Moderator Erell Posted November 27, 2019 Moderator Share Posted November 27, 2019 Hello Quick note To tell that oral solution is out of stock in France too. All I can advise for dear survivors is To try To call all drugstores in their area : it worked for me this morning as I found my med for another month. About January 2020 : In France we don't have a timeframe, I Will let you know when this out of stock Will end. Best wishes 1 2006 : 20mg Paroxetine + Bromazepam(no specific dose) (2008 : cold turkey of both) 2010 : 20mg Deroxat + Bromazepam 2013: Switch from Bromazepam To Prazepam (longer half-life) 2014-June2017 : Prazepam taper, 3% drops. 2018 to August 2019 : Paroxetine 20mg taper (3% every 15 days). - 22nd August updosed To 10mg (was at 8.4mg) 25th Sept 2019 To April 2020 : found SA, holding at 10mg Paroxetine. April 2020-August 2020 : Paxil to Prozac bridge. Details : https://www.survivingantidepressants.org/topic/21457-erell-struggling-with-paroxetine/?do=findComment&comment=499847 Current Supplements : magnesium citrate/ fish oil/ evening primrose oil Current medication : 7mg Fluoxetine + toothpick Paroxetine (since 20 Aug 2020) + 1mg Diazepam (since 29 Aug 2020) Website : https://selibererdelapsychiatrie.wordpress.com/ Link to post Share on other sites
goggins Posted June 14, 2020 Share Posted June 14, 2020 Hi guys. I'm going through a journey of tapering off paroxetine. My initial dose was 20mg that I've been on for years. Now at 11mg and just went through some tough times trying to get down to 10mg. Couldn't bear the symptoms so I'm resuming to 11mg for a while. I'm doing liquid paroxetine. Because it was so hard to taper off 1mg, I think it's time to start tapering off by smaller amounts. The problem is that the dispenser of the little bottles does only 1mg/droplet, so I need another way to dose. The concentration is 33mg/mL, which means 1mg/30.3uL. Doing the math, my current dose of 11mg means I'm at 333.33uL. My plan is to buy some 100uL precision syringe. With a 1uL scale, I'll be able to taper off as low as 33ug at a time. That will be a much slower pace which I'm sure my nervous system will tolerate much better. I was also thinking about doing my own solid tablets or capsules, mainly for convenience. That will allow me to do the dosing for a whole week or month in one sitting, and I won't have to be home every day by the time I need to take the pill. I can just carry the pill around with me and take it wherever I'm at. So that leads me to my actual questions: what's the best filler that I can use for the solid tablet or capsule? I mean, I want to dispense the liquid paroxetine dose into the tablet or capsule, but I'm not sure which solid substance or powder to use. It definitely needs to be something neutral that will not react with the paroxetine. I read about some herbal fillers such as Cayenne, Ginger or Turmeric. I'd love to hear thoughts on those, as well as any other suggestions. what are some good suppliers that I could get 100uL precision syringes? I'll have them shipped to Germany. any thoughts about my approach? am I doing something wrong? 🌬️Wim Hof Method practitioner ❄️ SSRI history: Paroxetine: 2008 - 2010 Paroxetine: 2012 - 2015 Wellbutrin, Escitalopram: 2015 (briefly) Paroxetine: 2015 - 2020 or 2021 (hopefully) 100% passionate about life, not willing to give up! Link to post Share on other sites
Moderator brassmonkey Posted June 14, 2020 Moderator Share Posted June 14, 2020 @goggins Very interesting questions. I have some ideas and comments but need some more information first. What is the total volume of liquid you wish to use per dose? 20 years on Paxil starting at 20mg and working up to 40mg. Sept 2011 started 10% every 6 weeks taper (2.5% every week for 4 weeks then hold for 2 additional weeks), currently at 7.9mg. Oct 2011 CTed 15oz vodka a night, to only drinking 2 beers most nights, totally sober Feb 2013. Since I wrote this I have continued to decrease my dose by 10% every 6 weeks (2.5% every week for 4 weeks and then hold for an additional 2 weeks). I added in an extra 6 week hold when I hit 10mg to let things settle out even more. When I hit 3mgpw it became hard to split the drop into 4 parts so I switched to dropping 1mgpw (pill weight) every week for 3 weeks and then holding for another 3 weeks. The 3 + 3 schedule turned out to be too harsh so I cut back to dropping 1mgpw every 4 weeks which is working better. Current dose 0.000mg 04-15-2017 "It's also important not to become angry, no matter how difficult life is, because you can loose all hope if you can't laugh at yourself and at life in general." Stephen Hawking Link to post Share on other sites
Administrator Altostrata Posted June 14, 2020 Author Administrator Share Posted June 14, 2020 You can increase the dilution by adding water. This will enable you to accurately measure small amounts. What size is your oral syringe, what is the smallest amount between ticks? (You usually can get 1mL or 0.5mL oral syringes from a pharmacist or veterinarian.) @brassmonkey will explain. This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to post Share on other sites
goggins Posted June 14, 2020 Share Posted June 14, 2020 hey @brassmonkey and @Altostrata, thanks for replying I also considered diluting in water, this can be an easy way to achieve similar results without going for a high grade precision syringe the problem with this approach is that the liquid volume could become restrictive to do the tablets or capsules, which is my main goal I've been looking into some syringes with 100uL volume. They have a scale of 1uL, which allows for great precision. For example this one: https://www.hamiltoncompany.com/laboratory-products/syringes/80630 @brassmonkey my current dose is 333uL. What I'm really curious about is which material to use for filling the capsules. I mean, I need the solid part, I can't just inject the liquid into empty gelatine capsules. And it needs to be something I'll know for sure won't interact with the paroxetine chemically. 🌬️Wim Hof Method practitioner ❄️ SSRI history: Paroxetine: 2008 - 2010 Paroxetine: 2012 - 2015 Wellbutrin, Escitalopram: 2015 (briefly) Paroxetine: 2015 - 2020 or 2021 (hopefully) 100% passionate about life, not willing to give up! Link to post Share on other sites
Administrator Altostrata Posted June 14, 2020 Author Administrator Share Posted June 14, 2020 1 hour ago, goggins said: the problem with this approach is that the liquid volume could become restrictive to do the tablets or capsules, which is my main goal Please explain. Are you putting liquid in capsules? Why? This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to post Share on other sites
goggins Posted June 14, 2020 Share Posted June 14, 2020 I don't want to do the dosing every day. I can become cumbersome and error-prone. I want to do a whole batch in one sitting, meant to last for at least a week or more. That's why I'm speculating around capsules and trying to find out what to use for the solid part. But it just occurred to me to use blotting paper, in the same fashion LSD is dispensed. Not that I'm advocating LSD or anything (much on the contrary). I just mean it as a reference of how small liquid doses are dispensed on large batches. 🌬️Wim Hof Method practitioner ❄️ SSRI history: Paroxetine: 2008 - 2010 Paroxetine: 2012 - 2015 Wellbutrin, Escitalopram: 2015 (briefly) Paroxetine: 2015 - 2020 or 2021 (hopefully) 100% passionate about life, not willing to give up! Link to post Share on other sites
Administrator Altostrata Posted June 14, 2020 Author Administrator Share Posted June 14, 2020 Sorry, we're fans of Keep It Simple. Please let us know what you find out. 1 This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to post Share on other sites
Adili13 Posted July 14, 2020 Share Posted July 14, 2020 Has anyone experimented with tapering down to 12.5 paroxetine ER and using that pill and it’s extended property to stabilize better than being on a liquid dose or paroxetine standard release. 2008: start Lexapro 10 mg which is quickly upped to 20 mg. 2008:2013 try at least four individual times to get off Lexapro, never get lower than 5mg, settle at 15 mg. 2015: again, attempt to get off Lexapro and get to 5 mg. After 6 months, feel i'm stabilizing but go back on a higher dose because of one stressful event. 2016: go to 20 mg from 15 mg due to work stresses, hit severe tolerance for the first time and become very suicidal. 2016-2017: try viibryd and cymbata in an attempt to feel better. Also add Lamictal 150 at some point. 2017: eventually land on paxil 37.5 and Lamictal 150. January 2018: cut paxil to 25. April-July 2018: reduce Lamictal in 50 mg increments till im off August. 2018: reduce paxil to 20 mg. december 2018: dropped Paxil to 18 mg, SEVERE CRASH. March updosed to 20 mg April 11: dropped to 19.4 mg due to akathsia (still experiencing akathsia symptoms from updose) April 20: 19 mg Paxil May 4: 18.7 Paxil July 5: 18.2 July 12: 17.8 Aug 19: 17.5 Aug 26: 17.3 Oct 20: 17.1 Nov 3: 16.9, 8/17/20: 16.6 after nine month hold, 8/24/20: 16.4, 8/31/20:16.2, 9/14/2020: 16.0, 9/21/20: 15.8, 9/28/20: 15.6, 10/19/20:15.4, 10/26/20: 15.2, 11/2/20: 15.1, 11/7/20: 14.8 Medication signature.docx Link to post Share on other sites
maree Posted July 27, 2020 Share Posted July 27, 2020 HI all, Today is monday here in New Zealand and I'm getting confused about conflicting information. The medical industry doctors, chemist etc are saying everything is going ot be ok and yet the media last week in the articles I posted said otherwise. Apparently my meds that were being supplied by Apotex has been supplied since last Dec by a drug company out of USA called 'Mylan' according to doctors office and chemist. So I'm calmer but still wondering. Maree and thanks again to everyone Maree 20 yrs on 60mg per day paroxitine(paxil)then: last 3 years tapering now on 30 mg per day 2-12 April/18 Unsuccessful taper by sliver off tabs. Aborted taper and stabilised My tablets are Paroxitine/Paxil Tables 20mg(APO) and the writing on the back of the foil sheet says: Apo-paroxitine 20mg (as hydrochloride)(B)NA3817 Reminder to myself: We recommend reductions at monthly intervals to give the nervous system a good 3 weeks to settle down between cuts. To save wear and tear on your nervous system, after a taper stay at that level for a month to see if withdrawal symptoms develop. Link to post Share on other sites
Moderator Emeritus ChessieCat Posted November 9, 2020 Moderator Emeritus Share Posted November 9, 2020 Rachelina posted this elsewhere: Diluting concentrated Paxil liquid: 7 hours ago, Rachelina said: I just realized it's been about a year since I started diluting my liquid Paxil, so I thought I'd give a quick update. It's going great. The solution that I make is ten times less concentrated than the original liquid, which means my measurement is ten times more accurate. That is huge. Liquid Paxil is so concentrated that any tiny variation in the amount taken, which is impossible to avoid with syringes, makes a big difference in the dose you are getting. This makes consistent daily dosing almost impossible, and I think that was a factor in how badly I was doing last year before starting to dilute. The other advantage of diluting is that I get to make drops as small as I want them, whereas before the smallest drop I could make was .02 mg. I knew for years that I was not getting accurate doses due to the high concentration of the liquid, but postponed diluting because I was afraid to change anything, afraid I wouldn't be able to figure out how to actually do it, afraid I would get the math wrong. Someone in this thread kindly got me started, and actually, it's totally easy. It's hardly any more work than before. So I just wanted to recommend dilution to anyone tapering a highly concentrated liquid medication. It will be vastly more accurate, which becomes more and more important the lower you get in dose. NEW!!! INTERVIEW with Altostrata, SA's founder NEW!!! REMINDER TO SELF: I don't need the drug now, but my still brain does. Current from 9 Jan 2021: Pristiq 0.405 mg ADs since ~1992: 25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq: 50mg 2012, 100mg beg 2013 (Serotonin Toxicity) Tapering Oct 2015 My tapering program My Intro (goes to my tapering graph) My website PLEASE NOTE: I am not a medical professional. I provide information and make suggestions. Link to post Share on other sites
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