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Cortisol-blocker metyrapone investigated for PTSD

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Altostrata

Drug may take the edge off bad memories - study

 

NEW YORK | Thu May 26, 2011 10:24pm EDT

 

May 27 (Reuters Life!) - Blocking a hormone involved in the body's response to stress may change the way people recall negative memories, said a study.

 

But it's still unclear exactly how the drug works, and whether it has implications for the treatment of conditions such as post-traumatic stress disorder (PTSD), according to the study, which appeared in the Journal of Clinical Endocrinology & Metabolism.

 

The drug, metyrapone, blocks the stress hormone cortisol and has been used to treat people with diseases related to cortisol production.

 

Cortisol is also involved in storing and retrieving memories, though, making researchers wonder if tinkering with its levels could change how people recall past events.

 

"We know that (cortisol) is important for memory," said Marie-France Marin, the study's lead author from the University of Montreal.

 

"Very high levels are bad for your memory, and very low levels are bad for your memory," she told Reuters Health.

 

....

The goal of such research would be something that might help treat PTSD that doesn't resolve with psychotherapy. About 3.5 percent of U.S. [veterans] suffer from PTSD, with estimates of up to 20 percent of veterans of the Iraq and Afghanistan wars, according to the National Institute of Mental Health.

 

More research is needed -- to see if women would have the same response as men, or to study other drugs that might have the same affect. Metyrapone is currently not on the market.

....

 

http://www.reuters.com/article/2011/05/27/health-memories-idUSL3E7GR06N20110527

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Neuroplastic

But it's still unclear exactly how the drug works, and whether it has implications for the treatment of conditions such as post-traumatic stress disorder (PTSD), according to the study, which appeared in the Journal of Clinical Endocrinology & Metabolism.

And as usual. :blink:

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angie007

Yet another mind bending psychiatric med that will cause

untold damage and distress for its users no doubt in time to come :unsure:

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Altostrata

Well, at least they're looking at cortisol.

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angie007

Absolutely, as i feel cortisol is a big problem for us all,

and is responsible for so many of our wd symptoms.

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