

 

In my opinion, "10,000 [times] less affinity for the benzodiazepine site of the GABAA than did diazepam" makes it a pretty weak, even fanciful, benzodiazepine-type effect.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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  • 2 months later...

Looked into this a little further and found several reputable brands on Amazon. I just purchased a chewable made for children. Contains 167 mg Lactium. I'll keep everyone posted once I receive and have a chance to try it. My insomnia is a BEAST. When I can fall asleep, as soon as I hit REM, my heart starts racing, which causes me to have dreams about people chasing me, or me running around in a frenzy trying to accomplish God only knows what. Of course I wake up and have to spend the next half hour trying to calm down and get back to sleep - and the fun starts all over again. This goes on all night long and inevitably ends with a racing trip to the bathroom (because the bowels are hyperactive as well.) Gotta love this withdrawal. Happy Happy Joy Joy.

Short term low dose Klonopin use back in 2004
Acute, protracted withdrawal after discontinuing
Began Lexapro in 2005 to ease Benzo withdrawal
Took 2 years to stabilize
Rapid taper from Lexapro in July/August 2012
Return of anxiety, insomnia and cardiac issues
Failed reinstatement early August 2012
Acute withdrawal for 9 months; intermittent symptoms for another 6

Relief on February 9, 2014 after addition of Taurine

Almost complete remission of symptoms w/addition of 12.5mg Atenolol daily

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Lactium is very mild, I hope it works for you, Lexhex.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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  • 1 year later...

hi guys i have like $140 on paypal and im planning to buy milk peptide and L-tryptophan on http://www.lef.org . or whatever online shop can you suggest where its best to buy supplements? what other products can you suggest? thanks all and stay strong! 

Dec 2012 tried 10 mg Lexapro caused panic attack 

                 titrated 5 mg, and finally settling at 2.5 mg for some time

Jan-May 2013 on and off carelessly experimented on doses from 1.5 mg to as high as 12.5 mg 

June 2013 had extreme anxiety/panic attacks/paranoia when I ran out of samples.

July 7 2013 - August 10 2013 went back to 2.5 mg to relieve the anxiety and it worked until i felt restless and agitated

August 11 2013 AD-free and substituted with 5-HTP and it seemed to work together with GABA after I read "The Mood Cure" by Julia Ross 

dec 20, 2013 switched to 5mg Valium from 0.25mg-0.5mg xanax daily and felt better

dec31 3.75mg V

 

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Please read this topic from the start. Swanson's Vitamins offers the best value for Lactium.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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  • 2 weeks later...

is it okay for men to use Swanson Ultra Women's Anti-Stress Formula ?

Dec 2012 tried 10 mg Lexapro caused panic attack 

                 titrated 5 mg, and finally settling at 2.5 mg for some time

Jan-May 2013 on and off carelessly experimented on doses from 1.5 mg to as high as 12.5 mg 

June 2013 had extreme anxiety/panic attacks/paranoia when I ran out of samples.

July 7 2013 - August 10 2013 went back to 2.5 mg to relieve the anxiety and it worked until i felt restless and agitated

August 11 2013 AD-free and substituted with 5-HTP and it seemed to work together with GABA after I read "The Mood Cure" by Julia Ross 

dec 20, 2013 switched to 5mg Valium from 0.25mg-0.5mg xanax daily and felt better

dec31 3.75mg V

 

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  • Administrator

Sure. Women's Anti-Stress Formula is a dumb name.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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  • 4 months later...
compsports

Decided to give this a try out of sheer desperation and because it seemed like the least risky option of all sleep remedies.   Good news is my apnea index was near zero.   Bad news is I only lasted 2.5 hours on the machine :( and they were useless as far as getting back to sleep.    Ended up also needing an ambien which I rarely take on a PRN basis.

 

I am beginning to wonder since I fall asleep very quickly if anything I take is going to have a paradoxical effect as far as sleep.   So far, that has been my experience with all med and OTC remedies that I have tried.

 

CS

Drug cocktail 1995 - 2010
Started taper of Adderall, Wellbutrin XL, Remeron, and Doxepin in 2006
Finished taper on June 10, 2010

Temazepam on a PRN basis approximately twice a month - 2014 to 2016

Beginning in 2017 - Consumption increased to about two times per week

April 2017 - Increased to taking it full time for insomnia

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  • 1 year later...
LeslieBarns

Thanks for the info;

...if the Lactium works through the GABA pathway, then it wont raise serotonin levels in the brain, eh?   That's what I'm afraid of, since I'm on Levodopa/carbidopa + lorazepam + citalopram (which I'm trying to ditch first).  Even tho' I've reduced the citalopram from 20 mg to 10 mg, I still feel like the serotonin is overwhelming everything else sometimes, especially when the sinemet/lorazepam dose wears off.

I've lost a lot of weight, including muscle mass, and the branched-chain AA's, leucine, isoleucine and valine are supposed to help build up muscle, and I was hoping they'd help with the withdrawal as well - I haven't found them yet here, but I'm going to try the Lactium.

Thanks again...gosh this is a fast place to get answers!

Retired in  May, 2010, still working part time  as Occupational Therapist in North Toronto Community Health Clinic - 6 family practice docs + vrs allied health professionals. I was resp. for  home or clinic "Barrier-free" patient population, i.e. CP/MS/MD/spinal cord inj/disease pts.- independent living but requiring Attendant Care - power wheelchair dependent people/; also Seniors' Advisory Ctte./Advocacy staff liaison to Board; [received good evaluation on mandatory College of OT's practice review].   Otherwise, stayed active in bicycling,  gym,  yoga, walking, theatre volunteering.  Enjoyed eating out in mid-level restaurants, liked my city on Lake Ontario. Enjoyed travel to Stratford, ON, time spent with friends and on farm.    I was not on any Rx drugs, no health problems, but took lots of health food dietary vitamins and supplements - stupid me [same corporations, same profit motive, no regulation of product by governmental or other oversight body.

  • I think dietary supplement SAMe either triggered or contributed to sudden and accelerating deterioration into Parkinsonism, esp. late in 2011- I have  since found several scientific journal articles to support my opinion - all of my 5 doctors (family doc and 4 neurologists ignored it.)
  • Diagnosed at two major Toronto hospitals with "Idiopathic Parkinsonism" in early 2012.
  • Primary sympt. at that time:  rigidity, spasticity, slowness, deteriorating cursive writing, shaking arms/hands, severe burning pain in feet/knees/back, severe insomnia - no tremor at that time.
  • First Rx drug: generic sinemet [Apo-levocarb] 100/25  (3x/day) April 21, 2012. This drug was never very effective; only had ~ 1 hr ''ON" time, no matter the dose./timing. Sometimes sinemet seemed to make things worse rather than better, i.e. more muscle tone./cogwheeling/severe night sweats/low blood pressure.  
  • Next Rx drug; Zopiclone; neuro said it was NOt a  benzo., but worked on same receptors, therefore she never warned me re withdrawal problems. Took it for ~ 3 years nearly every night. Seemed to work well.
  • Third RX drug: Lorazepam. I asked Neuro for it as it seemed to make the levocarb work better and helped wth anxiety.  Neuro advised it was addictive, but never explained about tolerance, withdrawal, down-regulation of receptors. I took 0.25 mg once or twice a WEEK at first and that tiny amound helped for a day at least.
  • Fourth RX drug: Mirapex. i was still plagued by mostly "down" time with rigidity and non-movement disorders, so agreed to try Mirapex.  i never got up to the therapeutic dose (near threshold) because it made me so sick and it seemed to make things worse, i.e. more muscle tone, problems with balance, severe nausea.  Read manufacturer's monograph updated to 2012 and decided the risk was worth it, benefit unlikely.

My self-initiated withdrawals.  Every time i've changed one drug, i've had to make changes in the others too, e.g. at 20 mg Citalopram i had too much sinemet (dyskinesias) so i lowered sinemet to ~1000 mg and that was better.  Also, as Citalopram has gone down, Lorazepam has had to increase 'cause it seem not to last as long or work as well.

  • So on my own, I decided to taper off Mirapex, not knowing a thing about withdrawal problems. Whew!  Thanks to zopiclone and increased frequency and dose of Lorazepam, i got off Mirapex in March 2013.
  • Next I took myself off Zopiclone after reading very negative things about its' long-term use.  I was doing this without guidance or help from MD's. I increased sinemet and lorazepam to cope with the withdrawal effects of Zopiclone. Going off Zopiclone made PD symptoms worse; neuro wanted to put me on Entacapone, but i declined it.

More MD's/more problems with Rx drugs.

  • Zopiclone withdrawal + Incr. levocarb and incr. lorazepam landed me in the ER at CAMH, where there is a priscription drug withdrawal program, so I thought they could help me. The doctor took me off Zopiclone and Lorazepam and substituted Clonazepam alone.  From the first day Clonazepam caused frightening and serious side effects, like periods of amnesia, loss of balance, dizziness, memory problems, mental processing problems, serious nausea - worst was interdose withdrawal every 4 hours resulting in 'panic attacks' - i was jumping out of my skin!
  • Another RX drug: My own neuro gave me Citalopram to help me withdraw from Clonazepam.  Didnt work; after 2-3 weeks the Citalopram became a bigger problem with side effects than the Clonazepam. Neuro switched Lorazepam to replace the Clonazepam, but left me on the Citalopram. 
  • Rapid loss of 40 lbs of body weight into undernourished zone.
  • I ended up in ER with my forehead bashed down to the bone as a result of 'syncope'; unconscious for unknown lenght of time, probably only a few minutes. Neuro threw me under the bus - now said i needed the Citalopram for depression and Lorazepam for anxiety disorder - said there was an emotional component to my complaints and made a referral to a psychiatrist. I didnt go to him, but tried to get into a addictions/withdrawal program at that hospital, did see a 5th year psych. MD there. 
  • i got copies of last few neuro/psych reports to my family doctor - I was shocked.  I think the neuro/family doc were afraid i'd sue them or complain to the College of Physicians and Surgeons, so; they set up a 'defense' with psychiatric diagnosis to explain drug side effects and head injury, even suggested i might have 'psyhogenic' Parkinsonism.

More self-initiated withdrawal.

  • I decided to get off most dangerous drug first - Citalopram; it never made me feel anything other than sick and near invalid from side-effects.
  • Have reduced dose from 20 mgs to, recently, 5 mg.  Having a terrible time - every day seems new problem - today it was akathisia coming out of nowhere - took Benadryl - it helps.
  • Nearly house-bound now. 

Current drugs:  Citalopram (taper: 20 mg to 15 mg to 12.5 to 10 to  5 to 2.5, then zero.)  44 days at zero, getting worse side effects now than when I was 'ON' it.  Apo-Levocarb, immediate release (recent dose =1500mg) =~1250mg in 10 doses/day;/2-3 levo-carb CR/day;/Lorazepam (from 1.0 mg to 2.5 or 3, or more mg/day. Benadryl as needed. Tylenol as needed to reduce 'fever' feeling in head and/or headache. Occasional Advil.

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  • 6 months later...

So is it a GABA antagonist?

I'm on 1800 mg of gabapentin 3x600, .325 Klonopin(.25 in am, .125 afternoon), in the evening I take cymbalta 30mg down from 60mg, remeron 30mg and lamictal 100 mg. Nausea and anxiety are my worst symptoms. C

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  • Administrator

Forget about all the hype about Lactium and GABA, please. It's the manufacturer's effort to get on the psych drug bandwagon.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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  • 3 months later...
daddybuggaorange

So affinity to GABA A receptors per all the research articles isn't a big deal? I came off klonopin last year and it was horible, so I am nervous about anything that impacts the GABA system as I do NOT want to go back "there".

Started klonopin 11/7/14 at 0.5 mg

on K consistently until week prior to Christmas

on/of Klonopin and 0.5 mg Xanax until 3rd week in February

tried c/t 3rd week in february, crashed hard, ER several times

1 mg klonopin last week in February until 2nd week in March

Quit Zoloft c/t 1st week of March 2015 & started Amitriptyline

Quit amitriptyline 2nd week in March & started Cymbalta

0.5 mg cut of Klonopin 2nd week in March

0.5 to 0 mg Klonopin taper March to June 2

off Klonopin since June 2

Stopped cymbalta august 24, started zoloft august 24

Seroquel taper from 75 to 0 over 12 days, last dose September 4.

Started Compazine Aug 12,  10 mg day

Stopped compazine aug 17, bad withdrawl

Started Remeron 3.75mg 10/12/15

Off Compazine 11/2/15

Off Zoloft 11/25/2015

Off Remeron 1/2/16

Brief encounter with Buspirone 1/13/16 - 1/18/16 2 tablets, bad reaction - severe depression

Tried Colonidine 1/14/16-1/20/16 - severe depression

Only Atenolol since 1/20/16

Reinstated Remeron 15mg 3/26/16

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  • 7 months later...

I know this is an old thread but I was wondering if Lactium would be safe to take while tapering off of a benzo?

 

Thanks for any thoughts on this.

Buspirone to 45mg, Cold Turkey St. John's Wort 600mg Jan 1, 2016. Cold Turkey Buproprion 150SR June 1 due to severe Akathisia that did not decrease with reducing the dosage.

Clonazepam 1.25mg, started daily liquid micro taper of clonazepam on Nov 1, 2016. Changed to sxs based taper 01/17. Slow and steady

11/10/16 .4104 3X day; 11/17/16 .4091 3x day; 11/28/16 .406 3x day; 12/4/16 .404 3x day; 12/11/16 .4028 3x

01/12/17 .39267 3x day holding; 02/25/17 .3902 3x day, holding. .3823mg 3x day. Tapering at .0007462mg as able;  09/21/18 .3542mg 3x day.  1/3/2019 .339mg 3x day. 6/25/19 .3307mg 3x day. 8/24/19 .317mg 3x day 2/13/20 .2886mg 3x day

L-theanine 200 mg, L-glycine 500mg 1x day and 1000mg 1x day, vit C 1000 mg sustained release 2x day. Fish oil 1800mg EPA + DHA. Vit E 400 IU, magnesium in various forms. Inositol 3x a day abt 14mg, Taurine 500mg.

5/20/16 Using Cranial Eletrotherapy Stimulation. 2x day 1 hour at level 1. Using Alph-Stim AID. 

 

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  • 4 months later...

I took a half of capsule and it kept me asleep until 2. I tried the same dosage the next and I was tossing all night and really tired the next day. Has anyone experienced this?

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  • 11 months later...

Hi guys, interested in this old thread as well. Swanson's won't ship the Lactium in Canada. People from Canada here who got a good lactium product elsewhere? Thanks for any input.

2000-2001: Effexor              2005-2012: Celexa, Zoloft, Effexor, desipramin, Wellbutrin, mirtazepin, Lamictal, Remeron, Abilify, nortriptylin, Cipralex, Cymbalta, and others I don't remember. Really bad side effects to all.
Sept-Nov 2012: Paxil 20mg, Wellbutrin 100mg, Imovane 5mg      Nov 2012: Paxil 20mg --> 10mg
Dec 2012: Paxil 10mg-->0; 1 week later: HUGE WD symptoms. Started to get informed on the internet and back to 10mg Paxil.
Dec 2012-Jan 2013: Paxil 10mg, Wellbutrin 100mg, Imovane 2.5mg        End Jan 2013: P 9mg, W 100mg, I 2.0mg
Feb 2013: P 8mg, W 100mg, I 1.5mg      April 2013: P 7mg, W 100mg, I 1.25mg       May 2013: P 7mg, W 90mg, I 1mg    

June 2013: P 7mg, W 80mg, I 0mg       July 1/2013: P 7, W 70     July 22/2013: P 7, W 60             Aug 2013: P 7, W 50       Sept 2013: P 6.1, W 50     Oct 2013: P up to 6.3, W 50     Nov 2013: P 6.2 to 5.9, W 50      Dec 2013: P 5.9, W 40      Jan 2014: P 5.3, W40        Feb 2014: P 5.3, W 30      March-April 2014: P 5.3, W 26    May 2014: P 5.3, W 20        June 2014: P 5.3 W 15     July 2014:  P 5.3, W 14       Aug 2014: P 5.3, W up to 15     Sept 2014: P 5.3, W 14    Oct 2014: P 4.8, W 14      Nov 2014: P 4.3, W 14     Dec 2014-Jan 2015: P 3.9, W 14     Feb 2015: P 3.9, W 12    March 2015: P 3.6, W 12   April-May 2015: P 3.3, W 12    June 2015: P 3.3, W 10    July 2015: P 3.3, W 8   Aug-Sept 2015: P 3.3, W 6   Oct 2015: P 3.0, W 6   Nov 2015: P 2.7, W 6   Dec 2015: P 2.4, W 6   Jan-Feb 2016: P 2.4, W 5  March 2016: P 2.2, W 5   April 2016: P 2.2, W 4   May-June 2016: P 2.2, W 3  July 2016: P 2.2, W 2  Aug 2016: P 2.2, W 1  Sept 2016: P 2.2, W 0!!  Oct 2016: P 2.0   Nov 2016-Jan 2017: P 1.8  Feb-Mar 2017: P 1.9  April-May 2017: P 1.8   June 2017: P 1.6 July-Dec 2017: P 1.5  Jan-April 2018: P 1.6

Others: Cytomel 25mcg (thyroid), vit. C, vit D, Omega-3 fish oil, Magnesium bisglycinate , Melatonin 1mg, 81mg Aspirin, Milk peptides, L-theanine, Valericalm tincture mix, scullcap tincture, Suan Zao Ren (jujube seeds)

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I found bioactive milkpeptides in the brand LifeExtension. They say it's the same component as Lactium. For those having a hard time to find one under the name Lactium shipped to their place...

2000-2001: Effexor              2005-2012: Celexa, Zoloft, Effexor, desipramin, Wellbutrin, mirtazepin, Lamictal, Remeron, Abilify, nortriptylin, Cipralex, Cymbalta, and others I don't remember. Really bad side effects to all.
Sept-Nov 2012: Paxil 20mg, Wellbutrin 100mg, Imovane 5mg      Nov 2012: Paxil 20mg --> 10mg
Dec 2012: Paxil 10mg-->0; 1 week later: HUGE WD symptoms. Started to get informed on the internet and back to 10mg Paxil.
Dec 2012-Jan 2013: Paxil 10mg, Wellbutrin 100mg, Imovane 2.5mg        End Jan 2013: P 9mg, W 100mg, I 2.0mg
Feb 2013: P 8mg, W 100mg, I 1.5mg      April 2013: P 7mg, W 100mg, I 1.25mg       May 2013: P 7mg, W 90mg, I 1mg    

June 2013: P 7mg, W 80mg, I 0mg       July 1/2013: P 7, W 70     July 22/2013: P 7, W 60             Aug 2013: P 7, W 50       Sept 2013: P 6.1, W 50     Oct 2013: P up to 6.3, W 50     Nov 2013: P 6.2 to 5.9, W 50      Dec 2013: P 5.9, W 40      Jan 2014: P 5.3, W40        Feb 2014: P 5.3, W 30      March-April 2014: P 5.3, W 26    May 2014: P 5.3, W 20        June 2014: P 5.3 W 15     July 2014:  P 5.3, W 14       Aug 2014: P 5.3, W up to 15     Sept 2014: P 5.3, W 14    Oct 2014: P 4.8, W 14      Nov 2014: P 4.3, W 14     Dec 2014-Jan 2015: P 3.9, W 14     Feb 2015: P 3.9, W 12    March 2015: P 3.6, W 12   April-May 2015: P 3.3, W 12    June 2015: P 3.3, W 10    July 2015: P 3.3, W 8   Aug-Sept 2015: P 3.3, W 6   Oct 2015: P 3.0, W 6   Nov 2015: P 2.7, W 6   Dec 2015: P 2.4, W 6   Jan-Feb 2016: P 2.4, W 5  March 2016: P 2.2, W 5   April 2016: P 2.2, W 4   May-June 2016: P 2.2, W 3  July 2016: P 2.2, W 2  Aug 2016: P 2.2, W 1  Sept 2016: P 2.2, W 0!!  Oct 2016: P 2.0   Nov 2016-Jan 2017: P 1.8  Feb-Mar 2017: P 1.9  April-May 2017: P 1.8   June 2017: P 1.6 July-Dec 2017: P 1.5  Jan-April 2018: P 1.6

Others: Cytomel 25mcg (thyroid), vit. C, vit D, Omega-3 fish oil, Magnesium bisglycinate , Melatonin 1mg, 81mg Aspirin, Milk peptides, L-theanine, Valericalm tincture mix, scullcap tincture, Suan Zao Ren (jujube seeds)

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I had high hopes for milk peptides helping with my insomnia but they did the opposite and I found them activating, I tried the swansons brand seen in link below:

 

https://www.amazon.co.uk/gp/product/B0017O95SQ/ref=oh_aui_detailpage_o02_s00?ie=UTF8&psc=1

 

will maybe try again in a few months as im starting to be less sensitive to supplements now, 

 

only things that help me is slow release melatonin and epsom salt baths

2001 - 2005 prozac,  2001 - 2017 various benzos, mainly diazapem and zanex,  2002 - 2017 olanzapine or seroquel,  2002 -2017 propanolol, 2005 - 2009 venlafaxine 75mg , forced to go cold turkey off venlafaxine as moved Thailand, doctor cut me off and couldn't get it there, severely ill for over 2 years, countered withdrawals with more zanex and seroquel

2014 returned to UK, mainly to get treatment getting off meds

doctor advised to taper seroquel over a few weeks, severely ill and bed bed-bound so reinstated it, 2015 tapered seroquel myself slower over a few months, was off it 2 months and was too ill so went on olanzapine, became zombie and too tired to get out of bed, went back on seroquel, very depressed so went back on venlafaxine, didnt work  so doctor swapped to zoloft became very agitated so back on venlafaxine

June 2016 - felt strong enough to begin tapering again, started what I thought was a slow taper of all meds,  2016 July Not had any alcoholic drink since this date, 

2016 October completely off diazepem, 2017 Feb completely off seroquel, 2017 March completely off proponanlol, 2017 April (day before birthday) completely off venlafaxine, OFF ALL MEDS 11/4/2017, was fine for nearly 3 months and then delayed withdrawal hit,

supplements taking: turmeric capsules, NiaCel (nicotinamide riboside), Vit B12 sublingual, Vit B3, Vit B6, Vit B1, apple cider vinegar, manuka umf 10 honey, camu camu powder,  melatonin when needed, epsom salt baths, juices, smoothies, 

Intro: http://survivingantidepressants.org/topic/15175-dj2010-off-all-meds-for-3-months-and-been-fine-now-bad-insomnia/

 

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  • 1 year later...
Courageous

This article has some food for thought—from a skeptical perspective it picks apart the studies done on Lactium:

 

http://www.dcscience.net/2009/11/26/lactium-more-rubbish-from-boots-the-chemists-and-a-more-serious-problem/

 

  • 2019-01-16 50 mg of Trazodone 2x/week
  • 01-23 up to 100 mg, various frequencies and dosages
  • 05-03 100 mg
  • 05-10 90 mg
  • 05-16 Starting tapering by 2.5 mg/day
  • 05-30 50 mg
  • 05-31 65 mg
  • 06-07 75 mg
  • 06-15 67.5 mg
  • 06-17 75 mg
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  • 5 months later...

@Altostrata I know this is an old thread. Does it still seem like Lactium is worth trying out?

3/21/19 started Bupropion XL 150 mg

3/21/19 started Risperidone 2mg

7/7/19 start Abilify half dose 5 mg. discontinue Risperidone

7/9/19 full dose Abilify 10 mg

7/29/19 discontinued Abilify due to panicky side effects

8/2/19 Began Latuda 20 mg

8/5/19 discontinued Latuda due to similar side effects 

8/10/19 discontinued Bupropion after realizing it was causing the insomnia

From 8/10/19 no drugs whatsoever

Currently taking Magnesium 150mgs daily

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