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Tips for tapering off stomach acid blockers or PPIs (esomeprazole, lansoprazole, omeprazole)


Altostrata

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I successfully tapered off of Lansoprazole 30mg after taking it for 9 years a year or so ago because it caused me to have low iron. This is the system that I came up with (with my doctor's support) because I was terrified of rebound acid. Each week, I dropped one daily dose to 15mg and held for 3-4 weeks because I'd read that it takes 3 weeks for your body to realize that it doesn't have to produce as much acid. I tried to keep the days spaced out. Example, first day I dropped was Saturday. After three weeks, I dropped Tuesday as well. Etc. Once I got down to 15mg each day, I started the same thing with just not taking a pill one day a week. Then I started putting more and more days between them. I can't remember how many days between I was doing before I stopped entirely. I found that the rebound acid was worst on the day after the drop. To combat that, I used Gaviscon. 

 

I still need to use Gaviscon periodically, but it's nothing like when I was maxing out the daily dosage every single day thanks to work stress. 

1994 - Prozac for 3 weeks, then Zoloft until 1997

2000 - Celexa for 3 days, then Luvox until 2002ish?

2001 - Risperdal for 4 months - Started Buspar around here, until 2003 maybe

2004 - Clonazepam

2005 - 2007 Paxil

2011 - Buspar again until 2016 or 2017

2011 - 2014 - Cipralex

2013 - Added Wellbutrin. Stable on 300mg Wellbutrin XL until Nov 2018 when shortages caused me to switch generics

Jan 30, 2019 - Beginning taper by first switching to 150mg SR twice a day. Taking Ativan periodically since November after not taking it for years

supplements: 2016 iron pills, 2017 2000IU Vit D, 250mg Magnesium, 300mg B2, Omegas all twice a day

 

 

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I don't know how tapering omeprazole will affect the escitalopram in your system. For your other questions, please read this topic from the beginning.

Hi,   What really helped me coming off my PPI was drinking Dandelion root tea, yarrow tea and sometimes liquorice tea. Just be careful with the liquorice tea as that can cause other issues i

I never new that...maybe that's why when I stopped lexapro it was so hard.    but I have YET to get off omeprozole. I went from 40 down to 30 but stopped there as the rebound heartburn was j

  • Administrator

Hi, Damianamae. Do you mean you skipped doses of lansoprazole?

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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I guess that’s what if amounts to, yes. I had read that there was powder inside so I didn’t want to open them up and I had no other idea of how to do it to help my body adjust.

 

I can delete my post if it’s seen as misleading to the other methods.

1994 - Prozac for 3 weeks, then Zoloft until 1997

2000 - Celexa for 3 days, then Luvox until 2002ish?

2001 - Risperdal for 4 months - Started Buspar around here, until 2003 maybe

2004 - Clonazepam

2005 - 2007 Paxil

2011 - Buspar again until 2016 or 2017

2011 - 2014 - Cipralex

2013 - Added Wellbutrin. Stable on 300mg Wellbutrin XL until Nov 2018 when shortages caused me to switch generics

Jan 30, 2019 - Beginning taper by first switching to 150mg SR twice a day. Taking Ativan periodically since November after not taking it for years

supplements: 2016 iron pills, 2017 2000IU Vit D, 250mg Magnesium, 300mg B2, Omegas all twice a day

 

 

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We just need a little more detail. How many capsules were you taking per day, at what dosage?

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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I started off taking a 30mg capsule once daily. When I was taking 15mg, they were also single capsules once daily.

1994 - Prozac for 3 weeks, then Zoloft until 1997

2000 - Celexa for 3 days, then Luvox until 2002ish?

2001 - Risperdal for 4 months - Started Buspar around here, until 2003 maybe

2004 - Clonazepam

2005 - 2007 Paxil

2011 - Buspar again until 2016 or 2017

2011 - 2014 - Cipralex

2013 - Added Wellbutrin. Stable on 300mg Wellbutrin XL until Nov 2018 when shortages caused me to switch generics

Jan 30, 2019 - Beginning taper by first switching to 150mg SR twice a day. Taking Ativan periodically since November after not taking it for years

supplements: 2016 iron pills, 2017 2000IU Vit D, 250mg Magnesium, 300mg B2, Omegas all twice a day

 

 

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JackieDecides

this reminds me my supposed taper of Omeprozole is stalled.

 

I started taking 2 pills a day and still take 1.5 a day months later but now I need 1 Ranitidine a day, almost always. so I've switched half an Ompeprazole for one Ranitidine, am I any better off? 

Currently taking Ramapril (blood pressure) 5 mg twice a day

Omeprazole 10 mg AM and 20 mg PM  (the taper has gone nowhere after the first cut)

Famotidine   once a day (and I still needs tums sometimes)

magnesium 200 mg at night

as of yesterday 2 fish oil capsules "EPA-DHA 1000"

 

off Lexapro as of 5/2018  - last dose had been 5 mg every other day for a couple years

 

highest dose had been 20 mg at which point I was diagnosed with Bipolar II, which went away when I cut the lexapro down to 15 mg. 

 

I spent years on Paxil before Lexapro (can't remember dose), briefly on Effexor and Abilify and others I have forgotten. in fact, when I was diagnoses with BPII I was put on all kinds of things which made me feel so bad I stopped them cold turkey within maybe 3 or 4 weeks, thank goodness. since then I've known these pills were terrible and I weaned down the Lexapro with zero help or support over I'm not sure how many years. 

 

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  • 1 year later...

Preparing to tapper PPI, but unsuccessful 

I made a mistake by slipping a dose and adding betaine. 

I felt anxious, now I feel as if I was smoking cigarettes!!! Kind of burning... 

- 12.03.2021- doxepin- 50mg

- 6.11.2020- 75mg

- 16.10.2020- 100mg

- 30.09.2020- doxepin- 125mg

- May 2020, omeprazole 40mg switched to esomeprazole 20mg

- 2012 re-started Doxepin 75mg, evening. Increased to 150mg

- 2012, Atenolol 25mg, twice a day

- 2016, Low dose of HRT in evening, Sandrena and Utrogestan 

- Long term of Nasal spray Otrivine

- 2012, PPI Omeprazole 40mg-evening

24.10.2014- Started ESCITALOPRAM-first 5mg and then 10mg; due to the adverse symptoms reduced on 5.01.2015- Escitalopram- 2.5mg 22.07.2016- re-started reduction by 1% at a time. Completed tappering on  19.03.2020 😇

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2 hours ago, ikam said:

Preparing to tapper PPI, but unsuccessful 

I made a mistake by slipping a dose and adding betaine. 

I felt anxious, now I feel as if I was smoking cigarettes!!! Kind of burning... 

 

Having read this topic from the beginning, what do you think you should do now?

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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1 hour ago, Altostrata said:

 

Having read this topic from the beginning, what do you think you should do now?

I need to tapper slowly, I think I will be opening the pills and count the beads... 

I have been on PPI for years, I want to stop. They caused me iron deficiency, anemia in the past... 

 

I am sure they have a bad impact on other aspects of my health... 

I was surprised last night with the symptoms I had, it felt like a short term WD... I had problems with severe sweating and generally I was waking up constantly... 

During the day, I had some strange excitation and anxiety... 

All this happened after skipping just one dose and adding betaine... 

 

I am unsure why I am so sensitive to betaine... I cannot also tolerate cider vinegar... 

 

I have been following a sensible diet, I have my bed risen, I have supplements, such as probiotics... 

I also noticed that I cannot eat a lot of things as I get severe nausea, I read that this may relate to being unable to digest as there is not enough acid in my stomach... 

 

I will wait few days now to stabilise and restart tappering really carefully... 

 

 

- 12.03.2021- doxepin- 50mg

- 6.11.2020- 75mg

- 16.10.2020- 100mg

- 30.09.2020- doxepin- 125mg

- May 2020, omeprazole 40mg switched to esomeprazole 20mg

- 2012 re-started Doxepin 75mg, evening. Increased to 150mg

- 2012, Atenolol 25mg, twice a day

- 2016, Low dose of HRT in evening, Sandrena and Utrogestan 

- Long term of Nasal spray Otrivine

- 2012, PPI Omeprazole 40mg-evening

24.10.2014- Started ESCITALOPRAM-first 5mg and then 10mg; due to the adverse symptoms reduced on 5.01.2015- Escitalopram- 2.5mg 22.07.2016- re-started reduction by 1% at a time. Completed tappering on  19.03.2020 😇

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  • Administrator

Please read the information we give you and use your common sense.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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15 hours ago, Altostrata said:

Please read the information we give you and use your common sense.

Thank you Alto. I will... It seems that I am really sensitive to smallest changes in my protocol... Years of being medicated... 

- 12.03.2021- doxepin- 50mg

- 6.11.2020- 75mg

- 16.10.2020- 100mg

- 30.09.2020- doxepin- 125mg

- May 2020, omeprazole 40mg switched to esomeprazole 20mg

- 2012 re-started Doxepin 75mg, evening. Increased to 150mg

- 2012, Atenolol 25mg, twice a day

- 2016, Low dose of HRT in evening, Sandrena and Utrogestan 

- Long term of Nasal spray Otrivine

- 2012, PPI Omeprazole 40mg-evening

24.10.2014- Started ESCITALOPRAM-first 5mg and then 10mg; due to the adverse symptoms reduced on 5.01.2015- Escitalopram- 2.5mg 22.07.2016- re-started reduction by 1% at a time. Completed tappering on  19.03.2020 😇

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5 hours ago, ikam said:

It seems that I am really sensitive to smallest changes in my protocol

 

Please remember to only make one change at a time and if trying something new to start with a small test dose to see how you respond.  And it's also a good idea to do some research about it here (I use a search engine and add site: surviving antidepressants.org to my search term) and check for side effects and interactions at drugs.com

 

the-rule-of-3kis-keep-it-simple-keep-it-slow-keep-it-stable

 

 

Edited by ChessieCat

FINISH LINE here I come!!!

🏁

Current from 25 September 2021:  Pristiq 0.02mg

ADs since ~1992:  25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq:  50mg 2012, 100mg beg 2013 (Serotonin Toxicity)  Tapering Oct 2015 

My tapering program   My Intro (goes to my tapering graph)  My website

PLEASE NOTE:  I am not a medical professional.  I provide information and make suggestions.

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  • 7 months later...
Sicksagittarius

Hi @Altostrata

 

I've been taking 20 mg of omeprazole for months and increased it 40 mg of omeprazole within the past few months. If I gradually wean off of the omeprazole, since it apparently increases the lexapro in my system, will Iget stronger SSRI withdrawal symptoms because there wont be as much lexapro in my system? I'm on the trying to stabilize phase on 2.5 mg right now and its been helping. I've been having horrible stomach side effects from withdrawals such as diarrhea, stomach cramping and burning, extreme weight loss and malnutrition, limited diet etc. I want to heal my stomach problems and I learned from this thread that omeprazole is working against stomach healing. What do you recommend taking after I wean off omeprazole to stop any reflux or heart burn? 

  • 2014: Lexapro/escitalopram 10 mg
  • 2015-2021: Lexapro/escitalopram 20 mg
  • November 2020 - March 2021: decreased 20 mg to 15 mg, 1 mg a month
  • April 2021: decreased to 10 mg, stayed on this for 11 days 
  • April 2021: decreased to 5 mg, stayed on this for 8 days
  • April 2021: 3-6 days after quitting lexapro, withdrawal symptoms so reinstated 2.5 mg
  • April 2021: over 4 days, tried 2.5 mg, then 5 mg, then 2.5, then 5 again
  • May 2021-current: 2.5 mg

 

  • medication for for EGD and 2nd EGD/colonscopy for stomach issues: horrible side effects afterwards

stomach medications: 

  • November 2020: omeprazole 20 mg
  • March 2021: omeprazole 40 mg - cutting by 25% a month currently, may stop due to current wave 
  • March 20, 2021-July 10: hyoscyamine: .375 mg, twice a day, DONE!
  • March 20, 2021-July 25: mesalamine 1.2 GM, 3 times a day, - dropped final 1.2 mg on August 1st -caused a wave until current
  • March 30, 2021: zofran: 4 mg, 3-4 times daily, now only as needed stopped zofran, DONE!

allergy medications:

  • montelukast or singular: 10 mg once daily
  • zyrtec: 10 mg once daily 

birth control:

  • 2014-February 2021: Tri-linyah: quit cold turkey middle of pack, combination pill = POST PILL PCOS, ovarian cysts since May 2021 to present

Current Supplements:

  • Nordic Naturals Ultimate Omega omega 3 fish pill: 1280 mg in 2 pills
  • Boswelia Complex: 2 a day

  • Tried supps at once and caused intense wave I have currently, cold turkeyed them after weeks:

  • Probiophage DF: 2 a day

  • Microbiome host defense powder: 1/2-1 tsp

  • DIM

  • Quicksilver Liposomal multivitamin liquid: biotin, zinc, Vitamins A, C, D E, K, Niacin,, Thiomine, Riboflavin,Vitamin B6, B12, - immediate absorption liquid once a day 1 tsp

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Altostrata

I don't know how tapering omeprazole will affect the escitalopram in your system. For your other questions, please read this topic from the beginning.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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SkydiverSZ

Hi,

 

What really helped me coming off my PPI was drinking Dandelion root tea, yarrow tea and sometimes liquorice tea. Just be careful with the liquorice tea as that can cause other issues if you drink too much. Also try avoiding tomatoes, sugar, carbonated beverages, alcohol and spicy food for a couple of weeks. I still drink dandelion root tea daily to maintain a healthy stomach. From the research I have done I have learned that omeprazole increases Lexapro levels by 90 to 100%. So if you are taking 2.5mg Lexapro with omeprazole it is like taking 5mg Lexapro. So you might want to raise your Lexapro slightly to avoid more withdrawal symptoms. Please keep that in mind when tapering omeprazole.

Hope that helps.

1999-2001 Clomipramine (can't remember dosage)

2001-2003 Citalopram 10mg

2003-2017 Citalopram 20mg (tried various other SSRI and SNRI during this period but always came back to Citalopram after a month or two)

Late 2017 Citalopram Cold Turkey

June 2018- March 2021 Escitalopram 10mg + 80mg Propranolol

March 2021 Escitalopram Cold turkey 

April 2021 reinstated at 2.5mg and quit again after 3 days.

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JackieDecides
15 hours ago, SkydiverSZ said:

From the research I have done I have learned that omeprazole increases Lexapro levels by 90 to 100%.

 

I never new that...maybe that's why when I stopped lexapro it was so hard. 

 

but I have YET to get off omeprozole. I went from 40 down to 30 but stopped there as the rebound heartburn was just too bad. 😕

 

and also I can't keep from drinking coffee. 

Currently taking Ramapril (blood pressure) 5 mg twice a day

Omeprazole 10 mg AM and 20 mg PM  (the taper has gone nowhere after the first cut)

Famotidine   once a day (and I still needs tums sometimes)

magnesium 200 mg at night

as of yesterday 2 fish oil capsules "EPA-DHA 1000"

 

off Lexapro as of 5/2018  - last dose had been 5 mg every other day for a couple years

 

highest dose had been 20 mg at which point I was diagnosed with Bipolar II, which went away when I cut the lexapro down to 15 mg. 

 

I spent years on Paxil before Lexapro (can't remember dose), briefly on Effexor and Abilify and others I have forgotten. in fact, when I was diagnoses with BPII I was put on all kinds of things which made me feel so bad I stopped them cold turkey within maybe 3 or 4 weeks, thank goodness. since then I've known these pills were terrible and I weaned down the Lexapro with zero help or support over I'm not sure how many years. 

 

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SkydiverSZ

I have found the study I was refering to: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297217/

 

During the time I was using escitalopram together with omeprazole my liver enzymes where raised. My GP put it down to my alcohol consumption. As soon as I was off the omeprazole my liver enzymes normalized. I now believe that my raised liver enzymes where caused by the combination of omeprazole and escitalopram. For anyone who is currently on this combination, it might be worth to get your liver checked.

 

It seems that a switch to lansoprazole would be a good idea as it only raises the escitalopram levels by 20% instead of omeprazoles 94%. 

 

@JackieDecides The rebound heart burn was difficult to deal with. The teas I have mentioned really helped with that. Also it was extremely important to stay away from any triggers. One piece of chocolate or a meal with tomato sauce would set me back weeks. You have got to know your triggers and completely avoid them for weeks to come. I am still careful with tomatoes and chocolate months after coming off of omeprazole.

1999-2001 Clomipramine (can't remember dosage)

2001-2003 Citalopram 10mg

2003-2017 Citalopram 20mg (tried various other SSRI and SNRI during this period but always came back to Citalopram after a month or two)

Late 2017 Citalopram Cold Turkey

June 2018- March 2021 Escitalopram 10mg + 80mg Propranolol

March 2021 Escitalopram Cold turkey 

April 2021 reinstated at 2.5mg and quit again after 3 days.

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  • 1 month later...
Miko789

OnI 

 

The gastrologist gave stomach omepraxole and ibutine ppi . He said to take for a month  does it need taper the ibutine and ppi ? Read about in This thread had pain in stomach from pmed and stressor. One said gall bladder Anybody have this with shiprexa after long term use

7years use of pmeds prexat shiprexa. 

He concurred that was the culprit 

Hope my stomach dont get ulcer from cortizol.

Hope  gets ok.

 

 

 

 

2011 protracted withdrawal symptoms from Effexor, managed to come off
2013-2015  risperidone consta 50 mg, started tapering from March 2015 to 1,66mg/day and from 02/2015 started seroxat 10mg/day

01/17 Seroxat 2,0mg,olanzapine 5mg,risperidone consta 25mg/every 15days

05/17 Seroxat 1mg,olanzapine 5mg,risp.consta 25mg/every 15days

06/17 Seroxat 2drops,olanzapine 5mg,liquid risperidone2mg

07/17 Seroxat 1 drop,olanzapine 5mg,Risperidone 0mg, 10/17 Seroxat 0mg,olanzapine,5mg,Risperidone 0mg, 12/17 Seroxat 1/2 drop, olanzapine 5mg,  04/18 Olanzapine 1,25mg, 04/18 xanax 0,5mg

24/06/2019 doc said to take 10mg olanzapine for 13days and down to 5mg
 been taking 10mg for 14 days, 5mg for 8 days  and  tapered to  3/4quart. 5mg  for 14 days, 1/2 for 14 days,

01/08/19 2,5mg

08/2021 5mg olanzapine

Supplements Omega 3, Turmeric, Bacopa monneri

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  • 1 month later...
morgana

hello i ended up with pancreatitis due to too much alcohol and when i came out of hospital 4 days later they gave me Esomeprazole 20mg, i didnt take it and ended up back in hospital a week later with chest pain and stomach pain, they told me to take it, i took it for about 4 weeks and ate mostly raw veggies with pasta and fruit and porridge, no meat or dairy. since than..it took a good year for my stomach pain to disappear...now days when i get chest pain, stomach pain i have usually eaten too much fatty foods such chocolate, butter, avocado's, creamy pasta dishes.. if the pain is too unbearable and i am finding it hard to sleep and breath i take a 20mg tablet usually that is enough to fix it,  until it happens again...probably need to take 1 or 2 tablets every couple of months or so... i also notice when i make changes in my taper off zyprexa which sometimes  causes me to have chest pains i find it helps with that too....just looked at pkt i got the prescription 0n 2nd Jan 2020 and i have taken 21 tablets from the pkt, so i dont use them very often..and i just looked at the use by date and its out of date....since june 2021...!....

dont know if what i have written has been any use to anyone but just thought i might add it...just in case it does

Cipramil  40mg  1996 to October 2017 stopped cold turkey

Zyprexa 10mg solid form  1996 to October 2017

Zyprexa 7.5mg solid form  October 2017 to October 2019

Zyprexa 5mg solid form  October 2019 to April 2020

Zyprexa 3.75mg solid form April 2020 to May 2020

Zyprexa 2.5mg solid form  May 2020 to feb 2021

Zyprexa 2.5mg solid 3/4 and 1/4 liquid w/ 5mls water 6th Feb 2021 to 2nd April 2021

Zyprexa 2.5mg 1/2 solid and 1/2 liquid w/10mls water 3rd April to 26th June 2021

Zyprexa 2.5mg disolved in 25mls of water from 27th june 2021 to present

Supplements: fish oil, Magnesium 

 

 

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  • 4 weeks later...
Sicksagittarius
On 5/22/2021 at 8:39 AM, SkydiverSZ said:

Hi,

 

What really helped me coming off my PPI was drinking Dandelion root tea, yarrow tea and sometimes liquorice tea. Just be careful with the liquorice tea as that can cause other issues if you drink too much. Also try avoiding tomatoes, sugar, carbonated beverages, alcohol and spicy food for a couple of weeks. I still drink dandelion root tea daily to maintain a healthy stomach. From the research I have done I have learned that omeprazole increases Lexapro levels by 90 to 100%. So if you are taking 2.5mg Lexapro with omeprazole it is like taking 5mg Lexapro. So you might want to raise your Lexapro slightly to avoid more withdrawal symptoms. Please keep that in mind when tapering omeprazole.

Hope that helps.

 @SkydiverSZ Thank you so much for this helpful information! Have you seen anyone on this site with the experience of tapering off omeprazole while tapering off lexapro I could tag to ask for their experience? Also, how would I figure out how much to raise my lexapro by and how much to decrease my omeprazole? Thanks!

  • 2014: Lexapro/escitalopram 10 mg
  • 2015-2021: Lexapro/escitalopram 20 mg
  • November 2020 - March 2021: decreased 20 mg to 15 mg, 1 mg a month
  • April 2021: decreased to 10 mg, stayed on this for 11 days 
  • April 2021: decreased to 5 mg, stayed on this for 8 days
  • April 2021: 3-6 days after quitting lexapro, withdrawal symptoms so reinstated 2.5 mg
  • April 2021: over 4 days, tried 2.5 mg, then 5 mg, then 2.5, then 5 again
  • May 2021-current: 2.5 mg

 

  • medication for for EGD and 2nd EGD/colonscopy for stomach issues: horrible side effects afterwards

stomach medications: 

  • November 2020: omeprazole 20 mg
  • March 2021: omeprazole 40 mg - cutting by 25% a month currently, may stop due to current wave 
  • March 20, 2021-July 10: hyoscyamine: .375 mg, twice a day, DONE!
  • March 20, 2021-July 25: mesalamine 1.2 GM, 3 times a day, - dropped final 1.2 mg on August 1st -caused a wave until current
  • March 30, 2021: zofran: 4 mg, 3-4 times daily, now only as needed stopped zofran, DONE!

allergy medications:

  • montelukast or singular: 10 mg once daily
  • zyrtec: 10 mg once daily 

birth control:

  • 2014-February 2021: Tri-linyah: quit cold turkey middle of pack, combination pill = POST PILL PCOS, ovarian cysts since May 2021 to present

Current Supplements:

  • Nordic Naturals Ultimate Omega omega 3 fish pill: 1280 mg in 2 pills
  • Boswelia Complex: 2 a day

  • Tried supps at once and caused intense wave I have currently, cold turkeyed them after weeks:

  • Probiophage DF: 2 a day

  • Microbiome host defense powder: 1/2-1 tsp

  • DIM

  • Quicksilver Liposomal multivitamin liquid: biotin, zinc, Vitamins A, C, D E, K, Niacin,, Thiomine, Riboflavin,Vitamin B6, B12, - immediate absorption liquid once a day 1 tsp

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Sicksagittarius
On 5/15/2021 at 6:40 PM, Altostrata said:

I don't know how tapering omeprazole will affect the escitalopram in your system. For your other questions, please read this topic from the beginning.

@AltostrataAccording to this journal article, (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297217/), Escitalopram  (lexapro) concentrations were significantly higher in patients treated with omeprazole by 93 percent. For some reason these two specific drugs interact and so I'm afraid of how to lower it in a timely manner without it putting me back into deep withdrawals

 

"most pronounced effect was seen when omeprazole or esomeprazole was combined with escitalopram, causing an almost 2-fold increase in the escitalopram levels. Thus, when omeprazole or esomeprazole is combined with escitalopram, it should be considered to reduce the dose of escitalopram. In contrast, the effects of the other PPIs on escitalopram and of all PPIs on citalopram and sertraline were so small that they could be considered clinically insignificant."

  • 2014: Lexapro/escitalopram 10 mg
  • 2015-2021: Lexapro/escitalopram 20 mg
  • November 2020 - March 2021: decreased 20 mg to 15 mg, 1 mg a month
  • April 2021: decreased to 10 mg, stayed on this for 11 days 
  • April 2021: decreased to 5 mg, stayed on this for 8 days
  • April 2021: 3-6 days after quitting lexapro, withdrawal symptoms so reinstated 2.5 mg
  • April 2021: over 4 days, tried 2.5 mg, then 5 mg, then 2.5, then 5 again
  • May 2021-current: 2.5 mg

 

  • medication for for EGD and 2nd EGD/colonscopy for stomach issues: horrible side effects afterwards

stomach medications: 

  • November 2020: omeprazole 20 mg
  • March 2021: omeprazole 40 mg - cutting by 25% a month currently, may stop due to current wave 
  • March 20, 2021-July 10: hyoscyamine: .375 mg, twice a day, DONE!
  • March 20, 2021-July 25: mesalamine 1.2 GM, 3 times a day, - dropped final 1.2 mg on August 1st -caused a wave until current
  • March 30, 2021: zofran: 4 mg, 3-4 times daily, now only as needed stopped zofran, DONE!

allergy medications:

  • montelukast or singular: 10 mg once daily
  • zyrtec: 10 mg once daily 

birth control:

  • 2014-February 2021: Tri-linyah: quit cold turkey middle of pack, combination pill = POST PILL PCOS, ovarian cysts since May 2021 to present

Current Supplements:

  • Nordic Naturals Ultimate Omega omega 3 fish pill: 1280 mg in 2 pills
  • Boswelia Complex: 2 a day

  • Tried supps at once and caused intense wave I have currently, cold turkeyed them after weeks:

  • Probiophage DF: 2 a day

  • Microbiome host defense powder: 1/2-1 tsp

  • DIM

  • Quicksilver Liposomal multivitamin liquid: biotin, zinc, Vitamins A, C, D E, K, Niacin,, Thiomine, Riboflavin,Vitamin B6, B12, - immediate absorption liquid once a day 1 tsp

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Altostrata

If you want to go off omeprazole, you will have to do it gradually and monitor the effects. If you feel you are getting withdrawal symptoms, it may make sense to increase escitalopram.

 

Please note you are taking only 2.5mg escitalopram. The liver enzymes involved in metabolized this tiny amount of escitalopram and whatever amount of omeprazole you're taking may be having no problems at all processing both drugs simultaneously. There may be no difference in escitalopram levels or effect when you go off omeprazole.

 

I doubt if any of the subjects in those studies were taking as low as 2.5mg escitalopram. They probably were taking 10mg, 20mg, or more.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

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