Jump to content

2009: FDA hears testimony about Cymbalta discontinuation syndrome


Altostrata

Recommended Posts

  • Administrator
Altostrata

NOTE Also see

 

Study finds some Cymbalta withdrawal "severe and persistant"
 
Doctor is shocked at severe Cymbalta withdrawal symptoms

 

Cymbalta Withdrawal Lawsuits Progressing in US

 

Tips for tapering off Cymbalta (duloxetine)

 


 

This presentation was part of the June 9, 2009 meeting minutes of the FDA Psychopharmacologic Drugs Advisory Committee meeting in Maryland. It contains many anecdotal reports of severe and long-lasting withdrawal syndrome from Cymbalta, a relatively new wonder drug.

Pdf at http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/PsychopharmacologicDrugsAdvisoryCommittee/UCM172866.pdf or http://www.mediafire.com/?hfigc5c6c04ekki

About the FDA Psychopharmacologic Drugs Advisory Committee: http://google2.fda.gov/search?q=Psychopharmacologic+Drugs+Advisory+Committee&x=6&y=10&client=FDAgov&site=FDAgov&lr=&proxystylesheet=FDAgov&output=xml_no_dtd&getfields=*

From the presentation to the FDA
 

Much anecdotal evidence has accumulated documenting the
injury, distress and life management impacts caused by
discontinuation of Cymbalta
The effects of discontinuation can be severe and extend for weeks or
even months

  • Extreme mood swings (anger, irritability)
  • Debilitating “Brain Zaps”
  • Physical and neurological problems
– Physical and psychological disturbances adversely affect job function
and family/social relationships
  • Employment risk
  • Negative impacts on care of family members
Edited by Altostrata
updated

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Link to post
Share on other sites

According to this article, Cymbalta is even worse than PAxil. I can hardly imagine a hell with even more scorching temperature as I went through... and that for years.

Good thing that the FDA has gotten access to this report. But I have little confidence that it will lead to appropriate action. The remarks about tapering are most important, the leaflets these days do contains warnings about the need for tapering off, but none of the manufacturers delivers a working scheme in the leaflet or refers to use of the liquid...

10 mg Paxil/Seroxat since 2002
several attempts to quit since 2004
Quit c/t again Oktober 2007, in protracted w/d since then
after 3.5 years slight improvement but still on the road

after 6 years pretty much recovered but still some nasty residual sypmtons
after 8.5 years working again on a 90% base and basically functioning normally again!

 

Link to post
Share on other sites
  • 10 months later...
  • Administrator

Sorry, this topic was closed by mistake. Post on!

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Link to post
Share on other sites

Is there a link to another version of that file? I can't open files at that site. :( I'd be fascinated to read the document, even though I'm not on that drug.

B

2005 St John's Wort / 2006-2012 Lexapro 20mg, 2 failed attempts to stop, tapered over 4.5 months in early 2012

January 2013 started Sertraline, over time worked up to 100mg

July 2014 Sertraline dropped from 100mg to 75mg, held for six months, slower tapering until 2019 22 Dec 3.2mg

2020 Sertraline 19 Jan 3.1mg, 26 Jan 3.0mg; 1 Mar 2.9, 7 Mar 2.8, May (some drops here) 24 May 2.5, May 29 2.4, June 21 2.3, June 28 2.2mg,  July 4 2.1mg, July 24 (or maybe a bit before) 2mg, early Nov switched to home made suspension; 29 Nov 1.8mg; approx 25 Dec 1.6mg)

2021 Some time in about Jan/Feb realised my dosing was off and as probably on more like 1.8mg and possible mixing error in making suspension; doses after 10 Feb accurate; 10 Feb 1.6mg; 7 Mar 1.4

 

My thread here at SA: https://www.survivingantidepressants.org/topic/1775-bubbles/page/17/

CurrentSertraline: 7 Mar 1.4mg / Armour Thyroid / endless allergy meds, erg

 

 

Link to post
Share on other sites
  • Administrator

Put this in Google:

 

Cymbalta (Duloxetine) Discontinuation Syndrome www.fda.gov

 

It is the search result on www.fda.gov, a pdf download

Edited by Altostrata
fixed text

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Link to post
Share on other sites

Thanks Alto.

B

2005 St John's Wort / 2006-2012 Lexapro 20mg, 2 failed attempts to stop, tapered over 4.5 months in early 2012

January 2013 started Sertraline, over time worked up to 100mg

July 2014 Sertraline dropped from 100mg to 75mg, held for six months, slower tapering until 2019 22 Dec 3.2mg

2020 Sertraline 19 Jan 3.1mg, 26 Jan 3.0mg; 1 Mar 2.9, 7 Mar 2.8, May (some drops here) 24 May 2.5, May 29 2.4, June 21 2.3, June 28 2.2mg,  July 4 2.1mg, July 24 (or maybe a bit before) 2mg, early Nov switched to home made suspension; 29 Nov 1.8mg; approx 25 Dec 1.6mg)

2021 Some time in about Jan/Feb realised my dosing was off and as probably on more like 1.8mg and possible mixing error in making suspension; doses after 10 Feb accurate; 10 Feb 1.6mg; 7 Mar 1.4

 

My thread here at SA: https://www.survivingantidepressants.org/topic/1775-bubbles/page/17/

CurrentSertraline: 7 Mar 1.4mg / Armour Thyroid / endless allergy meds, erg

 

 

Link to post
Share on other sites
  • 1 year later...
  • Administrator

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Link to post
Share on other sites
  • 4 weeks later...
  • Administrator

The FDA report about Cymbalta withdrawal is quoted here: http://www.prohealth.com/library/showarticle.cfm?libid=18811&vote=finished

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

Link to post
Share on other sites
×
×
  • Create New...

Important Information

Terms of Use Privacy Policy