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Pogliani, 2010 Paroxetine and neonatal withdrawal syndrome.


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As in all cases of this type, the researchers can report only the observable symptoms of neonatal distress. The researchers recommend the newborns "should be followed to assess the long-term effects of prolonged exposure to SSRIs" -- because nobody knows what this may be.
BMJ Case Rep. 2010 Apr 29;2010. pii: bcr1220092528. doi: 10.1136/bcr.12.2009.2528.

Paroxetine and neonatal withdrawal syndrome.

Pogliani L, Schneider L, Dilillo D, Penagini F, Zuccotti GV.




L Sacco Hospital, Department of Pediatrics, Milan, Italy.


Abstract and free full text at http://www.ncbi.nlm.nih.gov/pubmed/22736561


We report a case of neonatal withdrawal syndrome after in utero exposure to paroxetine 20 mg/day. The infant's symptoms, such as poor neonatal adaptation, respiratory distress, decerebrate posturing, irritability and tremors, commenced soon after birth and persisted for 5 days. All neonates exposed to antidepressants, particularly serotonin reuptake inhibitors (SSRIs), during the last trimester should be followed-up closely for adverse symptoms.

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  • 3 weeks later...

Very sad.

Pristiq tapered over 8 months ending Spring 2011 after 18 years of polydrugging that began w/Zoloft for fatigue/general malaise (not mood). CURRENT: 1mg Klonopin qhs (SSRI bruxism), 75mg trazodone qhs, various hormonesLitigation for 11 years for Work-related injury, settled 2004. Involuntary medical retirement in 2001 (age 39). 2012 - brain MRI showing diffuse, chronic cerebrovascular damage/demyelination possibly vasculitis/cerebritis. Dx w/autoimmune polyendocrine failure.<p>2013 - Dx w/CNS Sjogren's Lupus (FANA antibodies first appeared in 1997 but missed by doc).

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