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Tips for tapering off Zyprexa (olanzapine)


Altostrata

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hayduke

@Emily02I've been concerned about TD too, especially when my original prescriber said "it's not such a big deal".  Like a Hammer horror film or something, yuck.

 

I don't really have tremors, but feel more urges to stretch my fingers and hands while I taper.  A trend to more twitchy.

 

I think this, and akathisia, are probably largely induced by dopamine receptors opening up as the blockade reduces.  My hunch is it's not just about particular dopamine levels, especially once you hold and your neurology catches up, but about rate of change of dopamine levels.  I would love to taper faster but when things like this start looking like flaring up, I'd rather read the signs.

 

I found an old paper that reckoned Niacin and manganese worked in one trial.  I have both but don't take them that often. 

 

I had a blood test to check my manganese levels before getting the supplements to ensure it was safe.  It's good to do this before looking at any supplements, seeing where your body's already at with each of them.

 

I had a course of B12 booster shots which helped all round.  I had got a bit low on those.  I started taking 1500IU of Vitamin E, which I reduced to 1000IU after reading you don't want to overdo it.  I also found methyl folate helps, again you don't want to overdo it.

 

Probably the Vitamin E has been the most calming in the sense of most days seeing no tendency to tremor at all.  But still wise for me to hold when it seems helpful and let dopamine levels even out and my neurology readjust to increased amounts of it.

 

My taper visualised as a graph   |   My intro thread

I am not a health professional - your actions are your own

 

Backdrop:  10mg olanzapine 2003-06.  3mg risperidone 2006-2014.  Abortive x-taper to aripiprazole Dec 2014, back to 10mg olanzapine after 3 weeks.

2015:  10 -> 7 1/2 -> 6 2/3 -> 5mg olanzapine using pill cutter

2018:  Finer taper liquid suspension 5mg to 2.5 Mar-Aug and hold

2019: Jan 2.5 | Eostre EMDR@2.1mg | Jul 1.625 | Oct 1.3

2020: Jan 1.214 | Apr 0.88 | July 0.69 | Oct 0.525

2021: Jan EMDR@0.44 | Apr 0.38

"Ask not what you can do for your country, but what your country did to you"  -- KMFDM

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I'm kind of out of it right now and need to go to bed, but I just wanted to toss in my usual bit on the subject of making preparations for liquid tapering, which is: I personally don't worry about sol

Hi Lauren,   I'm a Zyprexa survivor...it can be done! Why don't you write a full intro with signature in the intro and update forum, especially if you are on other meds. I've made a lot of mistak

Just an update. I made a liquid solution with water and the orodispersible tablet. It forms a perfectly even solution so a daily taper should be accurate.

Some studies says Pyridoxine aka vitamin B6 reduces symptoms of TD. Here's a summary: https://cdn.mdedge.com/files/s3fs-public/Document/September-2018/cp01710042.pdf

 

There's some support for it as cure but more for it as at least symptom relief while taking it at 300 - 1200 mg/day. Adverse effects reported are low. However the tolerable upper limit for long term use is set by EFSA to 25 mg/day. The recommended daily intake is around 1.5 mg so those are large doses in the studies. 

 

 

A week of oxazepam 10mg with 1 day of zopiclone 7.5mg and concurrent Zyprexa totalling: 10mg 25 days , 7.5mg 18 days, 5mg 14 days, 2.5mg 11 days,  10x0mg + 4x1mg. Very bad condition reinstated: zyprexa 7.5mg zopiclone 8.5mg, 25mg Propiomazine. Next day 5mg Z. Then 6 months taper to nothing but Zyprexa and 0.0mg again. 6 days 0mg. Reinstated 0.12mg x2 days. 23 june: 0.25mg. 29 june: 0.12mg. 8th and 9th july 2020 also tried 0.375mg Melatonin. 9 july 0.16mg. Made an error of judgement in august and was forced on various drugs in hospital mainly landing on: Abilify injections + pills for a daily total of 5-15 mg (for 2½ month) + zyprexa 3 days of 10mg mostly 2.5mg but started cheating. 14 oct 2020 only zyprexa and due to cheating earlier able to go 0.31mg! 30 oct 0.21mg, 13 nov 0.14mg, 28 nov 0.10mg, 14 dec 0.07mg, 04 jan 2021 0.035mg, 25 jan 0.017mg, 4 feb 2021 0.000 mg

 

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Emily02

Hi @hayduke

TD ‘it’s not such a big deal’ OMG!

What I realised is that psychiatrists usually don’t have any empathy.

Thanks for your reply and the suggestions, I really appreciate them.

Thanks @Hopela for the excellent advice. I’ll starts supplementing with B6.

I hope you’re well.

Take care

2019 Nov-2020 January 5mg Olanzapine 

2020 January-2020 March 2,5 mg Olanzapine 

2020 March- 2020 August 5mg Olanzapine

2020 August-2020 Sept 2,5 mg Olanzapine 

2020 September-2020 November 5mg Olanzapine 

started 10% reduction 

2021 March 3,5 mg Olanzapine 

2021 April 2,5 mg Olanzapine 

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hayduke
1 hour ago, Emily02 said:

Hi @hayduke

TD ‘it’s not such a big deal’ OMG!

What I realised is that psychiatrists usually don’t have any empathy.

Thanks for your reply and the suggestions, I really appreciate them.

Thanks @Hopela for the excellent advice. I’ll starts supplementing with B6.

I hope you’re well.

Take care

 

Yeah I think he's a sadist.

 

I feel I should reiterate the SA policy of not recommending any supplements besides magnesium and omega-3.  I did my own homework and experiments with those I listed.

 

One potential snag with the Vitamin B6 @Hopela mentioned is that many members have reported it as tending to induce akathisia.  I found akathisia reduced a lot for me when I put aside the mega-B multivitamins for specific B vitamins.

 

Interestingly I generally find berocca helpful, but I was raised a drinker.

My taper visualised as a graph   |   My intro thread

I am not a health professional - your actions are your own

 

Backdrop:  10mg olanzapine 2003-06.  3mg risperidone 2006-2014.  Abortive x-taper to aripiprazole Dec 2014, back to 10mg olanzapine after 3 weeks.

2015:  10 -> 7 1/2 -> 6 2/3 -> 5mg olanzapine using pill cutter

2018:  Finer taper liquid suspension 5mg to 2.5 Mar-Aug and hold

2019: Jan 2.5 | Eostre EMDR@2.1mg | Jul 1.625 | Oct 1.3

2020: Jan 1.214 | Apr 0.88 | July 0.69 | Oct 0.525

2021: Jan EMDR@0.44 | Apr 0.38

"Ask not what you can do for your country, but what your country did to you"  -- KMFDM

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